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 UNITED
STATES

 SECURITIES
AND EXCHANGE COMMISSION

 WASHINGTON,
D.C. 20549

 FORM

 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For
the Fiscal Year ended December 31, 2023

 OR

 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 Commission
file number: 000-56257

SCIENCES, INC.

 (Exact
Name of Registrant as Specified in Its Charter)

 Delaware

 87-3774438

 (State
 of other jurisdiction of

 incorporation
 or organization)

 (I.R.S.
 Employer

 Identification
 No.)

 Penn Plaza, 19th Floor, #1954 New York, NY

 10001

 (Address
 of principal executive offices)

 (Zip
 Code)

 Registrant's
telephone number, including area code: 00 44 2074952379

 Securities
registered pursuant to Section 12(b) of the Act: None

 Securities
registered pursuant to Section 12(g) of the Act:

 Title
 of each class

 Trading
 Symbol(s)

 Name
 of each exchange on which registered

 Common
 Stock

 ACUT

 OTCQB
 Venture Marketplace ("OTCQB")

by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act Yes No

by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act Yes No

by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)
has been subject to such filing requirements for the past 90 days. Yes No

by check mark whether the Registrant has submitted electronically, every Interactive Data File required to be submitted pursuant to Rule
405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant
was required to submit such files). Yes No

by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer,"
"smaller reporting company," and "emerging growth company" in Rule 12b 2 of the Exchange Act.

 Large
 accelerated filer

 Accelerated
 filer

 Non-accelerated
 filer

 Smaller
 reporting company

 Emerging
 growth company

 If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

by check mark whether the registrant whether the registrant has filed a report on and attestation to its management's assessment
of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b))
by the registered public accounting firm that prepared or issued its audit report.

 If
securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant
included in the filing reflect the correction of an error to previously issued financial statements.

by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation
received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).

by check mark whether the registrant is a shell company (as defined in Rule 12b 2 of the Exchange Act). Yes No

 The
aggregate market value of the Company's common stock held by non-affiliates of the registrant was $ 15,998,614, computed by reference
to the closing sale price of the common stock on the OTCQB Venture Marketplace on June 30, 2023, the last business day of the registrant's
most recently completed second fiscal quarter.

 As
of March 22, 2024, there were 11,346,535 shares of Common Stock, $0.001 par value outstanding.

 DOCUMENTS
INCORPORATED BY REFERENCE: None

 PART
 I

 Item
 1.

 Business

 Item
 1A.

 Risk Factors

 Item
 1B.

 Unresolved Staff Comments

 Item
 1C.

 Cybersecurity

 Item
 2.

 Properties

 Item
 3.

 Legal Proceedings

 Item
 4.

 Mine Safety Disclosures

 PART
 II

 Item
 5.

 Market for Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

 Item
 6.

 [Reserved]

 Item
 7.

 Management's Discussion and Analysis of Financial Condition and Results of Operations

 Item
 7A.

 Quantitative and Qualitative Disclosures About Market Risk

 Item
 8.

 Financial Statements and Supplementary Data

 Item
 9.

 Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

 Item
 9A.

 Controls and Procedures

 Item
 9B.

 Other Information

 Item
 9C.

 Disclosure Regarding Foreign Jurisdictions that Prevent Inspections

 PART
 III

 Item
 10.

 Directors, Executive Officers and Corporate Governance

 Item
 11.

 Executive Compensation

 Item
 12.

 Security Ownership of Certain Beneficial Owners and Management and Related Stockholders Matters

 Item
 13.

 Certain Relationships and Related Transactions, and Director Independence

 Item
 14.

 Principal Accountant Fees and Services

 PART
 IV

 Item
 15.

 Exhibits, Financial Statements and Schedules

 Item
 16.

 Form 10-K Summary

 - 2 -

 SPECIAL
NOTE REGARDING FORWARD-LOOKING STATEMENTS AND OTHER INFORMATION CONTAINED IN THIS REPORT

 This
Annual Report on Form 10-K (this "Annual Report") contains "forward-looking statements" within the meaning of
Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, that are intended
to be covered by the "safe harbor" created by those sections. Forward-looking statements, which are based on certain assumptions
and describe our future plans, strategies and expectations, can generally be identified by the use of forward-looking terms such as "believe,"
"expect," "may," "will," "should," "would," "could," "seek,"
"intend," "plan," "goal," "project," "estimate," "anticipate,"
"strategy," "future," "likely" or the negative thereof or other variations thereon or other comparable
terminology. All statements other than statements of historical facts included in this Annual Report regarding our strategies, prospects,
financial condition, operations, costs, plans and objectives are forward-looking statements. Examples of forward-looking statements include,
but are not limited to, statements we make regarding: expectations for revenues, cash flows and financial performance and the anticipated
results of our ongoing development and business strategies.

 Forward-looking
statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations
and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy
and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks
and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial
condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these
forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those
indicated in the forward-looking statements include, but are not limited to, the following:

 the
 success, cost and timing of our clinical development of our products, including the progress of, and results from, our preclinical
 and

 clinical
 trials of StemPrintER products, our discovery programs and other potential product candidates;

 our
 ability to compete with companies currently marketing or engaged in the development of treatments for indications that our product
 candidates are designed to target;

 our
 plans to pursue research and development of other future product candidates;

 the
 potential advantages of our product candidates and those being developed;

 the
 rate and degree of market acceptance and clinical utility of our product candidates;

 the
 success of our collaborations and partnerships with third parties;

 our
 estimates regarding the potential market opportunity for our product candidates;

 our
 sales, marketing and distribution capabilities and strategy;

 our
 ability to establish and maintain arrangements for manufacture of our product candidates;

 our
 intellectual property position;

 our
 expectations related to the use of capital;

 our
 estimates regarding expenses, future revenues, capital requirements and needs for additional financing;

 the
 impact of government laws and regulations; and

 our
 competitive position.

 The
forward-looking statements are based upon management's beliefs and assumptions and are made as of the date of this report. We undertake
no obligation to publicly update or revise any forward-looking statements included in this report. You should not place undue reliance
on these forward-looking statements.

 This
report also contains or may contain estimates, projections and other information concerning our industry and our business, including
data regarding the estimated size of our markets and their projected growth rates. Information that is based on estimates, forecasts,
projections or similar methodologies is inherently subject to uncertainties and actual events or circumstances may differ materially
from events and circumstances reflected in this information. Unless otherwise expressly stated, we obtained these industry, business,
market and other data from reports, studies and similar data prepared by third parties, industry and general publications, government
data and similar sources. In some cases, we do not expressly refer to the sources from which these data are derived.

 Unless
otherwise stated or the context otherwise requires, the terms "AccuStem" "we," "us," "our"
and the "Company" refer collectively to AccuStem and, where appropriate, its subsidiaries.

 Summary
of Risk Factors

 Our
business is subject to numerous risks and uncertainties, including those highlighted in this section below, that represent challenges
that we face in connection with the successful implementation of our strategy. The occurrence of one or more of the events or circumstances
described in more detail in the risk factors below, alone or in combination with other events or circumstances, may have an adverse effect
on our business, cash flows, financial condition and results of operations. Such risks include, but are not limited to:

 We
 have incurred net losses in every year since our inception. We anticipate that we will continue to incur losses for the foreseeable
 future and may never achieve or maintain profitability.

 - 3 -

 We
 need substantial additional funding to complete the development of our product candidates, which may not be available on acceptable
 terms, if at all. Failure to obtain this necessary capital when needed may force us to delay, limit or terminate certain of our product
 development, research operations or future commercialization efforts, if any.

 Our
 recurring losses from operations raise substantial doubt about our ability to continue as a going concern. There is no assurance
 that we will be successful in executing upon our operating plan and be able to maintain an adequate level of liquidity, which would
 result in not being able to continue as a going concern.

 Our
 rights to develop and commercialize our product candidates are subject to the terms and conditions of licenses granted to us by others.
 If we fail to comply with our obligations under our existing and any future intellectual property licenses with third parties, we
 could lose license rights that are important to our business.

 If
 we are unable to obtain and maintain patent protection for our product candidates and technology, or if the scope of our patent protection
 is not sufficiently broad, our competitors could develop and commercialize similar products and technology.

 We
 do not have collaborations in place with institutions for utility studies and there is no guarantee that we will be able to demonstrate
 prospective clinical utility of the StemPrintER.

 We
 are dependent on third parties who provide certain resources and services to us, as we have limited resources.

 We
 operate in a competitive market and will face competition from competitors involved in multi-gene prognostic assay for the prediction
 of risk of recurrence in luminal (ER+/HER2-) breast cancer patients.

 We
 are reliant upon the expertise and continued service of a small number of key individuals of our management, Board of Directors and
 scientific advisors.

 Even
 if we are successful in completing all pre-clinical studies and clinical trials, we may not be successful in commercializing one
 or more of our product candidates.

 We
 will need to expand our organization and may experience difficulties in managing this growth, which could disrupt our operations.

 Our
 employees, independent contractors, consultants, commercial partners, collaborators and vendors may engage in misconduct or other
 improper activities, including noncompliance with regulatory standards and requirements.

 Item
1. Business

 Company Overview

 We
are a clinical stage diagnostics company dedicated to improving quality of life and outcomes for the more than 18 million people worldwide
who are diagnosed with cancer each year. Our plan is to develop and commercialize a suite of novel genomic tests that support decision
making along the entire continuum of oncology care. Our focus will be the commercialization of our proprietary genomic test, StemPrintER,
for patients with early stage breast cancer, and we estimate this market opportunity represents more than $1.3 billion in annual revenue.

 Our
primary product candidate is StemPrintER, a 20-gene prognostic assay intended to predict the risk of distant recurrence ("DR")
in luminal (ER+/HER2-negative) breast cancer patients. The assay was developed to measure the "stemness" of tumors, or how
much a tumor behaves like stem cells which could indicate how likely a cancer is to recur or be resistant to standard treatments, ultimately
impacting how patients are managed by their multi-disciplinary care team. StemPrintER has been validated in several clinical cohorts
and studies, the largest of which are a consecutive series of approximately 2,400 patients from the European Institute of Oncology ("IEO")
and approximately 800 patients from the TransATAC study. In the IEO cohort, StemPrintER High Risk patients ("SPRS High")
were 1.85 times more likely to have a distant recurrence compared to Low Risk ("SPRS Low") patients (Figure 1) and in the
TransATAC cohort, SPRS High patients were 4.27 times more likely to experience a distant recurrence compared to SPRS Low Risk patients
(Figure 2). Together, these data confirm that StemPrintER is highly prognostic for outcomes in patients with breast cancer and indicate
the potential utility of the test in the oncology clinic.

 Beyond
our initial plans for StemPrintER, we believe there is significant opportunity to expand our product portfolio. First, given the broad
applicability of tumor "stemness", which has been evaluated in a multitude of different cancers, we believe the StemPrint
platform will have meaningful clinical utility beyond breast cancer. As such, we will seek to validate and commercialize StemPrint for
a variety of different tumor types. In addition, we plan to offer ancillary commodity testing (e.g., hereditary genetic testing, somatic
mutation testing) that augments our proprietary assays and provides additional information and value to patients and physicians throughout
the patient care continuum.

 We
hold licensing rights for the MSC test (MicroRNA Signature Classifier), which is designed to help determine whether lung nodules identified
by LDCT screening are benign or malignant.

 - 4 -

 Emerging
Growth Company Status

 On
April 5, 2012, the Jumpstart Our Business Startups Act (the "JOBS Act") was enacted. Section 107 of the JOBS Act provides
that an "emerging growth company" can take advantage of the extended transition period provided in Section 7(a)(2)(B) of
the Securities Act for complying with new or revised accounting standards. In other words, an "emerging growth company" can
delay the adoption of certain accounting standards until those standards would otherwise apply to private companies.

 We
have chosen to take advantage of the extended transition periods available to emerging growth companies under the JOBS Act for complying
with new or revised accounting standards until those standards would otherwise apply to private companies provided under the JOBS Act.
As a result, our financial statements may not be comparable to those of companies that comply with public company effective dates for
complying with new or revised accounting standards.

 Subject
to certain conditions set forth in the JOBS Act, as an "emerging growth company," we intend to rely on certain of these exemptions,
including, without limitation, (i) providing an auditor's attestation report on our internal controls over financial reporting
pursuant to Section 404(b) of the Sarbanes-Oxley Act of 2002, as amended, and (ii) complying with the requirement adopted by the Public
Company Accounting Oversight Board regarding the communication of critical audit matters in the auditor's report on financial statements.
We will remain an "emerging growth company" until the earliest of (i) the last day of the fiscal year in which we have total
annual gross revenues of $1.235 billion or more; (ii) the last day of our fiscal year following the fifth anniversary of the date of
the completion of our IPO; (iii) the date on which we have issued more than $1 billion in nonconvertible debt during the previous three
years; or (iv) the date on which we are deemed to be a large accelerated filer under the rules of the SEC.

 - 5 -

 StemPrintER
and Market Opportunity in Breast Cancer

 Each
year, more than two million women are diagnosed with breast cancer worldwide. Endocrine receptor positive (ER+) breast cancers constitute
the majority of breast cancer cases (~75%) and display remarkable variability in clinical behavior. This heterogeneity makes prognosis
and therapy response often challenging to predict using the standard clinicopathological features of the tumor. Although the overall
prognosis for this group of patients is good, a significant proportion (~20%) of these patients will experience distant recurrence in
the first ten years post-surgery. For ER+ patients who also have a negative HER2 status (HER2-), the standard of care is endocrine therapy
with the addition of adjuvant chemotherapy in those patients considered to be at risk of recurrence according to clinicopathological
parameters. However, it has become apparent that these parameters are often insufficient to predict risk of recurrence in ER+/HER2- breast
cancer patients, and, as a consequence, a significant proportion of these patients are either over- or under-treated. We anticipate StemPrintER
will be used in conjunction with clinical evaluation to identify a patient's risk of recurrence to help physicians optimize treatment
planning throughout the care continuum.

 We
believe StemPrintER has a novel biological basis in the stem cell biology and interrogates the intrinsic content and aggressiveness of
cancer stem cells of the primary tumor. The assay uses a reliable real-time quantitative reverse transcription polymerase chain reaction
(qRT-PCR), formalin-fixed, paraffin-embedded (FFPE) platform for testing. StemPrintER was developed and clinically validated in a retrospective
analysis using a consecutive series of approximately 2,400 patients with breast cancer from the IEO. Subsequently, StemPrintER was independently
validated using a cohort of approximately 800 ER+/HER2- postmenopausal patients from the prospective, randomized TransATAC trial.

 Our
plan is to commercialize StemPrintER across all clinical subtypes of early stage breast cancer representing an estimated population of
798,000 patients, and translating to a serviceable market opportunity of more than $1.3 billion.

 StemPrintER
Scientific Background

 The
development and validation of multi-gene assays that interrogate the underlying biology of tumors for accurate prognostication of individual
cancer patients has represented an expanding area of research for more than a decade. The theory that all tumors arise from cancer stem
cells, and the increasing recognition of their relevance to tumor heterogeneity and disease course suggests that the knowledge of the
"degree of stemness" of a breast cancer, or how much a tumor behaves like stem cells, might substantially advance individualized
patient management. Research has shown that a "high stemness" signature in cancer is a primary rationale for disease recurrence
given cancer stem cells are highly adaptable and able to grow indefinitely. StemPrintER was developed to be a novel genomic predictor
of patient outcomes based on a cluster of 20 stem cell genes whose expression levels would be capable of stratifying patients into two
distinct groups: those at very low risk of cancer recurrence and those at an increased risk of their cancer returning. This information
is intended to inform treatment planning at various timepoints throughout the patient care continuum.

 Our
initial research focused on genes that could discriminate mammary stem cells from progeny cells in normal breast tissue. Only those genes
that were expressed at higher levels in mammary stem cells versus progeny were selected. Selection criteria were based on the premise
that cancer stem cells might display traits reminiscent of those present in normal mammary stem cells and, since cancer stem cells are
rare, the selection of overexpressed genes (mammary stem cells versus progeny) afforded a higher likelihood of scoring differences, with
respect to under-expressed genes.

 - 6 -

 Based
on existing published research, several of the 20 stem cell genes display evident connection to metastatic dissemination through their
role in matrix degradation, migration, invasion and engraftment (e.g., MMP1, SNF, MIEN1, PHLDA2, EPB41L5). For other genes in the signature
(RACGAP1, H2AFZ, H2AFJ, APOBEC3B, CENPW, TOP2A CDK1) it was considered possible, or even probable, that they were significant in the
establishment of cancer stem cell phenotypes and might be linked to involvement in genomic instability. A final set of genes, whose putative
role in metastasis is less obvious, includes those involved in: (a) metabolism reprogramming and mitochondrial physiology (MRPS23, NDUFB10,
Phb); (b) mRNA ribonucleoparticle biogenesis, mRNA transcription, splicing and export, and RNA processing and degradation events (ALYREF,
EXOSC4); and (c) survival/escape from apoptosis, which is connected to resistance to hormonal and/or chemotherapy through hijacking of
signaling pathways, such as TGF-beta and pi3k-AKT-mTOR (NOL3, LY6E, EIF4EBP1). Evidence for a mechanistic link between the 20 genes and
the cancer stem cell phenotype comes from the observation that these genes are frequently overexpressed in breast cancer, sometimes as
a consequence of gene amplification.

 StemPrintER
Clinical Research History

 Through
a validation study analyzing a large prospective, randomized cohort of breast cancer patients with high-quality follow-up, and a series
of retrospective studies based on the use of fresh tumor samples and gene expression profiles from additional breast cancer patients,
it has been established that StemPrintER predicts the individual likelihood of developing distant metastases in luminal (ER+/HER2-) and
triple negative breast cancers. Of note, our genomic predictor comprises a set of genes that do not belong (with one exception) to any
other genomic tool or molecular classifier described for triple negative or luminal breast cancers. We accordingly believe that the result
of our research is the development of a unique tool capable of probing into the "degree of stemness", and hence into the
clinical outcome, of breast cancers.

 The
largest validation study for StemPrintER involved the retrospective analysis of nearly 2,400 breast tumor samples collected through the
IEO clinical network. In this published study, StemPrint and StemPrintER were highly prognostic for early and late recurrences in luminal
(ER+/HER2-) and triple negative (ER-/PR-/HER2-) breast cancer patients, independent of standard clinical characteristics.

 In
the TransATAC cohort of ER+/HER2- post-menopausal breast cancer patients, a team of scientists from the IEO conducted an independent
validation of StemPrintER using banked study samples in collaboration with the Royal Marsden Hospital and Queen Mary University in London.
The likelihood ratio x2 (LRx2) and Kaplan-Meier survival analyses were used to assess prognostic information provided by StemPrintER
and OncotypeDX. Comparative analyses were made for DR risk over the entire 10-year follow-up period, as well as in the early (0-5 years)
or late (5-10 years) interval. Our study results showed that StemPrintER was highly prognostic for recurrence risk (Hazard Ration (High
Risk vs. Low Risk)= 4.27 (95% CI: 2.67-6.84), p<0.0001). Additionally, StemPrintER outperformed Oncotype DX RS in 10-year DR risk
prediction in all patients, as well as in N0 and N1-3 patients.

 Commercialization
of the StemPrint Platform and StemPrintER

 From
a clinical standpoint, although future studies are warranted to increase the level of clinical evidence of the reliability and applicability
of the 20-gene test, the recent independent validation using the TransATAC cohort demonstrates the immediate relevance of StemPrintER
for the clinical management of breast cancer patients, in particular for those with ER+/HER2- disease. These luminal patients represent
the majority (~75%) of newly-diagnosed cases and display high molecular heterogeneity and variability in their clinical behavior. Accordingly,
ER+/HER2- breast cancer patients can greatly benefit from accurate stratification of their risk of recurrence for the development of
an optimal treatment plan.

 Historically
in breast cancer, multi-gene assays have been used to inform the role of systemic therapy following surgery. While we believe that StemPrintER
may have the same ability, especially in identifying patients with excellent long-term prognosis who would not derive significant benefit
from adjuvant chemotherapy, we plan to focus on answering alternative clinical questions not addressed by current commercially-available
products. We will devote our resources to obtaining established cohorts of patients and running prospective clinical trials that may
demonstrate a broader utility for StemPrintER.

 - 7 -

 In
order to commercialize a proprietary genomic classifier, it must meet two important benchmarks- the test must have sufficient data to
be used in the clinical management of patients and have enough peer reviewed publications to obtain reimbursement from CMS and other
payers. As of February 2022, with our second validation publication in the European Journal of Cancer, we believe StemPrintER has met
the minimum threshold to enable commercialization. Thus, we plan to launch StemPrintER once we have achieved several key milestones.
First we will identify or build a laboratory ("commercial laboratory") that will be responsible for processing, testing and
reporting StemPrintER results for all commercial samples. Further, we plan to transfer StemPrintER from the laboratories in which they
were developed to the commercial laboratory. Finally, once testing is established in the commercial laboratory, we will seek to obtain
U.S. Clinical Laboratory Improvement Amendments of 1988 ("CLIA") certification so that we are able to report results for
clinical use and to seek reimbursement from the Centers for Medicare and Medicaid Services. We anticipate that it will take at least
18 months to complete these milestones. Once those tasks are complete, we plan to initially launch StemPrintER in the US and then expand
to other markets as we evaluate clinical need and revenue opportunity. See " - IEO/University of Milan License Agreement"
for information regarding the License which could impact our ability to implement our plans.

 To
augment the value proposition of StemPrintER, we also plan to offer additional "commodity" testing (e.g., IHC receptor testing,
hereditary genetic testing). These additional tests should create significant value for our customers while leveraging existing laboratory
equipment and processes for economy of scale and providing additional revenue opportunities to the Company.

 Given
the broad applicability of tumor "stemness", which has been evaluated in a multitude of different cancers, we believe the
StemPrint platform will have meaningful clinical utility beyond breast cancer. As such, we will seek to validate and commercialize StemPrint
in a variety of different tumor types. Each tumor type, where applicable, would also include ancillary testing to boost our value proposition
to customers.

 Reimbursement
Strategy

 Our
revenue is expected to be derived from different sources including standard private third-party and government medical insurance coverage
and reimbursement models. Prior to full commercial scaling, we expect to focus our sales efforts on a small number of early adopting
sites to establish ordering history with payers, effective logistics and additional clinical utility, subject to successful validation
trials and approvals under the CLIA certification or upon the obtaining of a CE mark for the test, which serves as proof of conformity
with European health, safety and environmental production standards.

 Competition

 Genetic
and genomic testing play an important and continually evolving role in the oncology space. In breast cancer, there are several companies
that offer genomic testing that might be competitive with StemPrintER.

 Breast
Cancer

 Breast
Cancer Index (Hologic) is an assay that is designed to predict the likelihood of late breast cancer recurrence and determine the need
for extended endocrine therapy (an additional five years of endocrine therapy beyond the standard five years). The test is for pre- and
post-menopausal patients with ER+/HER2- disease and up to three positive lymph nodes.

 EndoPredict
(Myriad) is a CE-marked assay that is designed to predict the likelihood of metastases developing within ten years of an initial breast
cancer diagnosis. The test is for pre- and post-menopausal patients with early stage ER+/HER2- breast cancer and up to three positive
lymph nodes.

 MammaPrint
(Agendia) is an FDA-cleared, CE-marked assay that is designed to assess the risk of distant recurrence within 5 years and whether a person
would benefit from chemotherapy. The test is for pre- and post-menopausal patients with stage 1 or 2 breast cancer, with a tumor size
of 5 centimeters or less, and LN-negative or LN-positive disease (up to three positive nodes). The test can be used irrespective of ER
and HER2 status.

 - 8 -

 OncotypeDX
is a CE-marked assay that is designed to assess the risk of distant metastasis and to predict the need for chemotherapy in patients with
ER+/HER2- breast cancer. The test can be used in pre- and post-menopausal patients with up to three positive lymph nodes.

 Prosigna
(Veracyte) is a CE-marked assay designed to provide information on breast cancer subtype and to predict distant recurrence-free survival
at ten years. The test is for postmenopausal patients with early-stage ER+/HER2- breast cancer that is LN-negative or LN-positive (up
to 3 positive nodes).

 Pan
Cancer

 The
"commodity" testing that we plan to offer (e.g., IHC receptor testing, somatic mutation testing, hereditary genetic testing)
has numerous competitors in industry (e.g., Ambry, Color Health, Foundation Medicine, Guardant, Invitae, Laboratory Corporation of America,
Natera, Neogenomics, Quest Diagnostics, Tempus) and academic and hospital settings.

 Government
Regulation

 U.S.
health regulatory overview

 The
following provides an overview of key aspects of laboratory service and medical device regulation within the U.S. It should be noted
this overview does not address every facet of regulation at the federal and state level, but only those that would generally be most
relevant to the activities described in this registration statement.

 Federal
and state clinical laboratory licensing requirements

 The
CLIA governs the operations of all clinical laboratories operating in or returning results to individuals in the U.S. CLIA is administered
by The Centers for Medicare & Medicaid Services ('CMS'), in partnership with state health departments. A clinical laboratory
is defined as a laboratory that performs testing on specimens derived from humans for the purpose of providing information for the diagnosis,
prevention or treatment of disease, or the assessment of health. Clinical laboratories must hold a certificate applicable to the type
of laboratory examinations they perform and must demonstrate compliance with regulations addressing, among other things, personnel qualification
and training, record keeping, quality control, and proficiency testing, all of which are intended to ensure the timeliness, reliability,
and accuracy of clinical laboratory testing services. CLIA requires that laboratories demonstrate or verify the analytical validity of
all tests they perform. Where a clinical laboratory analyses specimens based on a proprietary test method (i.e., a laboratory developed
test, 'LDT'), the laboratory must, among other things, document the accuracy, precision, specificity, sensitivity of, and
establish a reference range for, such test.

 CMS
provides for exemption from CLIA for states that develop clinical laboratory standards that are at least as stringent as federal requirements.
Both New York and Washington State are exempt from CLIA. The NYS Clinical Laboratory Evaluation Program requires all independent clinical
laboratories operating in, or testing specimens from, NYS to obtain a laboratory permit prior to commencing operations, and all clinical
laboratories performing LDTs to submit test validation documentation demonstrating the tests' analytical and clinical validity.

 Failure
to comply with CLIA certification and state clinical laboratory licensure requirements may result in a range of enforcement actions,
including certificate or license suspension, limitation, or revocation, directed plan of action, onsite monitoring, civil monetary penalties,
criminal sanctions, and revocation of the laboratory's approval to receive Medicare and Medicaid payment for its services, as well
as significant adverse publicity.

 Food
and Drug Administration

 The
FDA regulates, among other medical products, "medical devices" which include certain articles intended for use in the diagnosis,
prevention, cure, mitigation, or treatment of disease or intended to effect the structure or function of the body. Whether a product
is intended for use as a medical device is generally determined, in the first instance, based on the manufacturer's product labelling,
which includes the label affixed to the product, materials distributed with the product, and promotional communications concerning the
product.

 - 9 -

 Devices
classified as Class I (low risk), generally may be marketed without FDA pre-market review, but are subject to "general controls",
including establishment registration, device listing, record keeping, medical device reporting, and quality system regulations, including
design controls. Devices classified as Class II (moderate risk), may, in addition to general controls, also be subject to "special
controls" (e.g., performance standards / manufacturing standards, post-market surveillance, patient registries, special labelling
requirements, pre-market data requirements and guidelines), and also generally must obtain 510(k) premarket clearance or DeNovo authorization
from FDA. Class III (high risk) devices must, in addition to general controls, obtain FDA pre-market approval through the submission
of a pre- market approval application that contains evidence, including data from adequate and well- controlled clinical studies, demonstrating
that the device is safe and effective for its intended use. In general, devices that require FDA pre-market clearance or DeNovo authorization
may not be commercially distributed or promoted prior to obtaining such authorization, although they may be distributed and used for
the purpose of developing the clinical data necessary to support FDA marketing applications, subject to certain limitations. Post-market
changes to a cleared / authorized or approved device also may be subject to prior review by FDA, depending on the scope of the change
and its potential impact on device safety and effectiveness.

 It
should also be emphasized that this pre-market review process is only one facet of FDA's regulation. For example, FDA regulates
product labelling, including promotional claims; the manufacturing of medical devices, including their design, under FDA quality system
requirements; clinical trials with new or modified products; and post-market monitoring for, reporting of, and action related to, safety
concerns. Failure to comply with applicable pre and post-market device requirements can result in a determination by FDA that a device
is "adulterated" (Section 501) or "misbranded" (Section 502) in violation of the U.S. Federal Food, Drug, and
Cosmetics Act. The statute provides for a number of penalties, including seizure, injunction, criminal, and civil monetary penalties,
for the sale or distribution of adulterated or misbranded devices. In general, prior to undertaking enforcement action, FDA will notify
a regulated entity of a violation or suspected 36 violation through a communication, such as a "Warning Letter" or "Untitled
Letter". If FDA identifies violations during inspection of a manufacturer's facility, the agency will issue a Form 483 listing
the identified violation and directing the manufacturer to make the necessary corrections.

 FDA
regulation of software

 Commercially
distributed software applications that meet the definition of a medical device may be subject to FDA pre-market authorization, depending
on their classification and software function. These include both applications that are components of a hardware medical device and certain
"standalone" software. In 2017, FDA issued final guidance adopting international principles established by the International
Medical Device Regulators Forum for the clinical evaluation of software as a medical device ("SaMD"), which refers to software
that is intended to be used for one or more medical purposes that perform these purposes without being part of a hardware medical device.
In 2019, FDA issued a guidance that provides guidance on FDA's oversight of device software functions including mobile medical
apps that meet the definition of a device. While the guidance is not binding on either FDA or regulated industry, FDA intends to consider
the principles in developing regulatory approaches for SaMD as well as for digital health technologies.

 FDA
regulation of LDTs

 FDA
regulates a category of medical devices, called in vitro diagnostic medical devices, or IVDs, that are used in the collection, preparation,
and examination of specimens from the human body. IVDs include reagents, instruments, and systems that are intended for use in diagnosis
of disease or other conditions, including the state of health, in order to cure, mitigate, treat, or prevention disease or its sequelae.
FDA historically has taken the position that tests developed in-house by a clinical laboratory and used to analyze patient specimens
meet the definition of an IVD and fall within the agency's regulatory jurisdiction. At the same time, FDA historically has for
the most part exercised "enforcement discretion," i.e., has not required clinical laboratories performing LDTs to comply
with IVD device requirements. In the past, FDA has signaled intent to modify its enforcement discretion policy with regard to LDT regulation,
and in 2014 proposed a regulatory framework for LDTs, which it abandoned before implementation in 2016. The U.S. Department of Health
and Human Services (HHS) has determined that LDTs do not require a premarket review with FDA, but rather an applicant may voluntarily
submit a premarket notification or premarket approval (or an Emergency Use Authorization in the case of COVID-19 tests) for their LDT.
It is possible that Congress will enact legislation directing FDA to regulate LDTs.

