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 0001012477

 2023-01-01
 2023-12-31

 0001012477

 2023-06-30

 0001012477

 2024-04-24

 UNITED STATES

 SECURITIES AND EXCHANGE COMMISSION

 Washington, D.C. 20549

 FORM 10-K/A

 (Amendment No. 1)

 x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For
the fiscal year ended December
31, 2023

 OR

 TRANSITION
REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For the transition period ____________ to ____________

 Commission file number: 001-37977

 AVADEL PHARMACEUTICALS PLC

 (Exact name of registrant as specified in its
charter)

 Ireland

 98-1341933

 State
 or other jurisdiction of incorporation or organization

 (I.R.S.
 Employer Identification No.)

 10 Earlsfort Terrace

 Dublin
 2, Ireland

 D02 T380

 Not
 Applicable

 (Address
 of principal executive offices)

 (Zip
 Code)

 Registrant's
 telephone number, including area code: + 353 - 1 - 901-5201

 Securities registered pursuant to Section 12(b) of
the Act:

 Title
 of each class

 Trading
 Symbol(s)

 Name
 of exchange on which registered

 Ordinary
 Shares, nominal value $0.01 per share

 AVDL

 The
 Nasdaq Global Market

 Securities registered pursuant to Section 12(g) of
the Act: None

by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes x No

by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes No x

by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days. Yes x No

by check mark whether the registrant has submitted electronically, every Interactive Data File required to be submitted and pursuant
to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the
registrant was required to submit such files). Yes x No

 Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company.
See the definitions of "large accelerated filer", "accelerated filer", "smaller reporting company",
and "emerging growth company" in Rule 12b-2 of the Exchange Act.

 Large
accelerated filer x
 Accelerated filer

 Non-accelerated
filer
 Smaller reporting company

 Emerging
growth company

 If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness
of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the
registered public accounting firm that prepared or issued its audit report. x

 If securities
are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant
included in the filing reflect the correction of an error to previously issued financial statements.

by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation
received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).

by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes No x

 The aggregate market value of voting stock held
by non-affiliates of the registrant as of the last business day of the registrant's most recently completed second fiscal quarter
was $ 1,459,121,731 based on the closing sale price of the registrant's American Depositary
Shares as reported by the Nasdaq Global Market on June 30, 2023. Such market value excludes 781,680
 ordinary shares, $0.01 per share nominal value, which may be represented by the registrant's American Depositary Shares,
held by each officer and director and by shareholders that the registrant concluded were affiliates of the registrant on that date. Exclusion
of such shares should not be construed to indicate that any such person possesses the power, direct or indirect, to direct or cause the
direction of the management or policies of the registrant or that such person is controlled by or under common control with the registrant.

 The number of the registrant's ordinary
shares, $0.01 per share nominal value, outstanding as of April 24, 2024 was 96,116,323.

 DOCUMENTS INCORPORATED BY REFERENCE

 None.

 EXPLANATORY NOTE

 The registrant is filing this Amendment No. 1
to Annual Report on Form 10-K/A, or this Amendment (also referred to herein as this report), to amend the Annual Report on Form 10-K for the fiscal year ended December 31, 2023 (Commission File Number 001-37977), or the Annual Report on Form 10-K, as filed
by the registrant with the Securities and Exchange Commission, or the SEC, on February 29, 2024. The sole purpose of this Amendment
is to include in Part III the information previously omitted from the Annual Report on Form 10-K in reliance on General Instruction
G(3) to Form 10-K. This Amendment hereby amends the cover page, Part III, Items 10 through 14, and Part IV, Item
15 of the Annual Report on Form 10-K. In addition, as required by Rule 12b-15 under the Securities Exchange Act of 1934, as
amended, or the Exchange Act, new certifications by the registrant's principal executive officer and principal financial officer
are filed as exhibits to this Amendment.

 No attempt has been made in this Amendment to
modify or update the other disclosures presented in the Annual Report on Form 10-K. This Amendment does not reflect events occurring
after the filing of the original report (i.e., those events occurring after February 29, 2024) or modify or update those disclosures
that may be affected by subsequent events. Accordingly, this Amendment should be read in conjunction with the Annual Report on Form 10-K
and the registrant's other filings with the SEC.

 In this report, unless otherwise indicated
or the context otherwise requires, all references to "Avadel," "the registrant," "the company," "we,"
"us," and "our" refer to Avadel Pharmaceuticals plc and its consolidated subsidiaries.

 AVADEL PHARMACEUTICALS PLC

 2023 Annual Report on Form 10-K

 Amendment No. 1

 Page #

 Item
 10.

 Directors,
 Executive Officers and Corporate Governance

 Item
 11.

 Executive
 Compensation

 Item
 12.

 Security
 Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 Item
 13.

 Certain
 Relationships and Related Transactions, and Director Independence

 Item
 14.

 Principal
 Accounting Fees and Services

 Item
 15.

 Exhibits

 SIGNATURES

 - 3 -

 Item 10.
 Directors, Executive Officers
 and Corporate Governance.

 The following table sets forth for each director
and the executive officers of the Company, their ages and positions with the Company as of April 7, 2024.

 Name

 Age

 Position

 Chief Executive Officer
 and Director

 Chief Financial Officer

 Chief Commercial Officer

 Geoffrey M. Glass

 Chair of the Board of
 Directors

 Eric J. Ende, M.D.

 Mark A. McCamish, M.D., Ph. D.

 Linda S. Palczuk

 Peter J. Thornton

 Executive Officers

J. Divis was appointed Chief Executive Officer and became a member of the Board of Directors (the "Board") in
June 2019. He was appointed Executive Vice President and Chief Commercial Officer of Avadel in January 2017 and was promoted
to Chief Operating Officer in March 2018. Mr. Divis brings to this role more than 25 years of experience in the pharmaceutical
industry and is responsible for managing commercial strategy and execution across all of the Company's portfolio products. Prior
to joining Avadel, Mr. Divis served as an Executive Residence for Linden Capital, a middle-market healthcare-focused private equity
firm from June 2015 to December 2016. Prior to Linden Capital, from May 2010 to November 2014 Mr. Divis was
the President and Chief Executive Officer of Lumara Health (formerly known as K-V Pharmaceutical Company), a company engaged in the development
of proprietary drug delivery systems and formulation technologies, which was eventually acquired by AMAG Pharmaceuticals in November 2014.
Mr. Divis has also held such notable roles as President, Ther-Rx Corporation, Vice-President, Business Development & Lifecycle
Management at Sanofi-Aventis and Vice-President and General Manager, UK and Ireland, for Schering-Plough Corporation. Mr. Divis
is a graduate of the University of Iowa.

S. McHugh was appointed as Chief Financial Officer in December 2019. Before joining Avadel, Mr. McHugh was the Senior
Vice President, Finance at Ironshore Pharmaceuticals, a pharmaceutical company, from November 2018 to November 2019. From December 2014
to November 2018, Mr. McHugh worked as an independent consultant at KTC Advisors, a consulting firm. Prior to KTC Advisors,
from January 2009 to November 2014, Mr. McHugh was the Chief Financial Officer of K-V Pharmaceutical Company, or K-V,
a company engaged in the development of proprietary drug delivery systems and formulation technologies, which was eventually acquired
by AMAG Pharmaceuticals in November 2014. Mr. McHugh earned a B.S. in Finance from Bentley University and a M.S. in Accounting
from Northeastern University.

 Richard
J. Kim was appointed as Chief Commercial Officer in February 2021. Prior to joining Avadel, Mr. Kim served as the
President of U.S. Commercial & Strategic Marketing at Intercept Pharmaceuticals, Inc. ("Intercept"), a biopharmaceutical
company (Nasdaq: ICPT), from February 2018 to February 2021, and Senior Vice President of U.S. Commercial at Intercept, from
July 2015 to January 2018. Prior to joining Intercept, Mr. Kim worked at Bristol-Myers Squibb from September 2004
to July 2015, with his last leadership role being General Manager, Hepatitis C Worldwide Commercialization from September 2012
to July 2015. Prior to this, Mr. Kim held a number of roles of increasing responsibility leading sales, operational and strategic
marketing teams at Bristol-Myers Squibb, including Vice President, SPRYCEL Brand Lead, Oncology Global Marketing; Vice President,
U.S. In-Line Oncology and Global Marketing; and Vice President, East Area Sales, Cardiovascular and Metabolics. Prior to his time at
Bristol-Myers Squibb, Mr. Kim held a range of senior positions in the U.S., Canada and Australia at Schering- Plough, which was
acquired by Merck & Co., Inc. Mr. Kim earned a B.S. in Chemistry from the University of Alberta.

 - 4 -

 Non-Employee Directors

 Geoffrey
M. Glass has been a member of the Board since July 2018 and became Chair of the Board in December 2018. Since January 2021,
Mr. Glass has served as the Chief Executive Officer of Kiniciti, LLC, a company that invests in non-therapeutic companies supporting
cell and gene therapy innovation. He is also currently the Chairman of the Board at Ncardia, a drug discovery company focused on cardiovascular
and neurological diseases, serving in that role since November of 2021. Further, since June of 2022, Mr. Glass has served
as Chairman of the Board at Abzena, a biologics and bioconjugates development company. Mr. Glass has also been the Operating Partner
at LongueVue Capital. Previously, he was the Chief Executive Officer (from January 2018 through September 2018), and a member
of the board of directors (from November 2017 through December 2018), of Sancilio Pharmaceuticals, a specialty pharma company.
Mr. Glass was also a member of the board of directors for Locus Biosciences, a biotechnology company that develops CRISPR- engineered
precision antibacterial products, from August 2015 to October 2017. From April 2009 to April 2015, Mr. Glass
served as an executive committee member at Patheon N.V., a pharmaceutical contract development and manufacturing company. While at Patheon,
he held a number of senior leadership roles including President of Banner Life Sciences (a Patheon subsidiary), Executive Vice President
of Sales and Marketing, and Senior Vice President, Strategy, Corporate Development and Integration for Patheon. Before Patheon, Mr. Glass
worked in various executive positions at Valeant Pharmaceuticals (now Bausch Health), including Senior Vice President, Asia Region, and
Senior Vice President, Chief Information Officer, and in both roles was a member of the company's executive committee. Mr. Glass
began his career as a consultant in the life sciences practice for Capgemini Consulting (formerly EY Consulting). He received degrees
in Economics and Political Science from the University of Arizona.

 We believe Mr. Glass's extensive management
and financial experience makes him well qualified to serve as a director.

 Dr. Eric
J. Ende has been a member of the Board since December 2018. Dr. Ende is the President of Ende BioMedical Consulting
Group, a privately held consulting company focused on the life sciences industry, a position he has held since 2009. Since May 2017,
Dr. Ende has been a member of the board of directors of Matinas BioPharma, Inc., a clinical-stage biopharmaceutical company,
where he is currently Chairman of the Board in addition to serving on the Nominating and Corporate Governance Committee. Dr. Ende
also serves on the board of directors at Neubase Therapeutics, a company focused on genetic medicines development, and at Mount Sinai
Innovation Partners Technology, a healthcare research and development organization. From November 2019 to June 2020, Dr. Ende
served on the board of directors and as a member of the Audit, Compensation and Science Committees of Progenics Pharmaceuticals, Inc.,
a biopharmaceutical company, until it was acquired by Lantheus Holdings, Inc. From January 2015 to October 2016, he served
as Chairman of the Unsecured Creditor's Committee in the bankruptcy of Egenix, Inc. From 2010 to 2011, Dr. Ende served
on the board of directors and as a member of the Audit and Risk Management Committees of Genzyme Corp., a biotechnology company, until
it was acquired in 2011 by Sanofi S.A. From 2002 through 2008, Dr. Ende was the senior biotechnology analyst at Merrill Lynch; from
2000 through 2002 he was the senior biotechnology analyst at Bank of America Securities; and from 1997 to 2000 he was a biotechnology
analyst at Lehman Brothers. Dr. Ende received an MBA in Finance and Accounting from NYU - Stern Business School in 1997, an MD from
Mount Sinai School of Medicine in 1994, and a BS in Biology and Psychology from Emory University in 1990.