 - 10 -

 On
June 24, 2021, the U.S. Congress continued its effort to establish a new, risk-based framework for the review and approval of LDTs that
would accelerate innovation and improve the quality of testing, reintroduced a revised version of the Verifying Accurate Leading-edge
IVCT Development (VALID) Act. In its initial construction, the VALID Act may have a significant impact on clinical laboratories as they
will need to comply with several new requirements, including:

 Registration
 and listing with FDA;

 Quality
 requirements;

 Investigational
 studies;

 Premarket
 review and approval or clearance;

 Adverse
 event reporting; and

 Corrections
 and removals.

 While
the VALID Act outlines a framework for these elements (among others), the law, if enacted, would direct FDA over the following years
to promulgate regulations and issue guidance documents, giving clinical laboratories and others the opportunity to participate in shaping
the new IVCT regulatory program.

 The
U.S. Federal Trade Commission and Consumer Protection Laws

 Within
the U.S., the U.S. Federal Trade Commission ("FTC"), has authority to regulate advertising for most medical devices and for
laboratory services. In addition, various state consumer protection laws exist which can similarly regulate claims that are being made
by entities with respect to what benefits their products or services can provide to consumers. In some instances, FTC or U.S. states
have taken action with respect to medical products based on claims being made with respect to, e.g., their benefits to patients, seeking
various penalties, such as injunctions and substantial fines. Activities have focused more, to date, on products that are sold directly
to consumers, such as dietary supplements, as opposed to prescription products ordered by physicians, although the possibility exists
that FTC or other consumer protection bodies could take steps to regulate claims with respect to IVDs or LDTs.

 Fraud
and Abuse

 The
significant U.S. fraud and abuse laws include the:

 Anti-Kickback
 Statute: the federal U.S. Anti-Kickback Statute (42 U.S. Code § 1320a–7b(b) imposes criminal penalties on persons and
 entities for, among other things, knowingly and willfully soliciting, offering, receiving or providing remuneration (including any
 kickback, bribe or rebate), directly or indirectly, in cash or in kind, to induce or reward, or in return for, either the referral
 of an individual for, or the purchase, lease or order of a good, facility, item or service for which payment may be made under a
 government healthcare program such as Medicare and Medicaid.

 False
 Claims Act: the U.S. federal false claims and civil monetary penalties laws, including the federal civil U.S. False Claims Act (31
 USC. §§ 3729 – 3733), impose criminal and civil penalties, including through civil whistleblower or qui tam actions
 against individuals or entities for, among other things knowingly presenting or False Claims Act: the U.S. federal false claims and
 civil monetary penalties laws, including the federal civil U.S. False Claims Act (31 USC. §§ 3729 – 3733), impose
 criminal and civil penalties, including through civil whistleblower or qui tam actions against individuals or entities for, among
 other things knowingly presenting or causing to be presented false or fraudulent claims for payment by a federal healthcare program
 or making a false statement or record material to payment of a false claim or avoiding, decreasing, or concealing an obligation to
 pay money to the federal government, with potential liability including mandatory treble damages, significant per-claim penalties,
 and administrative penalties.

 - 11 -

 Transparency
requirements

 The
U.S. Physician Payments Sunshine Act (known as Affordable Care Act Section 6002: Transparency Reports and Reporting of Physician Ownership
or Investment Interests) requires certain manufacturers of drugs, devices, biologics, and medical supplies for which payment is available
under Medicare, Medicaid, or the Children's Health Insurance Program, with specific exceptions, to report annually to the CMS information
related to payments or transfers of value made to physicians and teaching hospitals, as well as information regarding ownership and investment
interests held by physicians and their immediate family members. Any failure to report or providing incomplete or misleading information
may subject the Company to penalties. Analogous state laws. Analogous state fraud and abuse laws and regulations, such as U.S. state
antikickback and false claims laws, can apply to sales or marketing arrangements, and claims involving healthcare items or services reimbursed
by governmental or non-governmental third-party payors. These laws are generally broad and are enforced by many different U.S. federal
and state agencies as well as through private actions. Some state laws require adherence to compliance guidelines promulgated by the
U.S. federal government and require device and drug manufacturers to report information related to payments and other transfers of value
to physicians and other healthcare providers or marketing expenditures.

 Data
privacy and security

 We
are subject to a number of federal, state and foreign laws and regulations that govern the collection, use, disclosure, and protection
of health-related and other personal information. In the United States, such laws and regulations include health information privacy,
data protection and security laws, data breach notification laws, and consumer protection laws and regulations, such as Section 5 of
the Federal Trade Commission Act. For example, HIPAA imposes obligations on "covered entities," including certain healthcare
providers, such as us, health plans, and healthcare clearinghouses, and their respective "business associates" that create,
receive, maintain or transmit individually identifiable health information for or on behalf of a covered entity, as well as their covered
subcontractors with respect to safeguarding the privacy, security and transmission of individually identifiable protected health information,
or PHI,. Entities that are found to be in violation of HIPAA, whether as the result of a breach of unsecured PHI, a complaint about privacy
practices, or an audit by HHS, may be subject to significant civil, criminal, and administrative fines and penalties and/or additional
reporting and oversight obligations if required to enter into a resolution agreement and corrective action plan with HHS to settle allegations
of HIPAA non-compliance.

 In
addition, certain state and non-U.S. laws, such as the CCPA, the CPRA, the GDPR, the UK GDPR and the UK Data Protection Act 2018, govern
the privacy and security of personal information, including health-related information in certain circumstances, some of which are more
stringent than HIPAA and many of which differ from each other in significant ways and may not have the same effect, thus complicating
compliance efforts.

 Failure
to comply with these laws, where applicable, can result in claims, litigations, regulatory investigations and other proceedings, and
the imposition of significant civil and/or criminal penalties and private litigation. Privacy, data protection and security laws, regulations,
and other obligations are constantly evolving, may conflict with each other to complicate compliance efforts, and can result in claims,
investigations, proceedings, or actions that lead to significant civil and/or criminal penalties, other liabilities, and restrictions
on data use, storage, and other processing.

 Health
Insurance Portability and Accountability Act of 1996 ("HIPAA")

 The
HIPAA imposes criminal and civil liability for, among other things, failing to protect the privacy of patient and security of patient
data. Additionally, the HIPAA by the Health Information Technology for Economic and Clinical Health Act and its implementing regulations,
also imposes obligations on covered entities and their business associates that perform certain functions or activities that involve
the use or disclosure of protected health information on their behalf, including mandatory contractual terms as well as implementing
reasonable and appropriate administrative, physical and technical safeguards with respect to maintaining the privacy, security and transmission
of protected health information.

 - 12 -

 Federal
Trade Commission ("FTC")

 The
FTC has taken an active role with regard to protection of personal information, relying on its broad consumer protection powers to seek
substantial penalties where companies that have made deceptive or misleading statements regarding practices of collecting and safeguarding
data or did not have adequate safeguards to protect information consistent with their claims regarding data security. State laws also
govern the privacy and security of health information in some circumstances, many of which differ from each other in significant ways
and often are not pre-empted by HIPAA, thus complicating compliance efforts.

 Government
and Third-Party Payor Reimbursement and Billing for Clinical Laboratory Services

 Medicare
coverage is limited to items and services that are within the scope of a Medicare benefit category that are reasonable and necessary
for the diagnosis or treatment of an illness or injury.

 Under
Medicare, payment for our tests would be made under the Clinical Laboratory Fee Schedule, or CLFS, with payment amounts assigned to specific
procedure billing codes. In April 2014, Congress passed the Protecting Access to Medicare Act, or PAMA, which included substantial changes
to the way in which clinical laboratory services will be paid under Medicare. Under PAMA, laboratories that receive the majority of their
Medicare revenue from payments made under the CLFS or the Medicare Physician Fee Schedule are required to report to CMS, beginning in
2017 and every three years thereafter (or annually for "advanced diagnostic laboratory tests"), private payor payment rates
and volumes for their tests. Laboratories that fail to report the required payment information may be subject to substantial civil monetary
penalties. As required under PAMA, CMS uses the rates and volumes reported by laboratories to develop Medicare payment rates for laboratory
tests equal to the volume-weighted median of the private payor payment rates for the tests.

 PAMA
also authorizes the adoption of new, temporary billing codes and unique test identifiers for FDA-cleared or approved tests, as well as
advanced diagnostic laboratory tests. The AMA's CPT Editorial Panel created a new section of billing codes to supplement the AMA's
existing Category I CPT code set and to facilitate implementation of this section of PAMA. These proprietary laboratory analyses codes,
or PLA codes, may be requested by a clinical laboratory or manufacturer to specifically identify their test. If approved, the codes are
issued by the AMA on a quarterly basis. While our testing products are not presently identified by any PLA codes, we may choose to seek
a specific PLA code or codes to describe some of our testing products in the future.

 Billing
for testing is complicated. Depending on the billing arrangement and applicable law, we must bill various payors, such as insurance companies,
Medicare, Medicaid, physicians, hospitals, employer groups and patients, all of which have different billing requirements. Additionally,
compliance with applicable laws and regulations as well as internal compliance policies and procedures adds further complexity to the
billing process. Changes in laws and regulations could negatively impact our ability to bill our clients or increase our costs. CMS also
establishes new procedures and continuously evaluates and implements changes to the coverage criteria and reimbursement process for billing
government programs. There is a potential that missing or incorrect information on test requisitions will add complexity to and slow
the billing process, create backlogs of unbilled tests, or generally increase the aging of accounts receivable and bad debt expense.
Failure to timely and correctly bill for testing services may lead to our not being reimbursed for our services or an increase in the
aging of our accounts receivable, which could adversely affect our results of operations and cash flows.

 Revenue
from governmental and third-party payors can be retroactively adjusted after a new examination during the claims settlement process or
as a result of post-payment audits. For example, Medicare reimbursement claims made by healthcare providers and suppliers are subject
to audit from time to time by governmental and third-party payors and their agents. To ensure compliance with Medicare, Medicaid and
other requirements and regulations, government agencies or their agents (including Recovery Audit Contractors, Unified Program Integrity
Contractors and other contractors operating under the Medicare and Medicaid programs) often conduct audits and request customer records
and other documents to support claims submitted for payment of services rendered and compliance with government program claim submission
requirements. Private payors conduct similar audits to ensure claims align with coverage requirements and may take legal action to recover
alleged overpayments. Negative audit findings or allegations of fraud or abuse may subject us to liability, including but not limited
to overpayment liability, refunds or recoupments of previously paid claims, payment suspension, or the revocation of billing or payment
privileges in governmental healthcare programs or termination of arrangements with third-party payors. Failure to comply with applicable
laws relating to billing federal healthcare programs could also lead to various penalties, including but not limited to:

 overpayments
 and recoupments of reimbursement received;

 exclusion
 from participation in Medicare/Medicaid programs;

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 asset
 forfeitures;

 civil
 and criminal fines and penalties; and

 the
 loss of various licenses, certificates and authorizations necessary to operate our business.

 Any
of these penalties or sanctions could have a material adverse effect on our results of operations or cash flows.

 Healthcare
Reform

 In
March 2010, the Patient Protection and Affordable Care Act of 2010, as amended by the Health Care and Education Reconciliation Act of
2010, collectively the Affordable Care Act, or ACA, was enacted in the United States The ACA made a number of substantial changes to
the way healthcare is financed by governmental and private insurers. The ACA, among other things, included provisions governing enrollment
in federal and state healthcare programs, reimbursement matters and fraud and abuse, which we expect will impact our industry and our
operations in ways that we cannot currently predict.

 Since
its enactment, there have been judicial, executive and Congressional challenges to certain aspects of the ACA. On June 17, 2021, the
U.S. Supreme Court dismissed the most recent judicial challenge to the ACA without specifically ruling on the constitutionality of the
ACA. Prior to the Supreme Court's decision, President Biden issued an executive order initiating a special enrollment period from
February 15, 2021 through August 15, 2021 for purposes of obtaining health insurance coverage through the ACA marketplace. The executive
order also instructed certain governmental agencies to review and reconsider their existing policies and rules that limit access to healthcare.
It is unclear how other healthcare reform measures of the Biden administration or other efforts, if any, to challenge, repeal or replace
the ACA will impact the ACA or our business.

 Other
legislative changes have been proposed and adopted since the ACA was enacted. These changes include aggregate reductions to Medicare
payments to providers of 2% per fiscal year pursuant to the Budget Control Act of 2011, which went into effect on April 1, 2013, and
due to subsequent legislative amendments to the statute, will remain in effect through 2030, with the exception of a temporary suspension
from May 1, 2020 through December 31, 2021, unless additional Congressional action is taken. The American Taxpayer Relief Act of 2012,
among other things, further reduced Medicare payments to several providers, including hospitals and cancer treatment centers, and increased
the statute of limitations period for the government to recover overpayments to providers from three to five years. Additional state
and federal health care reform measures may also be adopted in the future, any of which could have a material adverse effect on the clinical
laboratory industry.

 Regulation
of Medical Devices in the European Union

 The
European Union, or EU, has adopted specific directives and regulations regulating the design, manufacture, clinical investigations, conformity
assessment, labeling and adverse event reporting for medical devices (including in vitro diagnostic medical devices).

 In
the EU, there is currently no premarket government review of medical devices. However, the EU requires that all in vitro diagnostic medical
devices placed on the market in the EU must meet the essential requirements of the EU In Vitro Diagnostic Medical Devices Directive,
or Directive 98/79/EC, or the IVDD, including the requirement that an in vitro diagnostic medical device must be designed and manufactured
in such a way that it will not compromise the clinical condition or safety of patients, or the safety and health of users and others.
In addition, the device must achieve the performances intended by the manufacturer and be designed, manufactured, and packaged in a suitable
manner. The European Commission has adopted various standards applicable to medical devices. There are also harmonized standards relating
to design and manufacture. While not mandatory, compliance with these standards is viewed as the easiest way to satisfy the essential
requirements as a practical matter as it creates a rebuttable presumption that the device satisfies that essential requirement.

 - 14 -

 Compliance
with the essential requirements of the IVDD is a prerequisite for European Conformity Marking, or CE-Mark, without which in vitro diagnostic
medical devices cannot be marketed or sold in the EU. To demonstrate compliance with the essential requirements laid down in Annex I
to the IVDD, medical device manufacturers must undergo a conformity assessment procedure, which varies according to the type of medical
device and its (risk) classification. As a general rule, demonstration of conformity of in vitro diagnostic medical devices and their
manufacturers with the essential requirements must be based, among other things, on the evaluation of clinical data supporting the safety
and performance of the products during normal conditions of use. Specifically, a manufacturer must demonstrate that the device achieves
its intended performance during normal conditions of use, that the known and foreseeable risks, and any adverse events, are minimized
and acceptable when weighed against the benefits of its intended performance, and that any claims made about the performance and safety
of the device are supported by suitable evidence. Except for (general) in vitro diagnostic medical devices, where the manufacturer can
self-declare the conformity of its products with the essential requirements, a conformity assessment procedure requires the intervention
of a notified body. Notified bodies are independent organizations designated by EU member states to assess the conformity of devices
before being placed on the market. A notified body would typically audit and examine a product's technical dossiers and the manufacturers'
quality system (notified body must presume that quality systems which implement the relevant harmonized standards – which is ISO
13485:2016 for Quality Management Systems – conform to these requirements). If satisfied that the relevant product conforms to
the relevant essential requirements, the notified body issues a certificate of conformity, which the manufacturer uses as a basis for
its own declaration of conformity. The manufacturer may then apply the CE-Mark to the device, which allows the device to be placed on
the market throughout the EU.

 Throughout
the term of the certificate of conformity, the manufacturer will be subject to periodic surveillance audits to verify continued compliance
with the applicable requirements. In particular, there will be a new audit by the notified body before it will renew the relevant certificate(s).

 All
manufacturers placing in vitro diagnostic medical devices into the market in the EU must comply with the EU medical device vigilance
system. Under this system, incidents must be reported to the relevant authorities of the EU member states, and manufacturers are required
to take Field Safety Corrective Actions, or FSCAs, to reduce a risk of death or serious deterioration in the state of health associated
with the use of an in vitro diagnostic medical device that is already placed on the market. An incident is defined as any malfunction
or deterioration in the characteristics and/or performance of a device, as well as any inadequacy in the labeling or the instructions
for use which, directly or indirectly, might lead to or might have led to the death of a patient or user or of other persons or to a
serious deterioration in their state of health. An FSCA may include the recall, modification, exchange, destruction or retrofitting of
the device. FSCAs must be communicated by the manufacturer or its legal representative to its customers and/or to the end users of the
device through Field Safety Notices.

 The
advertising and promotion of in vitro diagnostic medical devices is subject to some general principles set forth by EU directives. According
to the IVDD, only devices that are CE marked may be marketed and advertised in the EU in accordance with their intended purpose. Directive
2006/114/EC concerning misleading and comparative advertising and Directive 2005/29/EC on unfair commercial practices, while not specific
to the advertising of medical devices, also apply to the advertising thereof and contain general rules, for example requiring that advertisements
are evidenced, balanced and not misleading. Specific requirements are defined at national level. EU member states laws related to the
advertising and promotion of medical devices, which vary between jurisdictions, may limit or restrict the advertising and promotion of
products to the general public and may impose limitations on promotional activities with healthcare professionals.

 Many
member states in the EU have adopted specific anti-gift statutes that further limit commercial practices for medical devices (including
in vitro diagnostic medical devices), in particular vis- -vis healthcare professionals and organizations. Additionally, there
has been a recent trend of increased regulation of payments and transfers of value provided to healthcare professionals or entities.
In addition, many EU member states have adopted national "Sunshine Acts" which impose reporting and transparency requirements
(often on an annual basis), similar to the requirements in the United States, on medical device manufacturers. Certain countries also
mandate implementation of commercial compliance programs.

 - 15 -

 In
the EU, regulatory authorities have the power to carry out announced and, if necessary, unannounced inspections of companies, as well
as suppliers and/or sub-contractors and, where necessary, the facilities of professional users. Failure to comply with regulatory requirements
(as applicable) could require time and resources to respond to the regulatory authorities' observations and to implement corrective
and preventive actions, as appropriate. Regulatory authorities have broad compliance and enforcement powers and if such issues cannot
be resolved to their satisfaction can take a variety of actions, including untitled or warning letters, fines, consent decrees, injunctions,
or civil or criminal penalties.

 The
EU regulatory landscape concerning medical devices is evolving. On April 5, 2017 Regulation (EU) 2017/746 of the European Parliament
and of the Council on in vitro diagnostic medical devices and repealing Directive 98/79/EC and Commission Decision 2010/227/EU, or the
IVDR, was adopted to establish a modernized and more robust EU legislative framework, with the aim of ensuring better protection of public
health and patient safety. Unlike directives, the IVDR does not need to be transposed into national law and therefore reduces the risk
of discrepancies in interpretation across the different European markets.

 The
IVDR will become applicable five years after publication (on May 26, 2022). Once applicable, the IVDR will among other things:

 strengthen
 the rules on placing devices on the market and reinforce surveillance once they are available;

 establish
 explicit provisions on manufacturers' responsibilities for the follow-up of the quality, performance and safety of devices
 placed on the market;

 establish
 explicit provisions on importers' and distributors' obligations and responsibilities;

 impose
 an obligation to identify a responsible person who is ultimately responsible for all aspects of compliance with the requirements
 of the new regulation;

 improve
 the traceability of medical devices throughout the supply chain to the end-user or patient through the introduction of a unique identification
 number, to increase the ability of manufacturers and regulatory authorities to trace specific devices through the supply chain and
 to facilitate the prompt and efficient recall of medical devices that have been found to present a safety risk;

 set
 up a central database (Eudamed) to provide patients, healthcare professionals and the public with comprehensive information on products
 available in the EU; and

 strengthen
 rules for the assessment of certain high-risk devices that may have to undergo an additional check by experts before they are placed
 on the market.

 Regulations
Related to Clinical Laboratories in the European Union

 The
EU does not have an overarching law or regulation that governs the legal framework surrounding the operations of clinical laboratories
in a way that would be analogous to CLIA in the United States. However, EU member states' laws may affect how our business as a
testing service provider is carried out.

 Other
laws and guidelines that impact clinical laboratories work include the Convention for the Protection of Human Rights and Dignity of the
Human Being with regard to the Application of Biology and Medicine, the Declaration of Helsinki adopted by the World Medical Association
and related codes of conduct and guidelines issued by the relevant research ethics committees.

 - 16 -

 Coverage
and Reimbursement

 In
international markets, reimbursement and healthcare payment systems vary significantly by country, and many countries have instituted
price ceilings on specific product lines and procedures. In the EU, member states impose controls on whether products are reimbursable
by national or regional health service providers and on the prices at which devices are reimbursed under state-run healthcare schemes.
More and more, local, product specific reimbursement law is applied as an overlay to medical device regulation, which has provided an
additional layer of clearance requirement.

 Intellectual
Property

 We
consider the protection of our proprietary technologies and products, as well as our ability to maintain patent protection that covers
the composition of matter of our product candidates, their methods of use, and other related technologies and inventions, to be a critical
element in the success of our business. As of March 4, 2024, our licensed intellectual property included three patent families.

 We
license rights to one patent family covering the StemPrintER algorithm and methods of stratifying breast cancer patients with issued
patents in the U.S. and in Europe which expire in 2037, and pending applications in Canada and the U.S. Any patent issuing from the
pending applications is expected to expire in 2037, without taking into account any potential patent term extensions or patent term adjustment.

 We
also license rights to one patent family covering the SPARE algorithm and methods of assessing risk of breast cancer recurrence,
which has pending applications in the U.S. and in Europe and Canada. Any patent issuing from these applications is expected to
expire in 2041, without taking into account any potential patent term extensions or patent term adjustment.

 We also license one patent family relating to miRNA-based methods of detecting lung cancer, which has one issued
patent in Europe which will expire in 2034, and a pending application in the U.S.. Any patent issuing from the pending U.S. application
is expected to expire in 2034, without taking into account any potential patent term extensions or patent term adjustment.

 IEO/University
of Milan License Agreement

 On
June 24, 2014, Tiziana entered into an exclusive license agreement (the "License") with IEO/University of Milan, pursuant
to which it obtained a worldwide, royalty-bearing, exclusive license under certain patents and a worldwide, royalty-bearing, non-exclusive
license under certain know-how of IEO/University of Milan to develop and commercialize licensed products in connection with a multi-gene
prognostic tool. The License was assigned to us as part of the arrangements contained in the demerger agreement on October 30, 2020.
Pursuant to the terms of the License, we are obliged to use reasonable efforts in connection with the development and commercialization
of the licensed products, including in accordance with specified diligence milestones.

 - 17 -

 On
November 9, 2022, AccuStem and the IEO/University of Milan amended the License to clarify the regulatory path and timeline for the commercialization
of StemPrintER. Specifically, the regulatory requirement language has been modified to (i) extend the timeline for regulatory approval
or clearance of a licensed product to 36 months from the date of the amendment, (ii) clarify that contractual regulatory requirements
can be satisfied by the approval or clearance of the test as a Laboratory Developed Test (i.e., approval or clearance can be achieved
via the CLIA regulatory path rather than the FDA) and (iii) the timeline for commercial launch has been extended for an additional 60
months from the date of the amendment. The amendment provides for a separate licensing payment of $175,000 to the IEO.

 The
License also provides additional payments by us of up to 300,000 (or $320,250 based on exchange rate of $1.0675: to 1.00)
in development milestone payments and payment of single digit percentage royalties on net sales. The License remains in effect until
the royalty term has expired with respect to all licensed products in all countries. The License may be terminated by either party in
the event of a material breach and in addition, we may terminate the License at any time upon 30 days' notice.

 Legal
Proceedings

 From
time to time, we may become a party to various legal actions and complaints arising in the ordinary course of business. In addition to
commitments and obligations in the ordinary course of business, we are subject to various claims, pending and potential legal actions
for damages, investigations relating to governmental laws and regulations and other matters arising out of the normal conduct of our
business. It is possible that cash flows or results of operations could be materially affected in any particular period by the unfavorable
resolution of one or more of these contingencies.

 Human
Capital

 As
of December 31, 2023, we had three full time employees. These employees are not represented by a labor union or covered by a collective
bargaining agreement, and we consider our relationship with our employees to be good.

 Compensation,
Benefits, and Development

 We
provide our employees with competitive salaries and bonuses, opportunities for equity ownership, and a robust employment package that
promotes well-being across all aspects of our employees' lives, including health care and paid time off.

 Diversity
and Inclusion

 We
value the diversity of our employees and take pride in our commitment to diversity and inclusion across all levels of our organizational
structure and with respect to our board of directors. We continue to focus on expanding our commitment to diversity and inclusion across
our entire workforce, including working with managers to develop strategies for building diverse teams and promoting the advancement
of employees from diverse backgrounds.

 CORPORATE
INFORMATION

 Our
legal name is AccuStem Sciences, Inc. Our registered office is situated at 5 Penn Plaza, 19th Floor, #1954 New York, NY, and our telephone
number is +44 (0) 20 7495 2379. We have one wholly owned subsidiary: StemPrintER Sciences Limited, a private company incorporated in
England and Wales with limited liability under the Companies Act. Our website address is www. AccuStem.com. The reference to our website
is an inactive textual reference only and information contained in, or that can be accessed through, our website or any other website
cited in this registration statement is not part of hereof.

 - 18 -

 Available
Information

 We
file annual, quarterly, and current reports, proxy statements, and other documents with the Securities and Exchange Commission ("SEC")
under the Securities Exchange Act of 1934, as amended (the "Exchange Act"). The SEC maintains an internet website, www.sec.gov,
that contains reports, proxy and information statements, and other information regarding issuers, including us, that file electronically
with the SEC.

 Copies
of each of our filings with the SEC on Form 10-K, Form 10-Q, and Form 8-K and all amendments to those reports, can be viewed and downloaded
free of charge at our website, www.accustem.com, as soon as reasonably practicable after the reports and amendments are electronically
filed with or furnished to the SEC.

 Our
code of ethics, other corporate policies and procedures, and the charters of our Audit Committee, Compensation Committee, and Nominating/Corporate
Governance Committee are available through our website at www.accustem.com.

 Item
1A. Risk Factors

 The
following risk factors may be important to understanding any statement in this Annual Report on Form 10-K or elsewhere. Our business,
financial condition and operating results can be affected by a number of factors, whether currently known or unknown, including but not
limited to those described below. Any one or more of such factors could directly or indirectly cause our actual results of operations
and financial condition to vary materially from past or anticipated future results of operations and financial condition. Any of these
factors, in whole or in part, could materially and adversely affect our business, financial condition, results of operations and stock
price.

 Risks
Specific to the Development of the Business

 We
do not have collaborations in place with institutions for utility studies and there is no guarantee that we will be able to demonstrate
prospective clinical utility of StemPrintER.

 Following
the completion of the initial retrospective validation studies with respect to StemPrintER, we are likely to run clinical utility studies
to support applications for reimbursement, which are necessary for successful commercialization and to provide further evidence to support
marketing claims. We have not yet identified which institutions will carry out the utility studies and have not yet entered into the
relevant agreements with these institutions. There is a risk that we will not be able to secure these collaborations, which would impact
our ability to proceed to the utility study stage.

 Furthermore,
we may not be able to demonstrate the clinical utility of StemPrintER in a real-world setting, which would impact our ability to secure
reimbursement. If such reimbursement is not achieved, it will make commercialization of StemPrintER significantly more challenging and
would impact our ability to generate revenue and, accordingly, result in a material adverse impact on our business, financial condition,
and results of operations.

 There
are risks associated with the process of establishing a CLIA laboratory and in offering StemPrintER which are outside our control.

 StemPrintER
is a 20-gene test that was designed to indicate the risk of recurrence for patients with early-stage breast cancer, primarily intended
for use in the ER+/HER2- population. We do not yet have a CLIA-certified laboratory that can run StemPrintER as a LDT.

 - 19 -

 Even
if we eventually obtain CLIA certification for a laboratory that will run our assay and proceed to commercialization, there are inherent
risks associated with offering the StemPrintER as a LDT that are outside our control, including test uptake, which would have an impact
on the amount of revenue we could generate. Further, we may not be able to generate any meaningful revenue from offering StemPrintER
as a LDT.

 We
will be dependent on third parties to provide certain resources and services to us, as we have limited resources

 We
plan to rely in part on external resources to conduct the research, development, supply of supplies and clinical testing of our StemPrintER
test, including in relation to our laboratory systems which we expect to rely on software developed by external manufacturers. The future
development of StemPrintER and other products will partly depend upon the performance of these third parties. We cannot guarantee that
the relevant third parties will be able to carry out their obligations under the relevant arrangements. In the future, we may depend
on external resources in marketing, sales and distribution of our products. We cannot guarantee that we will be able to assign competent
partners to conduct these tasks or that these tasks can be completed on the basis of terms which are beneficial to us. Additionally,
while management is responsible for making decisions on our behalf, management will rely to a certain extent on the advice of external
professional advisors. There is no guarantee that we will receive the correct advice from such advisors.

 Disagreements
between us and any third parties could lead to delays in our R&D program and/or commercialization plans. If any third parties were
to terminate their relationships with us, we would be required to obtain development and/or commercialization services from other third
parties or develop the relevant functions internally, which could have an adverse effect on our business, results of operations and financial
condition.

 We
are subject to research and product development risk

 We
may not be able to develop new products or to identify specific market needs that can be addressed by tests or solutions developed us.
Product development will be a key ongoing activity for us. However, there can be no assurance that further products will be developed,
successfully launched, or accepted by the market. All new product development has an inherent level of risk and can be a lengthy process
and suffer unforeseen delays, cost overruns and setbacks, such as difficultly recruiting patients into clinical trials. The nature of
the medical device industry may mean new products may become obsolete as a result of competition or regulatory changes which could have
a material adverse effect on our business, results of operations and financial condition.

 In
addition, R&D may be subject to various requirements, such as research subject protection for individuals participating in clinical
evaluations of new products, institutional review board oversight, regulatory authorizations, and design control requirements. Failure
to comply with requirements could result in penalties, delay, or prevent commercialization of products.

 We
are subject to risks associated with medical and technological change and obsolescence

 Demand
for our products could be adversely impacted by the development of alternative technology and alternative medicines. There can be no
assurance that the technology and products currently being developed by us will not be rendered obsolete. As a result, there is the possibility
that new technology or products may be superior to, or render obsolete, the technology and products that we are currently developing.
Any failure of ours to ensure that our products remain up to date with the latest advances may have a material adverse impact on our
competitiveness and financial performance. Our success will depend, in part, on our ability to develop and adapt our products or acquire
and integrate new technologies to meet these technological changes and industry trends and failure to do so could have a material adverse
effect on our business, results of operations and financial condition.