 We believe Dr. Ende's experience as
a director for other pharmaceuticals companies makes him well qualified to serve as a director.

 Dr. Mark
A. McCamish has been a member of the Board since December 2019. Since November 2020, Dr McCamish has served as President,
Chief Executive Officer and member of the board of directors of IconOVir Bio, Inc., a biotechnology company focused on development
of oncolytic virus therapies. From May 2017 to April 2020, Dr. McCamish served as President, Chief Executive Officer and
member of the board of directors of Forty Seven, Inc, a clinical-stage biopharmaceutical company, which was acquired by Gilead Sciences, Inc.
in April 2020. From July 2009 to April 2017, Dr. McCamish served as Global Head of Biopharmaceutical Development
at Sandoz Inc., a pharmaceutical company. He has over 30 years of experience in corporate management, clinical and pharmaceutical research
and academics. Dr. McCamish currently serves on the board of directors of Rafael Holdings, Inc., a publicly traded biopharmaceutical
company focused on development of cancer and immune therapies, and he has also served on the board of directors of Vincerx Pharma, Inc.
from December 2020 to May 2021. Dr. McCamish received both a Bachelor's and a Master's degree from the University
of California at Santa Barbara, a Ph. D. in Human Nutrition from the Pennsylvania State University and an M.D. from the University of
California at Los Angeles. He is Board Certified in Internal Medicine and Nutrition and Metabolism.

 - 5 -

 We believe Dr. McCamish's broad experience
in the life sciences industry makes him well qualified to serve as a director.

 Linda
S. Palczuk has been a member of the Board since July 2018. From September 2019 to December 2022, Ms. Palczuk
served as the Chief Operating Officer and a director of Envara Health, Inc., a medical nutrition technology company. Before that,
Ms. Palczuk was the Chief Operating Officer of Verrica Pharmaceuticals, Inc., a late-stage biopharmaceutical company focused
on medical dermatology products, from February 2018 to April 2019. Prior to joining Verrica Pharmaceuticals, from July 2017
to February 2018, Ms. Palczuk was President and Chief Executive Officer at Osiris Therapeutics, Inc., a regenerative medicines
biotechnology company. Prior to her position at Osiris Therapeutics, Ms. Palczuk had an extensive and successful 30-year career
with AstraZeneca Pharmaceuticals and its legacy companies, serving in senior-level commercial and general management roles, including
Vice President, Established Brands and Vice President, Global Commercial Excellence from January 2012 until March 2015, Vice
President, Sales & Marketing from March 2009 to December 2011, and Vice President, Sales from April 2006 to February 2009.
From June 2015 until July 2017, Ms. Palczuk was an independent consultant providing business expertise within the pharmaceutical
sector. Ms. Palczuk received a BA degree in Biology from Franklin and Marshall College and an MBA degree from the Alfred Lerner
College of Business and Economics at the University of Delaware.

 We believe Ms. Palczuk's extensive
pharmaceutical and biotechnology management experience makes her well qualified to serve as a director.

 Peter
J. Thornton has been a member of the Board since June 2017. He is the President and Chief Financial Officer of Envetec
Sustainable Technologies Limited, an Irish cleantech company focused on the carbon neutral treatment of biohazardous clinical material
and plastics at source. From January 2014 to January 2022, he was the Chief Financial Officer of Technopath Clinical Diagnostics,
which was acquired by LGC Group in January 2021. Prior to joining Technopath Clinical Diagnostics, from September 2011 to December 2013,
Mr. Thornton was Senior Vice President - Business Integration for Alkermes plc, a global biopharmaceuticals company headquartered
in Dublin, Ireland. From July 2007 to September 2011, he was Senior Vice President — Corporate and Business Development
for Elan Drug Technologies, an Elan Corporation plc division engaged in developing and manufacturing drug delivery technology based pharmaceutical
products. From September 2006 to July 2007, he was President and Chief Operating Officer of Circ Pharma Limited, a specialty
pharmaceutical company and from June 2004 to September 2006 he was Chief Financial Officer of Agenus Inc., a Nasdaq-listed
biotechnology company. Mr. Thornton has previously served as a non-executive director of both public and private companies and currently
is a non-executive director of Oculer Limited, a private company focused on rapid microbiology testing technology. Mr. Thornton
worked for the international public accounting firm of KPMG for seven years in Ireland and France and is a fellow of Chartered Accountants
Ireland. He holds a Bachelor of Commerce degree from University College Cork, Ireland.

 We believe Mr. Thornton's experience
as a chief financial officer and his financial expertise make him well qualified to serve as a director.

 Family Relationships

 There is no family relationship between any director
or executive officer of the Company. There are no material proceedings to which any director, officer or affiliate, or any associate
thereof, of the Company, any owner of record or beneficially of more than five percent of any class of voting securities of the Company,
or security holder is a party adverse to the Company or any of its subsidiaries or has a material interest adverse to the Company or
any of its subsidiaries. During the past ten years, none of our officers, directors, promoters or control persons have been involved
in any legal proceedings as described in Item 401(f) of Regulation S-K.

 - 6 -

 Corporate Governance Guidelines

 The Board has adopted corporate governance guidelines
that set forth the practices of the Board with respect to the qualification, selection and election of directors, director orientation
and continuing education, director responsibilities, Board composition and performance, director access to management and independent
advisors, director compensation guidelines, management evaluation and succession, policies regarding the independent directors, meetings
of the non-management directors, the policy on communicating with the non-management directors and various other issues. A copy of our
corporate governance guidelines is available at  A printed copy is available
free of charge to any shareholder who requests it by contacting the Company Secretary in writing at Ten Earlsfort Terrace, Dublin 2,
D02 T380 Ireland.

 Audit Committee

 Composition, Qualifications and Governance

 The Board has an Audit Committee composed of
Peter J. Thornton (Chair), Dr. Eric J. Ende, Geoffrey M. Glass and Dr. Mark A. McCamish. The Board has determined that all
of the members of the Audit Committee are independent within the meaning of applicable SEC regulations and the listing standards of Nasdaq,
and that each member is financially literate within the meaning of such listing standards. The Board has also determined that Mr. Thornton,
as the Chair of the Committee, (i) is independent within the meaning of applicable SEC regulations and the listing standards of
Nasdaq, (ii) is qualified as an audit committee financial expert within the meaning of SEC regulations, and (iii) has accounting
and related financial management expertise within the meaning of the listing standards of Nasdaq and that he is financially literate
within the meaning of such listing standards. In addition, the Board has determined that the composition satisfies the requirements of
the Companies Act.

 The Audit Committee has a written charter, which
is available on our website at  The Audit Committee
reviews the charter annually and works with the Board to amend it as appropriate to reflect the evolving role of the Audit Committee.

 Responsibilities and Duties

 The Audit Committee recommends to the Board the
selection of the Company's independent registered public accounting firm and reviews the findings of the auditors and operates
in accordance with the Audit Committee Charter. The Audit Committee Charter outlines the roles and responsibilities of the Audit Committee
which includes appointment, compensation and oversight of the work of any registered public accounting firm employed by the Company and
review of related party transactions pursuant to the Company's policy. The Audit Committee also assists the Board in oversight
of: (1) the integrity of the financial statements of the Company; (2) the adequacy of the Company's system of internal
controls; (3) compliance by the Company with legal and regulatory requirements; (4) the qualifications and independence of
the Company's independent auditors; and (5) the performance of the Company's independent and internal auditors. The
Audit Committee met five times during 2023.

 Changes to Procedures for Recommending Nominees
to Board of Directors

 None.

 Code of Conduct and Financial Integrity Policy

 We have adopted a written Code of Conduct (the
"Code") that applies to all of our employees, as well as a Financial Integrity Policy (the "Financial Integrity Policy")
that applies to our Chief Executive Officer, Chief Financial Officer, Chief Accounting Officer, Senior Tax Director and Controller (or
persons performing similar functions). These documents cover a broad range of professional conduct, including employment policies, conflicts
of interest, intellectual property and the protection of confidential information, as well as adherence to all laws and regulations applicable
to the conduct of our business. A copy of the Code and the Financial Integrity Policy is available at
If we make any substantive amendments to, or grant any waivers from, the Code or Financial Integrity Policy for any officer or director,
we intend to satisfy the disclosure requirement under Item 5.05 of Form 8-K by disclosing the nature of such amendment or waiver
on our website or in a current report on Form 8-K.

 - 7 -

 Item 11.
 Executive Compensation.

 EXECUTIVE COMPENSATION - COMPENSATION
DISCUSSION AND ANALYSIS

 Compensation Discussion and Analysis

 In this Compensation Discussion and Analysis,
we give an overview and analysis of our compensation philosophy, our compensation program, and the decisions we made in 2023 under those
programs with respect to our named executive officers. Included in this discussion is specific information about the compensation earned
or paid in 2023 to our named executive officers (the "Named Executive Officers"). Named Executive Officers for 2023 are:

 Name

 Position

 J. Divis

 Chief
 Executive Officer

 Richard
 J. Kim

 Chief
 Commercial Officer

 S. McHugh

 Chief
 Financial Officer

 Compensation Philosophy and Objectives

 The Compensation Committee's executive
compensation programs are designed to: (i) attract, retain and motivate executives with significant industry knowledge and the experience
and leadership capability necessary for us to achieve success; (ii) align incentives for our named executive officers with our corporate
strategies and business objectives and goals; and (iii) achieve key strategic performance measures aligned with the long-term interests
of our shareholders.

 Compensation Components

 Our executive compensation program has three
primary components: base salary, annual cash incentive awards and equity awards.

 Base
 Salary. We fix the base salary of each of our executive officers at a level we believe
 enables us to hire and retain individuals in a competitive environment and rewards satisfactory
 individual performance and a satisfactory level of contribution to our overall business goals.
 We take into account the base salaries paid by similarly situated companies in our peer group
 and, to the extent practicable, we set base salary levels for similarly situated executives
 within the Company at comparable levels to avoid divisiveness and encourage teamwork, collaboration,
 and a cooperative working environment.

 Cash
 Incentive Awards. We provide annual cash incentive awards that are based upon the achievement
 of corporate and individual objectives established by the Compensation Committee and the
 Board of Directors. These cash incentive awards are designed to focus our executive officers
 on achieving key clinical, regulatory, commercial, operational, strategic and financial objectives.

 Equity
 Awards. We use stock options, restricted share units and performance share units to reward
 long-term performance. These equity awards are intended to provide significant incentive
 value for each executive officer if the Company performance is outstanding and the Company
 achieves its long-term goals to align executive compensation with long-term shareholder interests.

 In addition to the primary components of compensation
described above, we provide our Named Executive Officers with employee benefits that are generally available to our salaried employees.
These benefits include health and medical benefits, flexible spending plans, matching 401(k) contributions and group life insurance.

 We have also entered into agreements with our
Named Executive Officers under which they are provided certain benefits in the event their employment with the Company is terminated
without cause or by the Named Executive Officer for good reason, following a change in control of the Company.

 - 8 -

 Compensation Policies and Process

 The Compensation Committee has oversight of our
compensation philosophy and programs and annually reviews and recommends all compensation decisions relating to our Chief Executive Officer,
our other Named Executive Officers and all other executive officers of the Company. The Chief Executive Officer provides specific information
to the committee relative to the performance of the other members of the executive management team. However, the Chief Executive Officer
is always excused from the Compensation Committee meetings when his compensation or employment is discussed. The Compensation Committee
considers any recommendations by the Chief Executive Officer; however, the committee recommends final compensation for all executives.
All compensation decisions are assessed within the framework of the Company's financial position and general economic conditions.
Our Board typically reviews and approves the compensation decisions made by the Compensation Committee.