 - 20 -

 Risks
Relating to Intellectual Property

 Our
rights to develop and commercialize our product candidates are subject to the terms and conditions of licenses granted to us by others.
If we fail to comply with our obligations under our existing and any future intellectual property licenses with third parties, we could
lose license rights that are important to our business.

 We
are reliant upon licenses and sublicenses from Istituto Europeo di Oncologia, Fondazione FIRC per l'Oncologia Molecolare and the
University of Milan ("IEO/University of Milan") to certain patent rights and proprietary technology that are important or
necessary to the development of our technology and product candidates, including the patents and know-how relating to manufacture.

 On
June 24, 2014, Tiziana entered into an exclusive license agreement (the "License") with IEO/University of Milan, pursuant
to which it obtained a worldwide, royalty-bearing, exclusive license under certain patents and a worldwide, royalty-bearing, non-exclusive
license under certain know-how, respectively, of IEO/University of Milan to develop and commercialize licensed products in connection
with a multi-gene prognostic tool. The License was assigned to us as part of the arrangements contained in the demerger agreement on
October 30, 2020. Pursuant to the terms of the License, we are obliged to use reasonable efforts in connection with the development and
commercialization of the licensed products, including in accordance with specified diligence milestones.

 If
we fail to meet our obligations under the License or if the License is terminated for any reason, we may be required to discontinue our
R&D program or any future commercialization efforts of StemPrintER product candidate, be unable to expand our operations or be unable
to otherwise capitalize on our business opportunities, as desired, which could harm our business and potentially cause a discontinuation
of our operations.

 The
License may also be terminated for other reasons including breach and insolvency.

 If
we are unable to obtain and maintain patent protection for our product candidates and technology, or if the scope of our patent protection
is not sufficiently broad, our competitors could develop and commercialize similar products and technology

 Our
success depends, in large part, on our ability to seek, obtain and maintain patent protection in the United States, U.K. and other countries
with respect to our product candidates and technology. Our licensors have sought, and we intend to seek, to protect our proprietary position
by filing patent applications in the United States, the U.K. and elsewhere, related to certain technologies and our product candidate,
StemPrintER, that are important to our business.

 Our
current patent portfolio contains a limited number of patent applications, which are in-licensed from third parties. If we are unable
to assert any such patents to prevent others from reproducing our technology and product candidates, or are unable to identify patentable
aspects of our R&D output before it is too late to obtain patent protection, failure to do so could have a material adverse effect
on our business, results of operations and financial condition.

 Our
intellectual property is open to challenge

 No
assurance can be given that any current or future trademark, design right or patent applications will result in registered trademarks,
design rights or patents, that the scope of any patent, design or trademark protection or the protection provided by copyright or database
rights or the right to bring actions for breach of confidentiality will exclude competitors or provide competitive advantages to us,
that any of our licensed-in patents, design rights or trademarks will be held valid if challenged or that third parties will not claim
rights or ownership of the patents, design rights, trademarks or other intellectual property rights held by us.

 If
we cannot successfully enforce our intellectual property rights, this could have a material adverse effect on our business, financial
condition and prospects. We may be subject to claims in relation to the infringement of patents, design rights, trademarks or other intellectual
property rights owned by third parties. Adverse judgments against us may give rise to significant liabilities in monetary damages, legal
fees and/or an inability to manufacture, market or sell products either at all or in particular territories.

 - 21 -

 Our
strategy involves generating commercially valuable intellectual property that can be protected

 We
intend to augment our intellectual property portfolio. No assurance can be given that any future patent applications will result in granted
patents, that the scope of any patent protection will exclude competitors or provide competitive advantages to us, that any of our patents
will be held valid if challenged or that third parties will not claim rights in or ownership of the patents and other proprietary rights
held by us. Should we fail to successfully obtain additional patent protection in respect its technology and products could have a material
adverse effect on our business, results of operations and financial condition.

and Competitive Risks

 We
operate in a competitive market and will face competition from competitors involved in multi-gene prognostic assay for the prediction
of risk of recurrence in luminal (ER+/HER2-) breast cancer patients

 We
may face competition from competitors involved in developing a multi-gene prognostic assay for the prediction of risk of recurrence in
luminal (ER+/HER2-) breast cancer patients. Many of our competitors will have access to greater research, development, marketing, financial
and personnel resources which may provide commercial advantages to those competitors. New products may be more effective, cheaper or
more effectively marketed than StemPrintER. A substantial increase in competition for any of these reasons could require us to, for example,
increase our marketing or capital expenditure or require us to change our business model to remain competitive, which may have an adverse
impact on our business including our profitability and/or financial condition.

 The
market opportunities for our product candidates may be smaller than we anticipate

 We
are focusing our R&D efforts on a multi-gene prognostic tool for predicting the recurrence of certain breast cancers. Our understanding
of both the number of people who have these diseases, as well as the subset of people with these diseases who have the potential to benefit
from our prognostic assay, is based on estimates. These estimates may prove to be incorrect and new studies may reduce the estimated
incidence or prevalence of these diseases. The number of patients in the United States, the United Kingdom ("U.K."), the
European Union ("EU") and elsewhere may turn out to be lower than expected, may not be otherwise amenable to assessment with
our product candidates or patients may become increasingly difficult to identify and access, all of which would adversely affect our
business, financial condition, results of operations and prospects.

 Further,
there are several factors that could contribute to making the actual number of patients who receive our potential products, if and when
approved, less than the potentially addressable market, such as the lack of widespread availability of, and limited reimbursement for,
new therapies in many underdeveloped markets.

 The
future commercial success of our product candidates will depend upon the degree of each product candidate's market acceptance by
physicians, patients, third-party payors and others in the medical community

 We
have no product authorized for marketing; our product candidates are at the validation study stage of development, and we may never have
a product available to be commercially sold or that becomes commercially successful. The commercial success of our product candidates
will depend, in part, on their acceptance by physicians, patients and third-party payors as medically necessary, cost-effective and safe.
If our future products do not achieve an adequate level of acceptance, we may not generate significant product revenue and may not become
profitable. Even if some product candidates achieve market acceptance, the market may not prove to be large enough to generate significant
revenues. The degree of market acceptance of our product candidates, if approved for commercial sale, will depend on several factors,
including, but not limited to:

 the
 effectiveness and safety of our product candidates as demonstrated in clinical trials;

 the
 potential and perceived advantages of our product candidates over alternative prognostic tools;

 the
 availability and cost of use relative to alternative prognostic tools;

 changes
 in the standard of care for the targeted indications for any product candidate;

 - 22 -

 the
 willingness of physicians to use, and the target patient population to try, new prognostic tools;

 product
 labelling or product insert requirements of the FDA, the U.K. Medicines and Healthcare products Regulatory Agency, the European
 Medicines Agency ("EMA") or other regulatory authorities, including any limitations or warnings contained in a product's
 approved labelling;

 the
 timing of market introduction of competitive products;

 sales,
 distribution and marketing support;

 publicity
 concerning our product candidates or competing products and treatments;

 potential
 product liability claims;

 any
 restrictions on the use of our products together with other medications; and

 favorable
 third-party payor coverage and adequate reimbursement.

 Even
if a potential product displays favorable clinical properties and safety profile in preclinical studies and clinical trials, market acceptance
of the product will not be fully known until after it is launched.

 The
insurance coverage and reimbursement status of newly approved products is uncertain. Failure to obtain or maintain adequate coverage
and reimbursement for our approved product candidates could limit our ability to market those products

 We
expect that coverage and adequate reimbursement by government and private payors will be essential for most patients to be able to afford
our approved product candidates. Accordingly, sales of our product candidates will depend substantially, both domestically and abroad,
on the extent to which the costs of our product candidates will be paid by health maintenance, managed care, pharmacy benefit and similar
healthcare management organizations, or will be reimbursed by government authorities, private health coverage insurers and other third-party
payors. Coverage and reimbursement by a third-party payor may depend upon several factors, including the third-party payor's determination
that use of a product is:

 a
 covered benefit under our health plan;

 safe,
 effective and medically necessary;

 appropriate
 for the specific patient;

 cost-effective;
 and

 neither
 experimental nor investigational.

 Obtaining
coverage and reimbursement for a product from third-party payors is a time-consuming and costly process that could require us to provide
to the payor supporting scientific, clinical and cost-effectiveness data. We may not be able to provide data sufficient to gain acceptance
with respect to coverage and reimbursement. If coverage and reimbursement are not available or delayed, or are available only at limited
levels, we may not be able to successfully commercialize our product candidates. Even if coverage is provided, the approved reimbursement
amount may not be adequate to realize a sufficient return on our investment and less favorable coverage policies and reimbursement rates
may be implemented in the future.

acceptance and sales of our products will depend significantly on the availability of adequate coverage and reimbursement from third-party
payors and may be affected by existing and future healthcare reform measures.

 - 23 -

 Regulatory
Risks

 Complying
with numerous regulations pertaining to our business is an expensive and time-consuming process, and any failure to comply could result
in substantial penalties.

 Once
we have our CLIA certified lab, we will be subject to CLIA, a federal law that regulates clinical laboratories that perform testing on
samples derived from humans for the purpose of providing information for the diagnosis, prevention or treatment of disease. CLIA regulations
mandate specific standards in the areas of personnel qualifications, administration, and participation in proficiency testing, patient
test management, quality control, quality assurance and inspections. We will be subject to survey and inspection every two years. Moreover,
CLIA inspectors may make random inspections of our clinical reference laboratory.

 Although
we are required to hold a certificate of accreditation or compliance under CLIA that allows us to perform high complexity testing, we
are not required to hold a certificate of accreditation through CAP. We could alternatively maintain a certificate of accreditation from
another accrediting organization or a certificate of compliance through inspection by surveyors acting on behalf of the CLIA program.

 The
failure to comply with CLIA requirements can result in enforcement actions, including the revocation, suspension, or limitation of our
CLIA certificate of accreditation, as well as a directed plan of correction, state on-site monitoring, civil money penalties, civil injunctive
suit and/or criminal penalties. We must maintain CLIA compliance and certification to be eligible to bill for tests provided to Medicare
beneficiaries. If we were to be found out of compliance with CLIA program requirements and subjected to sanctions, our business and reputation
could be harmed. Even if it were possible for us to bring our laboratory back into compliance, we could incur significant expenses and
potentially lose revenue in doing so.

 We
will be required to maintain a license to conduct testing in Arizona. Arizona laws establish standards for day-to-day operation of our
clinical reference laboratory, including the training and skills required of personnel and quality control. Moreover, several other states
require that we hold licenses to test samples from patients in those states. Other states may have similar requirements or may adopt
similar requirements in the future. Although we plan to obtain licenses from states where we believe we are required to be licensed,
we may become aware of other states that require out-of-state laboratories to obtain licensure in order to accept samples from the state,
and it is possible that other states currently have such requirements or will have such requirements in the future.

 If
we were to lose our CLIA certificate of accreditation or Arizona license, whether as a result of a revocation, suspension or limitation,
we would no longer be able to sell our testing products, which would limit our revenue and harm our business.

 If
we fail to comply with healthcare laws and regulations, we could face substantial penalties and our business, operations and financial
condition could be adversely affected.

 We
are also subject to healthcare fraud and abuse regulation by both the federal government and the states in which we conduct our business
and to similar foreign laws and regulations in the countries where we conduct our business. These laws include, without limitation, state
and federal anti-kickback, self-referral, fraud and abuse, false claims, and transparency laws and regulations with respect to payments
and other transfers of value made to physicians and other licensed health care professionals.

 The
Anti-Kickback Stature, or AKS, prohibits, among other things, knowingly and willfully offering, paying, soliciting or receiving any remuneration
(including any kickback, bribe or rebate), directly or indirectly, overtly or covertly, in cash or in kind, to induce or in return for
purchasing, leasing, ordering or arranging for the purchase, lease or order of any good, facility, item or service, including laboratory
services, reimbursable, in whole or in part, under Medicare, Medicaid or other federally financed healthcare programs. The term "remuneration"
has been broadly interpreted to include anything of value. The AKS has been interpreted to apply to arrangements between manufacturers
on one hand and prescribers, purchasers and formulary managers on the other. Although there are a number of statutory exceptions and
regulatory safe harbors protecting certain common activities from prosecution, the exceptions and safe harbors are drawn narrowly. Our
practices may not in all cases meet all of the criteria for safe harbor protection from anti-kickback liability. Failure to meet all
of the requirements of a particular applicable statutory exception or regulatory safe harbor, however, does not make the conduct per
se illegal under the AKS. Instead, the legality of the arrangement will be evaluated on a case-by-case basis based on a cumulative review
of all of its facts and circumstances. Several courts have interpreted the statute's intent requirement to mean that if any one
purpose of an arrangement involving remuneration is to induce referrals of federal healthcare covered business, the AKS has been violated.
Further, a person or entity does not need to have actual knowledge of the statute or specific intent to violate it in order to have committed
a violation.

 - 24 -

 On
June 25, 2014, the Office of Inspector General, or OIG, released a Special Fraud Alert, expressing concern regarding laboratory payments
made to referring physicians and physician group practices for blood sample collection, processing, and packaging. Specifically, the
OIG expressed concern that such arrangements may implicate the AKS when laboratories make payments to physicians for services that are
already covered and reimbursed by Medicare, or are not commercially reasonable or exceed fair market value, all in order to induce physicians
to order tests from such laboratory. Because the choice of laboratory and the decision to order laboratory tests is made or strongly
influenced by the physician, with little or no input from patients, such payment may induce physicians to order more laboratory tests
than are medically necessary, particularly when the payments are tied to, or take into account, the volume or value of business generated
by the physician. To the extent our arrangements with physicians and pathology medical groups for services related to sample collection,
transporting and handling are found to be inconsistent with applicable laws, we may be subject to significant penalties, including criminal
penalties, and exclusion from participation in U.S. federal or state health care programs.

 We
are also subject to the federal physician self-referral prohibitions, commonly known as the Stark Law, which prohibits, among other things,
physicians who have a financial relationship, including an investment, ownership or compensation relationship with an entity, from referring
Medicare patients for designated health services, which include clinical laboratory services, unless an exception applies. Similarly,
entities may not bill Medicare or any other party for services furnished pursuant to a prohibited referral. In addition, the government
may assert that a claim including items or services resulting from a violation of the Stark Law constitutes a false or fraudulent claim
for purposes of the false claims laws.

 The
federal civil and criminal false claims law, including the False Claims Act, prohibit, among other things, any person from knowingly
presenting or causing to be presented a false claim for payment to the federal government, or knowingly making or causing to be made
a false statement to get a false or fraudulent claim paid by the federal government. A claim includes "any request or demand"
for money or property presented to the U.S. government. In addition, the government may assert that a claim for items or services arising
from a violation of the AKS or Stark Law constitutes a false or fraudulent claim for purposes of the false claims laws. Private individuals
also have the ability to bring actions under these false claims laws in the name of the government alleging false and fraudulent claims
presented to or paid by the government (or other violations of the statutes) and to share in any amounts paid by the entity to the government
in fines or settlement. Such suits, known as qui tam actions, are pervasive in the healthcare industry.

 HIPAA
also established federal criminal statutes that prohibit, among other things, knowingly and willfully executing, or attempting to execute,
a scheme to defraud any healthcare benefit program, including private third-party payors, and knowingly and willfully falsifying, concealing
or covering up a material fact or making any materially false, fictitious or fraudulent statement in connection with the delivery of
or payment for healthcare benefits, items or services. Similar to the AKS, a person or entity does not need to have actual knowledge
of the statute or specific intent to violate it in order to have committed a violation.

 In
addition, under the federal civil monetary penalties statute, a person is prohibited from offering or transferring to a Medicare or Medicaid
beneficiary any remuneration, including waivers of co-payments and deductible amounts (or any part thereof), that the person knows or
should know is likely to influence the beneficiary's selection of a particular provider, practitioner or supplier of Medicare or
Medicaid payable items or services. Moreover, in certain cases, providers who routinely waive copayments and deductibles for Medicare
and Medicaid beneficiaries can also be held liable under the AKS and civil False Claims Act. One of the statutory exceptions to the prohibition
is non-routine, unadvertised waivers of copayments or deductible amounts based on individualized determinations of financial need or
exhaustion of reasonable collection efforts. The OIG emphasizes, however, that this exception should only be used occasionally to address
special financial needs of a particular patient. Although this prohibition applies only to federal healthcare program beneficiaries,
the routine waivers of copayments and deductibles offered to patients covered by commercial payors may implicate applicable state laws
related to, among other things, unlawful schemes to defraud, excessive fees for services, tortious interference with patient contracts
and statutory or common law fraud. To the extent our patient assistance programs are found to be inconsistent with applicable laws, we
may be required to restructure or discontinue such programs, or be subject to other significant penalties.

 - 25 -

 Under
the Physician Payments Sunshine Act, manufacturers of certain devices, drugs and biologics are required to report to CMS certain payments
and transfers of value by them and in some cases their distributors to physicians (defined to include doctors, dentists, optometrists,
podiatrists and chiropractors), certain other health care providers beginning in 2022, and teaching hospitals, as well as ownership and
investment interests held by physicians (as defined by the statute) and their immediate family members. Because we plan to manufacture
our own laboratory developed tests, or LDTs, solely for use by or within our own laboratory, we believe that we are currently exempt
from these reporting requirements. We cannot assure, however, that our regulators, principally the federal government, will agree with
our determination, and a determination that we have violated these laws and regulations, or a public announcement that we are being investigated
for possible violations, could adversely affect our business, prospects, results of operations or financial condition.

 Several
states in which we plan to operate have also adopted similar fraud and abuse laws as described above. The scope of these laws and the
interpretations of them vary from state to state and are enforced by state courts and regulatory authorities, each with broad discretion.
Some state fraud and abuse laws apply to items or services reimbursed by any payor, including patients and commercial insurers, not just
those reimbursed by a federally funded healthcare program.

 It
is possible that some of our business activities could be subject to challenge under one or more of such laws. Such a challenge, regardless
of the outcome, could have a material adverse effect on our business, business relationships, reputation, financial condition and results
of operations. Although an effective compliance program can mitigate the risk of investigation and prosecution for violations of these
laws, the risks cannot be entirely eliminated. Any action against us for violation of these laws, even if we successfully defend against
it, could cause us to incur significant legal expenses and divert our management's attention from the operation of our business.
Moreover, achieving and sustaining compliance with these laws may prove costly.

 If
we or our operations are found to be in violation of any of the laws described above or any other governmental regulations that apply
to us, we may be subject to significant penalties, including administrative, civil and/or criminal penalties, damages, fines, disgorgement,
individual imprisonment, exclusion from participation in U.S. federal or state health care programs, such as Medicare and Medicaid in
the United States and similar programs outside the United States, a corporate integrity agreement or other agreement to resolve allegations
of non-compliance with these laws, and the curtailment or restructuring of our operations, any of which could materially adversely affect
our ability to operate our business and our financial results. To the extent that any of our testing products are sold in a foreign country,
we may be subject to similar foreign laws and regulations, which may include, for instance, applicable post-marketing requirements, including
safety surveillance, anti-fraud and abuse laws, and implementation of corporate compliance programs and reporting of payments or transfers
of value to healthcare professionals. For instance, many member states in the European Union, or EU, have adopted specific anti-gift
statutes that further limit commercial practices for medical devices (including in vitro diagnostic medical devices), in particular vis- -vis
healthcare professionals and organizations.

 Additionally,
there has been a recent trend of increased regulation of payments and transfers of value provided to healthcare professionals or entities.
In addition, many EU member states have adopted national "Sunshine Acts" which impose reporting and transparency requirements
(often on an annual basis), similar to the requirements in the United States, on medical device manufacturers.

 Our
products and operations are subject to extensive government regulation and oversight both in the United States and abroad, and our failure
to comply with applicable requirements could harm our business.

 Our
product candidates are in vitro tests which can be regulated as medical devices in the United States and other jurisdictions. When applicable,
the FDA and foreign regulatory agencies regulate, among other things, with respect to medical devices: design, development and manufacturing;
testing, labeling, content and language of instructions for use and storage; clinical trials (to the extent applicable, clinical trials
encompass the notion of clinical investigations in the EU); product safety; establishment registration and device listing; marketing,
sales and distribution; premarket clearance, classification, approval, and certification; recordkeeping procedures; advertising and promotion;
recalls and field safety corrective actions; post-market surveillance, including reporting of deaths or serious injuries and malfunctions
that, if they were to recur, could lead to death or serious injury; post-market studies; and product import and export.

 - 26 -

 The
regulations to which we may be subject are complex and have tended to become more stringent over time. Regulatory changes could result
in restrictions on our ability to carry on or expand our operations, higher than anticipated costs or lower than anticipated sales. The
FDA and its foreign counterparts enforce its regulatory requirements through, among other means, periodic unannounced inspections. We
do not know whether we or any contract manufacturers or suppliers that we utilize will be found compliant in connection with any future
FDA or foreign inspections. Failure to comply with applicable regulations could jeopardize our ability to sell our products and result
in enforcement actions such as: warning letters; fines; injunctions; civil penalties; termination of distribution; recalls or seizures
of products; delays in the introduction of products into the market; total or partial suspension of production; refusal to grant future
marketing authorizations or certifications; withdrawals or suspensions of current marketing authorizations and certifications, resulting
in prohibitions on sales of our products; and in the most serious cases, criminal penalties.

 In
order to sell our products in EU member states, our products must comply with the essential requirements of the EU In Vitro Diagnostic
Medical Devices Directive (Directive 98/79/EC), or the IVDD. Compliance with these requirements is a prerequisite to be able to affix
the European Conformity, or CE, mark to our products, without which they cannot be sold or marketed in the EU. All medical devices placed
on the market in the EU must meet the essential requirements laid down in Annex I to the IVDD including the requirement that an in vitro
diagnostic medical device must be designed and manufactured in such a way that it will not compromise the clinical condition or safety
of patients, or the safety and health of users and others. In addition, the device must achieve the performances intended by the manufacturer
and be designed, manufactured, and packaged in a suitable manner. The European Commission has adopted various standards applicable to
medical devices. There are also harmonized standards relating to design and manufacture. While not mandatory, compliance with these standards
is viewed as the easiest way to satisfy the essential requirements as a practical matter as it creates a rebuttable presumption that
the device satisfies that essential requirement. To demonstrate compliance with the essential requirements we must undergo a conformity
assessment procedure, which varies according to the type of medical device and its (risk) classification. As a general rule, demonstration
of conformity of in vitro diagnostic medical devices and their manufacturers with the essential requirements must be based, among other
things, on the evaluation of clinical data supporting the safety and performance of the products during normal conditions of use. Specifically,
a manufacturer must demonstrate that the device achieves its intended performance during normal conditions of use, that the known and
foreseeable risks, and any adverse events, are minimized and acceptable when weighed against the benefits of its intended performance,
and that any claims made about the performance and safety of the device are supported by suitable evidence.

 Except
for (general) in vitro diagnostic medical devices, where the manufacturer can self-declare the conformity of its products with the essential
requirements of the IVDD, a conformity assessment procedure requires the intervention of a notified body. Notified bodies are independent
organizations designated by EU member states to assess the conformity of devices before being placed on the market. The notified body
would typically audit and examine the product's technical file and the manufacturer's quality system (notified body must
presume that quality systems which implement the relevant harmonized standards—which is ISO 13485:2016 for Quality Management Systems—conform
to these requirements). If satisfied that the relevant product conforms to the relevant essential requirements, the notified body issues
a certificate of conformity, which the manufacturer uses as a basis for its own declaration of conformity. The manufacturer may then
apply the CE-Mark to the device, which allows the device to be placed on the market throughout the EU.

 If
we fail to achieve compliance with applicable European laws and directives, we would be unable to continue to affix the CE mark to our
products, which would prevent us from selling them within the EU. In the EU, we must inform the notified body that carried out the conformity
assessment of the devices that we market or sell in the EU and European Economic Area, or EEA, of any planned substantial changes to
our quality system or substantial changes to our in vitro diagnostic medical devices that could affect compliance with the essential
requirements laid down in Annex I to the IVDD or cause a substantial change to the intended use for which the device has been CE marked.
The notified body will then assess the planned changes and verify whether they affect the product's ongoing conformity with the
IVDD. If the assessment is favorable, the notified body will issue a new certificate of conformity or an addendum to the existing certificate
attesting compliance with the essential requirements and quality system requirements laid down in the Annexes to the IVDD.

 - 27 -

 The
aforementioned EU rules are generally applicable in the EEA (which consists of the 27 EU member states plus Norway, Liechtenstein and
Iceland). Non-compliance with the above requirements would also prevent us from selling our products in these three countries.

 The
EU regulatory landscape concerning medical devices is evolving and a new regulation governing in vitro diagnostic medical devices became
applicable on May 26, 2022 and these modifications may have an effect on the way we plan to conduct our business in the EU and the EEA.

 The
FDA may modify its enforcement discretion policy with respect to laboratory developed tests, or LDTs, in a risk-based manner, and we
may become subject to extensive regulatory requirements and may be required to conduct additional clinical trials prior to continuing
to sell our existing tests or launching any other tests in the United States we may develop, which may increase the cost of conducting,
or otherwise harm, our business.

 LDTs
are in vitro tests that are intended for clinical use and are designed, manufactured, and used within a single laboratory. Although LDTs
are classified as medical devices and the FDA has statutory authority to ensure that medical devices are safe and effective for their
intended uses, the FDA has historically exercised enforcement discretion and has not enforced certain applicable FDA requirements, including
premarket review, with respect to LDTs. In addition, in August 2020, HHS announced that the FDA will not require premarket review of
LDTs absent notice-and-comment rulemaking. Although the Biden administration has not taken affirmative steps to rescind this August 2020
announcement issued by the previous administration, this 2020 policy statement is no longer posted on the HHS website.

 Legislative
and administrative proposals proposing to amend the FDA's oversight of LDTs have been introduced in recent years and we expect
that new legislative and administrative proposals will continue to be introduced from time to time. It is possible that legislation could
be enacted into law or regulations or guidance could be issued by the FDA which may result in new or increased regulatory requirements
for us to continue to offer our LDTs or to develop and introduce new tests as LDTs in the United States.

 For
example, the FDA could modify its current approach to LDTs in a way that would subject our tests that we market in the United States
as LDTs to the enforcement of additional regulatory requirements. In recent years, the FDA has stated its intention to modify its enforcement
discretion policy with respect to LDTs.

 Specifically,
on July 31, 2014, the FDA notified Congress of its intent to modify, in a risk-based manner, its policy of enforcement discretion with
respect to LDTs. On October 3, 2014, the FDA issued two draft guidance documents entitled "Framework for Regulatory Oversight of
Laboratory Developed Tests (LDTs)," or the Framework Guidance, and "FDA Notification and Medical Device Reporting for Laboratory
Developed Tests (LDTs)". The FDA halted finalization of the guidance in November 2016 to allow for further public discussion on
an appropriate oversight approach to LDTs and to give congressional authorizing committees the opportunity to develop a legislative solution,
and FDA issued a discussion paper on possible approaches to LDT regulation in January 2017.

 In
addition, the FDA and Congress have, for over the past decade, considered a number of proposals to end the FDA's enforcement discretion
policy for LDTs and subject LDTs to additional regulatory requirements. For example, Congress has recently worked on legislation to create
an LDT and in vitro diagnostic regulatory framework for all in vitro clinical tests that would be separate and distinct from the existing
medical device regulatory framework. In June 2021, members of the U.S. House of Representatives formally introduced the VALID Act (Verifying
Accurate Leading-edge IVCT Development Act of 2021) and an identical version of the bill was introduced in the U.S. Senate. If passed
in its current form, the VALID Act would create a new category of medical products separate from medical devices called "in vitro
clinical tests," or IVCTs, and bring all such products within the scope of FDA's oversight. The VALID Act appears to contemplate
that traditional LDTs would become subject to FDA regulation as IVCTs, and that all IVCTs would be categorized as either high-risk or
low-risk, distinct from FDA's existing classification for medical devices into Class I, Class II, or Class III. As proposed, the
risk classification for an IVCT would depend on certain factors, including the risk to the patient or public health of an inaccurate
result, the extent to which, the test is well-understood and/or how well-characterized it is, the clinical circumstances under which
the test is used, and the availability of other tests and any mitigating measures. Depending on the risk classification, new IVCTs, or
certain modifications to existing IVCTs, could be subject to premarket review. Notably, the bill currently includes a provision that
would "grandfather" certain tests that were commercialized before the enactment of the legislation, subject to certain requirements.
It is unclear whether the VALID Act or any other legislative proposals would be passed by Congress or signed into law by the President.

 - 28 -

 Even
if the FDA does not modify its policy of enforcement discretion, they may impose significant regulatory requirements, including the requirement
for premarket review and subsequent marketing authorization at some point in the future. We may also be required to conduct clinical
studies to support our planned product launches. If we are required to conduct such clinical trials, delays in the commencement or completion
of clinical testing could significantly increase our test development costs and delay commercialization of any products.

 If
we do not obtain and maintain any required international regulatory registrations and marketing authorizations or certifications for
our products, we will be unable to market and sell such products outside of the United States.

 Sales
of our products outside of the United States will remain subject to foreign regulatory requirements that vary widely from country to
country. In addition, the FDA regulates exports of medical devices from the United States. While the regulations of some countries may
not impose significant barriers to marketing and selling our products or only require notification to regulators or third parties, others
require that we obtain affirmative marketing authorization from a specified regulatory body. Complying with foreign regulatory requirements,
including obtaining registrations, marketing authorizations or certifications, can be expensive and time-consuming, and we may not receive
necessary marketing authorizations in each country in which we plan to market our products or we may be unable to do so on a timely basis.
The time required to obtain registrations and marketing authorizations, if required by other countries, may be longer than that required
for FDA marketing authorizations, and requirements for such registrations or authorizations may significantly differ from FDA requirements.
If we modify our products, we may need to apply for additional marketing authorizations before we are permitted to sell the modified
product. In addition, we may not continue to meet the quality and safety standards required to maintain the authorizations that we have
received. If we are unable to maintain our marketing authorizations in a particular country, we will no longer be able to sell the applicable
product in that country.

 Obtaining
marketing authorization in the United States from the FDA does not ensure similar marketing authorization or certification by regulatory
authorities or notified bodies in other countries, and registration, marketing authorization or certification by one or more foreign
regulatory authorities or notified bodies does not ensure registration, marketing authorization, or certification by regulatory authorities
or notified bodies in other foreign countries or by the FDA. However, a failure or delay in obtaining registration, marketing authorization
or certification in one country may have a negative effect on the regulatory process in others.

 Legislative
or regulatory reforms in the United States or the EU may make it more difficult and costly for us to obtain marketing authorizations
or certifications for any product candidate or to manufacture, market or distribute any product candidates after such authorizations
have been obtained.

 From
time to time, legislation is drafted and introduced in Congress that could significantly change the statutory provisions governing the
regulation of medical devices. In addition, the FDA may change its policies, adopt additional regulations or revise existing regulations,
or take other actions, which may prevent or delay marketing authorization in the United States of our future products under development
or impact our ability to modify any products for which we have already obtained marketing authorizations on a timely basis. Over the
last several years, the FDA has proposed reforms to its 510(k) clearance process, and such proposals could include increased requirements
for clinical data and a longer review period, or could make it more difficult for manufacturers to utilize the 510(k) clearance process
for their products. For example, in November 2018, FDA officials announced steps that the FDA intended to take to modernize the premarket
notification pathway under Section 510(k) of the FDCA. Among other things, the FDA announced that it planned to develop proposals to
drive manufacturers utilizing the 510(k) pathway toward the use of newer predicates. These proposals included plans to potentially sunset
certain older devices that were used as predicates under the 510(k) clearance pathway, and to potentially publish a list of devices that
have been cleared on the basis of demonstrated substantial equivalence to predicate devices that are more than ten years old. These proposals
have not yet been finalized or adopted, although the FDA may work with Congress to implement such proposals through legislation. Accordingly,
it is unclear the extent to which any proposals, if adopted, could impose additional regulatory requirements on us that could delay our
ability to obtain 510(k) clearances in the future, increase the costs of compliance, or restrict our ability to maintain any marketing
authorizations that we may obtain, or otherwise create competition that may negatively affect our business.

 - 29 -

 More
recently, in September 2019, the FDA issued revised final guidance describing an optional "safety and performance based"
premarket review pathway for manufacturers of "certain, well-understood device types" to demonstrate substantial equivalence
under the 510(k) clearance pathway by showing that such device meets objective safety and performance criteria established by the FDA,
thereby obviating the need for manufacturers to compare the safety and performance of their medical devices to specific predicate devices
in the clearance process. The FDA maintains a list of device types appropriate for the "safety and performance based" pathway
and continues to develop product-specific guidance documents that identify the performance criteria for each such device type, as well
as recommended testing methods, where feasible. The FDA may establish performance criteria for classes of devices similar to ours, and
it is unclear the extent to which such performance standards, if established, could impact our ability to obtain marketing authorization
or otherwise create competition that may negatively affect our business.

 In
addition, FDA regulations and guidance are often revised or reinterpreted by the FDA in ways that may significantly affect our business
and our products. Any new statutes, regulations or revisions or reinterpretations of existing regulations may impose additional costs
or lengthen review times of any product candidates or make it more difficult to obtain marketing authorizations for, manufacture, market
or distribute any product candidate we are developing. We cannot determine what effect changes in regulations, statutes, legal interpretation
or policies, when and if promulgated, enacted or adopted may have on our business in the future. Such changes could, among other things,
require: additional testing prior to seeking marketing authorization, changes to manufacturing methods recalls, replacement or discontinuance
of our products; or additional record keeping.

 The
FDA's and other regulatory authorities' policies may change and additional government regulations may be promulgated that
could prevent, limit or delay marketing authorization of any product candidates we develop. If we are slow or unable to adapt to changes
in existing requirements or the adoption of new requirements or policies, or if we are not able to maintain regulatory compliance, we
may be subject to enforcement action and we may not achieve or sustain profitability.

 The
EU regulatory landscape concerning medical devices is evolving. On April 5, 2017, Regulation (EU) 2017/746 of the European Parliament
and of the Council on in vitro diagnostic medical devices and repealing Directive 98/79/EC and Commission Decision 2010/227/EU, or the
IVDR, was adopted to establish a modernized and more robust EU legislative framework, with the aim of ensuring better protection of public
health and patient safety. Unlike directives, the IVDR does not need to be transposed into national law and therefore reduces the risk
of discrepancies in interpretation across the different European markets.

 The
IVDR will become applicable five years after publication (on May 26, 2022). Once applicable, the IVDR will among other things:

 strengthen
 the rules on placing devices on the market and reinforce surveillance once they are available;

 establish
 explicit provisions on manufacturers' responsibilities for the follow-up of the quality, performance and safety of devices
 placed on the market;

 establish
 explicit provisions on importers' and distributors' obligations and responsibilities;

 impose
 an obligation to identify a responsible person who is ultimately responsible for all aspects of compliance with the requirements
 of the new regulation;

 improve
 the traceability of medical devices throughout the supply chain to the end-user or patient through the introduction of a unique identification
 number, to increase the ability of manufacturers and regulatory authorities to trace specific devices through the supply chain and
 to facilitate the prompt and efficient recall of medical devices that have been found to present a safety risk;

 - 30 -

 set up a central database
 (Eudamed) to provide patients, healthcare professionals and the public with comprehensive information on products available in the
 EU; and

 strengthen rules for the
 assessment of certain high-risk devices that may have to undergo an additional check by experts before they are placed on the market.

 These
modifications may have an effect on the way we conduct our business in the EEA.

 Changes
in funding for, or disruptions caused by global health concerns impacting, the FDA and other government agencies could hinder their ability
to hire and retain key leadership and other personnel, or otherwise prevent new medical device products from being developed, authorized
or commercialized in a timely manner, which could negatively impact our business.

 The
ability of the FDA, foreign regulatory agencies and notified bodies to review, authorize and certify the sale of new products can be
affected by a variety of factors, including government budget and funding levels; its ability to hire and retain key personnel and accept
the payment of user fees; statutory, regulatory, and policy changes; and other events that may otherwise affect the FDA's ability
to perform routine functions. Average review times at the FDA have fluctuated in recent years as a result. In addition, government funding
of other government agencies that fund research and development activities is subject to the political process, which is inherently fluid
and unpredictable. Disruptions at the FDA and other agencies may also slow the time necessary for new devices, including in vitro diagnostics
to be reviewed and/or authorized for marketing by necessary government agencies, which would adversely affect our business. For example,
over the last several years, including for 35 days beginning on December 22, 2018, the U.S. government has shut down several times and
certain regulatory agencies, such as the FDA, have had to furlough critical FDA employees and stop critical activities.

 On
July 10, 2020, the FDA announced its intention to resume certain on-site inspections of domestic manufacturing facilities subject to
a risk-based prioritization system which had been postponed previously due to the COVID-19 pandemic. The FDA intends to use this risk-based
assessment system to identify the categories of regulatory activity that can occur within a given geographic area, ranging from mission
critical inspections to resumption of all regulatory activities. Other regulatory authorities may adopt similar restrictions or other
policy measures in response to the COVID-19 pandemic. If a prolonged government shutdown occurs, or if global health concerns continue
to prevent the FDA, other regulatory authorities or notified bodies from conducting business as usual or conducting inspections, reviews
or other regulatory activities, it could significantly impact the ability of the FDA to timely review and process our regulatory submissions,
which could have a material adverse effect on our business.

 For
instance, in the EU, notified bodies must be officially designated to certify products and services in accordance with the IVDR. Only
a few notified bodies have been designated so far but the COVID-19 pandemic has significantly slowed down their designation process.
Without IVDR designation, notified bodies may not yet start certifying devices in accordance with the new Regulation. As only a few notified
bodies have been IVDR-designated they are facing a heavy workload and their review times have lengthened. This situation could impact
the way we are conducting our business in the EU and the EEA.

 If
we are unable to effectively adapt to changes in the healthcare industry, including changes to laws and regulations regarding or affecting
the U.S. healthcare reform, our business may be harmed.

 Federal,
state and local legislative bodies frequently pass legislation and promulgate regulations relating to healthcare reform or that affect
the healthcare industry. We anticipate that there will continue to be increased government oversight and regulation of the healthcare
industry in the future. We cannot predict the ultimate content, timing or effect of any new healthcare legislation or regulations, nor
is it possible at this time to estimate the impact of potential new legislation or regulations on our business. It is possible that future
legislation enacted by Congress or state legislatures, or regulations promulgated by regulatory authorities at the federal or state level,
could adversely affect our business.

 - 31 -

 Our
failure to maintain compliance of our future clinical laboratory operations with applicable laws could result in substantial civil or
criminal penalties

 The
operation of a clinical laboratory by us will be in a highly regulated environment which, among other things, will require maintaining
compliance with CLIA certification and state clinical laboratory licensing requirements. Failure to maintain compliance with these requirements
may result in a range of enforcement actions, including certificate or license suspension, limitation, or revocation, directed plan of
action, onsite monitoring, civil monetary penalties and criminal sanctions. Such failure may also result in significant adverse publicity.
Any of these consequences could limit or entirely prevent our continued operation and therefore impact our financial performance.

 Failure
in, or security breaches or incidents impacting, our information technology, storage systems or our clinical laboratory equipment could
significantly disrupt our operations and our research and development efforts.

 Our
ability to execute our business strategy will depend, in part, on the continued and uninterrupted performance of our information technology,
or IT, systems, which support our operations, including at our proposed clinical laboratories, and our research and development efforts.
We are dependent on our IT systems for many aspects of our business, including our needs to retain and store our confidential and proprietary
business information and to receive and process test orders, securely store patient health records and deliver the results of our tests.
The integrity and protection of our own data, and that of our customers and employees, is critical to our business. The regulatory environment
governing information, security and privacy and data protection laws is increasingly demanding and continues to evolve. IT systems are
vulnerable to damage from a variety of sources, including telecommunications or network failures, cyberattacks (including ransomware
attacks) and other malicious human acts from criminal hackers, hacktivists, state-sponsored intrusions and other attacks, industrial
espionage and employee malfeasance, breaches and incidents due to employee error or negligence, and natural disasters. Moreover, despite
network security and back-up measures, some of our servers are potentially vulnerable to physical or electronic break-ins, computer viruses
and other malicious code similar disruptive problems.

 High-profile
security breaches and incidents at other companies and in government agencies have increased in recent years, and security industry experts
and government officials have warned about the risks of hackers and cyber-attacks targeting businesses such as ours. Cyber-attacks are
becoming more sophisticated and frequent, and in some cases have caused significant harm. Computer hackers and others routinely attempt
to breach the security of technology products, services and systems, and to fraudulently induce employees, customers, or others to disclosure
information or unwittingly provide access to systems or data. Much of our workforce currently works remotely rather than in our offices,
and we may be more susceptible to security breaches and incidents as a result. Our service providers may be more susceptible to security
breaches and other security incidents while social distancing measures restrict the ability of their employees to work at offices to
combat the COVID-19 pandemic.

 We
may in the future experience attempted or successful cyber-attacks of our IT systems or networks. To date, we have not experienced any
material cyber-attacks. However, any security breach or incident impacting, or interruption could compromise our networks and the information
stored therein, including algorithms relating to our products, could be accessed by unauthorized parties, publicly disclosed, lost, inaccessible
or unavailable, corrupted, or stolen. Despite the precautionary measures we have taken to prevent unanticipated problems that could affect
our IT systems, unauthorized access to our systems, or disruptions or other security breaches impacting our IT systems, and any unauthorized
access to, or, loss, inaccessibility, unavailability, corruption, theft or disclosure could also disrupt our operations, including our
ability to:

 process
 tests, provide test results, bill payors or patients;

 process
 claims and appeals;

 provide
 customer assistance services;

 conduct
 research and development activities;

 collect,
 process and prepare company financial information;

 provide
 information about our tests and other patient and healthcare provider education and outreach efforts through our website; and

 and
 manage the administrative aspects of our business and damage our reputation.

 - 32 -

 Any
such breach, incident, or other compromise of IT systems or data, or the perception that any of these has occurred, could result in legal
claims or proceedings, liability under laws that protect the privacy of personal information, such as the Health Insurance Portability
and Accountability Act of 1996, or HIPAA, similar U.S. state data protection regulations, including the California Consumer Privacy Act,
or CCPA, the EU General Data Protection Regulation, or GDPR, and other regulations, the breach of which could result in claims, complaints,
regulatory investigations and other proceedings, and significant fines, penalties, and other liability. We also may be required to incur
significant costs in an effort to detect and prevent security breaches and other security-related incidents. Additionally, information
obtained by third parties in connection with past or future cyberattacks or other security breaches or incidents could be used in ways
that adversely affect our company or our stockholders.

 Further,
third-party service providers who support our operations, and our independent contractors (including CROs), consultants, collaborators,
and service providers also may suffer interruptions and disruptions of systems and other breaches, incidents, or other compromises of
or impacting their IT systems or data that they process or maintain for us, which may lead to any of the foregoing. We and our third-party
service providers may not have the resources or technical sophistication to anticipate or prevent all cyberattacks or other sources of
security breaches or incidents, and we or they may face difficulties or delays in identifying and responding to cyberattacks and data
security breaches and incidents. In addition, the interpretation and application of consumer, health related and security, privacy and
data protection laws in the United States, Europe and elsewhere are often uncertain, contradictory and in flux, such as in the area of
international transfers of personal data. Complying with these various laws, and satisfying healthcare providers' and patients'
evolving expectations with respect to data protection, could cause us to incur substantial costs or require us to change our business
practices and compliance procedures in a manner adverse to our business.

 We
do not maintain insurance policies for cybersecurity-related matters, data handling or data security liabilities. The successful assertion
of one or more large claims against us could have a material adverse effect on our business, including our financial condition, operating
results, and reputation

 Potential
conflicts of interest between our management, Board of Directors, and significant stockholders and Tiziana could result in a divergence
of interest between management and investors.

 Certain
directors, management personnel, and significant stockholders of Tiziana are also our directors, officers and significant stockholders.
Additionally, a majority of the Board, as of the date hereof, consists of individuals who are also affiliated with Tiziana. Conflicts
of interest may arise between the best interest of our stockholders and Tiziana with respect to the performance of services by Tiziana
by us. There can be no assurances that any such conflicts will be resolved in our favor or will not adversely affect our business, operations
or operating results.

 Certain
members of our management do not devote their full time to our company and certain of our officers and directors may have conflicts of
interest.

 While
our executive officers devote such time to us as they deem reasonable and necessary to discharge the business of our company, our officers
have professional interests in a variety of activities other than those relevant to us and are not required to devote any minimum amount
of time to our business. Keeren Shah, our Chief Financial Officer also serves as Chief Financial Officer of Tiziana Life Sciences, OKYO
Pharma Ltd and Actavia Life Sciences, Inc. ( formerly known as Rasna Therapeutics Inc). Accordingly, conflicts may arise in the allocation
of time between our company and one or more of these activities. While we expect that our board of directors and management will exercise
their fiduciary obligation to our company, there are no assurances any conflicts of interest which may arise will be resolved in our
favor.

 - 33 -

 Risks
Specific to Our Financial Position and the Future Financing of the Business

 We
have incurred net losses in every year since our inception. We anticipate that we will continue to incur losses for the foreseeable future
and may never achieve or maintain profitability.

 We
are a clinical stage diagnostic company with a limited operating history. Since our inception in May 2013, we have incurred significant
net losses. Our net losses were $2,050,664 and $3,746,419 for the year ended December 31, 2023 and 2022, respectively. As of December
31, 2023, we had an accumulated deficit of $6,521,945. We expect that it could be several years, if ever, before we have a commercialized
product candidate. We expect to continue to incur significant and increasing operating expenses and losses for the foreseeable future.
These net losses will adversely impact our stockholders' equity and net assets and may fluctuate significantly from quarter to
quarter and year to year. We anticipate that our expenses will increase substantially if, and as, we:

 manufacture our product
 candidates in accordance with current good manufacturing practices, or cGMP, for clinical trials or potential commercial sales;

 establish a sales, marketing
 and distribution infrastructure to commercialize any product candidate for which we may obtain marketing approval;

 develop, maintain, expand
 and protect our intellectual property portfolio;

 identify, assess, and acquire
 or in-license other product candidates and technologies;

 secure, maintain or obtain
 freedom to operate for any in-licensed technologies and products;

 address any competing technological
 and market developments; and

 expand our operations in
 the United States and Europe.

 We
may never succeed in any or all of these activities and, even if we do, we may never generate revenues that are significant or large
enough to achieve profitability. If we do achieve profitability, we may not be able to sustain or increase profitability on a quarterly
or annual basis. Our failure to become and remain profitable would decrease the value of our company and could impair our ability to
raise capital, maintain our research and development, or R&D, efforts expand our business or continue our operations.

 We
need substantial additional funding to complete the development of its product candidates, which may not be available on acceptable terms,
if at all. Failure to obtain this necessary capital when needed may force us to delay, limit or terminate certain of our product development,
research operations or future commercialization efforts, if any

 Our
operations have consumed substantial amounts of cash since inception, and we expect our expenses to increase significantly in connection
with our ongoing activities, particularly as we continue the R&D of, initiate further clinical trials of and seek marketing approval
for, our product candidates. In addition, if we obtain marketing approval for our product candidates, we expect to incur significant
expenses related to product sales, marketing, manufacturing and distribution.

 Furthermore,
we expect to incur additional costs associated with operating as a public reporting company in the United States.

 If
we are unable to obtain adequate funding on a timely basis, we may be required to significantly curtail, delay or discontinue our R&D
programs of our product candidates or any future commercialization efforts, be unable to expand our operations or be unable to otherwise
capitalize on our business opportunities, as desired, which could harm our business and potentially cause a discontinuation of operations.

 - 34 -

 Our
financial condition and operating results have varied significantly in the past and losses are continuing and increasing due to a variety
of factors, many of which are beyond our control.

 Our
financial condition and operating results have varied significantly in the past and losses are continuing and increasing due to a variety
of factors, many of which are beyond our control. Factors relating to our business that may contribute to these fluctuations include:

 continuing
 our current research and development programs, including conducting preclinical and clinical studies for product candidates;

 initiating
 clinical trials for product candidates;

 the
 success of our clinical trials through all phases of clinical development;

 delays
 in the commencement, enrollment and timing of clinical trials;

 our
 ability to secure and maintain collaborations, licensing or other arrangements for the future development and/or commercialization
 of our product candidates, as well as the terms of those arrangements;

 our
 ability to obtain, as well as the timeliness of obtaining, additional funding to develop our product candidates;

 the
 results of clinical trials or marketing applications for product candidates that may compete with our product candidates;

 competition
 from existing products or new products that may receive marketing approval;

 potential
 side effects of our product candidates that could delay or prevent approval or cause an approved product to be taken off the market;

 any
 delays in regulatory review and approval of our product candidates;

 our
 ability to identify and develop additional product candidates;

 the
 ability of patients or healthcare providers to obtain coverage or sufficient reimbursement for our products;

 our
 ability, and the ability of third parties such as Clinical Research Organizations ("CROs") to adhere to clinical study
 and other regulatory requirements;

 the
 ability of third-party manufacturers to manufacture our product candidates and key ingredients needed to conduct clinical trials
 and, if approved, successfully commercialize our products;

 the
 costs to us, and our ability as well as the ability of any third-party collaborators, to obtain, maintain and protect our intellectual
 property rights;

 costs
 related to and outcomes of potential intellectual property litigation;

 our
 ability to adequately support future growth;

 our
 ability to attract and retain key personnel to manage our business effectively; and

 our
 ability to build our finance infrastructure and, to the extent required, improve our accounting systems and controls.

 - 35 -

 Developing
new products and services is a speculative and risky endeavor. Products or services that initially show promise may fail to achieve the
desired results or may not achieve acceptable levels of analytical accuracy or clinical utility. We may need to alter our products in
development and repeat clinical studies before we identify a potentially successful product or service. Product development is expensive,
may take years to complete and can have uncertain outcomes. Failure can occur at any stage of the development. If, after development,
a product or service appears successful, we may, depending on the nature of the product or service, still need to obtain U.S. Food and
Drug Administration, or FDA, and other regulatory clearances, authorizations or approvals before we can market it. The FDA's clearance,
authorization or approval pathways are likely to involve significant time, as well as additional research, development and clinical study
expenditures. The FDA may not clear, authorize or approve any future product or service we develop. Even if we develop a product or service
that receives regulatory clearance, authorization or approval, we would need to commit substantial resources to commercialize, sell and
market it before it could be profitable, and the product or service may never be commercially successful. Additionally, development of
any product or service may be disrupted or made less viable by the development of competing products or services.

 New
potential products and services may fail any stage of development or commercialization and if we determine that any of our current or
future products or services are unlikely to succeed, we may abandon them without any return on our investment. If we are unsuccessful
in developing additional products or services, our potential for growth may be impaired.

 In
cases where we are successful in obtaining regulatory approval to market one or more of our product candidates, our revenue will be dependent,
in part, upon the size of the markets in the territories for which we gain regulatory approval, the accepted price for the product, the
ability to obtain coverage and reimbursement, and whether we own the commercial rights for that territory. If the number of our addressable
patients is not as significant as we estimate, the indication approved by regulatory authorities is narrower than we expect, or the treatment
population is narrowed by competition, physician choice or treatment guidelines, we may not generate significant revenue from sales of
such products, even if approved.

 We
expect our research and development expenses to continue to be significant in connection with our continued investment in our ongoing
and planned clinical trials for our current product candidates and any future product candidates we may develop. Furthermore, if we obtain
regulatory approval for our product candidates, we expect to incur increased sales and marketing expenses. In addition, once we are a
public company, we will incur additional costs associated with operating as a public company. As a result, we expect to continue to incur
significant and increasing operating losses and negative cash flows for the foreseeable future. These losses have had and will continue
to have a material adverse effect on our stockholders' equity, financial position, cash flows and working capital.

 Our
recurring losses from operations raise substantial doubt about our ability to continue as a going concern

 Since
inception, we have incurred cumulative losses from operations, negative cash flows from operating activities and have accumulated deficits
of $6,521,945 and $4,471,281 as of December 31, 2023 and 2022, respectively. We expect to continue to generate significant operating
losses for the foreseeable future. Based on our recurring losses from operations since inception and continued cash outflows from operating
activities, in our audited consolidated financial statements for the years ended December 31, 2023 and 2022, we concluded that this circumstance
raised substantial doubt about our ability to continue as a going concern within one year from the original issuance date of such financial
statements. Similarly, in its report on the consolidated financial statements for the years ended December 31, 2023 and 2022, our independent
registered public accounting firm included an emphasis of matter paragraph stating that our recurring losses from operations and continued
cash outflows from operating activities raised substantial doubt about our ability to continue as a going concern. Our consolidated financial
statements for the years ended December 31, 2023 and 2022 do not include any adjustments that may result from the outcome of this uncertainty.

 - 36 -

 Risks
Related to our Business Operations

 Risks
relating to managing growth, employee matters and other risks relating to our business

 As
of December 31, 2023, we had three full-time employees. As we mature, we expect to expand our full-time employee base and hire more scientists,
technicians and other skilled and experienced personnel. Our management may need to divert a disproportionate amount of its attention
away from the day-to-day activities and devote a substantial amount of time toward managing these growth activities. We may not be able
to effectively manage the expansion of our operations, which may result in weaknesses in our infrastructure, operational mistakes, loss
of business opportunities, loss of employees and reduced productivity among remaining employees. Our expected growth could require significant
capital expenditures and may divert financial resources from other projects, such as the development of additional products or technologies.
If the management is unable to effectively manage our growth, our expenses may increase more than expected, the ability to generate and/or
grow revenues could be reduced, and we may not be able to implement our business strategy. Our future financial performance and our ability
to commercialize products and compete effectively will depend, in part, on our ability to effectively manage any future growth.

 Challenges
in identifying and retaining key personnel could impair our ability to conduct and grow our operations effectively

 Our
ability to compete in the highly competitive medical device industry depends upon our ability to attract and retain highly qualified
management and sales teams. We are intending to recruit our own commercial team and expand our existing central infrastructure team.
Many of the other pharmaceutical companies and academic institutions that we compete against for qualified personnel have greater financial
and other resources, different risk profiles and a longer history in the industry than it does. We might not be able to attract or retain
these key persons on conditions that are economically acceptable. Our inability to attract and retain these key persons could have a
material adverse effect on our business, prospects, financial conditions and results of operation.

 We
are reliant upon the expertise and continued service of a small number of key individuals of our management, Board of Directors and scientific
advisors

 We
rely on the expertise and experience of a small number of key individuals of our management, Directors and scientific advisors to continue
to develop and manage our business. The retention of their services cannot be guaranteed. Accordingly, the departure of these key individuals
could have a negative impact on our operations, financial condition, our ability to execute our business strategy and future prospects.

 We
intend to rely, in part, on the recruitment of appropriately qualified personnel, including personnel with a high level of scientific
and technical expertise in the industry. We may be unable to find a sufficient number of appropriately highly trained individuals to
satisfy its growth rate which could affects its ability to develop products as planned.

 In
addition, if we fail to succeed in pre-clinical or clinical studies, it may make it more challenging to recruit and retain appropriately
qualified personnel. Our inability to recruit key personnel or the loss of the services of key personnel or consultants may impede the
progress of our R&D objectives as well as the commercialization of our lead and other products, which could have a material adverse
effect on our business, results of operations and financial condition. We do not have employment agreements with any of our executive
officers, and they may voluntarily terminate their employment with us at any time.

 We
may become subject to product liability claims

 We
face an inherent risk of product liability and associated adverse publicity as a result of the clinical testing of our products and sales
of our products once marketing approval is received from relevant regulatory authorities.

 Criminal
or civil proceedings might be filed against us by study subjects, patients, relevant regulatory authorities, pharmaceutical companies,
and any other third party using or marketing our products. Any such product liability claims may include allegations of defects in manufacturing
or design, negligence, strict liability, a breach of warranties and a failure to warn of dangers inherent in the product.

 - 37 -

 If
we cannot successfully defend ourself against product liability claims, we may incur substantial liabilities or be required to limit
commercialization of our products, if approved. Even if we successfully defend ourself against such product liability claims it could
require significant financial and management resources. Regardless of the merits or eventual outcome, product liability claims may result
in:

 decreased
 demand for our products due to negative public perception;

 injury
 to our reputation;

 withdrawal
 of clinical study participants or difficulties in recruiting new study participants;

 initiation
 of investigations by regulators;

 costs
 to defend or settle the related litigation;

 diversion
 of management's time and our resources;

 substantial
 monetary awards to patients, study participants or subjects;

 product
 recalls, withdrawals or labelling, marketing or promotional restrictions;

 loss
 of revenues from product sales; or

 the
 inability to commercialize any our products, if approved.

 Although
we intend to maintain levels of insurance customary for our sector to cover our current and future business operations, any claim that
may be brought against us could result in a court judgment or settlement in an amount that is not covered, in whole or in part, by our
insurance or that is in excess of the limits of our insurance coverage. Our insurance policies also have various exclusions, and we may
be subject to a product liability claim for which we have no coverage. In such cases, we would have to pay any amounts awarded by a court
or negotiated in a settlement that exceed our coverage limitations or that are not covered by our insurance, and we may not have, or
be able to obtain, sufficient capital to pay such amounts. Any such judgment could adversely affect our business, financial condition,
results of operations, business reputation and could adversely affect the market for our products.

 If
we or our partners, licensees and subcontractors were unable to obtain and maintain appropriate insurance coverage at an acceptable cost,
or to protect ourself or themselves in any way against actions for damages, this would seriously affect the marketing of our products
and, more generally, be detrimental to our business, prospects, results of operations or financial condition.

and economic conditions may negatively impact our business, financial condition and share price.

 Concerns
over medical epidemics, energy costs, geopolitical issues, the U.S. mortgage market and a deteriorating real estate market, unstable
global credit markets and financial conditions, and volatile oil prices have led to periods of significant economic instability, diminished
liquidity and credit availability, declines in consumer confidence and discretionary spending, diminished expectations for the global
economy and expectations of slower global economic growth, increased unemployment rates, and increased credit defaults in recent years.
Our general business strategy may be adversely affected by any such economic downturns (including the current downturn related to inflation
and the Russia-Ukraine conflict), volatile business environments and continued unstable or unpredictable economic and market conditions.
If these conditions continue to deteriorate or do not improve, it may make any necessary debt or equity financing more difficult to complete,
more costly, and more dilutive. Failure to secure any necessary financing in a timely manner and on favorable terms could have a material
adverse effect on our growth strategy, financial performance, and share price and could require us to delay or abandon development or
commercialization plans.

 Clinical
trials are expensive, time-consuming, and may not be successful.

 Clinical
trials are expensive, time-consuming, and may not be successful. They involve the evaluation of diagnostic tests to determine the safety
and efficacy of the diagnostic tests necessary for an approved diagnostic technology. Many tests and products in human clinical trials
fail to demonstrate the desired safety and efficacy characteristics. Even if our tests and products candidates progress successfully
through initial or subsequent human testing, they may fail in later phases of development. We may engage others to conduct our clinical
trials, including clinical research organizations and government-sponsored agencies. These trials may not start or be completed as we
forecast or may not achieve desired results.

 We
may experience numerous unforeseen events during, or as a result of, clinical trials that could delay or prevent our ability to receive
marketing authorization or commercialize our diagnostic technologies, including:

 regulators
 or institutional review boards may not authorize us or our investigators to commence a clinical trial or conduct a clinical trial
 at a prospective trial site;

 we
 may experience delays in reaching, or fail to reach, agreement on acceptable clinical trial contracts or clinical trial protocols
 with prospective trial sites;

 clinical
 trials may produce negative or inconclusive results, and we may decide, or regulators may require us, to conduct additional clinical
 trials or abandon product and test development programs;

 the
 number of patients required for clinical trials may be larger than we anticipate, enrollment in these clinical trials may be slower
 than we anticipate, or participants may drop out of these clinical trials at a higher rate than we anticipate;

 our
 third-party contractors may fail to comply with regulatory requirements or meet their contractual obligations to us in a timely manner,
 or at all;

 we
 may have to suspend or terminate clinical trials for various reasons, including a finding that the participants are being exposed
 to unacceptable health risks;

 - 38 -

 regulators
 or institutional review boards may require that we or our investigators suspend or terminate clinical research for various reasons,
 including noncompliance with regulatory requirements or a finding that the participants are being exposed to unacceptable health
 risks;

 the
 cost of clinical trials may be greater than we anticipate; or

 regulators
 may revise the requirements for approving our diagnostic technologies, or such requirements may not be as we anticipate.

 If
we are required to conduct additional clinical trials or other testing beyond those that we currently contemplate, if we are unable to
successfully complete clinical trials or other testing, if the results of these trials or tests are not positive or are only modestly
positive or if there are safety concerns, we may:

 be
 delayed in obtaining marketing approval;

 not
 obtain marketing approval at all, which would seriously impair our viability;

 obtain
 marketing approval in some countries and not in others;

 obtain
 approval for indications or patient populations that are not as broad as we intend or desire;

 obtain
 approval with labeling that includes significant use or distribution restrictions or safety warnings;

 be
 subject to additional post-marketing testing requirements; or

 have
 the diagnostic test removed from the market after obtaining marketing approval.

 Our
product and test development costs will increase if we experience delays in clinical testing or marketing approvals. We do not know whether
any of our preclinical studies or clinical trials will begin as planned, will need to be restructured, or will be completed on schedule
or at all. Significant preclinical or clinical trial delays also could shorten any periods during which we may have the exclusive right
to commercialize our diagnostic technology or allow our competitors to bring diagnostic tests to market before we do, potentially impairing
our ability to successfully commercialize our diagnostic technologies and harming our business and results of operations.