 Our Compensation Committee has engaged Aon's
Human Capital Solutions Practices, a division of Aon plc ("Aon") specializing in executive compensation, as its independent
compensation consultant. In connection with the Compensation Committee's executive compensation decisions for 2023, Aon reviewed
and advised on principal aspects of our executive compensation program and performed the following services:

 conducted
 a competitive assessment of the Company's then current executive compensation arrangements,
 including analyzing peer group Proxy Statements, compensation survey data, and other publicly
 available data;

 provided
 recommendations on the composition of the Company's peer group; and

 reviewed
 and advised on equity compensation and on industry best practices.

 The Compensation Committee has determined that
the work of Aon and the individual compensation advisors employed by Aon does not create any conflict of interest. In making that determination,
the Compensation Committee took into consideration the following factors: (i) the provision of other services to the Company by
the consultant; (ii) the amount of fees the Company paid the consultant as a percentage of the consultant's total revenue;
(iii) the consultant's policies and procedures that are designed to prevent conflicts of interest; (iv) any business
or personal relationship of the consultant or the individual compensation advisors employed by the consultant with any Company executive
officer; (v) any business or personal relationship of the individual compensation advisors with any member of the Compensation Committee;
and (vi) any Company stock owned by the consultant or the individual compensation advisors employed by the consultant.

 Peer Group

 In an effort to provide competitive total compensation
to our executive officers, the Compensation Committee approved a group of comparable companies as our peer group as recommended by Aon.
The peer group was selected on the basis of similarity to the Company on the following criteria: business comparability, stage of product
development and commercialization, number of employees, market capitalization and revenue. The following companies were identified as
our "peer group" for 2023:

 2023
 Peer Group

 Aldeyra

 Deciphera

 Amylyx

 Harmony
 Biosciences Holdings, Inc.

 Anika

 Harrow, Inc.

 Ardelyx, Inc.

 Intercept

 Axsome

 Liquidia
 Corporation

 BioXcel

 Marinus

 Collegium
 Pharmaceutical, Inc.

 Mirum

 CymaBay

 Rhythm

 - 9 -

 Say-on-Pay and Say-on-Frequency

 We have developed a compensation policy that
is designed to attract and retain key executives responsible for our success and motivate management to enhance long-term shareholder
value. We believe our compensation policy strikes an appropriate balance between the implementation of responsible, measured compensation
practices and the effective provision of incentives for our named executive officers to exert their best efforts for our success.

 As required by Section 14A(a)(1) of
the Exchange Act, periodically we must provide our shareholders with an opportunity to provide an advisory vote related to the compensation
of our named executive officers, commonly known as the "say-on-pay" proposal. The SEC say-on-pay vote generally covers the
calendar year prior to the date of our proxy statement. As such vote is advisory, it is not binding upon our Board or our Compensation
Committee and neither the Board nor the Compensation Committee is required to take any action as a result of the outcome of such vote.
However, our Compensation Committee carefully considers the outcome of this vote when considering future executive compensation policies.

 As reported in our report on Form 8-K, filed
with the SEC on August 5, 2022, at our 2022 annual general meeting, approximately 93% of the votes cast on our SEC Say-on-Pay proposal
supported the compensation paid to our named executive officers. At our 2022 annual general meeting, we also held a separate non-binding
advisory shareholder vote on the frequency of future shareholder advisory votes regarding the compensation program for our named executive
officers, commonly referred to as a "say-on-frequency" vote. At the 2022 annual general meeting, our shareholders approved,
on an advisory basis, a proposal to take the say-on-pay vote every two years until the next required say-on-frequency vote. Accordingly,
our next say-on-pay vote will occur at the 2024 annual general meeting and our next say-on-frequency vote will occur at the 2028 annual
general meeting.

 Base Salary

 The Company provides base salaries to attract
and retain executives with the proper experiences and skill sets required to assist us in achieving our specific business objectives,
as well as our future growth and success. Base salaries provide a guaranteed base level of compensation that reflects a belief that base
salary for executive officers should be targeted at market-competitive levels. Base salaries for a particular fiscal year are generally
established at the end of the prior year. In establishing the base salaries for 2023, the Compensation Committee considered each Named
Executive Officer's role and level of responsibility at the Company, recent individual performance, perceived impact on Company
results and overall Company performance. The base salaries of our Named Executive Officers during 2022 and 2023 were as follows:

 Name

 2022 Base
 Salary ($)

 2023 Base
 Salary ($)

 Increase
 (%)

 561,144

 600,000

 %

 437,750

 454,161

 %

 420,343

 437,997

 %

 Annual Cash Incentive

 The goal of the annual cash incentive program
in 2023 was to align a meaningful portion of the total compensation potential for the Named Executive Officers to the achievement of
specified quantitative and qualitative Company performance targets, as well as individual performance targets. The achievement of these
targets advances the Company's specific business objectives and results in long-term shareholder value. The target levels of the
annual cash incentive awards were established as part of the Named Executive Officer's individual employment agreements. Each of
these employment agreements provides that the Named Executive Officer will receive an annual cash incentive award determined at the discretion
of the Compensation Committee and the Board based on the Company's performance against its objectives and individualized objective
and subjective criteria, with a target award amount equal to a percentage of the Named Executive Officer's base salary. The award
criteria include specific objectives, relating to the achievement of clinical, regulatory, commercial, business and/or financial milestones.
The table below sets forth each Named Executive Officer's target incentive compensation for 2023:

 - 10 -

 Name

 2023 Target
 Bonus (% of
 Base Salary)

 2023 Target
 Bonus ($)

 2023 Actual

 Bonus ($) (1)

 %

 360,000

 360,000

 %

 204,373

 194,154
 (2)

 %

 197,099

 212,867

 (1)
 Actual bonus paid to our Named Executive
 Officers based on the Company's performance.

 (2)
 In
 addition to payment of an annual target bonus based upon corporate and individual performance,
 Mr. Kim was eligible for an additional bonus based upon achievement of certain commercial
 milestones. Accordingly, in addition to the $194,154 paid to Mr. Kim for 2023 performance,
 Mr. Kim received an additional $109,438 related to the achievement of certain commercial
 milestones which were met in 2023.

 Our approved 2023 corporate goals consisted of:

 Achieving
 LUMRYZ launch revenue and patient demand targets

 Execution
 of financial strategy and organizational plan

 Execution
 of portfolio and pipeline expansion

 The
Compensation Committee determined that the Company's corporate performance score was 100% for 2023 based solely on the Compensation
Committee's assessment of the Company's level of achievement against the approved 2023 corporate performance goals set forth
above.

 Mr. Divis' 2023 annual cash incentive
bonus was based entirely upon achievement of the corporate performance goals described above. Accordingly, the Compensation Committee
awarded an aggregate annual cash incentive with respect to 2023 for Mr. Divis in the amount of $360,000.

 The process for determining the annual cash incentive
for our other Named Executive Officers is generally similar to what is described above with respect to our Chief Executive Officer. For
2023, the Compensation Committee took into account the Company's performance with respect to the financial and strategic performance
goals discussed above. The Compensation Committee assessed the individual performance of the other Named Executive Officers and also
considered the recommendations of Mr. Divis. The other Named Executive Officers reported directly to Mr. Divis as Chief Executive
Officer and so, the Compensation Committee believes Mr. Divis was in a position to provide a meaningful assessment of their capabilities
and contributions to the Company.

 The Compensation Committee determined 2023 annual
cash incentives for the other Named Executive Officers in the following amounts: Richard J. Kim - $194,154 and Thomas S.
McHugh - $212,867. Richard J. Kim received an additional $109,438 related to the achievement of certain commercial milestones
related to LUMRYZ that were met in 2023.

 Equity Compensation

 The Compensation Committee believes equity compensation
awards help to align the interests of our executive officers with those of shareholders because the value of the equity awards to the
recipient increases only with the appreciation of the price of our ordinary shares. Furthermore, the Compensation Committee believes
granting equity awards that vest over time encourages executives to remain with the Company. The authority to grant equity awards to
our executive officers lies with the Compensation Committee and Board. The Compensation Committee takes into consideration the peer group
data provided by Aon and the recommendations of our Chief Executive Officer (other than for himself). Generally, the Compensation Committee
has granted stock options to our executive officers upon commencement of their employment with the Company.

 In addition to new hire stock options, at least
annually, the Compensation Committee considers equity awards for our executive officers. These awards may consist of stock options, restricted
share units ("RSUs"), performance share units ("PSUs") or performance stock options ("PSOs"). In
August 2023, the Compensation Committee determined it would be appropriate to award PSUs to our Named Executive Officers. The Compensation
Committee believed that supplemental awards in the form of PSUs would further align our Named Executive Officers' long-term incentive
compensation with the interests of our shareholders. Specifically, the PSUs will be determined to be granted and to vest based upon achieving
at least a majority of corporate objectives as well as exceeding revenue forecasts and/or patient demand forecast for the applicable
performance periods. Achievement of the corporate, revenue and/or patient demand is at the discretion of the Compensation Committee.
1/3 of the PSUs were tied to performance during the second half of 2023 and 2/3 of the PSUs are tied to performance during calendar year
2024. The following table below reflects the target number of PSUs awarded to each of our Named Executive Officers:

 - 11 -

 Name

 Target PSUs

 90,000

 90,000

 In determining the number of PSUs to grant to
a particular Named Executive Officer, the Compensation Committee takes into account numerous factors, including: the executive's
role and level of responsibility within the Company, the Company's performance with respect to the financial and strategic goals
and objectives for that year, and comparative peer group data as presented by Aon.

 Compensation Risk Assessment

 The Company regularly reviews compensation plans
and practices to ensure they are appropriately structured and aligned with business objectives, and not designed to encourage executives
to take unwarranted risks. Specifically, the overall design of the compensation philosophy and plans mitigate risks because: (1) the
financial performance objectives of the short and long-term incentive plans are reviewed and approved annually by the Board; (2) the
plans consist of multiple performance objectives, thus lessening the focus on any one in particular; and (3) short and long-term
incentive payouts are capped for all participants.

 General Employee Benefits

 Avadel offers competitive health, dental and
life insurance and vacation pay for all employees, including Named Executive Officers. In addition, the senior executives are eligible
to receive matching 401(k) plan contributions on the same basis as other employees.

 Severance and Change-in-Control Benefits

 Pursuant to employment agreements, each of our
Named Executive Officers has a provision in his or her employment agreement with the Company that entitles such Named Executive Officer
to certain specified benefits in the event of termination of their employment under specified circumstances, including termination following
a change in control of the Company. These benefits are described in the " Employment Agreement " section below, and
certain estimates of these severance and change-in-control benefits are provided in " Potential Payments Upon Termination or
Change in Control " below.

 Retirement Benefits

 The Company believes offering competitive retirement
benefits is important to attract and retain top executives. The Company's U.S.-based executives participate in a traditional defined
contribution 401(k) plan. For our Company's 401(k) plan, the Company generally contributed approximately $12,000 to $13,000
to each eligible executive's 401(k) account during 2023, which was the maximum contribution match allowable under the Company's
401(k) Plan, provided the participant contributed the maximum in order to receive the maximum match and contributed based off of
$330,000 of wages, the maximum allowable under the IRS limits. Additional details regarding retirement benefits are provided in the tables
below entitled " Summary Compensation Table."