 If
testing of a particular diagnostic test or product candidate does not yield successful results, then we will be unable to commercialize
that test or product candidate.

 We
must demonstrate that the product safety and efficacy of our candidates for diagnostic tests and product candidates in humans through
extensive clinical testing. Our research and development programs are at an early stage of development. We may experience numerous unforeseen
events during, or as a result of, the testing process that could delay or prevent commercialization of any test or product, including
the following:

 the
 results of pre-clinical studies may be inconclusive, or they may not be indicative of results that will be obtained in human clinical
 trials;

 safety
 and efficacy results attained in early human clinical trials may not be indicative of results that are obtained in later clinical
 trials;

 after
 reviewing test results, we may abandon projects that we might previously have believed to be promising;

 we
 or our regulators may suspend or terminate clinical trials because the participating subjects or patients are being exposed to unacceptable
 health risks; and

 our
 test or product candidates may not have the desired effects or may include undesirable side effects or other characteristics that
 preclude regulatory approval or limit their commercial use if approved.

 - 39 -

 Even
if our diagnostic tests or product candidates receive marketing approval, they may fail to achieve the degree of market acceptance by
physicians, patients, third-party payers and others in the medical community necessary for commercial success.

 Even
if our products receive marketing approval, they may nonetheless fail to gain sufficient market acceptance by physicians, patients, third-party
payers, and others in the medical community. If we do not generate significant product revenues, we may not become profitable. The degree
of market acceptance of our products and tests, if approved for commercial sale, will depend on a number of factors, including:

 their efficacy, safety
 and other potential advantages compared to alternative tests or products;

 our ability to offer them
 for sale at competitive prices;

 their convenience and ease
 of administration compared to alternative diagnostics or treatments;

 the willingness of the
 target patient population to try new diagnostic tests and of physicians to order these tests;

 the willingness of the
 target patient population to try new therapies and of physicians to prescribe these therapies;

 the strength of marketing
 and distribution support;

 the availability of governmental
 agencies and third-party medical insurance and adequate reimbursement for our diagnostic tests or product candidates;

 any restrictions on the
 use of our diagnostic tests or product candidates together with other diagnostic methods or therapeutic treatments;

 any restrictions on the
 use of our diagnostic tests or product candidates together with other medications;

 inability of certain types
 of patients to produce adequate samples for analysis in the use of our diagnostic tests; and

 inability of certain types
 of patients to use our diagnostic tests.

 If
we are unable to address and overcome these and similar concerns, our business and results of operations could be substantially harmed.

 If
we are unable to establish effective sales, marketing, and distribution capabilities or enter into agreements with third parties with
such capabilities, we may not be successful in commercializing our diagnostic tests or product candidates if and when they are approved.

 We
do not have a sales or marketing infrastructure and have limited experience in the sale, marketing, or distribution of our diagnostic
tests or product candidates. To achieve commercial success for any diagnostic test or product candidates for which we obtain marketing
approval, we will need to successfully establish and maintain relationships directly and with third parties to perform sales and marketing
functions.

 Factors
that may inhibit our efforts to commercialize our diagnostic tests or product candidates on our own include:

 our inability to recruit,
 train, and retain adequate numbers of effective sales, technical support, and marketing personnel;

 the inability of sales
 personnel to obtain access to or educate physicians on the benefits of our diagnostic tests or product candidates;

 - 40 -

 the lack of complementary
 diagnostic tests or products to be offered by sales personnel, which may put us at a competitive disadvantage relative to companies
 with more extensive diagnostic tests or product lines;

 unforeseen costs and expenses
 associated with creating an independent sales, technical support, and marketing organization; and

 the inability to obtain
 sufficient coverage and reimbursement from third-party payors and governmental agencies.

 If
we do not establish sales, marketing, and distribution capabilities successfully, either on our own or in collaboration with third parties,
we will not be successful in commercializing our diagnostic tests or product candidates.

 If
we are unable to convince physicians as to the benefits of our proposed diagnostic tests or product candidates, we may incur delays or
additional expense in our attempt to establish market acceptance.

 Broad
use of our proposed diagnostic tests and products may require pathology laboratories and physicians to be informed regarding our proposed
diagnostic tests and products and the intended benefits. Inability to carry out this physician education process may adversely affect
market acceptance of our proposed diagnostic tests or products. We may be unable to timely educate physicians regarding our proposed
diagnostic tests or products in sufficient numbers to achieve our marketing plans or to achieve acceptance of our diagnostic tests or
products. Any delay in physician education may materially delay or reduce demand for our diagnostic tests or products. In addition, we
may expend significant funds toward physician education before any acceptance or demand for our proposed diagnostic tests or products
is created, if at all.

 We
face substantial competition, which may result in others discovering, developing, or commercializing competing diagnostic tests or products
before or more successfully than we do.

 The
development and commercialization of new diagnostic technologies is highly competitive. We face competition and will face competition
with respect to any diagnostic technology that we may seek to develop or commercialize in the future, from major diagnostic and pharmaceutical
companies, LDT laboratories, smaller diagnostic and pharmaceutical companies, and biotechnology companies worldwide. Potential competitors
also include academic institutions, government agencies, and other public and private research organizations that conduct research, seek
patent protection, and establish collaborative arrangements for research, development, manufacturing, and commercialization.

 A
substantial number of the companies against which we are competing have or, against which we may compete in the future may have, significantly
greater financial resources, established presence in the market, and expertise in research and development, manufacturing, preclinical
testing, conducting clinical trials, obtaining regulatory approvals, and marketing approved diagnostic tests or products than we do.
Mergers and acquisitions in the diagnostic, pharmaceutical, and biotechnology industries may result in even more resources being concentrated
among a smaller number of our competitors.

 Smaller
and other early-stage companies may also prove to be significant competitors, particularly through collaborative arrangements with large
and established companies. These third parties compete with us in recruiting and retaining qualified scientific, sales, marketing, and
management personnel, establishing clinical trial sites and patient registration for clinical trials, and acquiring technologies complementary
to, or necessary for, our programs.

 Our
commercial opportunity could be reduced or eliminated if our competitors develop and commercialize diagnostic tests or products that
are more accurate, more convenient, or less expensive than any diagnostic tests or products that we may develop. Our competitors also
may obtain FDA or other regulatory approval for their diagnostic tests or products more rapidly than we may obtain approval for ours,
which could result in our competitors establishing a stronger market position. In addition, our ability to compete may be affected in
many cases by insurers or other third-party payors.

 - 41 -

 We
may be unable to compete in our target marketplaces, which could impair our ability to generate revenues, thus causing a material adverse
impact on our results of operations.

 If
users of our proposed diagnostic tests or products are unable to obtain adequate reimbursement from third-party payers or governmental
agencies or if new restrictive legislation is adopted, market acceptance of our proposed tests or products may be limited, and we may
not achieve revenues.

 The
continuing efforts of government and insurance companies, health maintenance organizations ("HMOs") and other payers of healthcare
costs to contain or reduce costs may affect our future revenues and profitability, as well as the future revenues and profitability of
our potential customers, suppliers, and collaborative partners and the availability of capital. For example, in certain international
markets, pricing or profitability of diagnostic tests and products is subject to government control. In the U.S., given recent federal
and state government initiatives directed at lowering the total cost of healthcare, the U.S. Congress and state legislatures will likely
continue to focus on healthcare reform, the cost of medical devices, tests and prescription pharmaceuticals, and Medicare and Medicaid
reforms. While we cannot predict whether any such legislative or regulatory proposals will be adopted, the announcement or adoption of
such proposals could materially harm our business, financial condition, and results of operations.

 Our
ability to commercialize our proposed tests or products will depend in part on the extent to which appropriate reimbursement levels for
the cost of our tests or products are obtained by governmental authorities, private health insurers, and other organizations such as
HMOs. Governmental agencies and third-party payers are increasingly challenging the prices charged for medical tests, drugs, and services.
Also, the trend toward managed healthcare in the U.S. and the concurrent growth of organizations such as HMOs, which could control or
significantly influence the purchase of healthcare services, diagnostics, and drugs, as well as legislative proposals to reform healthcare
or reduce government insurance programs, may all result in lower prices for or rejection of our tests or products.

 Our
employees, independent contractors, consultants, commercial partners and vendors may engage in misconduct or other improper activities,
including noncompliance with regulatory standards and requirements.

 Our
business operations and current and future relationships with investigators, healthcare professionals, consultants, third-party payors
and customers will be subject, directly or indirectly, to federal and state healthcare fraud and abuse laws, false claims laws, health
information privacy and security laws, and other healthcare laws and regulations. If we are unable to comply, or have not fully complied,
with such laws, we could face substantial penalties. We are exposed to the risk of employee fraud or other illegal activity by our employees,
independent contractors, consultants, commercial partners, vendors and agents acting on behalf of us or our affiliates. Misconduct by
these parties could include intentional, reckless and/or negligent conduct that fails to: comply with the regulations of the FDA or foreign
health authorities; provide true, complete and accurate information to the FDA or foreign health authorities; comply with manufacturing
standards we have established; comply with healthcare fraud and abuse laws in the United States and similar foreign fraudulent misconduct
laws; or report financial information or data accurately or to disclose unauthorized activities to us.

 The
market for our proposed tests and products is competitive and rapidly changing, and new diagnostic technologies which may be developed
by others could impair our ability to maintain and grow our business and remain competitive.

 The
diagnostic industry is subject to rapid and substantial technological change. Developments by others may render our proposed tests or
products noncompetitive or obsolete, or we may be unable to keep pace with technological developments or other market factors. Technological
competition from diagnostic, pharmaceutical and biotechnology companies, universities, governmental entities, and others diversifying
into the field is intense and is expected to increase.

 Our
resources are limited, and we may experience technical challenges inherent in such technologies. Competitors have developed or are in
the process of developing technologies that are, or in the future may be, the basis for competition. Some of these technologies may have
an entirely different approach or means of accomplishing similar diagnostic efficacy compared to our proposed tests or products. Our
competitors may develop diagnostic technologies that are more effective or less costly than our proposed tests or products and therefore
present a serious competitive threat.

 - 42 -

 The
potential widespread acceptance of diagnostic tests that are alternatives to ours may limit market acceptance of our proposed tests or
products, even if commercialized. Many of our targeted diseases and conditions can also be detected by other tests or treated by other
medications. These tests and treatments may be widely accepted in medical communities and have a longer history of use. The established
use of these competitive technologies may limit the potential for our technologies, formulations, tests and products to receive widespread
acceptance if commercialized.

 Risks
Related to Our Reliance on Third Parties

 We
rely, and expect to continue to rely, on third parties to conduct our preclinical studies and clinical trials. If these third parties
do not successfully carry out their contractual duties or meet expected deadlines, we may not be able to obtain regulatory approval for
or commercialize our product candidates.

 We
have relied upon and plan to continue to rely upon third parties, including independent clinical investigators and third-party contract
research organizations ("CROs"), to conduct our preclinical studies and clinical trials and to monitor and manage data for
our ongoing preclinical and clinical programs. In engaging these third parties, we typically have to, and expect to have to, negotiate
budgets and contracts, which may result in delays to our development timelines and increases costs. Additionally, there is a limited
number of qualified third-party service providers that specialize or have the expertise required to achieve our business objectives,
and so it may be challenging to find alternative investigators or CROs, or do so on commercially reasonable terms. We rely on these parties
for execution of our preclinical studies and clinical trials, and control only certain aspects of their activities. Nevertheless, we
are responsible for ensuring that each of our preclinical studies and clinical trials is conducted in accordance with the applicable
protocol and legal, regulatory and scientific standards, and our reliance on these third parties does not relieve us of our regulatory
responsibilities. We and our third-party contractors and CROs are required to comply with Good Clinical Practice ('GCP')
requirements, which are regulations and guidelines enforced by the FDA, the Competent Authorities of the Member States of the European
Economic Area and comparable foreign regulatory authorities for all of our product candidates in clinical development. Regulatory authorities
enforce these GCP requirements through periodic inspections of trial sponsors, principal investigators and clinical trial sites. If we
fail to exercise adequate oversight over any of our CROs or if we or any of our CROs fail to comply with applicable GCP requirements,
the clinical data generated in our clinical trials may be deemed unreliable and the FDA, EMA or other regulatory authorities may require
us to perform additional clinical trials before approving our marketing applications. We cannot assure you that upon a regulatory inspection
of us or our CROs or other third parties performing services in connection with our clinical trials, such regulatory authority will determine
that any of our clinical trials complies with GCP regulations. In addition, our clinical trials must be conducted with product produced
under applicable cGMP regulations. Our failure to comply with these regulations may require us to repeat clinical trials, which would
delay the regulatory approval process.

 Further,
these investigators and CROs are not our employees and we will not be able to control, other than by contract, the amount of resources,
including time, which they devote to our product candidates and clinical trials. If independent investigators or CROs fail to devote
sufficient resources to the development of our product candidates, or if their performance is substandard, it may delay or compromise
the prospects for approval and commercialization of our product candidates. These investigators and CROs may also have relationships
with other commercial entities, including our competitors, for whom they may also be conducting clinical studies or other product development
activities, which could affect their performance on our behalf. In addition, the use of third-party service providers requires us to
disclose our proprietary information to these parties, which increases the risk that a competitor will discover them or that this information
will be misappropriated or disclosed.

 If
any of our relationships with these third-party CROs terminate, we may not be able to enter into arrangements with alternative CROs or
to do so on commercially reasonable terms. If CROs do not successfully carry out their contractual duties or obligations or meet expected
deadlines, if they need to be replaced or if the quality or accuracy of the clinical data they obtain is compromised due to the failure
to adhere to our clinical protocols, regulatory requirements or for other reasons, our clinical trials may be extended, delayed or terminated
and we may not be able to obtain regulatory approval for or successfully commercialize our product candidates. As a result, our results
of operations and commercial prospects would be harmed, our costs could increase and our ability to generate revenues could be delayed.

 - 43 -

 Repeating
clinical trials or switching or engaging additional CROs involves additional cost and requires our management's time and focus.
In addition, there is a natural transition period when a clinical trial has to be repeated or when a new CRO commences work. As a result,
delays could occur, which could materially impact our ability to meet our desired clinical development timelines.

 Our
failure to find third party collaborators to assist or share in the costs of product development could materially harm our business,
financial condition and results of operations.

 Our
strategy for the development and commercialization of our proprietary product candidates may include the execution of collaborative arrangements
with third parties. Future collaborators will have significant discretion in determining the efforts and resources they apply and may
not perform their obligations as expected. Potential third-party collaborators include biopharmaceutical, pharmaceutical and biotechnology
companies, academic institutions and other entities. Third-party collaborators may assist us in:

 funding
 research, pre-clinical development, clinical trials and manufacturing;

 seeking
 and obtaining regulatory approvals; and

 successfully
 commercializing any future product candidates.

 If
we are not able to establish collaboration agreements, we may be required to undertake product development and commercialization at our
own expense. Such an undertaking may limit the number of product candidates that we will be able to develop, significantly increase our
capital requirements and place additional strain on our internal resources. Our failure to enter into additional collaborations could
materially harm our business, financial condition and results of operations.

 In
addition, our dependence on licensing, collaboration and other agreements with third parties may subject us to a number of risks. These
agreements may not be on terms that prove favorable to us and may require us to relinquish certain rights in our product candidates.
To the extent we agree to work exclusively with one collaborator in a given area, our opportunities to collaborate with other entities
could be curtailed. Lengthy negotiations with potential new collaborators may lead to delays in the research, development or commercialization
of product candidates. The decision by our collaborators to pursue alternative technologies or the failure of our collaborators to develop
or commercialize successfully any product candidate to which they have obtained rights from us could materially harm our business, financial
condition and results of operations.

 Risks
Related to Commercialization of Our Product Candidates

 Even
if we are successful in completing all pre-clinical studies and clinical trials, we may not be successful in commercializing one or more
of our product candidates.

 Even
if we complete the necessary pre-clinical studies and clinical trials, the marketing approval process is expensive, time-consuming and
uncertain and may prevent us from obtaining approvals for the commercialization of some or all of our product candidates. If we are not
able to obtain, or if there are delays in obtaining, required regulatory approvals, we will not be able to commercialize our product
candidates, and our ability to generate revenue will be materially impaired.

 Our
product candidates and the activities associated with their development and commercialization, including their design, testing, manufacture,
safety, efficacy, recordkeeping, labeling, storage, approval, advertising, promotion, sale and distribution, export and import are subject
to comprehensive regulation by the FDA and other regulatory agencies in the United States and by the EMA and similar regulatory authorities
outside of the United States. Failure to obtain marketing approval for a product candidate will prevent us from commercializing the product
candidate. We have not submitted an application for or received marketing approval for any of our product candidates in the United States
or in any other jurisdiction.

 - 44 -

 We
have only limited experience in filing and supporting the applications necessary to gain marketing approvals and expect to rely on third-party
clinical research organizations or other third-party consultants or vendors to assist us in this process. Securing marketing approval
requires the submission of extensive pre-clinical and clinical data and supporting information to regulatory authorities for each indication
to establish the product candidate's safety and efficacy. Securing marketing approval also requires the submission of information
about the drug manufacturing process to, and inspection of manufacturing facilities by, the regulatory authorities.

 The
process of obtaining marketing approvals, both in the United States and abroad, is expensive, may take many years, if approval is obtained
at all, and can vary substantially based upon a variety of factors, including the type, complexity and novelty of the product candidates
involved. Changes in marketing approval policies during the development period, changes in or the enactment of additional statutes or
regulations, or changes in regulatory review for each submitted drug application, may cause delays in the approval or rejection of an
application. Regulatory authorities have substantial discretion in the approval process and may refuse to accept any application or may
decide that our data is insufficient for approval and require additional pre-clinical, clinical or other studies. In addition, varying
interpretations of the data obtained from pre-clinical studies and clinical trials could delay, limit or prevent marketing approval of
a product candidate. Any marketing approval we ultimately obtain may be limited or subject to restrictions or post-approval commitments
that render the approved drug not commercially viable.

 Risks
Related to Our Common Stock

 Further
issuances of Common Shares may be dilutive

 We
may decide to offer additional shares in the future for capital raising or other purposes. Shareholders who do not take up or who are
not eligible to take such an offer will find their proportionate ownership and voting interests in us to be reduced. An additional offering
could also have a material adverse effect on the market price of the Common Shares as a whole.

 Economic
conditions and current economic weakness

 Any
economic downturn either globally or locally in any area in which we operate may have an adverse effect on the demand for our services.
A more prolonged economic downturn may restrict our ability to generate a profit.

 In
addition, although signs of economic recovery have been perceptible in certain countries, the sustainability of a global economic upturn
is not yet assured. If economic conditions remain uncertain this might have an adverse impact on our operations and business results.

 We
presently do not intend to pay cash dividends on our common stock.

 We
expect that no cash dividends will be paid on the common stock in the foreseeable future. While our dividend policy will be based on
the operating results and capital needs of the business, it is anticipated that all earnings, if any, will be retained to finance the
future expansion of our business.

 Our
principal shareholder has a significant holding in the company which may give them influence in certain matters requiring approval by
shareholders, including approval of significant corporate transactions in certain circumstances

 As
of December 31, 2023, Gabriele Cerrone and Planwise Group Limited, a company in which Mr. Cerrone is the sole beneficial owner, held
a beneficial ownership interest in aggregate of approximately 33.77% of our outstanding common stock. Accordingly, Mr. Cerrone will,
as a practical matter, be able to significantly influence certain matters requiring approval by stockholders, including approval of significant
corporate transactions in certain circumstances. Such concentration of ownership may also have the effect of delaying or preventing any
future proposed change in control of the Company. The trading price of the common stock could be adversely affected if potential new
investors are disinclined to invest in us because they perceive disadvantages to a large shareholding being concentrated in the hands
of a single shareholder.

 - 45 -

 We
are an "emerging growth company", and there are reduced disclosure requirements applicable to emerging growth companies

 We
are an "emerging growth company" as defined in the SEC's rules and regulations and we will remain an emerging growth
company until the earlier to occur of (1) the last day of 2025, (2) the last day of the fiscal year in which we have total annual gross
revenues of at least $1.235 billion, (3) the last day of the fiscal year in which we are deemed to be a "large accelerated filer",
under the SEC's rules, which means the market value of our equity securities that is held by non-affiliates exceeds $700 million
as of the prior June 30th, and (4) the date on which we have issued more than $1.0 billion in non-convertible debt during the prior three-year
period. For so long as we remain an emerging growth company, we are permitted and intend to rely on exemptions from certain disclosure
requirements that are applicable to other public companies that are not emerging growth companies. These exemptions include:

not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act;

reduced disclosure obligations regarding executive compensation; and

an exemption from the requirement to seek nonbinding advisory votes on executive compensation or golden parachute arrangements.

 We
may choose to take advantage of some, but not all, of the available exemptions. We have taken advantage of reduced reporting burdens
in this registration statement. In particular, we have not included all of the executive compensation information that would be required
if we were not an emerging growth company.

 In
addition, the JOBS Act provides that an emerging growth company may take advantage of an extended transition period for complying with
new or revised accounting standards. This allows an emerging growth company to delay the adoption of certain accounting standards until
those standards would otherwise apply to private companies. We are considering whether we will take advantage of the extended transition
period for complying with new or revised accounting standards.

 Our
internal computer systems, or those of our collaborators or other contractors or consultants, may fail or suffer security breaches, which
could result in a material disruption of our product development programs.

 Our
internal computer systems and those of our current and any future collaborators and other contractors or consultants are vulnerable to
damage from computer viruses, unauthorized access, natural disasters, terrorism, war and telecommunication and electrical failures. While
we have not experienced any such material system failure, accident or security breach to date, if such an event were to occur and cause
interruptions in our operations, it could result in a disruption of our development programs and our business operations, whether due
to a loss of our trade secrets or other proprietary information or other similar disruptions. For example, the loss of clinical trial
data from future clinical trials could result in delays in our regulatory approval efforts and significantly increase our costs to recover
or reproduce the data. To the extent that any disruption or security breach were to result in a loss of, or damage to, our data or applications,
or inappropriate disclosure of confidential or proprietary information, we could incur liability, our competitive position could be harmed
and the further development and commercialization of our product candidates could be delayed.

 We
could be subject to risks caused by misappropriation, misuse, leakage, falsification or intentional or accidental release or loss of
information maintained in the information systems and networks of our company and our vendors, including personal information of our
employees and study subjects, and company and vendor confidential data. In addition, outside parties may attempt to penetrate our systems
or those of our vendors or fraudulently induce our personnel or the personnel of our vendors to disclose sensitive information in order
to gain access to our data and/or systems. We may experience threats to our data and systems, including malicious codes and viruses,
phishing and other cyberattack. The number and complexity of these threats continue to increase over time. If a material breach of, or
accidental or intentional loss of data from, our information technology systems or those of our vendors occurs, the market perception
of the effectiveness of our security measures could be harmed and our reputation and credibility could be damaged. We could be required
to expend significant amounts of money and other resources to repair or replace information systems or networks. In addition, we could
be subject to regulatory actions and/or claims made by individuals and groups in private litigation involving privacy issues related
to data collection and use practices and other data privacy laws and regulations, including claims for misuse or inappropriate disclosure
of data, as well as unfair or deceptive practices. Although we develop and maintain systems and controls designed to prevent these events
from occurring, and we have a process to identify and mitigate threats, the development and maintenance of these systems, controls and
processes is costly and requires ongoing monitoring and updating as technologies change and efforts to overcome security measures become
increasingly sophisticated. Moreover, despite our efforts, the possibility of these events occurring cannot be eliminated entirely. As
we outsource more of our information systems to vendors, engage in more electronic transactions with payors and patients, and rely more
on cloud-based information systems, the related security risks will increase and we will need to expend additional resources to protect
our technology and information systems. In addition, there can be no assurance that our internal information technology systems or those
of our third-party contractors, or our consultants' efforts to implement adequate security and control measures, will be sufficient
to protect us against breakdowns, service disruption, data deterioration or loss in the event of a system malfunction, or prevent data
from being stolen or corrupted in the event of a cyberattack, security breach, industrial espionage attacks or insider threat attacks
which could result in financial, legal, business or reputational harm.

 - 46 -

 Significant
disruptions of information technology systems or breaches of data security could adversely affect our business.

 Our
business is increasingly dependent on critical, complex, and interdependent information technology systems, including Internet-based
systems, to support business processes as well as internal and external communications. These systems are also critical to enable remote
working arrangements, which have been growing in importance. The size and complexity of our computer systems make us potentially vulnerable
to IT system breakdowns, internal and external malicious intrusion, and computer viruses and ransomware, which may impact product production
and key business processes. We also have outsourced significant elements of our information technology infrastructure and operations
to third parties, which may allow them to access our confidential information and may also make our systems vulnerable to service interruptions
or to security breaches from inadvertent or intentional actions by such third parties or others.

 In
addition, our systems are potentially vulnerable to data security breaches - whether by employees or others - which may expose sensitive
data to unauthorized persons. Data security breaches could lead to the loss of trade secrets or other intellectual property, result in
demands for ransom or other forms of blackmail, or lead to the public exposure of personal information (including sensitive personal
information) of our employees, clinical trial patients, customers, and others. Such attacks are of ever-increasing levels of sophistication
and are made by groups and individuals with a wide range of motives (including industrial espionage or extortion) and expertise, including
by organized criminal groups, "hacktivists," nation states, and others. As a company with an increasingly global presence,
our systems are subject to frequent attacks. There is the potential that our systems may be directly or indirectly affected as nation-states
conduct global cyberwarfare, including in connection with the current Russia-Ukraine or Hamas-Israel armed conflict.

 Due
to the nature of some of these attacks, there is a risk that an attack may remain undetected for a period of time. While we continue
to make investments to improve the protection of data and information technology, and to oversee and monitor the security measures of
our suppliers and/or service providers, there can be no assurance that our efforts will prevent service interruptions or security breaches.
In addition, we depend in part on third-party security measures over which we do not have full control to protect against data security
breaches.

 If
we or our suppliers and/or service providers fail to maintain or protect our information technology systems and data security effectively
and in compliance with U.S. and foreign laws, or fail to anticipate, plan for, or manage significant disruptions to these systems, we
or our suppliers and/or service providers could have difficulty preventing, detecting, or controlling such disruptions or security breaches,
which could result in legal proceedings, liability under U.S. and foreign laws that protect the privacy of personal information, disruptions
to our operations, government investigations, breach of contract claims, and damage to our reputation (in each case in the U.S. or globally),
which could have a material adverse effect on our business, prospects, operating results, and financial condition.

 We
will incur increased costs as a result of operating as a U.S. public company, and our management will be required to devote substantial
time to new compliance initiatives

 As
a U.S. public company, and particularly after we are no longer an emerging growth company, we will incur significant legal, accounting
and other expenses that we will not incur as a private company. In addition, the Sarbanes-Oxley Act of 2002, and rules subsequently implemented
by the SEC have imposed various requirements on public companies, including establishment and maintenance of effective disclosure and
financial controls and corporate governance practices. Our management and other personnel will need to devote a substantial amount of
time to these compliance initiatives. Moreover, these rules and regulations will increase our legal and financial compliance costs and
will make some activities more time-consuming and costly. For example, we expect that these rules and regulations may make it more difficult
and more expensive for us to obtain director and officer liability insurance.

 Pursuant
to Section 404, we will be required to furnish a report by our management on our internal control over financial reporting, including
an attestation report on internal control over financial reporting issued by our independent registered public accounting firm. However,
while we remain an emerging growth company, we will not be required to include an attestation report on internal control over financial
reporting issued by our independent registered public accounting firm. To achieve compliance with Section 404 within the prescribed period,
we will be engaged in a process to document and evaluate our internal control over financial reporting, which is both costly and challenging.
In this regard, we will need to continue to dedicate internal resources, potentially engage outside consultants and adopt a detailed
work plan to assess and document the adequacy of internal control over financial reporting, continue steps to improve control processes
as appropriate, validate through testing that controls are functioning as documented and implement a continuous reporting and improvement
process for internal control over financial reporting. Despite our efforts, there is a risk we will not be able to conclude within the
prescribed timeframe that our internal control over financial reporting is effective as required by Section 404. This could result in
an adverse reaction in the financial markets due to a loss of confidence in the reliability of our financial statements.

 - 47 -

 If
we are unable to maintain an effective system of internal control over financial reporting, we may not be able to accurately report our
financial results or prevent fraud. As a result, shareholders could lose confidence in our financial and other public reporting, which
would harm our business

 Effective
internal controls over financial reporting are necessary for us to provide reliable financial reports and, together with adequate disclosure
controls and procedures, are designed to prevent fraud. Any failure to implement required new or improved controls, or difficulties encountered
in their implementation could cause us to fail to meet our reporting obligations. In addition, any testing by us conducted in connection
with Section 404, or any subsequent testing by our independent registered public accounting firm, may reveal deficiencies in our internal
controls over financial reporting that are deemed to be material weaknesses or that may require prospective or retroactive changes to
our financial statements or identify other areas for further attention or improvement. Inferior internal controls could also cause you
to lose confidence in our reported financial information.

 Our
management will be required to assess the effectiveness of these controls annually. However, for as long as we are an emerging growth
company, our independent registered public accounting firm will not be required to attest to the effectiveness of our internal controls
over financial reporting pursuant to Section 404. We could be an emerging growth company for up to five years. An independent assessment
of the effectiveness of our internal controls over financial reporting could detect problems that our management's assessment might
not. Undetected material weaknesses in our internal controls over financial reporting could lead to financial statement restatements
and require us to incur the expense of remediation.

 We
have been a private company with limited accounting personnel to adequately execute our accounting processes and limited supervisory
resources with which to address our internal control over financial reporting. As a newly public company, we have designed a control
environment as required of public companies under the rules and regulations of the SEC. The Company identified a material weakness as
of December 31, 2023 over internal controls over financial reporting due to a lack of accounting resources. If we fail to remediate a
material weakness, or if we experience material weaknesses in the future or otherwise fail to maintain an effective system of internal
controls in the future, we may not be able to accurately or timely report our financial condition or results of operations, which may
adversely affect investor confidence in us and, as a result, the value of our common stock.

 Our
disclosure controls and procedures may not prevent or detect all errors or acts of fraud

 Our
disclosure controls and procedures are designed to reasonably assure that information required to be disclosed by us in reports we file
or submit under the Exchange Act is accumulated and communicated to management, recorded, processed, summarized and reported within the
time periods specified in the rules and forms of the SEC. We believe that any disclosure controls and procedures or internal controls
and procedures, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of
the control system are met. These inherent limitations include the realities that judgments in decision-making can be faulty, and that
breakdowns can occur because of simple error or mistake. Additionally, controls can be circumvented by the individual acts of some persons,
by collusion of two or more people or by an unauthorized override of the controls. Accordingly, because of the inherent limitations in
our control system, misstatements or insufficient disclosures due to error or fraud may occur and not be detected.