 - 12 -

 Deductibility of Executive Compensation

 Generally, Section 162(m) of the Internal
Revenue Code of 1986, as amended (the "Code") disallows a federal income tax deduction for public corporations of remuneration
in excess of $1 million paid for any fiscal year to "covered employees" of the Company. The Board and the Compensation Committee
believe shareholder interests are best served if they retain maximum flexibility to design executive compensation programs that meet
stated business objectives. For that reason, while our Board and Compensation Committee consider the potential effects of Section 162(m) of
the Code on the compensation paid to our named executive officers, in light of the constraints imposed by Section 162(m) and
our desire to maintain flexibility in compensation decisions, the Board and the Compensation Committee do not necessarily limit compensation
to amounts deductible under Section 162(m).

 Taxation of "Parachute" Payments

 Sections 280G and 4999 of the Code provide that
executive officers and directors who hold significant equity interests and certain other service providers may be subject to significant
additional taxes if they receive payments or benefits in connection with a change in control of the Company that exceeds certain prescribed
limits, and that the Company (or a successor) may forfeit a deduction on the amounts subject to this additional tax. Our compensation
arrangements for executive officers, including our Named Executive Officers, do not provide tax gross-ups for any type of payments, including
payments for severance or in connection with a change of control of the Company.

 Securities Trading Policy

 The Company has a policy that prohibits executive
officers and directors from trading in the Company's securities while aware of material non-public information or engaging in hedging
transactions or short sales and trading in "puts" and "calls" involving the Company's securities. This
policy is described in our Code of Conduct, which may be viewed on our website at  In addition,
executive officers and directors are prohibited from pledging the Company's securities.

 Compensation Recovery Policy

 In October 2023, we adopted a compensation
recovery policy (the "Clawback Policy"), in compliance with the requirements of the Dodd-Frank Act, final SEC rules and
applicable Nasdaq listing standards, which covers our current and former executive officers, including all of our named executive officers.
Under the Clawback Policy, if we are required to prepare a restatement of previously issued financial statements of the Company due to
the material noncompliance of the Company with any financial reporting requirement under federal securities laws, the Company will recover
any incentive-based compensation received by any current or former executive officer after the effective date of the policy and during
the three-year period preceding the date on which the Company is required to prepare the restatement that is in excess of what would
have been paid or earned by such executive officer had the financial results been properly reported.

 - 13 -

 2023 Compensation of Named Executive Officers

 Summary Compensation Table

 The following table sets
forth the compensation paid or accrued during the fiscal years ended December 31, 2023, 2022 and 2021 to our Named Executive Officers:

 Name
 and Principal

 Position

 Year

 Base
 Salary

 ($) (1)

 Stock

 Awards

 ($) (2)

 Option

 Awards

 ($) (3)

 Non-Equity

 Incentive

 Plan

 Compensation ($) (4)

 All
 Other

 Compensation ($) (5)

 Total

 Compensation ($)

 J. Divis

 Chief Executive Officer

 2023

 600,000

 -

 -

 360,000

 25,200

 985,200

 2022

 561,144

 -

 -

 168,343

 24,200

 753,687

 2021

 544,800

 -

 1,668,854

 294,192

 23,600

 2,531,446

 Richard
 J. Kim

 Chief Commercial Officer

 2023

 454,161

 -

 -

 303,592

 13,200

 770,953

 2022

 437,750

 -

 -

 98,494

 12,200

 548,444

 2021

 373,510

 -

 2,836,088

 157,781

 11,600

 3,378,979

 S. McHugh

 Chief Financial Officer

 2023

 437,997

 -

 -

 212,867

 12,280

 663,144

 2022

 420,343

 -

 -

 94,577

 11,079

 525,999

 2021

 396,550

 -

 807,510

 142,758

 10,697

 1,357,515

 (1) Represents salaries before any employee
contributions under our 401(k) Plan. Mr. Kim joined us in February 2021 and, accordingly, his salary for 2021 reflects
his partial years of service.

 (2) Represents
the aggregate grant date fair value of share awards granted in 2022, 2021 and 2020, respectively, calculated in accordance with FASB
ASC Topic 718. For a full description of the assumptions we use in calculating these amounts, see Note 16 to our consolidated financial
statements for the year ended December 31, 2023 which are included in our Annual Report on Form 10-K filed with the SEC on
February 29, 2024. The actual value a Named Executive Officer may receive depends on market prices and there can be no assurance
that the amounts reflected in the Stock Awards column will actually be realized. The amounts reported in this table do not include the
grant date fair value of PSUs granted in 2021, as achievement was not probable on the grant date. Assuming maximum achievement, the grant
date fair value of the PSUs granted in 2021 to each of Mr. Divis, Mr. McHugh and Mr. Kim for 2021 would have been $1,389,900,
$492,000 and $451,004, respectively. All such PSUs were forfeited. In addition, the amounts reported for 2023 do not reflect PSU s
awarded in August 2023 as the grant date of such awards for accounting purposes did not occur in 2023. 1/3 of the PSUs that were
tied to performance during the second half of 2023 were forfeited.

 (3) Amounts reported reflect the aggregate
grant date fair value of options granted or modified in 2023, 2022 and 2021, respectively, calculated in accordance with FASB ASC Topic
718. For a full description of the assumptions we use in calculating these amounts, see Note 16 to our consolidated financial statements
for the year ended December 31, 2023 which are included in our Annual Report on Form 10-K filed with the SEC on February 29,
2024. The actual value a Named Executive Officer may receive depends on market prices and there can be no assurance that the amounts
reflected in the Option Awards column will actually be realized. No gain to a named executive officer is possible without an appreciation
in stock value after the date of grant. For 2022, the amounts reported in this table to Mr. Divis, Mr. McHugh and Mr. Kim
do not include the grant date fair value of the PSOs, as achievement was not probable on the grant date. Assuming maximum achievement,
the grant date fair value of the PSOs granted in 2022 to each of Mr. Divis, Mr. McHugh and Mr. Kim would have been $1,297,738,
$648,869 and $648,869, respectively.

 (4) Non-equity incentive plan compensation
represents cash bonuses for meeting Company and, if applicable, personal performance targets.

 (5) For 2023, amounts include (i) for
Mr. Divis, $13,200 in employer 401(k) contributions and $12,000 in auto allowance, (ii) for Mr. Kim, $13,200 in employer
401(k) contributions and (iii) for Mr. McHugh, $12,280 in employer 401(k) contributions.

 - 14 -

 Grants of Plan-Based Awards 2023

 The following table presents
information regarding grants of plan-based awards to the named executive officers during the year ended December 31, 2023:

 Estimated Future

 Payouts Under
 Non-Equity Incentive
 Plan Awards (1)

 Estimated Future

 Payouts Under
 Equity Incentive
 Plan Awards (2)

 Grant
 Date Fair

 Value of
 Stock and
 Option Awards (2)

 Name

 Grant Date

 Target ($)

 Target
 (#)

 ($)

 360,000

 --

 --

 204,373

 --

 --

 197,099

 --

 --

 (1) Represents the target amount that may
be earned based on achievement of pre-determined performance criteria during fiscal year 2023. Our Compensation Committee has not set
threshold or maximum amounts associated with non-equity incentive plan awards.

 (2) The Compensation Committee awarded PSUs to our named executive
officers in 2023 as described above in the section entitled " Compensation Discussion and Analysis—Equity Compensation".
However, these PSUs do not yet have a grant date for accounting purposes due to the discretionary nature of the performance criteria
and, accordingly, have been excluded from this table.

 - 15 -

 Outstanding Equity Awards at Fiscal Year-End
2023

 The following table sets
forth specified information concerning stock options and stock awards for each of the named executive officers outstanding as of December 31,
2023.

 Option Awards

 Name

 Grant Date

 Number
 of
 Securities
 Underlying
 Unexercised
 Options (#)
 Exercisable (1)

 Number
 of
 Securities
 Underlying
 Unexercised
 Options (#)
 Unexercisable (1)

 Equity
 Incentive
 Plan Awards:
 Number of
 Securities
 Underlying
 Unexercised
 Unearned
 Options (#)

 Option
 Exercise
 Price
 ($)

 Option
 Expiration
 Date

 12/14/2016

 150,000

 -

 -

 10.40

 12/14/2026

 12/12/2017

 100,000

 -

 -

 8.95

 12/12/2027

 3/22/2018

 50,000

 -

 -

 7.06

 3/22/2028

 3/7/2019

 100,000

 -

 -

 1.85

 3/7/2029

 5/30/2019

 400,000

 -

 -

 1.71

 5/30/2029

 12/8/2020

 375,000

 125,000
 (2)

 -

 6.79

 12/8/2030

 12/7/2021

 155,000

 155,000
 (3)

 -

 8.20

 12/7/2031

 8/4/2022

 (4)

 -

 4.69

 8/4/2032

 2/15/2021

 (5)

 -

 8.99

 2/15/2031

 12/7/2021

 68,750

 68,750
 (6)

 -

 8.20

 12/7/2031

 8/4/2022

 87,500

 87,500
 (4)

 -

 4.69

 8/4/2032

 10/22/2019

 250,000

 -

 -

 3.45

 10/22/2029

 12/8/2020

 150,000

 50,000
 (7)

 -

 6.79

 12/8/2030

 12/7/2021

 75,000

 75,000
 (8)

 -

 8.20

 12/7/2031

 8/4/2022

 87,500

 87,500
 (4)

 -

 4.69

 8/4/2032

 (1) Unless otherwise noted, options to purchase
shares become exercisable in four equal annual installments following the grant date.

 (2) Includes the unvested portion of the
December 2020 option grant under the Avadel 2020 Omnibus Plan, all of which will vest on December 8, 2024.

 (3) Includes the unvested portion of the
December 2021 option grant under the Avadel 2020 Omnibus Plan, 77,500 of which will vest on each of December 7, 2024, and December 7,
2025.

 (4) Includes the unvested portion of the
August 2022 PSO grant under the Avadel 2020 Omnibus Plan. The PSOs vested based upon achievement of commercial milestones related
to LUMRYZ, with 50% vesting immediately upon the achievement of those milestones on June 5, 2023 and the other 50% vesting on June 5,
2024.

 (5) Includes the unvested portion of the
February 2021 option grant under the Avadel 2020 Omnibus Plan, 87,500 of which will vest on each of February 15, 2024, and
February 15, 2025.

 (6) Includes the unvested portion of the
December 2021 option grant under the Avadel 2020 Omnibus Plan, 34,375 of which will vest on each of December 7, 2024, and December 7,
2025.

 (7) Includes the unvested portion of the
December 2020 option grant under the Avadel 2020 Omnibus Plan, all of which will vest on December 8, 2024.

 (8) Includes the unvested portion of the
December 2021 option grant under the Avadel 2020 Omnibus Plan, 37,500 of which will vest on each of December 7, 2024, and December 7,
2025.

 Options Exercised and Shares Vested During
Fiscal Year 2023

 The following table sets
forth specified information concerning share options exercised and share awards vested for each of the named executive officers during
fiscal year 2023:

 Option Awards

 Share Awards

 Name

 Number of
 shares
 acquired on
 exercise (#)

 Value
 realized on
 exercise ($)

 Number of
 shares
 acquired on
 vesting (#)

 Value
 realized on
 vesting ($)

 -

 -

 -

 -

 -

 -

 -

 -

 -

 -

 -

 -

 - 16 -

 Employment Agreements

 We have written employment
agreements with each of our Named Executive Officers, which were each amended on September 28, 2022. Each employment agreement provides
that the individual's employment will continue until either we or the Named Executive Officer provides written notice of termination
in accordance with the terms of the agreement. In addition, each of these agreements prohibit the Named Executive Officer from disclosing
confidential information and competing with us during the term of their employment with the Company and for a specified time period thereafter.
The agreements also contain customary non-solicitation and non-disparagement provisions. Under the terms of their respective employment
agreements, each of the Named Executive Officers is entitled to receive an annual base salary, subject to annual review, an annual cash
incentive and an annual equity award, each component of which is subject to the discretion of our board.

 Pursuant to their employment
agreements, each of our Named Executive Officers is entitled to certain severance benefits in the event he or she terminates his or her
employment for "Good Reason" or if his or her employment is terminated by the Company for any reason other than for "Cause,"
including non- renewal by the Company at the end of the employment term. Upon such a termination, each of the Named Executive Officers
is entitled to receive all accrued but unpaid bonuses for any completed fiscal year and vacation pay, expense reimbursement and other
benefits due under any Company-provided benefit plans, policies and arrangements. In addition, Mr. Divis is entitled to receive:
(1) severance equal to 1.5 times his base salary, payable in substantially equal installments in accordance with the Company's
normal payroll practices; and (2) payment of monthly COBRA health insurance premiums for up to 18 months, and Mr. Kim and Mr. McHugh
are entitled to receive (1) severance equal to 1.0 times their base salary, payable in substantially equal installments in accordance
with the Company's normal payroll practices; and (2) payment of monthly COBRA health insurance premiums for up to 12 months.

 In addition to the above,
if such a termination occurs during a Change in Control Period (as defined below), Mr. Divis is entitled to receive (i) the
highest of (x) his target bonus in effect for the fiscal year in which the applicable change in control occurs, (y) his target
bonus in effect for the fiscal year in which the termination of employment occurs; or (z) his actual bonus for performance during
the calendar year prior to the calendar year during which the termination of employment occurs.

 In addition, if such a termination
occurs during a Change in Control Period (as defined below), each of the Named Executive Officers is entitled to receive (i) the
immediate vesting of 100% of his outstanding and unvested share options and any other equity awards under the Company's compensation
plans and (ii) outstanding and vested stock options held by each of the Named Executive Officers as of his termination of employment
date will remain exercisable until the eighteen (18) month anniversary of the termination of employment date (not to extend beyond the
original maximum term as of the original date of grant).

 For purposes of each of the Named Executive Officer's
agreements:

 "Good
 Reason" is defined as

 o
 For
 Mr. Divis: (i) the failure of the Company to timely pay to the employee any compensation
 owed under the agreement; (ii) the Company's diminution in the employee's
 authority, duties or responsibilities in any material respect or the Company's assignment
 to the employee of duties that are materially inconsistent with the duties stated in the
 agreement; (iii) the relocation of the place of the employee's employment more
 than sixty (60) miles outside the greater St. Louis metropolitan area; (iv) a material
 breach by the Company of the agreement; or (v) the failure of the Company to have the
 agreement assumed in full by any successor in the case of any merger, consolidation, or sale
 of all or substantially all of the assets of the Company.

 o
 For
 Mr. Kim and Mr. McHugh: (i) the Company's diminution in the employee's
 authority, duties or responsibilities in any material respect or the Company's assignment
 to the employee of duties that are materially inconsistent with the duties stated in the
 agreement; (ii) the relocation of the place of the employee's employment which
 increases such employee's one-way commute by more than sixty (60) miles for such employee;
 or (iii) a material breach by the Company of the agreement.

 - 17 -

 "Cause"
 means: (i) conviction of or plea of nolo contendere to a felony or crime involving moral
 turpitude; (ii) fraud, theft, or misappropriation of any asset or property of the Company,
 including, without limitation, any theft or embezzlement or any diversion of any corporate
 opportunity; (iii) breach of any of the material obligations contained in the agreement;
 (iv) conduct materially contrary to the material policies of the Company; (v) material
 failure to meet the goals and objectives established by the Company without cure within a
 reasonable period of time after written notice thereof; or (vi) conduct that results
 in a material detriment to the Company, its program, or goals or is inimical to the Company's
 reputation and interests without cure within a reasonable period of time after written notice
 thereof.

 "Change
 of Control Period" means the period beginning six (6) months prior to, and ending
 eighteen (18) months following, a Change of Control for Mr. Divis and Mr. McHugh
 and means the period ending eighteen (18) months following, a Change of Control for Mr. Kim.

 "Change
 of Control" means the occurrence of any of the following events: (i) A change
 in the ownership of the Company which occurs on the date that any one person, or more than
 one person acting as a group ('Person'), acquires ownership of the equity interests
 of the Company that, together with the shares held by such Person, constitutes more than
 fifty percent (50%) of the total voting power of the shares of the Company; provided, however,
 that for purposes of this subsection, the acquisition of additional shares by any one Person,
 who is considered to own more than fifty percent (50%) of the total voting power of the shares
 of the Company will not be considered a Change or Control; or (ii) A change in the effective
 control of the Company which occurs on the date that a majority of the members of the Board
 is replaced during any twelve (12) month period by Directors whose appointment or election
 is not endorsed by a majority of the members of the Board prior to the date of the appointment
 or election. For purposes of such definition, if any Person is considered to be in effective
 control of the Company, the acquisition of additional control of the Company by the same
 Person will not be considered a Change of Control; or (iii) A change in the ownership
 of a substantial portion of the Company's assets which occurs on the date that any
 Person acquires (or has acquired during the twelve (12) month period ending on the date of
 the most recent acquisition by such person or persons) assets from the Company that have
 a total gross fair market value equal to or more than fifty percent (50%) of the total gross
 fair market value of all of the assets of the Company immediately prior to such acquisition
 or acquisitions.

 The benefits provided are
designed to protect earned benefits in the case that one or more of such Named Executive Officers is terminated without cause or as a
result of a Change in Control of the Company, in order to encourage such Named Executive Officers to act in the best interests of the
shareholders at all times during the course of a change in control transaction or other significant event involving our Company.

 - 18 -

 Potential Payments upon Termination or Change of Control

 The following table sets
forth information regarding potential payments that each Named Executive Officer would have received if the Named Executive Officer's
employment had terminated as of December 31, 20223 under the circumstances set forth above.

 Name

 Termination without Cause or
 Resignation for Good Reason
 Not in Connection with a
 Change in Control
 ($)

 Termination without Cause or
 Resignation for Good Reason
 in Connection with a
 Change in Control
 ($)

 Cash Severance Payment

 900,000
 (1)

 1,260,000
 (3)

 Value of Benefits

 45,481
 (2)

 45,481
 (2)

 Equity Acceleration

 --

 3,484,100
 (4)

 Richard Kim

 Cash Severance Payment

 454,161
 (1)

 454,161
 (3)

 Value of Benefits

 30,321
 (2)

 30,321
 (2)

 Equity Acceleration

 --

 2,129,875
 (4)

 Cash Severance Payment

 437,997
 (1)

 437,997
 (3)

 Value of Benefits

 20,802
 (2)

 20,802
 (2)

 Equity Acceleration

 --

 1,635,625
 (4)

 (1) Includes 18 months base salary continuation
for Mr. Divis and 12 months' base salary for Mr. Kim, and Mr. McHugh.

 (2) Includes 18 months' COBRA continuation
for Mr. Divis and 12 months' COBRA continuation for Mr. Kim and Mr. McHugh.

 (3) Includes 18 months base salary and target
annual bonus for Mr. Divis and 12 months base salary for Mr. Kim and Mr. McHugh.

 (4) Amounts reflect intrinsic value of unvested
stock options whose vesting will be accelerated based on the closing price of one ADS on December 29, 2023, the last trading day
of 2023 ($14.12).

 - 19 -

 COMPENSATION COMMITTEE REPORT

 The Compensation Committee has reviewed and discussed
the Compensation Discussion and Analysis required by Item 402(b) of Regulation S-K with management and, based on such review and
discussion, the Compensation Committee recommended to the Board that it be included in this Annual Report on Form 10-K.

 THE COMPENSATION COMMITTEE

Linda S. Palczuk, Chair

Dr. Mark A. McCamish

Peter J. Thornton

 The "Compensation Committee Report"
above shall not be deemed incorporated by reference by any general statement incorporating this Annual Report on Form 10-K into
any filing under the Securities Act of 1933 or under the Securities Exchange Act of 1934, as amended, except to the extent that we specifically
incorporate this information by reference and shall not otherwise be deemed filed under such Acts.

 Compensation Risk Assessment

 As part of its oversight of our executive compensation
program, the Compensation Committee considers the impact of our executive compensation program, and the incentives created by the compensation
awards that it administers, on our risk profile. In addition, we review all our compensation policies and procedures, including the incentives
that they create and factors that may reduce the likelihood of excessive risk-taking, to determine whether they present a significant
risk to us. The Compensation Committee concluded that our compensation programs are designed with the appropriate balance of risk and
reward in relation to our overall business strategy and that the balance of compensation elements discourages excessive risk-taking.
The Compensation Committee, therefore, determined that the risks arising from our compensation policies and practices for employees are
not reasonably likely to have a material adverse effect on us. The Compensation Committee will continue to consider compensation risk
implications while deliberating the design of our executive compensation programs. In its discussions, the Compensation Committee considered
the attributes of our programs, including:

 Appropriate
 pay philosophy in light of our business model;

 Balance
 with respect to the mix of cash and equity compensation, and measures of performance against
 both annual and multi-year standards;

 Short
 and long-term incentives linked to share price performance;

 Performance
 goals are set at levels that are sufficiently high to encourage strong performance and support
 the resulting compensation expense, but within reasonably attainable parameters to discourage
 pursuit of excessively risky business strategies;

 Long-term
 incentives generally have multi-year vesting to ensure a long-term focus and appropriate
 balance against short-term goals;

 Independent
 Compensation Committee oversight, with Compensation Committee discretion to reduce incentives
 based on subjective evaluation of individual performance; and

 Anti-hedging/pledging
 policies.

 - 20 -

 PAY RATIO DISCLOSURE

 Under Section 953(b) of the Dodd-Frank
Wall Street Reform and Consumer Protection Act and Item 402(u) of Regulation S-K, the Company is required to provide the ratio of
the annual total compensation of Mr. Divis, who is the Company's Chief Executive Officer, to the annual total compensation
of the median employee of the Company (the "Pay Ratio Disclosure").

 For fiscal year 2023, the median annual total
compensation of all employees of the Company and its consolidated subsidiaries (other than the Chief Executive Officer) was $299,923.
Mr. Divis' annual total compensation for fiscal year 2023 was $985,200. Based on this information, for fiscal year 2023, the
ratio of the compensation of the Chief Executive Officer to the median annual total compensation of all other employees was estimated
to be 3 to 1.

 To identify, and to determine the annual total
compensation of, the median employee, we used the following methodology:

 We
 collected the payroll data of all employees globally, whether employed on a full-time, part-time,
 temporary or seasonal basis as of December 31, 2023.

 We
 annualized the compensation of all permanent full-time and part-time employees who were hired
 by the Company and its consolidated subsidiaries between January 1, 2023, and December 31,
 2023.

 We
 then identified our median employee from our employee population based on this compensation
 measure.

 This
 process resulted in the identification of an employee whose compensation was anomalous, as
 that individual was newly hired in 2023. As a result, we substituted an employee near the
 median whose compensation was viewed as more representative of our median employee.

 The median employee's annual total compensation
represents the amount of such employee's compensation for fiscal year 2023 that would have been reported in the Summary Compensation
Table in accordance with the requirements of Item 402(c)(2)(x) of Regulation S-K if the employee was a Named Executive Officer,
and the annual total compensation of the Chief Executive Officer represents the amount reported in the "Total" column of
our "Summary Compensation Table" on page 15 of this Annual Report on Form 10-K.

 The Pay Ratio Disclosure presented above is a
reasonable estimate. Because the SEC rules for identifying the median employee and calculating the pay ratio allow companies to
use different methodologies, exemptions, estimates and assumptions, the Pay Ratio Disclosure may not be directly comparable to the pay
ratio reported by other companies.