 Future
changes to tax laws could materially adversely affect our company and reduce net returns to our shareholders

 Recently
enacted U.S. tax legislation has significantly changed the U.S. federal income taxation of U.S. corporations, including by reducing the
U.S. corporate income tax rate, limiting interest deductions, modifying or repealing many business deductions and credits (including
reducing the business tax credit for certain clinical testing expenses incurred in the testing of certain drugs for rare diseases or
conditions generally referred to as "orphan drugs"), adopting elements of a territorial tax system, imposing a one-time transition
tax, or repatriation tax, on all undistributed earnings and profits of certain U.S.- owned foreign corporations, revising the rules governing
net operating losses and the rules governing foreign tax credits, and introducing new anti-base erosion provisions. Many of these changes
are effective immediately, without any transition periods or grandfathering for existing transactions.

 - 48 -

 While
some of the changes made by the tax legislation may adversely affect us in one or more reporting periods and prospectively, other changes
may be beneficial on a going forward basis.

 Trading
on the OTC Markets may be volatile and sporadic, which could depress the market price of our common stock and make it difficult for our
stockholders to resell their shares.

 Our
common stock is quoted on the OTC Markets. Trading in stock quoted on the OTC Markets is often thin and characterized by wide fluctuations
in trading prices, due to many factors that may have little to do with our operations or business prospects. This volatility could depress
the market price of our common stock for reasons unrelated to operating performance. Moreover, the OTC Markets is not a stock exchange,
and trading of securities on the OTC Markets is often more sporadic than the trading of securities listed on a quotation system like
NASDAQ or a stock exchange like the NYSE MKT. Accordingly, shareholders may have difficulty reselling any of their shares and the lack
of liquidity may negatively impact our ability to pursue strategic alternatives.

 Climate
change initiatives could materially and adversely affect our business, financial condition, and results of operations.

 Both
domestic and international legislation to address climate change by reducing greenhouse gas emissions and establishing a price on carbon
could create increases in energy costs and price volatility. Considerable international attention is now focused on development of an
international policy framework to address climate change. Consumers and businesses also may change their behavior on their own as a result
of these concerns. We will need to respond to new laws and regulations as well as consumer and business preferences resulting from climate
change concerns. We may face cost increases, asset value reductions and operating process changes. The impact on our business will likely
vary depending on specific attributes, including reliance on or role in carbon intensive activities.

 Item
1b. Unresolved Staff Comments

 Not

 1c.
Cybersecurity

 We
believe cybersecurity is critical to advancing our technological advancements. As a biopharmaceutical company, we face a multitude of
cybersecurity threats that range from attacks common to most industries, such as ransomware and denial-of service. Our customers, suppliers,
subcontractors, and business partners face similar cybersecurity threats, and a cybersecurity incident impacting us or any of these entities
could materially adversely affect our operations, performance, and results of operations. These cybersecurity threats and related risks
make it imperative that we expend resources on cybersecurity.

 - 49 -

 Our
Board of Directors oversees management's processes for identifying and mitigating risks, including cybersecurity risks, to help
align our risk exposure with our strategic objectives. Senior leadership, including our cybersecurity consultant, regularly briefs the
Board of Directors on our cybersecurity and information security posture and the Board of Directors is apprised of cybersecurity incidents
deemed to have a moderate or higher business impact, even if immaterial to us. The full Board retains oversight of cybersecurity because
of its importance. In the event of an incident, we intend to follow our detailed incident response playbook, which outlines the steps
to be followed from incident detection to mitigation, recovery, and notification, including notifying functional areas (e.g., legal),
as well as senior leadership and the Board, as appropriate. Our Cybersecurity consultant has extensive information technology and program
management experience. We have implemented a governance structure and processes to assess, identify, manage, and report cybersecurity
risks.

 As
a medical diagnostic company, we must comply with extensive regulations, including requirements imposed by the Federal Drug Administration
related to adequately safeguarding patient information and reporting cybersecurity incidents to the SEC. We work with our cybersecurity
consultant on assessing cybersecurity risk and on policies and practices aimed at mitigating these risks. We believe we are positioned
to meet the requirements of the SEC. In addition to following SEC guidance and implementing pre-existing third party frameworks, we have
developed our own practices and frameworks, which we believe enhance our ability to identify and manage cybersecurity risks. Third parties
also play a role in our cybersecurity. We engage third-party services to conduct evaluations of our security controls, whether through
penetration testing, independent audits, or consulting on best practices to address new challenges. Assessing, identifying, and managing
cybersecurity related risks are factored into our overall business approach.

 We
rely heavily on our supply chain to deliver our products and services, and a cybersecurity incident at a supplier, subcontractor or business
partner could materially adversely impact us. We require that our subcontractors report cybersecurity incidents to us so that we can
assess the impact of the incident on us. Notwithstanding the extensive approach we take to cybersecurity, we may not be successful in
preventing or mitigating a cybersecurity incident that could have a material adverse effect on us. While we maintain cybersecurity insurance,
the costs related to cybersecurity threats or disruptions may not be fully insured. See "Risk Factors" for a discussion of
cybersecurity risks.

 Item
2. Properties

 We
do not own any property but utilize approximately 75 square feet of office space in London from Tiziana for which we reimburse Tiziana
at cost through a shared services agreement. We believe that our existing facilities are adequate to meet our current needs for the foreseeable
future, and that suitable additional alternative spaces will be available in the future on commercially reasonable terms if needed.

 Item
3. Legal Proceedings

 We
are not party to any material legal matters or claims. In the future, we may become party to legal matters and claims arising in the
ordinary course of business, the resolution of which we do not anticipate would have a material adverse impact on our financial position,
results of operations or cash flows.

 Item
4. Mine Safety Disclosures

 Not

 - 50 -

 Item
5. Market for Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

information

 Our
common stock has traded on the OTC QB under the symbol "ACUT" since March 23, 2022.

 Number
of Stockholders

 As
of March 22, 2024, we had approximately 510 holders of record of our common stock.

 Dividend
Policy

 Historically,
we have not paid any dividends to the holders of shares of our common stock, and we do not expect to pay any such dividends in the foreseeable
future as we expect to retain our future earnings for use in the operation and expansion of our business.

 Transfer
Agent

 Our
transfer agent for our common stock is Pacific Stock Transfer Company.

 Item
6: [Reserved]

 Not

 Item
7: Management's Discussion and Analysis of Financial Condition and Results of Operations

 Overview

 We
are a clinical stage diagnostics company dedicated to improving quality of life and outcomes for the more than 18 million people worldwide
who are diagnosed with cancer each year. Our plan is to develop and commercialize a suite of novel genomic tests that support decision
making along the entire continuum of oncology care. Our focus will be the commercialization of our proprietary genomic test, StemPrintER,
for patients with early-stage breast cancer, and we estimate this market opportunity represents more than $1.3 billion in annual revenue.

 Our
primary product candidate is StemPrintER, a 20-gene prognostic assay intended to predict the risk of distant recurrence ("DR")
in luminal (ER+/HER2-negative) breast cancer patients. The assay was developed to measure the "stemness" of tumors, or how
much a tumor behaves like stem cells which could indicate how likely a cancer is to recur or be resistant to standard treatments, ultimately
impacting how patients are managed by their multi-disciplinary care team. StemPrintER has been validated in several clinical cohorts
and studies, the largest of which are a consecutive series of approximately 2,400 patients from the European Institute of Oncology ("IEO")
and approximately 800 patients from the TransATAC study. In the IEO cohort, StemPrintER High Risk patients ("SPRS High")
were 1.85 times more likely to have a distant recurrence compared to Low Risk ("SPRS Low") patients (Figure 1) and in the
TransATAC cohort, SPRS High patients were 4.27 times more likely to experience a distant recurrence compared to SPRS Low Risk patients
(Figure 2). Together, these data confirm that StemPrintER is highly prognostic for outcomes in patients with breast cancer and indicate
the potential utility of the test in the oncology clinic.

 *SPRS-
StemPrintER Recurrence Score; SPRS High- StemPrintER High Risk; SPRS Low- StemPrintER Low Risk

 Beyond
our initial plans for StemPrintER, we believe there is significant opportunity to expand our product portfolio. First, given the broad
applicability of tumor "stemness", which has been evaluated in a multitude of different cancers, we believe the StemPrint
platform will have meaningful clinical utility beyond breast cancer. As such, we will seek to validate and commercialize StemPrint for
a variety of different tumor types. Each tumor type, where applicable, would also include ancillary testing to boost our value proposition
to physicians and their patients. In addition, we plan to offer ancillary commodity testing (e.g., hereditary genetic testing, somatic
mutation testing) that augments our proprietary assays and provides additional information and value to patients and physicians throughout
the patient care continuum.

 - 51 -

 We
plan to launch StemPrintER once we have achieved several key milestones. First, we plan to identify or build a laboratory that will be
responsible for processing, testing and reporting StemPrintER results for all commercial samples. Further, we plan to transfer the StemPrintER
assay from the laboratories in which they were developed to our commercial laboratory. Finally, upon establishing testing capabilities
in our commercial laboratory, we will seek to obtain U.S. Clinical Laboratory Improvement Amendments of 1988 ("CLIA") certification
so that we are able to report results for clinical use and to seek reimbursement from the Centers for Medicare and Medicaid Services.
We anticipate that it will take at least 18 months to complete these milestones. Once those tasks are complete, we plan to initially
launch StemPrintER in the US and then expand to other markets as we evaluate clinical need and revenue opportunity.

 Since
our inception, we have devoted substantially all of our resources to conducting research and development of our product candidate. Our
revenue is expected to be derived from different sources including standard private third-party and government medical insurance coverage
and reimbursement models.

 Financial
Operations Overview

 We
have no products approved for commercial sale and have not generated revenue to date. We have never been profitable and have incurred
net losses in each year since inception. We incurred net losses of $2,050,664 and $3,746,419 for the year ended December 31, 2023 and
2022, respectively. As of December 31, 2023, we had an accumulated deficit of $6,521,945. Substantially all of our net losses resulted
from expenses incurred in connection with our research and development programs and from general and administrative costs associated
with our operations.

 Segment
Information

 As
of December 31, 2023, we viewed our operations and managed our business as one operating segment consistent with how our chief operating
decision maker, our Chief Executive Officer, makes decisions regarding resource allocation and assessing performance. As of December
31, 2023, substantially all of our assets were located in the United States. Our headquarters and operations are located in New York,
NY and London, UK.

and development expense

and development costs are expensed as incurred. These costs consist of internal and external expenses, as well as depreciation expense
on assets used within our research and development activities. Internal expenses include the cost of salaries, benefits, and other related
costs, including share-based compensation, for personnel serving in our research and development functions. External expenses include
development, clinical trials, patent costs, and regulatory compliance costs incurred with research organizations, contract manufacturers,
and other third-party vendors. License fees paid to acquire access to proprietary technology are expensed to research and development,
unless it is determined that the technology is expected to have an alternative future use. All patent-related costs incurred in connection
with filing and prosecuting patent applications are expensed as incurred to research and development expense due to the uncertainty about
the recovery of the expenditure. We record costs for certain development activities, such as preclinical studies and clinical trials,
based on our evaluation of the progress to completion of specific tasks. Payments for these activities are based on the terms of the
individual arrangements, which may differ from the pattern of costs incurred, and are reflected in the consolidated financial statements
as prepaid or accrued research and development expense, as applicable. Our recording of costs for certain development activities requires
us to use estimates. We believe our estimates and assumptions are reasonable under the current conditions; however, actual results may
differ from these estimates.

 - 52 -

and development expenses account for a significant portion of our operating expenses. We plan to incur research and development expenses
for the foreseeable future as we expect to continue the development of our product candidates. We anticipate that our research and development
expenses will be higher in fiscal year 2024 and subsequent periods as compared to the prior periods presented herein as we prepare to
establish a CLIA certified lab.

 Our
research and development expenses are not currently tracked on a program-by-program basis for indirect and overhead costs. We use our
personnel and infrastructure resources across multiple research and development programs directed toward identifying, developing, and
commercializing product candidates.

 At
this time, due to the inherently unpredictable nature of preclinical and clinical developments as well as regulatory approval (or authorization)
and commercialization, we are unable to estimate with any certainty the costs we will incur and the timelines we will require in our
continued development and commercialization efforts. As a result of these uncertainties, successful development and completion of clinical
trials as well as regulatory authorization or approval and commercialization are uncertain and may not result in authorized or approved
and commercialized products. Completion dates and completion costs can vary significantly for each product candidate and are difficult
to predict. We will continue to make determinations as to which product candidates to pursue and how much funding to direct to each product
candidate on an ongoing basis in response to our ability to enter into collaborations with respect to each product candidate, the scientific
and clinical success of each product candidate as well as ongoing assessments as to the commercial potential of each product candidate.

and administrative expense

and administrative expense consists primarily of personnel expenses, including salaries, benefits, insurance, and share-based compensation
expense, for employees in executive, accounting, commercialization, human resources, and other administrative functions. General and
administrative expense also includes expenses related to pre-commercial activities, corporate facility costs, insurance premiums, legal
fees related to corporate matters, and fees for auditing, accounting, and other consulting services.

 We
anticipate that our general and administrative expenses will increase in fiscal year 2024 as compared to the prior periods presented
herein as a result of higher corporate infrastructure costs including, but not limited to accounting, legal, human resources, consulting,
investor relations, and public company insurance fees.

 Results
of Operations

 The
following discussion and analysis of our results of operations includes a comparison of the years ended December 31, 2023 and 2022:

 December

 31, 2023

 December

 31, 2022

 $
 Change

 %
 Change

 Revenue

 $

 —

 $

 —

 $

 —

 —

 %

 and development expenses

 139,663

 266,933

 (127,270)

 -48

 %

 and administrative expenses

 1,911,001

 3,479,486

 (1,568,485)

 -45

 %

 Loss
 from operations

 2,050,664

 3,746,419

 (1,695,755)

 -45

 %

 Loss,
 before income tax

 (2,050,664)

 (3,746,419)

 1,695,755

 -45

 %

 tax benefit (expense)

 —

 —

 —

 —

 %

 Net
 loss

 $

 (2,050,664)

 $

 (3,746,419)

 $

 1,695,755

 -45

 %

 - 53 -

and development

and development expenses decreased $127,270 in 2023 as compared to 2022 from $266,993 to $139,663, primarily due to decreases in patent
related expenses, and laboratory work and consulting.

and administrative

and administrative expenses decreased $1,568,485 in 2023 as compared to 2022 from $3,479,486 to $2,050,664, primarily due to
increase an decrease of payroll related costs as a result of the a change in the management team structure, change in bonus accrual
estimate, as well as costs related to legal fees and other compliance expenses.

 Liquidity
and Capital Resources

 Sources
of Liquidity

 Since
our inception, we have not generated any revenue and have incurred significant operating losses. Our potential products are at various
phases of development. We do not expect to generate significant revenue from product sales for several years, if at all. Pursuant to
the demerger, Tiziana transferred $1,353,373 ( 1,000,000) in cash in January 2022 to us. In addition, subject to the terms of the
supplemental demerger agreement, Tiziana invested $2,675,940 ( 2,000,000) in cash in March 2022 for additional shares of the Company.
Our cash flows may fluctuate and are difficult to forecast and will depend on many factors. As of December 31, 2023, our cash balance
is $21,481 which is not adequate for our current planned level of operations, through at least April 2024.

 Our
cash flows may fluctuate and are difficult to forecast and will depend on many factors.

 Cash
Flows

 The
following table summarizes our cash flows:

 2023

 2022

 Cash flows used in operating activities

 $
 (1,615,643
)

 $
 (1,806,053
)

 Cash flows used in investing activities

 —

 (10,999
)

 Cash flows from financing activities

 903,146

 2,551,030

 Net increase (decrease) in cash and cash equivalents

 (712,497
)

 Cash and cash equivalents at beginning of period

 —

 Cash and cash equivalents at end of period

 $
 21,481

 $

 Operating
Activities

 There
was a decrease in cash flows from operating activities during the year ended December 31, 2023. The net loss of $2,050,664 was offset
by depreciation expense of $3,630, stock based compensation expense of $78,634, and changes in operating assets and liabilities of $352,757.

 Investing
Activities

 There
were no cash flows from operating activities during the year ended December 31, 2023.

 The
cash flow used in investing activities increased during the year ended December 31, 2022 due to the purchase of computer equipment.

 Financing
Activities

 We
generated cash flows from financing activities during the year ended December 31, 2023 due to advances from related party of $1,246,757,
offset by payments on a note payable of $343,611. We generated cash flows from financing activities during the year ended December 31,
2022 due to proceeds from the issuance of common stock to Tiziana.

Capital Expenditure Commitments

 We
have no material commitment for capital expenditures.

 - 54 -

 Funding
Requirements

 We
expect that our expenses will increase and operating losses will be generated for several years. We have an accumulated deficit of $6,521,945
as of December 31, 2023. Based on our current plans, we believe our existing cash and cash equivalents will not be sufficient to fund
our operations and capital expenditure requirements beyond April 2024. We expect to incur substantial additional expenditures in the
near term to support our acceleration of activities. We expect to incur net losses for the foreseeable future. Our ability to fund our
product development and clinical operations as well as commercialization of our product candidates, will depend on the amount and timing
of cash received from planned financings. Our future capital requirements will depend on many factors, including:

 the
 costs, timing and outcomes of clinical trials and regulatory reviews associated with our product candidates;

 the
 costs of commercialization activities, including product marketing, sales and distribution;

 the
 costs of preparing, filing and prosecuting patent applications and maintaining, enforcing and defending intellectual property-related
 claims;

 the
 emergence of competing technologies and products and other adverse marketing developments;

 the
 effect on our product development activities of actions taken by the FDA, EMA or other regulatory authorities;

 our
 degree of success in commercializing our product candidates, if and when approved; and

 the
 number and types of future products we develop and commercialize.

 A
change in the outcome of any of these or other variables with respect to the development of any of our product candidates could significantly
change the costs and timing associated with the development of that product candidate. Further, our operating plans may change in the
future, and we may need additional funds to meet operational needs and capital requirements associated with such operating plans.

 Until
such time, if ever, as we can generate substantial product revenue, we expect to finance our operations through a combination of equity
financings, debt financings, collaborations with other companies or other strategic transactions. We do not currently have any committed
external source of funds. To the extent that we raise additional capital through the sale of equity or convertible debt securities, your
ownership interest will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect
your rights as a common stockholder. Debt financing and preferred equity financing, if available, may involve agreements that include
covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making acquisitions or capital
expenditures or declaring dividends. If we raise additional funds through collaborations, strategic alliances or marketing, distribution
or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams,
research programs or product candidates or grant licenses on terms that may not be favorable to us. If we are unable to raise additional
funds through equity or debt financings or other arrangements when needed, we may be required to delay, limit, reduce or terminate our
research, product development or future commercialization efforts or grant rights to develop and market product candidates that we would
otherwise prefer to develop and market ourselves.

 - 55 -

 Further,
our operating plans may change, and we may need additional funds to meet operational needs and capital requirements for clinical trials
and other research and development activities. We currently have no credit facility or committed sources of capital. Because of the numerous
risks and uncertainties associated with the development and commercialization of our product candidates, we are unable to estimate the
amounts of increased capital outlays and operating expenditures associated with our current and anticipated product development programs.

 Critical
Accounting Policies

 Our
consolidated financial statements are prepared in accordance with US GAAP. The preparation of our consolidated financial statements and
related disclosures requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, costs and expenses,
and the disclosure of contingent assets and liabilities in our consolidated financial statements. We base our estimates on historical
experience, known trends and events and various other factors that we believe are reasonable under the circumstances, the results of
which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other
sources. We evaluate our estimates and assumptions on an ongoing basis. Our actual results may differ from these estimates under different
assumptions or conditions.

 While
our significant accounting policies are described in more detail in our consolidated financial statements, we believe that the following
accounting policies are those most critical to the judgments and estimates used in the preparation of our consolidated financial statements.

 Share-based
Compensation

 We
account for share-based payment awards issued to employees and members of our Board by measuring the fair value of the award on the date
of grant and recognizing this fair value as share-based compensation using a straight-line basis over the requisite service period, generally
the vesting period.

 Related
parties

 Parties
are related to us if the parties, directly or indirectly, through one or more intermediaries, control, are controlled by, or are under
common control with us. Related parties also include our principal owners, our management, members of the immediate families of our principal
owners and our management and other parties with which we may deal with if one party controls or can significantly influence the management
or operating policies of the other to an extent that one of the transacting parties might be prevented from fully pursuing its own separate
interests.

 Off-Balance
Sheet Arrangements

 We
have no off-balance sheet arrangements that have had, or are reasonably likely to have, a material current or future effect on our consolidated
financial statements or changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures
or capital resources.

 Recent
Accounting Pronouncements

 For
information on recent accounting pronouncements, see our consolidated financial statements - Note 2 and the related notes found elsewhere
in this annual report.

 Item
7A. Quantitative and Qualitative Disclosure About Market Risk

 As
of December 31, 2023, we are not subject to any material market risk, including interest rate risk and foreign currency exchange rate
risk. We additionally do not have material commodity price or equity price risks.

 - 56 -

 Item
8. Financial Statements and Supplementary Data

to the Consolidated Financial Statements

 December
31, 2022

 Page

 Report of Independent Registered Public Accounting Firm ( Mazars USA LLP, New York, New York, PCAOB ID 339)

 Consolidated Balance Sheets as of December 31, 2023 and 2022

 Consolidated Statements of Operations for the years ended December 31, 2023 and 2022

 Consolidated Statements of Shareholders' Equity for the years ended December 31, 2023 and 2022

 Consolidated Statements of Cash Flows for the years ended December 31, 2023 and 2022

 Notes to Consolidated Financial Statements

 - F-16

 F- 1

 REPORT
OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

 To
the Board of Directors and

Shareholders of AccuStem Sciences Inc.

 Opinion
on the Financial Statements

 We
have audited the accompanying consolidated balance sheets of AccuStem Sciences Inc. (the Company) as of December 31, 2023 and 2022, and
the related consolidated statements of operations, shareholders' equity, and cash flows for each of the
years in the two-year period ended December 31, 2023, and the related notes (collectively referred to as the consolidated financial statements).
In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company
as of December 31, 2023 and 2022, and the results of its operations and its cash flows for each of the years in the two-year period ended
December 31, 2023, in conformity with accounting principles generally accepted in the United States of America.

 Explanatory
Paragraph Regarding Going Concern

 The
accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As discussed
in Note 1 to the consolidated financial statements, the Company has incurred operating losses since inception. The Company also had an
accumulated deficit of $6,521,945 at December 31, 2023. The Company is dependent on obtaining necessary funding from institutional investors
or others, in order to continue their operations. These conditions raise substantial doubt about its ability to continue as a going concern.
Management's plans regarding those matters also are described in Note 1. The consolidated financial statements do not include any
adjustments that might result from the outcome of this uncertainty.

 Basis
for Opinion

 These
consolidated financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion
on the Company's consolidated financial statements based on our audits. We are a public accounting firm registered with the Public
Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance
with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

 We
conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud.
The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part
of our audits, we are required to obtain an understanding of internal control over financial reporting, but not for the purpose of expressing
an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly, we express no such opinion.

 Our
audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error
or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding
the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles used
and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements.
We believe that our audits provide a reasonable basis for our opinion.

 /s/
 Mazars USA LLP

 We
 have served as the Company's auditor since 2022.

 New
 York, NY

 March
 22, 2024

 F- 2

 CONSOLIDATED
BALANCE SHEETS

 December 31, 2023

 December 31, 2022

 ASSETS

 Current Assets

 Cash

 $
 21,481

 $

 Prepaid expenses

 108,368

 168,430

 Other Current Assets

 -

 29,603

 Total Current Assets

 $
 129,849

 $
 932,011

 Equipment, net

 4,048

 7,678

 TOTAL ASSETS

 $
 133,897

 $
 939,689

 LIABILITIES AND STOCKHOLDERS' EQUITY

 Current Liabilities

 Accounts payable

 $
 578,378

 $
 311,834

 Related party payable

 1,454,986

 142,229

 Accrued expenses

 156,434

 518,625

 Note Payable

 55,679

 106,551

 Total Current Liabilities

 2,245,477

 1,079,239

 TOTAL LIABILITIES

 2,245,477

 1,079,239

 Stockholders' Equity

 Preferred stock $.001 par value; 10,000,000 shares authorized; none issued and outstanding

 $
 -

 $
 -

 Common stock $.001 par value; 150,000,000 shares authorized; 11,346,535 shares issued and outstanding as of December 31, 2023 and December 31, 2022, respectively

 Additional paid-in capital

 4,399,019

 4,320,385

 Accumulated deficit

 ( 6,521,945
)

 ( 4,471,281
)

 TOTAL STOCKHOLDERS' EQUITY

 ( 2,111,580
)

 ( 139,550
)

 TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY

 $
 133,897

 $
 939,689

 F- 3

 CONSOLIDATED
STATEMENTS OF OPERATIONS

 Year Ended

 Year Ended

 2023

 2022

 OPERATING EXPENSES

 Research and development expenses

 $
 139,663

 $
 266,933

 General and administrative expenses

 1,911,001

 3,479,486

 Total operating expenses

 2,050,664

 3,746,419

 LOSS FROM OPERATIONS

)

)

 LOSS, BEFORE INCOME TAX

)

)

 Income tax benefit (expense)

 —

 —

 NET LOSS

 $
)

 $
)

 Net loss per share attributable to common stockholders, basic and diluted

 $
 ( 0.18
)

 $
 ( 0.34
)

 Weighted average common shares outstanding used in computing net loss per share attributable to common stockholders, basic and diluted

 11,016,165

 F- 4

 CONSOLIDATED
STATEMENTS OF SHAREHOLDERS' EQUITY

 Number of Shares

 Amount

 Paid-in
 Capital

 Subscription
 Receivable

 Comprehensive

 Accumulated
 Deficit

 Stockholders'
 Equity

 Common Stock

 Additional

 Related Party

 Accumulated Other

 Number of Shares

 Amount

 Paid-in
 Capital

 Subscription
 Receivable

 Comprehensive

 Accumulated
 Deficit

 Stockholders'
 Equity

 Balance at December 31, 2021

 9,999,132

 9,999

 1,503,434

 ( 204,879
)

 66,981

 ( 724,862
)

 650,673

 Share-based compensation

 —

 —

 133,889

 —

 —

 —

 133,889

 Issuance of common stock

 1,337,970

 1,338

 2,674,602

 —

 —

 —

 2,675,940

 Receipt of subscription receivable

 —

 —

 —

 204,879

 —

 —

 204,879

 Exercise of common stock options

 9,433

 8,460

 —

 —

 —

 8,469

 Foreign currency translation adjustment

 —

 —

 —

 —

 ( 66,981
)

 —

 ( 66,981
)

 Net loss

 —

 —

 —

 —

 —

)

)

 Balance at December 31, 2022

 $

 $
 4,320,385

 $
 —

 $
 —

 $
 ( 4,471,281
)

 $
 ( 139,550
)

 Balance

 $

 $
 4,320,385

 $
 —

 $
 —

 $
 ( 4,471,281
)

 $
 ( 139,550
)

 Share-based compensation

 —

 —

 78,634

 —

 —

 —

 78,634

 Net loss

 —

 —

 —

 —

 —

)

)

 Balance at December 31, 2023

 4,399,019

 —

 —

 ( 6,521,945
)

 ( 2,111,580
)

 Balance

 4,399,019

 —

 —

 ( 6,521,945
)

 ( 2,111,580
)

 F- 5

 CONSOLIDATED
STATEMENTS OF CASH FLOWS

 2023

 2022

 For the Year Ended December 31

 2023

 2022

 Operating Activities

 Net loss

)

)

 Adjustments to reconcile net loss to net cash provided by operating activities

 Foreign currency translation

 -

 ( 66,981
)

 Depreciation

 3,630

 3,321

 Share-based compensation

 78,634

 133,889

 Change in operating assets and liabilities:

 Related party receivable

 -

 1,353,373

 Prepaid expenses

 343,122

 270,692

 Other current assets

 29,603

 ( 29,603
)

 Accounts payable

 266,544

 ( 76,846
)

 Related party payable

 66,000

 ( 48,609
)

 Accrued expenses

 ( 352,512
)

 401,130

 Net cash used in operating activities

 ( 1,615,643
)

 ( 1,806,053
)

 Investing Activities

 Purchases of equipment

 -

 ( 10,999
)

 Net cash used in investing activities

 -

 ( 10,999
)

 Financing Activities

 Advances from related party

 1,246,757

 -

 Proceeds from receipt of subscription receivable

 -

 204,879

 Proceeds from issuance of common stock

 -

 2,675,940

 Proceeds from exercise of options

 -

 8,469

 Payments on note payable

 ( 343,611
)

 ( 338,258
)

 Net cash provided by financing activities

 903,146

 2,551,030

 Increase (decrease) in cash

 ( 712,497
)

 Cash, beginning of year

 -

 Cash, end of year

 21,481

 Supplemental disclosure of noncash investing and financing activities

 Issuance of Note Payable for payment of prepaid expense

 372,879

 439,122

 Amendment of Issuance of Note Payable for payment of prepaid expense

 ( 89,818
)

 -

 Supplemental cash flow information

 Cash paid for interest

 7,192

 7,474

 F- 6

 NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS

 1. DESCRIPTION OF BUSINESS

 AccuStem
Sciences Inc. and its subsidiary (the "Company") is a clinical stage diagnostics company dedicated to improving quality of
life and outcomes for the more than 18 million people worldwide who are diagnosed with cancer each year.

 Liquidity
and Going Concern

 The
consolidated financial statements have been prepared on the going concern basis, which contemplates the realization of assets and discharge
of liabilities in the normal course of business.

 The
Company has financed its activities principally from support from a related party. The Company has incurred a net loss in every fiscal
period since inception. For the year ended December 31, 2023, the Company incurred a net loss of $ 2,050,664. The Company has an accumulated
deficit as of December 31, 2023 of $ 6,521,945. The Company anticipates operating losses to continue for the foreseeable future due to,
among other things, costs related to research funding, further development of its technology and products, and expenses related to the
commercialization of its products.

 Management
believes that the Company does not have sufficient cash and current assets to support its operations through at least 12 months from
the issuance date of these consolidated financial statements, and will require significant additional cash resources to continue its
planned research and development activities.

 The
Company will need additional funds for promoting new products and working capital required to support research and development activities
and generate sales from its products. There can be no assurance, however, that such financing will be available when needed, if at all,
or on favorable terms and conditions. The precise amount and timing of the funding needs cannot be determined accurately at this time,
and will depend on a number of factors, including the quality of product development efforts, management of working capital, and the
continuation of normal payment terms and conditions for purchase of services.

 In
order to address its capital needs, including its planned research and development activities and other expenditures, the Company is
actively pursuing additional equity financing. The Company has been in ongoing discussions with institutional investors and other parties
with respect to such possible offerings. Adequate financing opportunities might not be available to the Company, when and if needed,
on acceptable terms or at all. If the Company is unable to obtain additional financing in sufficient amounts or on acceptable terms or
if the Company fails to consummate the private placement or a public offering, the Company will be forced to delay, reduce or eliminate
some or all of its research and development programs and product portfolio expansion, which could adversely affect its operating results
or business prospects. Although management continues to pursue these plans, there is no assurance that the Company will be successful
in obtaining sufficient funding in terms acceptable to the Company to fund continuing operations, if at all. After considering the uncertainties,
management determined it is appropriate to continue to adopt the going concern basis in preparing the consolidated financial statements.

 2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

 The
principal accounting policies applied in the preparation of these consolidated financial statements are set out below.

 Basis
of Presentation

 The
accompanying financial statements have been prepared in accordance with U.S. Generally Accepted Accounting Principles ("U.S. GAAP")
and applicable rules and regulations of the U.S. Securities and Exchange Commission ("SEC"). Unless otherwise indicated,
all references to "$" are to U.S. dollars, and all references to " " or "GBP" are to Great
Britain Pounds. The Company's reporting currency is U.S. dollars.

 F- 7

 Basis
of Consolidation

 The
accompanying audited consolidated financial statements include the accounts of AccuStem Sciences Inc. as well as its wholly-owned subsidiary
after elimination of intercompany transactions and balances.

 Use
of Estimates

 The
preparation of financial statements in conformity with U.S GAAP requires management of the Company to make estimates and assumptions
that affect the reported amounts of assets and liabilities, and disclosure of contingent assets and liabilities at the date of the
financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from
those estimates.

 Risk
and Uncertainties

 The
Company is subject to a number of risks similar to those of other companies of similar size in its industry, including but not limited
to, the success of its exploration to research and development activities, need for additional capital (or financing) to fund operating
losses, competition from substitute products and services from larger companies, protection of proprietary technology, patent litigation,
dependence on key individuals, and risks associated with changes in information technology.

 Cash

 The
Company considers all highly liquid investments purchased with an original maturity date of three months or less at the date of purchase
and money market accounts to be cash equivalents. At December 31, 2023, the Company had no cash equivalents and all cash amounts consisted
of cash on deposit.

 Concentrations
of Credit Risk

 Financial
instruments that potentially subject the Company to significant contribution of credit risk consist of cash. Periodically, the Company
maintains deposits in financial institutions in excess of government insured limits. Management believes that the Company is not exposed
to significant credit risk as the Company's deposits are held at financial institutions that management believes to be of high
credit quality and the Company has not experienced any losses in these deposits.

 Equipment,
net

 Equipment
is stated at cost, less accumulated depreciation. The Company depreciates its equipment for financial reporting purposes using the straight-line
method over the estimated useful lives of the assets. The Equipment consists of computer equipment, which has a useful life of 3 years.
Maintenance and repairs are expensed when incurred. Additions and improvements that extend the economic useful life of the asset are
capitalized and depreciated over the remaining useful lives of the assets. The cost and accumulated depreciation of assets sold or retired
are removed from the respective accounts, and any resulting gain or loss is reflected in current earnings.

 F- 8

Taxes

 The
Company accounts for income taxes under ASC 740 - Income Taxes. For federal and state income taxes, deferred tax assets and liabilities
are recognized based upon the differences between the financial statement and the tax basis of assets and liabilities. In addition, deferred
tax assets are also recorded with respect to net operating losses and other tax attribute carryforwards. Deferred income taxes are based
upon prescribed rates and enacted laws applicable to periods in which differences are expected to reverse. A valuation allowance is recorded
when it is not more likely than not that the tax benefit from the deferred tax assets will be realized.

 The
Company intends to continue maintaining a full valuation allowance on its deferred tax assets until there is sufficient evidence to support
reversal of all or a portion of the allowances. In establishing the full valuation allowance position, the Company considered all available
evidence, including all potential sources of taxable income, future reversals of taxable temporary differences, projections of taxable
income, and income from tax planning strategies, as well as any other available and relevant information. Existing valuation allowances
are re-examined each period. If it were determined that it is more likely than not that a deferred tax asset will be realized, the appropriate
amount of the valuation allowance, if any, would be released in the period this determination is made.

 Tax
positions not deemed to meet a more-likely-than-not threshold would be recorded as a tax expense in the current year. There were no uncertain
tax positions that require accrual or disclosure to the financial statements as of December 31, 2023 and 2022. Tax positions taken or
expected to be taken in the course of preparing the Company's tax returns are required to be evaluated to determine whether the
tax positions are "more-likely-than-not" of being sustained by the applicable tax authority. As of December 31, 2023, open
years related to federal and state jurisdictions are 2020, 2021, 2022 and 2023.

and Development Expenses

and product development costs are expensed as incurred under ASC 730 - Research and Development. Research and development expenses
primarily consist of costs associated with the preclinical and clinical development of the Company's product candidate portfolio,
including but not limited to payments to Clinical Research Organizations ("CROs"), the manufacturing of clinical trial material,
preclinical research activities, consultants and personnel needed to perform research and development activities, intellectual property,
as well as costs to license intellectual property that is an in-process research and development asset with no alternative future use.

 Segment
Information

 The
Company applies ASC 280, Segment Reporting, in determining reportable segments for its financial statement disclosure. Operating
segments are defined as components of an entity for which separate financial information is available and that is regularly reviewed
by the Chief Operating Decision Maker ("CODM") in deciding how to allocate resources to an individual segment and in assessing
performance. The Company's CODM is its Chief Executive Officer ("CEO"). The Company has determined that it operates
as a single operating segment and has one reportable segment.

 Fair
Value of Financial Instruments

 The
Company classifies a financial instrument, or its component parts, as a financial liability, a financial asset or an equity instrument
in accordance with the substance of the contractual arrangement and the definitions of a financial liability, a financial asset and an
equity instrument.

 The
Company evaluates the terms of the financial instrument to determine whether it contains an asset, a liability or an equity component.
Such components shall be classified separately as financial assets, financial liabilities or equity instruments.

 The
Company's financial liabilities include trade and other payables. The carrying value of such amounts approximate fair value based
on the short-term nature of the items. The Company does not hold any financial assets or liabilities at fair value through profit or
loss or fair value through other comprehensive income.

 F- 9

 Share-based
Compensation

 The
Company may award stock options, performance-based options and other equity-based instruments to its employees, directors and consultants.
Compensation cost related to equity-based instruments is based on the fair value of the instrument on the grant date, and is recognized
over the requisite service period on a straight-line basis over the vesting period except for performance-based options. Performance-based
stock options vest based on the achievement of performance targets. Compensation costs associated with performance-based option awards
are recognized over the requisite service period based on probability of achievement. Performance-based stock options require management
to make assumptions regarding the likelihood of achieving performance targets.

 The
Company estimates the fair value of service based and performance-based stock option awards, including modifications of stock option
awards, using the Black-Scholes option pricing model. This model derives the fair value of stock options based on certain assumptions
related to expected stock price volatility, expected option life, risk-free interest rate and dividend yield.

 Loss
per Share

 The
Company computes loss per share in accordance with ASC 260 - Earnings per Share. Basic net loss per common share is computed by
dividing net loss by the weighted average number of shares of common shares outstanding during the period. Diluted net loss per share
of common stock is computed by giving effect to all potential dilutive shares of common stock, including options and performance awards.
Basic and diluted net loss per share of common stock were the same for all periods presented as the impact of all potentially dilutive
securities outstanding was anti-dilutive.

 Foreign
Currencies

 The
consolidated financial statements are presented in United States dollars which is the Company's reporting and functional
currency as the Company's operating and capital costs are transacted in U.S. dollars. The Company's fully consolidated
subsidiary functional currency continued to be GBP, which is the currency of the primary economic environment in which the entities
operated. There was no activity in the subsidiary for the periods ended December 31, 2023 and 2022.

 The
financial results and position of foreign operations whose functional currency was different from the Company's reporting currency
were translated as follows:

 assets
 and liabilities were translated at year-end exchange rates prevailing at that reporting date;

 income
 and expenses were translated at average exchange rates for the period; and

 equity
 transactions including retained earnings/accumulated deficit were translated at the exchange rates prevailing at the date of the
 transaction.

 Gains
and losses arising from translations or settlements of foreign currency denominated transactions or balances were included in the determination
of income.

 Recently
Issued and Adopted Accounting Standards

 None

Accounting Standards Not Yet Adopted

 There are no recently issued accounting standards that have not been adopted that would affect the financial statements
of the Company.

 F- 10

 3.
 EQUIPMENT

 Equipment
consists of the following:

OF PROPERTY AND EQUIPMENT

 2023

 2022

 Computer equipment

 $
 10,999

 10,999

 Less: Accumulated depreciation

 6,951

 3,321

 Equipment, net

 $
 4,048

 7,678

 Depreciation
expense was approximately $ 3,630 and $ 3,321, respectively, for the year ended December 31, 2023 and 2022, respectively.

 Depreciation
expense is included within General and Administrative expenses in the accompanying Consolidated Statement of Operations.

 4.
 ACCRUED EXPENSES

 Accrued
expenses consist of the following:

 SCHEDULE OF ACCRUED EXPENSES

 2023

 2022

 Corporate bonus

 $
 -

 369,528

 Legal expense

 146,594

 124,245

 Other

 9,840

 24,852

 Total accrued expenses

 $
 156,434

 $
 518,625

 5.
 NOTE PAYABLE

 On
May 20, 2023, the Company renewed its Directors and Officers Liability Insurance agreement for $ 372,880. Under the terms of the agreement,
the Company made a down payment of $ 75,000, with the remaining balance financed over the remaining term at an annual percentage rate
of 7.50 %. Beginning June 2023, the Company will make 10 monthly payments of $ 30,822, with the last payment expected to be made in March
2024. In August 2023, the Company amended the agreement, which reduced the monthly payment from $ 30,822 to $ 18,792. At December 31, 2023,
the outstanding balance on the note payable was $ 55,679.

 On
May 20, 2022, the Company entered into a one-year Directors and Officers Liability Insurance agreement for $ 439,122. Under the terms
of the agreement, the Company made a down payment of $ 88,000, with the remaining balance financed over the remaining term at an annual
percentage rate of 3.95 %. The Company makes monthly payments of $ 35,751, with the last payment expected to be made in March 2023. At
December 31, 2023, the outstanding balance on the note payable was $ 106,551.

 6.
 LICENSE

 On
November 9, 2022, AccuStem and the IEO/University of Milan amended the License to clarify the regulatory path and timeline for the commercialization
of StemPrintER. Specifically, the regulatory requirement language has been modified to (i) extend the timeline for regulatory approval
or clearance of a licensed product to 36 months from the date of the amendment, (ii) clarify that contractual regulatory requirements
can be satisfied by the approval or clearance of the test as a Laboratory Developed Test (i.e., approval or clearance can be achieved
via the CLIA regulatory path rather than the FDA) and (iii) the timeline for commercial launch has been extended for an additional 60
months from the date of the amendment. The amendment provides for a separate licensing payment of $ 175,000 to the IEO.

 In
addition, for the term of the license, the following milestone payments are required to be made ( converted from EUROS to USD using exchange
rate of 1:$1.0675)

 50,000
 ($ 53,375) within 30 days of completion of development of a commercial test;

 100,000
 ($ 106,750) within 30 days of the first commercial sale of a licensed product; and

 150,000
 ($ 160,125) within 30 days of first regulatory approval in the U.S. or any other major market.

 The
License may be terminated by either party in the event of a material breach and in addition, we may terminate the License at any time
upon 30 days' notice.

 For
the years ended December 31, 2023 and 2022, the Company did not recognize any expense related to this license agreement as no milestones
were reached.

 F- 11

 7.
LOSS PER SHARE

 Basic
and diluted net loss per common share were the same since the inclusion of common shares issuable pursuant to the exercise of options
in the calculation of diluted net loss per common shares would have been antidilutive.

 For
the years ended December 31, 2023 and 2022, loss per share of the Company are as follows:

OF LOSS PER SHARE

 For the Year Ended

 For the Year Ended

 2023

 2022

 Numerator:

 Net Loss

 $
)

 $
)

 Net loss attributable to common shareholders

 $
)

 $
)

 Denominator:

 Weighted-average common shares outstanding, basic and diluted

 11,016,165

 Net loss per common share, basic and diluted

 $
 ( 0.18
)

 $
 ( 0.34
)

 The
Company's potentially dilutive securities, which include stock options and warrants, have been excluded from the computation of
diluted net loss per common share as the effect would be to reduce the net loss per share. Therefore, the weighted-average number of
common shares outstanding used to calculate both basic and diluted net loss per share attributable to common shareholders is the same.

 The
Company excluded the following from the computation of diluted net loss per share attributable to common stockholders for the years ended
December 31, 2023 and 2022 because including them would have had an anti-dilutive effect:

OF COMPUTATION OF DILUTED NET LOSS PER SHARE

 For the Year Ended

 For the Year Ended

 2023

 2022

 Stock options to purchase common stock outstanding

 1,261,115

 1,360,115

 Warrants to purchase common stock outstanding

 Total

 1,611,115

 1,710,115

 Anti-dilutive shares

 1,611,115

 1,710,115

 8.
 SHARE-BASED COMPENSATION

 In
August 2021, Limited adopted the 2021 Omnibus Equity Incentive Plan (the "Incentive Plan"). The Incentive Plan provides that
the Company may grant Options, Stock Appreciation Rights, Restricted Stock, Restricted Stock Units, and Other Share-Based Awards to selected
employees, directors, and independent contractors of the Company.

 Each
Award shall be exercisable at such time or times and subject to such terms and conditions set forth in the Incentive Plan, as shall be
determined by the administrator in the applicable award agreement. Total shares authorized by the plan was 2,500,000. Awards under the
Incentive Plan are exercisable for up to 10 years from the date of issuance. There are 1,229,452 remaining available shares to be issued
under the Incentive Plan at December 31, 2023. The number of shares of Common Stock that are reserved and available for issuance under
the Incentive Plan shall be subject to an annual increase on the first day of each calendar year beginning with the first January 1 following
the effective date and ending with the last January 1 during the initial ten-year term of the Plan as defined in Section 4(a) of the
Incentive Plan.

 Options

 The
Company issued 1,322,239 options during the year ended December 31, 2022 for employees, directors and non-employees under the Incentive
Plan. The options granted have an exercise price ranging from $ 1.00 to $ 2.13 and expire on the ten-year anniversary of the grant date.
The Company did not issue any options during the year ended December 31, 2023.

 F- 12

 For
the year ended December 31, 2022, stock option activity for time-based options of the Company are as follows:

 SCHEDULE OF STOCK OPTION ACTIVITY

 Number of Time-Based Share

Options

 Weighted Average Exercise

 Price

 Weighted Average Remaining Contractual Life (in

years)

 Aggregate Intrinsic Value

 Outstanding at January 1, 2022

 100,005

 $
 0.42

 9.72

 $
 —

 378,239

 2.03

 9.20

 —

 ( 9,433
)

 0.90

 —

 —

 ( 52,696
)

 0.28

 —

 —

 Outstanding at December 31, 2022

 416,115

 $
 1.86

 9.13

 $
 57,207

 Vested and exercisable December 31, 2022

 57,115

 $
 0.44

 8.68

 $
 51,957

 For
the year ended December 31, 2023, stock option activity for time-based options of the Company are as follows:

 Number of Time-Based Share Options

 Weighted Average Exercise Price

 Weighted Average Remaining Contractual Life (in years)

 Aggregate Intrinsic Value

 Outstanding at January 1, 2023

 416,115

 $
 1.86

 9.13

 $
 57,207

 -

 -

 -

 —

 -

 -

 —

 —

 ( 49,500
)

 2.13

 —

 —

 Outstanding at December 31, 2023

 366,615

 $
 1.82

 8.14

 $
 15,686

 Vested and exercisable December 31, 2023

 119,765

 $
 1.29

 7.97

 $
 15,686

 For
the year December 31, 2023, stock option activity for performance-based options of the Company are as follows:

 SCHEDULE OF STOCK OPTION ACTIVITY

 Number of Performance- Based Share Options

 Weighted Average Exercise
 Price

 Weighted Average Remaining Contractual Life (in
 years)

 Aggregate Intrinsic
 Value

 Outstanding at January 1, 2023

 944,000

 $
 1.45

 9.11

 $
 174,000

 —

 —

 —

 —

 —

 —

 —

 —

 ( 49,500
)

 —

 —

 —

 Outstanding at December 31, 2023

 894,500

 $
 1.41

 8.11

 $
 —

 Vested and exercisable December 31, 2023

 —

 —

 —

 —

 The
aggregate intrinsic value is calculated as the difference between the estimated fair value of the underlying common stock as of December
31, 2023 and the option exercise price.

 Total
share-based compensation was approximately $ 76,634 and $ 133,889, respectively, for the year ended December 31, 2023 and 2022, respectively.

 F- 13

 Total
share-based compensation expense is included in General and Administrative expenses on the Condensed Consolidated Statement of Operations.

 The
weighted average grant date fair value for stock options granted was $ 0.76 and $ 0.42 during the year ended December 31, 2022. The performance-based
and time-based stock options are equity-classified. There was no stock options granted during the year ended December 31, 2023.

 The
Company uses the Black-Scholes option pricing model to estimate the fair value of the option awards. The table below summarizes the resulting
weighted average inputs used to calculate the estimated fair value of options awarded for the year ended December 31, 2023 and 2023.

 SCHEDULE OF STOCK VALUATION ASSUMPTIONS

 2023

 2022

 Risk-free interest rate

 —

 1.54 - 4.2 0
 %

 Expected dividend yield

 —

 —
 %

 Expected term

 —

 5.00 – 8.50 years

 Expected volatility

 —

 57.2 - 65.7
 %

 The
risk-free interest rate assumption is determined using the yield currently available on U.S. Treasury zero- coupon issues with a remaining
term commensurate with the expected term of the award. The Company has historically been a private company and lacks company-specific
historical and implied volatility information. Management has estimated expected volatility based on similar public companies. Expected
life of the option represents the period of time options are expected to be outstanding. The estimate for dividend yield is 0 % because
the Company has not historically paid, and does not intend to pay, a dividend on common stock in the foreseeable future.

 As
of December 31, 2023, there was $ 772,580 unrecognized compensation expense related to options. $ 102,213 of this cost is subject to time-based
conditions, and is to be recognized over a period of approximately 2.3 years. The remaining $ 670,368 of unrecognized compensation expense
relates to performance-based conditions for unvested options.

 As
of December 31, 2022, there was $ 872,662 unrecognized compensation expense related to options. $ 179,324 of this cost is subject to time-based
conditions, and is to be recognized over a period of approximately 3.3 years. The remaining $ 693,338 of unrecognized compensation expense
relates to performance-based conditions for unvested options.

 These
costs are expected to be recognized over the required service period once the performance condition has occurred or becomes probable.
Compensation costs related to the performance stock options are evaluated at each reporting period and subsequently adjusted for changes
in the expected outcomes of the performance conditions. There was no unrecognized compensation expense related to options at December
31, 2021.

 Warrants

 In
March 2022, the Company issued 350,000 common stock warrants to a non-employee under the Incentive Plan. The common stock warrants are
subject to vesting and, grantees become fully vested and exercisable when certain performance requirements are met.

 The
common stock warrants granted have an exercise price of $ 1.06. The common stock warrants expire on the ten-year anniversary of the grant
date. There were no warrants issued during the year ended December 31, 2023.

 A
summary of the Company's warrants to purchase common stock activity is as follows:

 SCHEDULE OF WARRANTS OUTSTANDING

 Number of Shares

 Weighted Average Exercise Price

 Weighted Average Remaining Contractual Life (in years)

 Aggregate Intrinsic Value

 Outstanding at January 1, 2022

 —

 $
 —

 —

 $
 —

 1.06

 9.07

 —

 —

 —

 —

 —

 —

 —

 —

 —

 Outstanding at December 31, 2022

 $
 1.06

 9.07

 $
 —

 Vested and exercisable December 31, 2022

 —

 —

 —

 —

 F- 14

 Number of Shares

 Weighted Average Exercise Price

 Weighted Average Remaining Contractual Life (in years)

 Aggregate

Intrinsic

Value

 Outstanding at January 1, 2023

 $
 1.06

 9.07

 $
 —

 —

 —

 —

 —

 —

 —

 —

 —

 —

 —

 —

 —

 Outstanding at December 31, 2023

 $
 1.06

 8.07

 $
 —

 Vested and exercisable December 31, 2023

 —

 —

 —

 —

 The
grant date fair value for these warrants of $ 0.66 per warrant for a total fair value of $ 232,490. The table below summarizes the resulting
weighted average inputs used to calculate the estimated fair value of the common stock warrants options awarded for the year ended December
31, 2023.

OF WARRANTS STOCK VALUATION ASSUMPTIONS

 2023

 2022

 Risk-free interest rate

 —

 1.75
 %

 Expected dividend yield

 —

 —

 Expected term

 —

 8.50 years

 Expected volatility

 —

 63.9
 %

 There
was no share-based compensation expense recognized during the year ended December 31, 2023 and 2022 for warrants.

 As
of December 31, 2023, there was $ 232,490 of total performance-based unrecognized compensation costs related to unvested common stock
warrants. These costs are expected to be recognized once the performance condition has occurred or becomes probable.

 On
October 10, 2022, our stockholders approved an amendment to our Amended and Restated Certificate of Incorporation (the "Charter"),
to effect a reverse stock split of our outstanding shares of common stock by a ratio of any whole number between one-for-two and one-for-fifteen,
at any time prior to October 10, 2023, the implementation and timing of which shall be subject to the discretion of our board of directors.

 9.
 RELATED PARTY TRANSACTIONS

 Tiziana
is a related party as the entity is controlled by a person that has a significant influence over the group. The Company and Tiziana share
some directors, an officer and significant shareholders. The Company has also been formed due to an acquisition of a subsidiary company
from Tiziana. As of December 31, 2023, Tiziana owns approximately 11.8 % of the Company.

 Effective
with the demerger agreement, the Company entered into a shared services agreement, where the Company outsources certain limited management
and administrative services. The Company notes that the fees consist of payroll costs associated with time spent providing services for
the Company and are based on actual time spent and the allocated payroll costs. In addition, the Company is charged at cost, for utilization
of certain office space. There was no mark-up associated with fees charged for these services. Total cost for the year ended December
31, 2023 and 2022 were $ 17,971 and $ 35,668, respectively.

 As
of December 31, 2023 and 2022, $ 176,501 and $ 76,229 respectively, was also due to Tiziana, as Tiziana had paid for expenses on behalf
of the Company.

 In
January 2022, the Company and Gabriele Cerrone, who is the Chairman of the Board of Directors and the largest shareholder, entered into
an agreement in which he will provide consulting services to the Company for a monthly fee of $ 5,500. As of December 31, 2023 and 2022,
$ 132,000 and $ 66,000, respectively, was due to Gabriele Cerrone.

 F- 15

 10.
 INCOME TAXES

 A
reconciliation of the provision for income taxes to the amount computed by applying the statutory income tax rate of 21% to the net loss
before income taxes for the year ended December 31, 2023 and 2022 are as follows:

OF PROVISION FOR INCOME TAXES

 Rate reconciliation

 2023

 2022

 Pre-tax Book Income

 21.00
 %

 21.00
 %

 Permanent differences

 ( 0.81
)%

 ( 0.96
)%

 Foreign net operating loss write-off

 ( 0.00
)%

 ( 2.56
)%

 Increase in valuation allowance

 ( 23.58
)%

 ( 18.84
)%

 State taxes

 3.39
 %

 1.36
 %

 Total tax expense

 0.00
 %

 0.00
 %

Tax Expenses attributable to income for continuing operations consists of the following:

OF INCOME TAX EXPENSES

 Income tax expense

 Current

 Deferred

 Total

 Federal

 -

 -

 -

 State

 -

 -

 -

 Foreign

 -

 -

 -

 Total taxes

 -

 -

 -

 Deferred
income taxes reflect the net tax effects of temporary differences between the carrying value of the asset and liabilities for financial
reporting purposes, and amounts used for income tax purposes.

 The
temporary differences resulted in the deferred tax assets and liabilities as follows:

OF DEFERRED TAX ASSETS AND LIABILITIES

 2023

 2022

 Net operating loss carryforwards

 $
 1,230,980

 $
 731,909

 Compensation accruals

 -

 88,423

 Fixed assets

 Patents

 26,588

 25,998

 R&D expenses

 101,024

 28,793

 Total deferred tax assets

 1,358,885

 875,375

 Less: valuation allowance

 $
 ( 1,358,885
)

 $
 ( 875,375
)

 Net deferred tax asset

 -

 -

 At
December 31, 2023 and 2022, the Company had net operating losses of approximately $ 5,350,379 and $ 3,276,370 for federal income tax purposes,
and approximately $ 3,865,989 and $ 1,133,327 for state income tax purposes.

 In
assessing the realizability of the deferred tax assets, management determined whether it is more likely than not that some portion or
all of the deferred tax assets will not be realized. Management considers the scheduled reversal of deferred tax liabilities, projected
future taxable income, net operating loss carryback potential and tax planning strategies in making these assessments.

 Based
on the above criteria, the Company believes that it is more likely than not that the full amount of the remaining net deferred tax assets
will not be realized. Accordingly, the Company has recorded a full valuation allowance of approximately $ 1,358,885 against net deferred
tax assets that is not expected to be realized for the period ended December 31, 2023 and approximately $ 875,375 for the period ended
December 31, 2022.

 The
Company recognizes interest accrued to unrecognized tax benefits and penalties as income tax expense. The Company accrued no penalties
or interest during the years ended December 31, 2023 and 2022.

 The
Company files tax returns as prescribed by the laws of the jurisdictions in which they operate. In the normal course of business, the
Company is subject to examination by federal and state jurisdictions where applicable based on the statute of limitations that apply
in each jurisdiction. As of December 31, 2023, open years related to federal and state jurisdictions are 2020, 2021, 2022 and 2023.

 The
Company has no open tax audits with any tax authority of December 31, 2023.

 The
federal net operating loss carryforward will be carried forward indefinitely, and the state net operating loss carryforward will expire
beginning in 2041.

 In
accordance with Section 382 of the Internal Revenue code, the usage of the Company's net operating loss carryforwards may be limited
in the event of a change in ownership. A full Section 382 analysis has not been prepared and NOLs could be subject to limitation under
Section 382.

 F- 16

 Item
9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

 Not

 Item
9A. Controls and Procedures

 Management's
Annual Report on Internal Control over Financial Reporting

 Our
management is responsible for establishing and maintaining adequate internal controls over financial reporting as defined in Rules 13a-15(f)
and 15d-15(f) under the Exchange Act. Our internal control over financial reporting is a process designed to provide reasonable assurance
regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with
generally accepted accounting principles ("US GAAP").

 Because
of their inherent limitations, internal controls over financial reporting may not prevent or detect misstatements. Also, projections
of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in
conditions, or that the degree of compliance with the policies or procedures may deteriorate.

 Under
the supervision and with the participation of management, our Chief Executive Officer and the Chief Financial Officer, we conducted an
evaluation of the effectiveness of our internal control over financial over financial reporting based on the framework described in Internal
Control-Integrated Framework issued by the Commission of Sponsoring Organizations of the Treadway Commission, as revised in 2013. Based
on that evaluation, management has concluded that we did not maintain effective internal control over financial reporting as of the period
ended December 31 2022 due to the existence of the material weaknesses in internal control over financial reporting described below.

 Material
Weaknesses in Internal Controls Over Financial Reporting

 A
material weakness is a deficiency, or a combination of deficiencies, in internal controls over financial reporting, such that there is
a reasonable possibility that a material misstatement of our annual or interim financial statements will not be prevented or detected
on a timely basis.

 Management
has determined that we did not maintain effective internal control over financial reporting as of the period ended December 31, 2023
due to a lack of accounting resources resulting in inadequate monitoring controls and other oversight procedures. Our management has
determined that our disclosure controls and procedures and internal controls were ineffective due to weaknesses in our financial closing
process, inadequate segregation of duties over authorization, review and recording of transactions, lack of accounting resources, as
well as the financial reporting of such transactions.

 Management's
Plan to Remediate the Material Weakness

 Management
intends to remediate this item in the following manner:

 i.
Recruit appropriately skilled accounting resources (the "Remediation Plan")

 Accordingly,
management has determined that these control deficiencies constitute a material weakness. Management has begun implementing the Remediation
Plan described herein and intends to continue working on it through the year ended December 31, 2024 when appropriate funding is received.

 - 57 -

 Changes
in Internal Control over Financial Reporting

 There
have been no changes in our internal control over financial reporting during the year ended December 31, 2022 that has materially affected,
or is reasonably likely to materially affect, our internal control over financial reporting.

 Item
9B. Other Information

 None

 Item
9C. Disclosure Regarding Foreign Jurisdictions that Prevent Inspections

 None

 Item
10. Directors, Executive Officers and Corporate Governance

 The following table sets forth the names and ages
of all of our current directors and executive officers. Our officers are appointed by, and serve at the pleasure of, the Company's
Board of Directors (referred to herein as the "Board") and/or our Chief Executive Officer.

 Name

 Age

 Position

 Wendy Blosser

 Chief Executive Officer and Director

 Joe Flanagan

 Chief Business Officer

 Keeren Shah

 Chief Financial Officer

 Gabriele Cerrone

 Willy Simon

 John Brancaccio

 Sean McDonald

 Wendy
Blosser

 Wendy
E. Blosser has served as our Chief Executive Officer since March 2022. Prior to joining our company, Ms. Blosser held various roles launching,
relaunching and building organizations in the diagnostic, surgical and capital spaces, with a primary focus in oncology and women's
health. Prior to joining us, Ms. Blosser took a one year sabbatical for personal reasons. From May of 2019 through March 2021, Ms. Blosser
served as Chief Commercial Officer at Agendia N.V.. From March 2018 to May 2019, Ms. Blosser held multiple executive roles for the Caravel
Ventures portfolio (Animated Dynamics, Strand Diagnostics). From February 2015 to March 2018, Ms. Blosser was Vice President of Sales
(February 2015 to March 2017) and then Chief Commercial Officer (March 2017 to March 2018) for Biodesix. Prior to that, Ms. Blosser served
as VP of Sales with Integrated Oncology (LabCorp subsidiary). Ms. Blosser began her career in diagnostics at Cytyc Corporation holding
several leadership positions in her eight years with the company. We believe Ms. Blosser's background launching and relaunching
products in the diagnostics space, experience providing advisory support to various companies and track record in corporate leadership
roles qualifies her to be a member of the Board of Directors.