 - 21 -

 DIRECTOR COMPENSATION

 Non-Employee Director Compensation

 We compensate our non-executive directors with
a basic cash fee plus supplementary fees to chairpersons and for meeting attendance. The amount of each component of such director cash
compensation may change from year to year and is generally established by the Board in conjunction with our annual general meeting of
shareholders for the period until the next annual general meeting. The fees paid to non-employee directors for service on the Board of
Directors and for service on each committee of the Board of Directors on which the director is a member are as follows:

 The annual retainers in effect for service in
2023 were as follows:

 Annual Cash
 Retainers

 Board of Directors:

 All non-employee members

 $
 52,100

 Additional retainer for Non-Executive Chair of the Board

 $
 35,000

 Audit Committee:

 Chair

 $
 20,000

 Non-Chair members

 $
 10,000

 Compensation Committee:

 Chair

 $
 15,000

 Non-Chair members

 $
 7,500

 Nominating and Corporate Governance Committee:

 Chair

 $
 10,000

 Non-Chair members

 $
 5,000

 In addition, during 2023, our non-employee directors
were awarded stock options, as described in footnote 3 to the " Director Compensation " table below.

 Director Compensation Table

 The following table presents information relating
to total compensation of each person who served as a director for the year ended December 31, 2023.

 Name

 Fees Earned
 or
 Paid in Cash
 ($) (1)

 Option

 Awards
 ($) (2)(3)

 Stock
 Awards
 ($)

 Total
 Compensation
 ($)

 Geoffrey M. Glass (4)

 102,100

 -

 482,340

 Dr. Eric J. Ende (5)

 72,100

 -

 452,340

 Dr. Mark A. McCamish (6)

 69,600

 -

 449,840

 Linda S. Palczuk (7)

 72,100

 -

 452,340

 Peter J. Thornton (8)

 79,600

 -

 459,840

 (1) Fees earned or paid in cash for Mr. Thornton
were earned in U.S. Dollars but were paid in Euro at the applicable exchange rate on the date of payment.

 (2) Amounts reported reflect the aggregate
grant date fair value of options granted in 2023 calculated in accordance with FASB ASC Topic 718. For a full description of the assumptions
used in calculating these amounts, see Note 16 to our consolidated financial statements for the year ended December 31, 2023, which
are included in our Annual Report on Form 10-K filed with the SEC on February 29, 2024. The actual value a director may receive
depends on market prices, and there can be no assurance that the amounts reflected in these columns will actually be realized.

 (3) On August 1, 2023, non-employee
directors Peter J. Thornton, Geoffrey M. Glass, Eric J. Ende, Mark A. McCamish and Linda S. Palczuk were each awarded an option to purchase
33,000 shares under the Company's 2020 Plan. Each award vests 100% on the one-year anniversary of the award.

 (4) As of December 31, 2023, Mr. Glass held 219,000
unexercised share options and no unvested ADSs.

 (5) As of December 31, 2023, Dr. Ende held 227,057
unexercised share options and no unvested ADSs.

 (6) As of December 31, 2023, Dr. McCamish
held 269,000 unexercised share options and no unvested ADSs.

 (7) As of December 31, 2023, Ms. Palczuk held 219,000
unexercised share options and no unvested ADSs.

 (8) As of December 31, 2023, Mr. Thornton held 219,000
unexercised share options and no unvested ADSs.

 - 22 -

 Item 12.
 Security Ownership of Certain
 Beneficial Owners and Management and Related Stockholder Matters.

 Equity Compensation Plan Information

 The following table provides information as of
December 31, 2023, regarding ordinary shares that may be issued under our equity compensation plans, consisting of our 2017 Omnibus
Incentive Compensation Plan (the "2017 Omnibus Plan") our 2020 Omnibus Incentive Compensation Plan, our 2017 Employee Stock
Purchase Plan (the "ESPP") and our 2021 Inducement Plan (the "Inducement Plan").

 Plan category

 Number
 of securities
 to be issued upon
 exercise of
 outstanding options
 and rights (1)

 Weighted-average

 exercise price of
 outstanding options
 and rights (2)

 Number
 of securities
 remaining available
 for future issuance
 under equity
 compensation plans
 (excluding securities

 reflected in column (a)) (3)

 (a)

 (b)

 (c)

 Equity compensation plans approved by security holders

 9,170,261

 6.96

 7,617,506

 Equity compensation plans not approved by security holders

 1,152,000

 9.84

 348,000
 (4)

 Total

 10,322,261

 7.29

 7,965,506

 (1)

 22,757 ordinary shares that have previously been granted as RSUs but are pending issuance upon vesting date; the beneficiary is not
 required to pay any exercise price upon issuance of such 22,757 shares of RSUs. The remaining 10,299,504 ordinary shares are issuable
 pursuant to the exercise of outstanding options upon payment of the weighted-average exercise price shown in column (b) of this
 table.

 (2)

 The
 weighted-average exercise price shown in column (b) applies to 10,299,504 ordinary shares issuable pursuant to the exercise
 of outstanding options included in the total number shown in column (a) of this table. As to the 22,757 shares attributable
 to free shares awards, the beneficiary is not required to pay any exercise price upon issuance of such shares.

 (3)

 On
 April 17, 2023, upon the recommendation of the Compensation Committee, the Board approved an amendment (the "Amendment")
 of the Avadel Pharmaceuticals plc 2020 Omnibus Incentive Compensation Plan ("as amended, the "2020 Plan"), subject
 to shareholder approval. The Amendment, among other things, increased the aggregate number of shares authorized for issuance under
 the 2020 Plan by 6,500,000 shares. At the Annual Meeting held on August 1, 2023, the Company's shareholders approved the
 Amendment to the 2020 Plan.

 (4)

 Represents
 shares reserved for issuance pursuant to our Inducement Plan. Please see Note 16 to our Annual Report on Form 10-K for the year
 ended December 31, 2023, filed with the SEC on February 29, 2024, for additional information regarding the Inducement Plan.

 Beneficial Ownership Table

 The following table sets forth certain information
regarding the beneficial ownership of our issued and outstanding ordinary shares by (i) each person who is known by the Company
to own beneficially more than five percent of the outstanding ordinary shares, (ii) each Named Executive Officer of the Company,
(iii) each director and director nominee of the Company and (iv) all directors and executive officers as a group. Except as
otherwise indicated in the footnotes below, such information is provided as of April 7, 2024. On April 15, 2024, the Company's
ordinary shares became directly listed on the Nasdaq Stock Market ("Nasdaq"). According to SEC rules, a person is the "beneficial
owner" of securities if he, she or it has or shares the power to vote them or to direct their investment or has the right to acquire
beneficial ownership of such securities within 60 days through the exercise of an option, warrant or right, the conversion of a security
or otherwise.

 - 23 -

 Name and address of beneficial owner (1)

 Beneficial Ownership (2)

 Percentage of Class (2)

 > 5% Stockholders:

 Entities Affiliated with Janus Henderson Group plc (3)
 201 Bishopsgate
 EC2M 3AE, United Kingdom

 11,125,330

 11.6
 %

 Entities Affiliated with RTW Investments, LP (4)
 40 10th Avenue, Floor 7,
 New York, New York 10014

 8,798,558

 9.2
 %

 Entities Affiliated with Polar Capital (5)
 16 Palace Street
 London, SW1E 5JD

 6,751,782

 7.0
 %

 Entities Affiliated with Tontine Asset Associates, LLC (6)
 1 Sound Shore Drive, Suite 304
 Greenwich, CT 06830-7251

 5,685,350

 5.9
 %

 Named Executive Officers and Directors:

J. Divis (7)

 1,839,100

 1.9
 %

S. McHugh (8)

 730,500

 *

 Richard
J. Kim (9)

 506,250

 *

 Geoffrey
M. Glass (10)

 310,700

 *

 Dr. Eric
J. Ende (11)

 361,957

 *

 Dr. Mark
A. McCamish (12)

 303,025

 *

 Linda
S. Palczuk (13)

 238,400

 *

 Peter
J. Thornton (14)

 269,055

 *

 All executive officers and directors as a group (8 persons)

 4,558,987

 4.6
 %

 * Represents beneficial ownership of less than 1% of our outstanding ordinary shares.

 (1)
 Except
 as stated in the table above or the footnotes below, the address of the named person is c/o
 Avadel Pharmaceuticals plc, Ten Earlsfort Terrace, Dublin 2, D02 T380 Ireland.

 (2)
 Unless
 otherwise stated in the footnotes to this table, we believe each of the shareholders named
 in this table has sole voting and dispositive with respect to the ordinary shares indicated
 as beneficially owned. Ownership percentages are based on 96,096,871 ordinary shares outstanding
 on April 7, 2024. On April 15, 2024, the Company's ordinary shares
 became directly listed on Nasdaq. Accordingly, some of the Schedule 13Gs filed by investors
 prior to April 15, 2024 still reference ADSs, which were exchanged for ordinary shares
 on the April 15, 2024. The number of shares beneficially owned includes ordinary shares
 issuable pursuant to the exercise of stock options or warrants that are exercisable and "free
 shares," if any, that will vest within 60 days of April 7, 2024. Ordinary shares
 issuable pursuant to the exercise of stock options or warrants that are exercisable and "free
 shares," if any, that will vest within 60 days of April 7, 2024 are deemed to
 be outstanding and beneficially owned by the person to whom such shares are issuable for
 the purpose of computing the percentage ownership of that person, but they are not deemed
 to be outstanding for the purpose of computing the percentage ownership of any other person.

 (3)
 Information
 herein is solely based on a Schedule 13G/A filed with the SEC by Janus Henderson Group plc
 ("JHG") on February 13, 2024. JHG reports that it has shared voting power
 and shared dispositive power over 11,125,330 shares which are held directly by one or more
 funds or portfolios managed by JHG. The principal business address of JHG is 201 Bishopsgate,
 EC2M 3AE, United Kingdom.

 (4)
 Information
 herein is based on (i) a Schedule 13G/A filed by RTW Investments, LP ("RTW Investments")
 and Mr. Roderick Wong on February 14, 2024 and (ii) information provided by
 RTW Investments. Consists of 8,798,558 ordinary shares held by certain funds (the "RTW
 Funds") affiliated with RTW Investments. RTW Investments is the investment adviser
 to the RTW Funds. Mr. Wong is the Managing Partner and Chief Investment Officer of RTW
 Investments, with respect to the shares directly held by the RTW Funds.

 (5)
 Information
 herein is solely based on a Schedule 13G filed with the SEC by Polar Capital Holdings Plc
 and Polar Capital LLP on February 13, 2024. Consists of 6,751,782 ADSs beneficially
 held by Polar Capital Holdings Plc and Polar Capital LLP, which were automatically exchanged
 for ordinary shares on April 15, 2024 when the Company's ordinary shares became
 directly listed on Nasdaq.

 - 24 -

 (6)
 Information
 herein is solely based on a Schedule 13G/A filed by Tontine Capital Overseas Master Fund
 II, L.P. ("TCOM II"), Tontine Asset Associates, LLC ("TAA") and Mr. Jeffrey
 L. Gendell on February 13, 2024. Consists of (i) 3,539,782 ADSs held by TCOM II,
 (ii) 2,075,568 ADSs held by Tontine Financial Partners, L.P. ("TFP") and
 (iii) 70,000 ADSs, held by Mr. Gendell, which were automatically exchanged for
 ordinary shares on April 15, 2024 when the Company's ordinary shares became directly
 listed on Nasdaq. Mr. Gendell serves as the Managing Member of TAA and also serves as
 the Managing Member of Tontine Management, L.L.C., a limited liability company organized
 under the laws of the State of Delaware ("TM"), which serves as general partner
 of TFP.

 (7)
 options to purchase 1,680,000 ordinary shares that are exercisable within 60 days of April 7,
 2024.

 (8)
 options to purchase 650,000 ordinary shares that are exercisable within 60 days of April 7,
 2024.