 Joe
Flanagan

 Joe
Flanagan has been our Chief Business Officer since January 2022. Mr. Flanagan has more than 25 years of sales excellence experience and
is a strategic expert, playing a leading role in the commercial development and successful launch of several product offerings from early-stage
diagnostic startups to large pharmaceutical companies. Prior to joining us, from April 2021 to January 2022, Mr. Flanagan held a commercial
leadership role with Ambry Genetics in their oncology franchise. From July 2019 to March 2021, Mr. Flanagan served as the Vice President
of Market Development for Agendia N.V. where he led strategic sales initiatives. From July 2018 to July 2019, he was Vice President of
Sales for Circulogene where he led the company's efforts to sell blood-based genomic and genetic testing for patients with cancer.
From March 2015 through July 2018, Mr. Flanagan was the Area Vice President of Sales, East for Biodesix where he was responsible for
sales and revenue for the Eastern United States.

Shah

Shah has been our Chief Financial Officer since August 2021. Ms. Shah has also served as the Chief Financial Officer of OKYO Pharma Limited
since March 2021 and the Finance Director of Tiziana Life Sciences Limited and Rasna Therapeutics, Inc. since August 2020, having previously
served as the Financial Controller for Tiziana and its related companies from June 2016 to July 2020. Previously, Ms. Shah spent ten
years at Visa, Inc. as a senior leader in its finance team where she was responsible for key financial controller activities, financial
planning and analysis, and core processes as well as leading and participating in key transformation programmes and Visa Inc.'s
initial public offering. Before joining Visa, Ms. Shah also held a variety of finance positions at other leading companies including
Arthur Andersen and BBC Worldwide. She holds a Bachelor of arts with honours in Economics and is a member of the Chartered Institute
of Management Accountants.

 - 58 -

Cerrone

 Mr.
Gabriele Marco Antonio Cerrone has served as a director of our company since March 2021. Mr. Cerrone founded ten biotechnology companies
in oncology, infectious diseases and molecular diagnostics, and has listed seven of these companies on Nasdaq, two on the London Stock
Exchange Main Market and AIM Market in London. Mr. Cerrone founded Tiziana Life Sciences Ltd. and has been its Executive Chairman since
April 2014. Mr. Cerrone co-founded Cardiff Oncology, Inc., an oncology company and served as its Co-Chairman; he was a co-founder and
served as Chairman of both Synergy Pharmaceuticals, Inc. and Callisto Pharmaceuticals, Inc. and was a Director of and led the restructuring
of Siga Technologies, Inc. Mr. Cerrone also co-founded FermaVir Pharmaceuticals, Inc. and served as Chairman of the Board until its merger
in September 2007 with Inhibitex, Inc. Mr. Cerrone served as a director of Inhibitex, Inc. until its US$2.5bn sale to Bristol Myers Squibb
Co in 2012. Mr. Cerrone is the Co-Founder of Rasna Therapeutics Inc., a company focused on the development of therapeutics for leukemias;
Co-Founder of Hepion Pharmaceuticals, Inc.; Executive Chairman and Co-Founder of Gensignia Life Sciences, Inc., a molecular diagnostics
company focused on oncology using microRNA technology; and founder of BioVitas Capital Ltd. Mr. Cerrone graduated from New York University's
Stern School of Business with a master's degree in business administration (MBA). We believe Mr. Cerrone's business and financial
expertise qualifies him to be a member of the Board.

 Willy
Simon

 Mr.
Simon has served as a director of the company since March 2021. He is a banker and worked at Kredietbank N.V. and Citibank London before
serving as an executive member of the Board of Generale Bank NL from 1997 to 1999 and as the chief executive of Fortis Investment Management
from 1999 to 2002. He acted as chairman of Bank Oyens & van Eeghen from 2002 to 2004. He was chairman of AIM-tradedVelox3 plc (formerly
24/7 Gaming Group Holdings plc) until 2014 and had been a director of Playlogic Entertainment Inc., a Nasdaq OTC listed company. Willy
Simon has been the chairman of Bever Holdings, a company listed in Amsterdam, since 2006 and Chairman of Ducat Maritime since 2015. He
is also a non-executive director of OKYO Pharma Ltd. and Tiziana Life Sciences Ltd. We believe Mr. Simon's business expertise qualifies
him to be a member of the Board.

 John
Brancaccio

 Mr.
Brancaccio, a retired CPA, has served as a director of our company since March 2021. From April 2004 until May 2017, Mr. Brancaccio
was the Chief Financial Officer of Accelerated Technologies, Inc., an incubator for medical device companies. Mr. Brancaccio served as
a director of Callisto Pharmaceuticals, Inc. from April 2004 until its merger with Synergy Pharmaceuticals, Inc. in January 2013 and
has been a director of Tamir Biotechnology, Inc. (formerly Alfacell Corporation) since April 2004, as well as a director of Hepion Pharmaceuticals,
Inc. since December 2013, Rasna Therapeutics, Inc. since September 2016, Okyo Pharma Ltd. since June 2020 and Tiziana Life Sciences Ltd.
since July 2020. Mr. Brancaccio served as a director of Synergy from July 2008 until April 2019. We believe Mr. Brancaccio's financial
experience qualifies him to be a member of the Board.

 Sean
McDonald

 Mr.
McDonald has served as a director of our company since November 2022. Since January 2015, Mr. McDonald has been President and CEO of
Ocugenix, Inc., a biotech company focused on ocular diseases. From 2015 to 2016 Mr. McDonald was
a venture partner with Adams Capital Management, a venture capital firm specializing in early-stage applied technology investments. Prior
to that, from 2001 to 2014, Mr. McDonald served as the CEO of Precision Therapeutics, one of the first biotechnology companies
to marry breakthroughs in understanding of cancer biology and the use of machine learning with the goal of developing products that would
help cancer patients get the most effective cancer treatment. We believe Mr. McDonald's business and management experience qualifies
him to be a member of the Board.

 Board
of Directors

 Our
Board of Directors currently consists of five members consisting of the CEO and four Non-Executive Directors.

 Board
of Directors Meetings and Committees

 Our
Board of Directors has established an audit committee, a nomination committee and a compensation committee. Each of these committees
operates under formally delegated duties and responsibilities.

 Audit
Committee

 The
audit committee of the Board comprises John Brancaccio and Willy Simon. It is chaired by John Brancaccio, and is responsible for:

 monitoring
 the quality of internal controls and ensuring our financial performance is properly measured and reported on;

 consideration
 of the Directors' risk assessment and suggesting items for discussion at the full Board;

 receipt
 and review of reports from our management and auditors relating to the interim and annual accounts, including a review of accounting
 policies, accounting treatment and disclosures in the financial reports;

 - 59 -

 consideration
 of the accounting and internal control systems in use throughout the Company and its subsidiaries; and

 overseeing
 our relationship with external auditors, including making recommendations to the Board as to the appointment or re-appointment of
 the external auditors, reviewing their terms of engagement, and monitoring the external auditors' independence, objectivity
 and effectiveness.

 The
audit committee meets not less than twice in each financial year and has unrestricted access to our auditors.

 Our
Board of Directors has determined that John Brancaccio is an "audit committee financial expert" as defined under section
5605(a)(2) of the Nasdaq Listing Rules.

 In
order to satisfy the independence criteria for audit committee members set forth in Rule 10A-3 under the Exchange Act, each member of
an audit committee of a listed company may not, other than in his or her capacity as a member of the audit committee, the Board of Directors,
or any other board committee, accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the listed company
or any of its subsidiaries or otherwise be an affiliated person of the listed company or any of its subsidiaries. We believe that the
composition of our audit committee will meet the requirements for independence under current SEC rules and regulations.

 Compensation
Committee

 The
compensation committee of the Board comprises Willy Simon and John Brancaccio. It is chaired by Willy Simon, and is responsible for:

 the
 review of the performance of the Executive Directors;

 recommendations
 to the Board on matters relating to the remuneration and terms of service of the Executive Directors; and

 recommendations
 to the Board on proposals for the granting of share options and other equity incentives pursuant to any share option scheme or equity
 incentive scheme in operation from time to time.

 In
making their recommendations, the compensation committee will have due regard to our stockholders' interests and our performance.

 In
order to satisfy the independence criteria for compensation committee members set forth in Rule 10C-1 under the Exchange Act, all factors
specifically relevant to determining whether a director has a relationship to such company which is material to that director's
ability to be independent from management in connection with the duties of a compensation committee member must be considered, including,
but not limited to: (1) the source of compensation of the director, including any consulting advisory or other compensatory fee paid
by such company to the director; and (2) whether the director is affiliated with the company or any of its subsidiaries or affiliates.
We believe the composition of our compensation committee will meet the requirements for independence under current SEC rules and regulations.

 None
of the members of our compensation committee is, or has ever been, an officer or employee of our company.

 Nomination
Committee

 The
nomination committee of the Board comprises John Brancaccio and Willy Simon. It is chaired by John Brancaccio, and is responsible for:

 drawing
 up selection criteria and appointment procedures for Directors;

 recommending
 nominees for election to our Board of Directors and its corresponding committees;

 assessing
 the functioning of individual members of our Board of Directors and executive officers and reporting the results of such assessment
 to our Board of Directors; and

 developing
 corporate governance guidelines.

 - 60 -

 Code
of Ethics

 We
have adopted a formal Code of Business Conduct and Ethics applicable to all Board members, officers and employees. Our Code of Business
Conduct and Ethics can be found on our website at www. AccuStem.com. A copy of our Code of Business Conduct and Ethics may be obtained
without charge upon written request to Secretary, AccuStem Sciences, Inc., 5 Penn Plaza, 19th Floor, #1954 New York, NY 10001. If we
make any substantive amendments to our Code of Business Conduct and Ethics or grant any waiver from a provision of the Code of Business
Conduct and Ethics to any executive officer or director, we will promptly disclose the nature of the amendment or waiver on our website,
 www. AccuStem.com, and/or in our public filings with the SEC.

 Item
11. Executive Compensation

 Summary
Compensation Table

 The
following table provides certain summary information concerning compensation awarded to, earned by or paid to our Principal Executive
Officer and our other highest paid executive officers whose total annual salary and bonus exceeded $100,000 (collectively, the "named
executive officers") for fiscal year ended December 31, 2023 and 2022.

 Name and Principal Position

 Year

 Salary
 ($)

 All Other
 Compensation
 ($)

 Total
 ($)

 Wendy Blosser (Chief Executive Officer)

 2023

 425,000

 -

 425,000

 2022

 349,263

 105,841

 455,104

 Jeff Fensterer (Chief Operating Officer) 3

 2023

 138,654

 26,589

 165,243

 2022

 317,308

 30,000

 347,308

 Joe Flanagan (Chief Business Officer)

 2023

 300,000

 -

 300,000

 2022

 287,692

 30,000

 317,692

 1)

 $58,028
 relates to consultancy compensation prior to full time appointment on March 4, 2023 and $47,813 relates to bonus payment

 2)

 Amount
 relates to bonus payment

 3)

 On
June 5, 2023, Jeff Fensterer, Chief Operating Officer, resigned his position with the Company for personal reasons, effective as of June
16, 2023. Jeff Fensterer moved into a consulting position with the Company.

 4)

 Amount
 relates to consulting fees

 Offer
Letters

 Wendy
Blosser

 We
entered into an offer letter with Ms. Blosser on February 18, 2022 which was effective on March 4, 2022. This offer letter entitles Ms.
Blosser to receive an initial annual base salary of $425,000 per year. Ms. Blosser is eligible to receive an annual bonus of up to 45%
of her base salary, such bonus amount to be determined by our board of directors in its sole discretion, provided that $47,813 of such
bonus was guaranteed as paid in the first quarter of 2022. Ms. Blosser received a stock option to purchase 81,667 shares of common stock
at an exercise price of $15.96 per share which options vest 10% of the shares on each of the first, second, and third anniversaries of
March 4, 2022, 20% of the shares upon the fourth anniversary of March 4, 2022, 25% of the shares upon our completion of a single equity
financing which results in net proceeds to us of not less than $30,000,000 and 25% of the shares upon us launching a CLIA certified lab
in the US by the end of 2023. The agreement provides that Ms. Blosser's employment with us is at-will. Additionally,
Ms. Blosser is subject to a one year non-competition and non-solicitation covenant.

 - 61 -

 Joe
Flanagan

 We
entered into an offer letter with Mr. Flanagan on December 6, 2021 which was effective on January 17, 2022. This offer letter entitles
Mr. Flanagan to receive an initial annual base salary of $300,000 per year. Mr. Flanagan is eligible to receive an annual bonus of up
to 40% of his base salary, such bonus amount to be determined by our board of directors in its sole discretion. Mr. Flanagan received
a stock option to purchase 16,500 shares of common stock at an exercise price of $15.96 per share which options vest 10% of the shares
on each of the first, second, and third anniversaries of March 4, 2022, 20% of the shares upon the fourth anniversary of March 4, 2022,
25% of the shares upon our completion of a single equity financing which results in net proceeds to us of not less than $30,000,000 and
25% of the shares upon us launching a CLIA certified lab in the US by the end of 2023. The agreement provides that Mr. Flanagan employment
with us is at-will. Additionally, Mr. Flanagan is subject to a one year non-competition and non-solicitation covenant.

 Consulting
Agreements

Shah

 We
entered into a consultancy agreement with Ms. Shah on March 1, 2021 to provide finance director services. This agreement entitles Ms.
Shah to receive a base fee of 15,000 ($16,554, based on an exchange ratio of 1.00 to $1.1036 of as of December 31, 2023)
per annum. Ms. Shah may also be eligible to receive a bonus in an amount to be determined in our sole discretion.

 Ms.
Shah is not entitled to any fringe benefits. If Ms. Shah's consultancy with the Company is terminated without cause, Ms. Shah will
be entitled to a payment in lieu of the fee in an amount equal to her base fee for all or any remaining part of the relevant period of
notice.

 Ms.
Shah is also subject to a 6-month non-solicitation covenant.

Cerrone

 We
entered into a consultancy agreement with Mr. Cerrone on January 1, 2022 to provide business development, strategic planning and corporate
finance advice, as well as to fulfill the role of Executive Chairman of the board. This agreement entitles Mr. Cerrone to receive a base
fee of $66,000 per annum. Mr. Cerrone may also be eligible to receive a bonus in an amount to be determined in our sole discretion.

 Mr.
Cerrone is not entitled to any fringe benefits. If Mr. Cerrone's consultancy with the Company is terminated without cause, Mr.
Cerrone will be entitled to a payment in lieu of the base fee in an amount equal to his base fee for all or any remaining part of the
relevant period of notice.

 Mr.
Cerrone is also subject to a six-month non-solicitation covenant.

 Annual
Bonus

 Currently,
our senior leadership team has annual bonus opportunities of 40-45% of his or her respective salaries. The bonus plan is based upon achievement
of key corporate milestones and is contingent upon board approval. We plan to expand the bonus program as the company hires additional
employees.

 - 62 -

 Outstanding
equity awards at fiscal year end

 The
following table sets forth information for the named executive officers regarding the number of shares subject to both exercisable and
unexercisable stock options as well as the exercise prices and expiration dates thereof, as of December 31, 2023. Except for the options
set forth in the table below, no other equity awards were held by any of our named executive officers as of December 31, 2023.

 Option Awards 1

 Name and Principal Position

 Number of Securities Underlying Unexercised Options (#)
 Exercisable

 Number of Securities Underlying Unexercised Options (#) Unexercisable

 Option Exercise
 Price ($)

 Option
 Expiration Date

 Wendy Blosser

 98,000

 392,000
 (2)(4)

 $
 2.13

 3/23/2032

 Chief Executive Officer

 Joe Flanagan

 19,800

 79,200
 (3)(5)

 $
 2.13

 1/25/2032

 Chief Business Officer

 1)

 For
 each executive officer, the shares listed in this table are subject to a single stock option award carrying the varying exercise
 prices as set forth herein. The option awards remain exercisable until they expire ten years from the date of grant, subject to earlier
 expiration following termination of employment.

 2)

 49,000
 stock options vested on January 25, 2024

 3)

 9,900
 stock options vested on January 25, 2024

 4)

 5)

 147,000
 of the options are time-based and 245,000 are performance based.

 29,700
 of the options are time-based and 49,500 are performance based.

and Non-Employee Compensation

 The
following table presents the total compensation for each person who served as a non-employee member of our Board and received compensation
for such service during the fiscal year ended December 31, 2023. Other than as set forth in the table and described more fully below,
we did not pay any compensation, make any equity awards or non-equity awards to, or pay any other compensation to any of the non-employee
members of our Board in 2023. Directors who are also employees do not receive cash or equity compensation for service on our Board of
Directors in addition to compensation payable for their service as employees of the Company.

 Name

 2023 Fees
 Earned or
 Paid in Cash ($)

 Gabriele Cerrone

 66,000

 Willy Simon

 50,000

 John Brancaccio

 50,000

 Sean McDonald

 50,000

 - 63 -

 Item
12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 The
following table sets forth information with respect to the beneficial ownership of our common stock as of December 31, 2023 by:

 each
 of our Directors;

 each
 of our executive officers; and

 each
 person, or group of affiliated persons, who is known by us to beneficially own more than 5 per cent. of our outstanding Common Stock.

 Name of Beneficial Owner

 Shares

 Number of Ordinary
 Shares Beneficially Owned
 Percentage (1)

 Named Executive Officers and Directors

 Gabriele Cerrone (2) (3) (4)

 3,872,264

 34.00
 %

 Willy Simon

 9,789

 *

 Keeren Shah (5)

 5,251

 *

 John Brancaccio (6)

 8,964

 *

 Wendy Blosser (7)

 100,000

 *

 Joe Flanagan (8)

 19,800

 *

 All executive officers and directors as a group (six persons)

 4,016,068

 34.86
 %

 5% Stockholders

 Planwise Group Limited (1) (2)

 3,294,338

 29.03
 %

 Tiziana Lifesciences Ltd

 1,337,970

 11.79
 %

 *

 Represents
 beneficial ownership of less than one percent.

 (1)

 "Percentage
 of Shares Beneficially Owned" is based on 11,346,535 common stock issued and outstanding as at December 31, 2023.

 (2)

 Cerrone, a director of our company, is the beneficial owner of the entire issued share capital of Planwise Group Limited. Planwise
 Group Limited is incorporated in the British Virgin Islands with a registered address at Offshore Incorporations Centre, P.O. Box
 957, Road Town, Tortola, British Virgin Islands.

 (3)

 This
 includes shares held by Mr. Cerrone personally and shares held by Planwise Group Limited and Panetta Partners Limited (being entities
 in which Mr. Cerrone is considered to have a beneficial interest).

 (4)

 of 41,041 stock options which are currently exercisable or exercisable within 60 days of December 31, 2023

 (5)

 of 5,001 stock options which are currently exercisable or exercisable within 60 days of December 31, 2023

 (6)

 of 8,964 stock options which are currently exercisable or exercisable within 60 days of December 31, 2023

 (7)

 of 98,000 stock options which are currently exercisable or exercisable within 60 days of December 31, 2023

 (8)

 of 19,800 stock options which are currently exercisable or exercisable within 60 days of December 31, 2023

 Beneficial
ownership is determined in accordance with the rules and regulations of the SEC and includes voting or investment power with respect
to our common stock. Common stock subject to options that are currently exercisable or exercisable within 60 days after December 31,
2023 are considered outstanding and beneficially owned by the person holding the options for the purpose of calculating the percentage
ownership of that person but not for the purpose of calculating the percentage ownership of any other person. Except as otherwise noted,
the persons and entities in this table have sole voting and investment power with respect to all of the common stock beneficially owned
by them, subject to community property laws, where applicable. The information in the table above is based on information known to us
or ascertained by us from public filings made by the shareholders.

 We have also set forth below information known to us regarding any
significant change in the percentage ownership of our common stock by any major shareholders during the past three years. The major shareholders
listed below do not have voting rights with respect to their common stock that are different from the voting rights of other holders
of our common stock.

 - 64 -

 Equity
Compensation Plan Information

 Summary
Description of the 2021 Omnibus Equity Incentive Plan

 Effective
August 1, 2021 ("Adoption Date"), the Company adopted the 2021 Omnibus Equity Incentive Plan (the "Incentive Plan")
to provide an additional incentive, strengthen the commitment, motivate to faithful and diligently perform responsibilities, attract
and retain competent and dedicated individuals whose efforts will result in the long-term growth and profitability of the company, to
selected employees, directors, and independent contractors of the company or its affiliates whose contributions are essential to the
growth and success of the company. The Plan provides that the company may grant Options, Stock Appreciation Rights, Restricted Stock,
Restricted Stock Units, and Other Stock-Based Awards. Any employee, director or consultant of the Company or any of its subsidiaries
will be eligible to participate in the 2021 Plan. The number of shares of the Company Common Stock that reserved for issuance under the
2021 Plan is 2,500,000.

 Item
13. Certain Relationships and Related Transactions, and Director Independence

 The
following includes a summary of transactions since January 1, 2022 to which we have been a party in which the amount involved exceeded
or will exceed the lesser of $120,000 or 1% of the average of our total assets as of December 31, 2023 and 2022, and in which any of
our directors, executive officers or, to our knowledge, beneficial owners of more than 5% of our capital stock or any member of the immediate
family of any of the foregoing persons had or will have a direct or indirect material interest, other than equity and other compensation,
termination, change in control and other arrangements, which are described elsewhere in this prospectus. We also describe below certain
other transactions with our directors, executive officers, and stockholder.

 Agreements
with Our Executive Officers and Directors

 We
entered into a consulting agreement with Ms. Shah on March 1, 2021 to provide finance director services. This agreement entitles Ms.
Shah to receive a base fee of 15,000 ($16,554, based on an exchange ratio of 1.00 to $1.1036 of as of December 31, 2023)
per annum. Ms. Shah may also be eligible to receive a bonus in an amount to be determined in our sole discretion.

 Ms.
Shah is not entitled to any fringe benefits. If Ms. Shah's consulting agreement is terminated without cause, Ms. Shah will be entitled
to a payment in lieu of notice to the equal to her base fee for all or any remaining part of the relevant period of notice.

 Ms.
Shah is also subject to a six-month non-solicitation covenant.

Cerrone

 We
entered into a consultancy agreement with Mr. Cerrone on January 1, 2022 to provide business development, strategic planning and corporate
finance advice, as well as to fulfill the role of Executive Chairman of the board. This agreement entitles Mr. Cerrone to receive a base
fee of $66,000 per annum. Mr. Cerrone may also be eligible to receive a bonus in an amount to be determined in our sole discretion.

 Mr.
Cerrone is not entitled to any fringe benefits. If Mr. Cerrone's consultancy with the Company is terminated without cause, Mr.
Cerrone will be entitled to a payment in lieu of the base fee in an amount equal to his basic fee for all or any remaining part of the
relevant period of notice.

 Mr.
Cerrone is also subject to a 6-month non-competition and non-solicitation covenant.

 GenSignia
IP Ltd. License Agreement

 On
June 23, 2022, we entered into an Assignment and Assumption Agreement with GenSignia pursuant to which GenSignia assigned all of its
rights under a license agreement between Biomirna Holdings Ltd. and GenSignia Inc. effective as of December 21, 2011, as amended (the
"MSC License"), to us. Gabriele Cerrone, our Chairman is the Chairman of GenSignia. The MSC License provides for the payment
of up to $400,000 in milestone payments and low single digit percentage in royalties based on net sales. The MSC License remains in effect
until the royalty term has expired with respect to all licensed products in all countries. The MSC License may be terminated by either
party in the event of a material breach and in addition, we may terminate the MSC License at any time upon 90 days' notice.

 Family
Relationships

 There
are no family relationships among any of our directors or executive officers.

Independence

 Our
board of directors has undertaken a review of the independence of each director. Based on information provided by each director concerning
his background, employment and affiliations, our board of directors has determined that Messrs. Simon, Brancaccio and McDonald do not
have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director
and that each of these directors is "independent" as that term is defined under the listing standards of the Nasdaq Capital
Market. In making these determinations, our board of directors considered the current and prior relationships that each non-employee
director has with our company and all other facts and circumstances our board of directors deemed relevant in determining their independence,
including the beneficial ownership of our capital stock by each non-employee director, and the transactions involving them described
in this section.

 - 65 -

 Item
14. Principal Accountant Fees and Services

 Mazars
LLP has been our auditor since our incorporation on June 5, 2020 and for registration statement filed on Form 20-F filed under International
Financial Reporting Standards (IFRS); its address is Tower Bridge House, St Katharine's Way, London E1W 1DD, United Kingdom. Mazars
is registered to perform audits in the U.K. by the Institute of Chartered Accountants in England and Wales and is a registered auditor
with the PCAOB. In March 2022, the Audit Committee approved the appointment of Mazars USA LLP; its address 135 West 50th Street, New
York 10020 as the Company's new independent registered public accounting firm. Mazars USA LLP completed the audit of the Company
under US GAAP for the periods ended December 31, 2023 and 2022.

 Current
Independent Registered Public Accounting Firm Fees

 The
Audit Committee works with our management in order to negotiate appropriate fees with its independent registered public accounting firm
and is ultimately responsible for approving those fees. The following is a summary and description of fees for services provided by the
independent registered public accounting firms in fiscal years 2023 and 2022. Other than as set forth below, no professional services
were rendered or fees billed by Mazars USA LLP or Mazars LLP during fiscal years 2023 and 2022.

 2023

 2022

 Audit Fees

 $
 130,740

 $
 142,500

 All Other Fees

 -

 13,067

 Total

 $
 130,740

 $
 155,567

 Item
15. Exhibits, Financial Statement Schedules

 3.1

 Amended
 and Restated Certificate of Incorporation of AccuStem Sciences Inc. (incorporated by reference to Exhibit 3.1 to Form 8-K filed December
 3, 2021)

 3.2

 Bylaws
 of AccuStem Sciences Inc. (incorporated by reference to Exhibit 3.2 to Form 8-K filed December 2, 2021)

 4.1

 Form
 of common stock certificate (incorporated by reference to Exhibit 4.1 to Form S-1 filed November 17, 2022)

 4.2

 Demerger
 Agreement between Tiziana Life Sciences PLC and AccuStem Sciences Limited dated October 5, 2020 (incorporated by reference to Exhibit
 4.3 to Form 20-F filed March 12, 2021)

 - 66 -

 4.3

 Supplemental
 Demerger Agreement between Tiziana Life Sciences PLC and AccuStem Sciences Limited dated October 30, 2020 (incorporated by reference
 to Exhibit 4.4 to Form 20-F filed March 12, 2021)

 4.4

 Description
 of the Registrant's Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

 10.1

 License
 Agreement dated June 24, 2014 by and between TTFactor Srl and Fondazione Firc per l'Oncologia Molecolare and Universita degli
 Studi di Milano and Tiziana Life Sciences plc (incorporated by reference to Exhibit 4.5 to Form 20-F filed May 7, 2021)

 10.2

 Form
 of Indemnification Agreement (incorporated by reference to Exhibit 10.1 to Form 8-K filed December 3, 2021)

 10.3

 AccuStem
 Sciences Inc. 2021 Omnibus Equity Incentive Plan (incorporated by reference to Exhibit 10.2 to Form 8-K filed December 3, 2021)

 10.4

 Shared
 Services Agreement by and between Accustem Sciences Ltd. and Tiziana Life Sciences plc dated as of January 1, 2021 (incorporated
 by reference to Exhibit 10.4 to Form S-1 filed November 17, 2022).

 10.5

 Offer
 Letter dated February 18, 2022 between Accustem Sciences, Inc. and Wendy Blosser (incorporated by reference to Exhibit 10.5 to Form
 S-1 filed November 17, 2022).

 10.6

 Offer
 Letter dated November 25, 2021 between Accustem Sciences, Inc. and Jeff Fensterer (incorporated by reference to Exhibit 10.6 to Form
 S-1 filed November 17, 2022)

 10.7

 Offer
 Letter dated December 6, 2021 between Accustem Sciences, Inc. and Joe Flanagan (incorporated by reference to Exhibit 10.7 to Form
 S-1 filed November 17, 2022)

 10.8

 Consulting
 Agreement dated March 21, 2021 between Keeren Shah and Accustem Sciences, Inc. (incorporated by reference to Exhibit 10.8 to Form
 S-1 filed November 17, 2022)

 10.9

 Consulting
 Agreement dated January 1, 2022 between Gabriele Cerrone and Accustem Sciences, Inc. (incorporated by reference to Exhibit 10.9 to
 Form S-1 filed November 17, 2022).

 10.10

 First
 Amendment to License Agreement by and between AccuStem Sciences, Inc., Istituto Europeo di Oncologia Srl and Universita degli Studi
 di Milano, dated November 9, 2022 (incorporated by reference to Exhibit 10.10 to Form S-1 filed November 17, 2022)
.

 10.11

 Amendment
 to Consulting Agreement dated July 22, 2021 between Keeren Shah and Accustem Sciences, Inc. (incorporated by reference to Exhibit
 10.11 to Form S-1 filed November 17, 2022)

 21.1

 List
 of Subsidiaries (incorporated by reference to Exhibit 8.1 to Form 20-F filed May 7, 2021)

 24.1

 Power
 of Attorney (included on signature page)

 31.1

 Certification
 of Principal Executive Officer required under Rule 13a-14(a)/15d-14(a) under the Exchange Act.

 31.2

 Certification
 of Principal Financial Officer required under Rule 13a-14(a)/15d-14(a) under the Exchange Act.

 32.1

 Certification
 of Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
 2002.

 32.2

 Certification
 of Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
 2002.

 97.1

 Accustem Sciences, Inc. Clawback Policy

 101.INS*

 101.SCH*

 101.CAL*

 101.DEF*

 101.LAB*

 101.PRE*

 Cover

 Item
16. Form 10-K Summary

 Not

 - 67 -

 SIGNATURES

 Pursuant
to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed
on its behalf by the undersigned, thereunto duly authorized on March 22, 2024.

 SCIENCES, INC.

 (Registrant)

 /s/
 Keeren Shah

 Shah

 Chief
 Financial Officer

 POWER
OF ATTORNEY

 KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Wendy Blosser and Keeren
Shah as his or her attorney-in-fact, with full power of substitution and resubstitution, for him or her in any and all capacities, to
sign any and all amendments to this Annual Report on Form 10-K, and to file the same, with exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact full power and authority to do and perform
each and every act and thing requisite and necessary to be done in connection therewith as fully to all intents and purposes as he might
or could do in person, hereby ratifying and confirming all that said attorney-in-fact, or his substitute or substitutes, may lawfully
do or cause to be done by virtue hereof.

 In
accordance with the Securities Exchange Act of 1934, this Report has been signed below on March 22, 2024 by the following persons on
behalf of the Registrant and in the capacities indicated.

 /s/
 Wendy Blosser

 Wendy
 Blosser

 Chief
 Executive Officer and Director

 /s/
 Keeren Shah

 Shah

 Chief
 Financial Officer

 /s/
 Gabriele Cerrone

 Cerrone

 /s/
 Sean McDonald

 Sean
 McDonald

 /s/
 Willy Simon

 Willy
 Simon

 /s/
 John Brancaccio

 John
 Brancaccio

 - 68 -