 (9)
 options to purchase 506,250 ordinary shares that are exercisable within 60 days of April 7,
 2024.

 (10)
 (i) options to purchase 186,000 ordinary shares that are exercisable within 60 days
 April 7, 2024, (ii) 65,700 ordinary shares held by Geoffrey M. Glass Revokable
 u/t/d August 26, 2020, of which Mr. Glass and members of his immediate family are
 the sole beneficiaries and Mr. Glass serves as its trustee and (iii) 59,000 ordinary
 shares held by The Geoffrey Glass Trust of which Mr. Glass is a co-trustee and sole
 beneficiary.

 (11)
 options to purchase 194,057 ordinary shares that are exercisable within 60 days of April 7,
 2024.

 (12)
 (i) options to purchase 236,000 ordinary shares that are exercisable within 60 days
 of April 7, 2024, and (ii) 67,025 ordinary shares held by Matthew 5 LLC. The Mark &
 Barbara McCamish Family Trust is the sole owner of Matthew 5 LLC, and Dr. McCamish serves
 as its manager.

 (13)
 options to purchase 186,000 ordinary shares that are exercisable within 60 days of April 7,
 2024.

 (14)
 options to purchase 186,000 ordinary shares that are exercisable within 60 days of April 7,
 2024.

 Item 13.
 Certain Relationships and
 Related Transactions, and Director Independence.

 Policies and Procedures for Related Person
Transactions

 The Audit Committee reviews all related party
transactions and similar matters to the extent required by listing standards. The Nominating and Corporate Governance Committee further
assists to ensure that all such related party transactions are thoroughly reviewed on a regular basis so that such transactions are and
remain at arms' length terms, thus promoting long term shareholder value.

 For purposes of related person transactions as
managed by our Audit and Nominating and Corporate Governance Committees, a "related person transaction" is a transaction,
arrangement or relationship (or any series of similar transactions, arrangements or relationships) in which we (or any of our subsidiaries)
were, are or will be a participant, and the amount involved exceeds $120,000 and in which any related person had, has or will have a
direct or indirect interest. For purposes of determining whether a transaction is a related person transaction, the Committees rely upon
Item 404 of Regulation S-K, promulgated under the Securities Exchange Act of 1934, as amended.

 A "related person"
is defined as:

 Any
 person who is, or at any time since the beginning of our last fiscal year was, one of our
 directors or executive officers or a nominee to become one of our directors;

 Any
 person who is known to be the beneficial owner of more than five percent of any class of
 our voting securities;

 Any
 immediate family member of any of the foregoing persons, which means any child, stepchild,
 parent, stepparent, spouse, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law,
 brother- in-law or sister-in-law of the director, executive officer, nominee or more than
 five percent beneficial owner, and any person (other than a tenant or employee) sharing the
 household of such director, executive officer, nominee or more than five percent beneficial
 owner; and

 Any
 firm, corporation, or other entity in which any of the foregoing persons is employed or is
 a general partner or principal or in a similar position or in which such person has a ten
 percent or greater beneficial ownership interest.

 - 25 -

 Related Party Transactions

 Other than the compensation agreements and other
arrangements described under Item 11 of this Annual Report on Form 10-K, since January 1, 2023, there has not been and there
is not currently proposed, any transaction or series of similar transactions to which we were, or will be, a party in which the amount
involved exceeded, or will exceed, $120,000 and in which any director, executive officer, holder of five percent or more of any class
of any class of our voting securities or any member of the immediate family of, or entities affiliated with, any of the foregoing persons,
had, or will have, a direct or indirect material interest.

 2023 Public Offering

 In April 2023, we closed a registered public
offering pursuant to which we issued and sold an aggregate of 12,205,883 ordinary shares, in the form of ADSs (including up to 2,205,882
ordinary shares, in the form of ADSs sold pursuant to the underwriter's full exercise of its option to purchase additional ADSs)
at a public offering price of $8.50 per ADS and (ii) an aggregate of 4,705,882 Series B Non-Voting Convertible Preferred Shares
("Series B Preferred Shares") at a public offering price of $8.50 per Series B Preferred Share (the "Offering").
The following table sets forth the number of securities purchased in the Offering by holders of five percent or more of our securities:

 Name

 Series B
 Preferred
 Shares
 Purchased

 Total
 Purchase Price

 RTW Master Fund. Ltd.*

 2,746,902

 $
 23,348,667

 RTW Innovation Master Fund, Ltd.*

 1,844,098

 $
 15,674,833

 RTW Venture Fund Limited*

 114,882

 $
 976,497

 *
 RTW Investments, LP is a holder of five percent or more of our securities and may be deemed to beneficially own such securities
purchase in the Offering.

 Board Standards of Independence

 The Board sets our independence standards in
our corporate governance guidelines. The director independence standards provide that a majority of the Board must be independent under
the independence standards established by the corporate governance guidelines, Nasdaq, and the SEC as in effect from time to time. For
a Board member or candidate for election to the Board to qualify as independent, the Board must determine that the person and his or
her immediate family members do not have a material relationship with us (either directly or as a partner, shareholder or officer of
an organization that has a relationship with us) or any of our affiliates. Under the categorical standards adopted by the Board, a member
of the Board is not independent if:

 The
 director is, or has been within the last three years, our employee, or an immediate family
 member is, or has been within the last three years, an executive officer of the Company;

 The
 director has received, or has an immediate family member who has received, during any twelve-month
 period within the last three years, more than $120,000 in direct compensation from us, other
 than director and committee fees and pension or other forms of deferred compensation for
 prior service (provided such compensation is not contingent in any way on continued service);

 (i) The
 director is a current partner or employee of a firm that is our internal or external auditor;
 (ii) the director has an immediate family member who is a current partner of such a
 firm; (iii) the director has an immediate family member who is a current employee of
 such a firm and personally works on our audit; or (iv) the director or an immediate
 family member was within the last three years a partner or employee of such a firm and personally
 worked on our audit within that time;

 - 26 -

 The
 director or an immediate family member is, or has been within the last three years, employed
 as an executive officer of another company where any of our present executive officers at
 the same time serves or served on that company's compensation committee; or

 The
 director is a current employee, or an immediate family member is a current executive officer,
 of a company that has made payments to, or received payments from, us for property or services
 in an amount which, in any of the last three fiscal years, exceeds the greater of $1 million,
 or two percent, of such other company's consolidated gross revenues.

 The Board will also consider a director's
charitable relationships. Contributions to tax-exempt organizations are not considered payments for purposes of the test in the final
bullet point above, provided that we are required to disclose in our annual Proxy Statement any such contributions made by us to any
tax-exempt organization in which any independent director serves as an executive officer if, within the preceding three years, contributions
in any single fiscal year from us to the organization exceeded the greater of $1 million, or two percent, of such tax-exempt organization's
consolidated gross revenues.

 For purposes of the above independence standards,
an "immediate family member" includes a person's spouse, parents, children, siblings, mothers- and fathers-in-law,
sons- and daughters-in-law, brothers- and sisters-in-law and anyone (other than domestic employees) who shares such person's home.
When applying the look-back provisions set forth above, the Board need not consider individuals who are no longer immediate family members
as a result of legal separation or divorce, or those who have died or become incapacitated.

 The Board has affirmatively determined that each
member of the Board (besides Gregory J. Divis, our Chief Executive Officer) is independent in accordance with the above standards. Additionally,
we made no contributions during fiscal year 2023 to any charitable organization in which an independent director serves as an executive
officer in any single fiscal year within the preceding three fiscal years in an amount in excess of the greater of $1 million, or two
percent, of the charitable organization's consolidated gross revenues.

 Item 14.
 Principal Accountant Fees
 and Services.

 Our independent public accounting firm is Deloitte
and Touche LLP, St. Louis, Missouri (PCAOB Auditor ID: 34).

 The following table summarizes the aggregate
fees of our independent registered public accounting firms, billed to us for the fiscal years ended December 31, 2023 and December 31,
2022 for audit and other services:

 Fiscal Year Ended

December 31,

 2023

 2022

 Audit Fees

 $
 1,178,158

 $
 1,055,165

 Audit-related Fees

 —

 —

 Tax Fees

 —

 —

 All Other Fees

 —

 —

 Total Fees

 $
 1,178,158

 $
 1,055,165

 Audit
Fees. Audit fees include professional services rendered by public accounting firms for the audit of our annual financial statements
in 2022 and 2023, including the reviews of the financial statements included in our quarterly reports on Form 10-Q. This category
also includes fees for assistance with complex accounting and transactions, fees for audits provided in connection with statutory filings
or services that generally only the principal auditor can reasonably provide to a client, and consents and assistance with and review
of documents filed with the SEC.

 - 27 -

 Audit-Related
Fees. Audit-related fees consist of amounts for assurance and related services that are reasonably related to the performance
of the audit or review of our financial statements that are not reported under "Audit Fees."

 Tax
Fees. Tax fees include original and amended tax returns, studies supporting tax return amounts as may be required by Internal
Revenue Service regulations, claims for refunds, assistance with tax audits and other work directly affecting or supporting the payment
of taxes, planning, research and advice supporting our efforts to maximize the tax efficiency of our operations for fiscal years 2022
and 2023.

 All
Other Fees. All other fees are fees for products or services other than those in the above three categories.

 Pre-Approval Policy

 The Audit Committee has adopted a policy for
the provision of audit services and permitted non-audit services by our independent registered public accounting firm and all fees described
above were pre-approved by our Audit Committee. Our Chief Financial Officer has primary responsibility to the Audit Committee for administration
and enforcement of this policy and for reporting non-compliance. Under the policy, our Audit Committee receives a presentation of an
annual budget and plan for audit services and for any proposed audit-related, tax or other non-audit services to be performed by the
independent registered public accounting firm.

 - 28 -

 Item 15.
 Exhibits and Financial Statement
 Schedules

 (a)
 Documents filed as part of this
 report:

 1.
 Financial Statements

 See Item 8 -
Financial Statements and Supplementary Data of Part II of the 2023 Annual Report on Form 10-K.

 2.
 Financial Statement Schedules

 The following financial statement schedule of
the Company was filed as part of the Annual Report on Form 10-K and should be read in conjunction with the consolidated statements
of the Company.

 All other schedules are omitted as they are not
applicable, not required or the information is included in the consolidated financial statements or related notes to the consolidated
financial statements.

 (b)
 Exhibits – the following
 exhibits are included herein or incorporated herein by reference:

 Index to Exhibits

 Exhibit Number

 Exhibit Description

 3.1

 Constitution
 (containing the Memorandum and Articles of Association) of Avadel Pharmaceuticals plc (incorporated by reference to Appendix 15 of
 Exhibit 2.1 to the registrant's current report on Form 8-K, filed on July 1, 2016)

 3.2

 Certificate
 of Designation of Series A Non-Voting Convertible Preferred Shares of Avadel Pharmaceuticals plc, dated February 20, 2020
 (incorporated by reference to Exhibit 3.1 to the registrant's current report on Form 8-K, filed on February 24,
 2020)

 3.3

 Certificate
 of Designation of Series B Non-Voting Convertible Preferred Shares of Avadel Pharmaceuticals plc, dated March 29, 2023
 (incorporated by reference to Exhibit 3.1 to the registrant's current report on Form 8-K, filed on March 30,
 2023)

 4.1

 Deposit
 Agreement dated as of January 3, 2017 among Avadel Pharmaceuticals plc, The Bank of New York, as Depositary, and holders from
 time to time of American Depositary Shares issued thereunder (including as an exhibit the form of American Depositary Receipt) (incorporated
 by reference to Exhibit 1.1 to the registrant's current report on Form 8-K12B, filed on January 4, 2017 and
 amended January 6, 2017)

 4.2

 Description
 of Securities (incorporated by reference to Exhibit 4.2 to the registrant's Annual Report on Form 10-K for the year
 ended December 31, 2023, filed on February 29, 2024)

 10.1*

 Exclusive
 License Agreement by and between Perrigo Pharma International DAC (f/k/a Elan Pharma International Limited) and Flamel Ireland Limited
 dated September 30, 2015, as amended by the First Amendment to Exclusive License Agreement dated December 21, 2018 (incorporated
 by reference to Exhibit 10.1 to the registrant's Annual Report on Form 10-K for the year ended December 31,
 2020, filed on March 9, 2021)

 10.2

 Office
 Lease Agreement by and between Grove II LLC and Eclat Pharmaceuticals LLC dated October 5, 2015, as amended (incorporated by
 reference to Exhibit 10.2 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2020,
 filed on March 9, 2021)

 10.3

 December 2015
 Stock Option Rules (incorporated by reference to Exhibit 10.25 to the registrant's Annual Report on Form 10-K
 for the year ended December 31, 2015, filed on March 15, 2016)

 10.4

 Form of
 Stock Option Grant Letter (incorporated by reference to Exhibit 10.26 to the registrant's Annual Report on Form 10-K
 for the year ended December 31, 2015, filed on March 15, 2016)

 - 29 -

 10.5

 Rules Governing
 the Free Share Plan - August 2016 (incorporated by reference to Exhibit 99.1 to the registrant's Registration Statement
 (No. 333-213154) on Form S-8, filed on August 16, 2016)

 10.6

 August 2016
 Stock Option Rules (incorporated by reference to Exhibit 99.2 to the registrant's Registration Statement (No. 333-213154)
 on Form S-8, filed on August 16, 2016)

 10.7

 August 2016
 Stock Warrant Rules (incorporated by reference to Exhibit 99.3 to the registrant's Registration Statement (No. 333-213154)
 on Form S-8, filed on August 16, 2016)

 10.8

 Form of
 stock option grant letter for 2016 Stock Option Rules (incorporated by reference to Exhibit 10.31 to the registrant's Annual
 Report on Form 10-K for the year ended December 31, 2016, filed on March 28, 2017)

 10.9

 Amended
 Employment Agreement dated as of June 3, 2019 between Avadel Management Corporation and Gregory J. Divis (incorporated by reference
 to Exhibit 10.1 to the registrant's current report on Form 8-K, filed on June 5, 2019)

 10.10

 First
 Amendment to Employment Agreement, dated as of September 28, 2022, between Avadel Management Corporation and Gregory J. Divis
 (incorporated by reference to Exhibit 10.1 to the registrant's Quarterly Report on From 10-Q, for the quarter ended September 30,
 2022, filed on November 9, 2022)

 10.11

 Employment
 Agreement dated as of May 15, 2020 between Avadel Management Corporation and Thomas S. McHugh (incorporated by reference to
 Exhibit 10.2 to the registrant's current report on Form 10-Q, filed on August 10, 2020)

 10.12

 First
 Amendment to Employment Agreement, dated as of September 28, 2022, between Avadel Management Corporation and Thomas S. McHugh
 (incorporated by reference to Exhibit 10.2 to the registrant's Quarterly Report on From 10-Q, for the quarter ended September 30,
 2022, filed on November 9, 2022)

 10.13*

 Asset
 Purchase Agreement by and among Cerecor, Inc. and Avadel Pharmaceuticals (USA), Inc., Avadel Pediatrics, Inc., FSC
 Therapeutics, LLC, Avadel US Holdings, Inc. and Avadel Pharmaceuticals plc dated as of February 12, 2018 (incorporated
 by reference to Exhibit 10.43 to the registrant's Annual Report on Form 10-K for the year ended December 31,
 2017, filed on March 16, 2018)

 10.14*

 Guarantee
 by Avadel US Holdings, Inc. and Avadel Pharmaceuticals plc in favor of Deerfield CSF, LLC, Peter Steelman and James Flynn dated
 as of February 16, 2018 (incorporated by reference to Exhibit 10.45 to the registrant's Annual Report on Form 10-K
 for the year ended December 31, 2017, filed on March 16, 2018)

 10.15*

 Guarantee
 by Armistice Capital Master Fund, Ltd. in favor of Avadel US Holdings, Inc. dated as of February 16, 2018 (incorporated
 by reference to Exhibit 10.46 to the registrant's Annual Report on Form 10-K for the year ended December 31,
 2017, filed on March 16, 2018)

 10.16

 Avadel
 Pharmaceuticals plc 2017 Omnibus Incentive Compensation Plan and related equity award agreements (incorporated by reference to Exhibit 10.18
 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2020, filed on March 9, 2021)

 - 30 -

 10.17

 Avadel
 Pharmaceuticals plc 2020 Omnibus Incentive Compensation Plan (incorporated by reference to Exhibit 10.19 to the registrant's
 Annual Report on Form 10-K for the year ended December 31, 2020, filed on March 9, 2021)

 10.18

 Amendment
 to the Avadel Pharmaceuticals plc 2020 Omnibus Incentive Compensation Plan (incorporated by reference to Exhibit 10.1 to the
 registrant's current report on Form 8-K, filed August 3, 2023)

 10.19

 Employment
 Agreement dated as of February 15, 2021 between Avadel Management Corporation and Richard Kim (incorporated by reference to
 Exhibit 10.1 to the registrant's Quarterly report on Form 10-Q, for the quarter ended March 31, 2021, filed
 on May 10, 2021)

 10.20

 First
 Amendment to Employment Agreement, dated as of September 28, 2022, between Avadel Management Corporation and Richard Kim (incorporated
 by reference to Exhibit 10.3 to the registrant's Quarterly Report on From 10-Q, for the quarter ended September 30,
 2022, filed on November 9, 2022)

 10.21

 Avadel
 Pharmaceuticals plc 2021 Inducement Plan and related equity award agreements (incorporated by reference to Exhibit 10.20 to
 the registrant's Annual Report on Form 10-K, for the year ended December 31, 2021, filed on March 16, 2022)

 10.22+^

 Manufacturing
 Agreement by and between Flamel Ireland Limited and Recipharm Pessac, dated as of October 1, 2022 (incorporated by reference
 to Exhibit 10.21 to the registrant's Annual Report on Form 10-K for the year ended December 31, 2022, filed
 on March 29, 2023)

 10.23+^

 Generic
 API Supply Agreement by and between Euticals Inc. and Avadel CNS Pharmaceuticals, LLC, dated as of January 2, 2020 (incorporated
 by reference to Exhibit 10.22 to the registrant's Annual Report on Form 10-K for the year ended December 31,
 2022, filed on March 29, 2023)

 10.24+^

 Purchase
 and Sale Agreement, dated March 29, 2023, between Avadel CNS Pharmaceuticals, LLC, the Company, Flamel Ireland Ltd., and RTW
 Royalty II DAC (incorporated by reference to Exhibit 10.2 to the registrant's current report on Form 8-K, filed on
 March 30, 2023)

 10.25+^

 Generic
 API Supply Agreement and Manufacturing Agreement by and between Catalent Pharma Solutions LLC and Flamel Ireland Limited, dated as
 of March 29, 2018 (incorporated by reference to Exhibit 10.8 to the registrant's Annual Report on Form 10-K
 for the year ended December 31, 2023, filed on February 29, 2024)

 14.1

 Code
 of Business Conduct and Ethics (incorporated by reference to Exhibit 10.8 to the registrant's Annual Report on Form 10-K
 for the year ended December 31, 2023, filed on February 29, 2024)

 14.2

 Financial
 Integrity Policy (incorporated by reference to Exhibit 14.2 to the registrant's current report on Form 8-K, filed
 on March 7, 2017)

 21.1

 List
 of Subsidiaries (incorporated by reference to Exhibit 21.1 to the registrant's Annual Report on Form 10-K
 for the year ended December 31, 2023, filed on February 29, 2024)

 23.1

 Consent
 of Deloitte & Touche LLP (incorporated by reference to Exhibit 23.1 to the registrant's Annual Report
 on Form 10-K for the year ended December 31, 2023, filed on February 29, 2024)

 31.1

 Certification
 of the Chief Executive Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant
 to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 31.1 to the registrant's
 Annual Report on Form 10-K for the year ended December 31, 2023, filed on February 29, 2024)

 - 31 -

 31.2

 Certification
 of the Principal Financial Officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act, as adopted pursuant
 to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 31.2 to the registrant's Annual
 Report on Form 10-K for the year ended December 31, 2023, filed on February 29, 2024)

 32.1

 Certification
 of the Chief Executive Officer pursuant to USC Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act
 of 2002 ( (incorporated by reference to Exhibit 32.1 to the registrant's Annual Report on Form 10-K for the
 year ended December 31, 2023, filed on February 29, 2024)

 32.2

 Certification
 of the Principal Financial Officer pursuant to USC Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley
 Act of 2002 (incorporated by reference to Exhibit 32.2 to the registrant's Annual Report on Form 10-K for
 the year ended December 31, 2023, filed on February 29, 2024)

 97.1

 Avadel Pharmaceuticals plc Compensation Recovery Policy (incorporated by reference to Exhibit 97.1 to the registrant's Annual Report on
Form 10-K for the year ended December 31, 2023, filed on February 29, 2024)

 101.PRE

 Inline
 Annual Report on Form 10-K for the year ended December 31, 2023, filed on February 29, 2024)

 Cover

 *
 Confidential treatment has been requested for the redacted portions of this agreement. A complete copy of the agreement, including
the redacted portions, has been filed separately with the Securities and Exchange Commission.

 # The representations and warranties contained
in this agreement were made only for purposes of the transactions contemplated by the agreement as of specific dates and may have been
qualified by certain disclosures between the parties and a contractual standard of materiality different from those generally applicable
under securities laws, among other limitations. The representations and warranties were made for purposes of allocating contractual risk
between the parties to the agreement and should not be relied upon as a disclosure of factual information relating to the Company, the
Investors or the transaction described in the Current Report on Form 8-K.

 Management contract or compensatory plan or arrangement filed pursuant to Item 15(b) of Form 10-K.

 + Certain exhibits and schedules to these agreements
have been omitted pursuant to Item 601 of Regulation S-K. The registrant will furnish copies of any of the exhibits and schedules to
the Securities and Exchange Commission upon request.

 ^ Certain portions of this exhibit have been
omitted because they are not material, and the registrant customarily and actually treats that information as private or confidential.

 (1) This certification accompanies the Form 10-K
to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into
any filing of the registrant under the Securities Act of 1933 or the Securities Exchange Act of 1934 (whether made before or after the
date of the Form 10-K), irrespective of any general incorporation language contained in such filing.

 - 32 -

 SIGNATURES

 Pursuant to the requirements of Section 13
or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this Report to be signed on its behalf by the undersigned,
thereunto duly authorized.

 Avadel
 Pharmaceuticals plc

 Dated:
 April 26, 2024

 By:

 /s/

 Name: Gregory
 J. Divis

 Title: Chief
 Executive Officer

 Pursuant to the requirements of the Securities
Exchange Act of 1934, this Report has been signed below by the following persons on behalf of the registrant and in the capacities and
on the dates indicated.

 Signature

 Title

 Date

 /s/

 Director,
 Chief Executive Officer and Principal Executive Officer

 2024

 J. Divis

 /s/ Thomas
 S. McHugh

 Chief
 Financial Officer and Principal Financial and Accounting Officer

 2024

 S. McHugh

 *

 Non-Executive
 Chairman of the Board and Director

 2024

 Geoffrey
 M. Glass

 *

 2024

 Dr. Eric
 J. Ende

 *

 2024

 Mark
 A. McCamish, MD, Ph. D.

 *

 2024

 Linda
 S. Palczuk

 *

 2024

 Peter
 J. Thornton

 * /s/ Gregory L. Divis

 Gregory L. Divis

 Attorney-in-Fact

 - 33 -