UNITED STATES

 SECURITIES AND EXCHANGE COMMISSION

 Washington, D.C. 20549

 FORM 10-K/A

 (Amendment No. 1)

 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For the fiscal year ended December 31, 2024

 or

 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For the transition period from _______ to
_______

 Commission File Number: 001-00100

 THERAPEUTICSMD, INC.

 (Exact name of Registrant as specified in its
Charter)

 Nevada

 87-0233535

 (State or other jurisdiction of

incorporation or organization)

 (I.R.S. Employer
 Identification No.)

 951 Yamato Road, Suite 220

 Boca Raton, Florida

 33431

 (Address of principal executive offices)

 (Zip Code)

 561 - 961-1900

 (Registrant's telephone number, including
area code)

 Securities registered pursuant to Section 12(b)
of the Act:

 Title of Each Class

 Trading symbol

 Name of each exchange on which registered

 Common Stock, par value $0.001 per share

 TXMD

 The Nasdaq Stock Market LLC

 Securities registered pursuant to Section 12(g)
of the Act: None

 Indicate by check mark if the registrant is a well-known seasoned issuer,
as defined in Rule 405 of the Securities Act. Yes No

 Indicate by check mark if the registrant is not required to file reports
pursuant to Section 13 or Section 15(d) of the Act. Yes No

 Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.
 Yes No

 Indicate by check mark whether the registrant has submitted electronically
every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the
preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes
No

 Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of "large accelerated filer," "accelerated filer," "smaller reporting company" and "emerging
growth company" in Rule 12b-2 of the Exchange Act:

 Large Accelerated Filer

 Accelerated filer

 Non-accelerated filer

 Smaller reporting company

 Emerging growth company

 If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 13(a) of the Exchange Act.

 Indicate by check mark whether the registrant has filed a report on
and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section
404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.

 If securities are registered pursuant to Section 12(b) of the Act,
indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to
previously issued financial statements.

 Indicate by check mark whether any of those error corrections are restatements
that required a recovery analysis of incentive-based compensation received by any of the registrant's executive officers during
the relevant recovery period pursuant to §240.10D-1(b).

 Indicate by check mark whether the registrant is a shell company (as
defined in Rule 12b-2 of the Exchange Act). Yes No

 As of June 30, 2024, the registrant's most recently completed
second fiscal quarter, the aggregate market value of the voting and non-voting common equity held by non-affiliates computed by reference
to the market price at which the common equity was last sold was $ 13,408,634.

 As of April 18, 2025, there were outstanding 11,574,362 shares of the
registrant's common stock, par value $0.001 per share.

 Auditor Name:

 Auditor Location:

 Auditor Firm ID:

 Berkowitz Pollack Brant, Advisors + CPAs

 West Palm Beach, FL

 EXPLANATORY NOTE

 This Amendment No. 1 on Form 10-K/A, or the Form
10-K/A, is being filed by TherapeuticsMD, Inc., or the Company, in order to disclose information required by Items 10, 11, 12, 13 and
14 of Part III of Form 10-K, which information was omitted from the Company's Form 10-K for the fiscal year ended December 31, 2024
(the "Original Form 10-K"), in reliance on Instruction G to Form 10-K. The Original Form 10-K was filed with the Securities
and Exchange Commission, or SEC, on March 27, 2025.

 The Company does not expect to file its definitive
proxy statement for its upcoming annual stockholders' meeting within one hundred twenty (120) days of the end of its most recent
fiscal year (as required under Instruction G to Form 10-K). Therefore, the Company is filing this Form 10-K/A in order to include information
that would have been contained in the definitive proxy statement into the Original Form 10-K. The Company is also filing as exhibits to
this Form 10-K/A new certifications with respect to this filing by its principal executive officer and principal financial officer pursuant
to Section 302 of the Sarbanes-Oxley Act of 2002; accordingly, Item 15 of Part IV has also been amended to reflect the filing of these
new exhibits. Because no financial statements are being filed in this Form 10-K/A, and this Form 10-K/A does not contain or amend any
disclosure with respect to Items 307 and 308 of Regulation S-K, paragraphs 3, 4 and 5 of the certifications have been omitted. The Company
is also not filing new certifications required under Section 906 of the Sarbanes-Oxley Act of 2002, since no financial statements are
being filed with this Form 10-K/A. Finally, the Company is filing this Form 10-K/A to delete the reference on the cover of the Original
Form 10-K to the incorporation by reference of portions of its definitive proxy statement into Part III of the Original Form 10-K.

 This Form 10-K/A is limited in scope to the items
identified above and should be read in conjunction with the Original Form 10-K and the Company's other filings with the SEC. This
Form 10-K/A does not reflect events occurring after the filing of the Original Form 10-K or modify or update those disclosures affected
by subsequent events. Consequently, all other information is unchanged and reflects the disclosures made at the time of the filing of
the Original Form 10-K.

 Page

 Item 10.

 Directors, Executive Officers and Corporate Governance

 Item 11.

 Executive Compensation

 Item 12.

 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 Item 13.

 Certain Relationships and Related Transactions, and Director Independence

 Item 14.

 Principal Accountant Fees and Services

 Item 15.

 Exhibits and Financial Statement Schedules

 Signatures

 i

 Item 10. Directors, Executive Officers and Corporate Governance

 Directors

 The following table sets forth certain information regarding the current
directors of the Company.

 Name

 Age

 Position

 Tommy G. Thompson

 Chairman of the Board (2)

 Cooper C. Collins

 Director (1)(2)

 Gail K. Naughton, Ph. D.

 Director (1)

 Justin H. Roberts

 Director (1)(2)

 (1)
 Member of the Compensation
Committee.

 (2)

 Member of the Audit Committee.

 TOMMY G. THOMPSON

 Chairman of the Board

 Director Since: 2012

 Age: 82

 Committee:

 Audit

 Biographical Information

 Tommy G. Thompson has served as a director of our company since May
 2012 and as the Chairman of the Board of Directors since March 2024. He previously served as the Chairman of the Board of Directors from
 May 2012 until September 2022 and as Executive Chairman of the Board from September 2022 until March 2024. From July 2020 until March
 2022, Secretary Thompson served as the Interim President of the University of Wisconsin system. Secretary Thompson also serves as the
 Chief Executive Officer of Thompson Holdings, a consulting firm. As the Governor of Wisconsin from January 1987 to February 2001, Secretary
 Thompson was perhaps best known for his efforts to revitalize the Wisconsin economy, for his national leadership on welfare reform, and
 for his work toward expanding healthcare access across all segments of society. As the former Secretary of the U.S. Department of Health
 & Human Services, or HHS, from February 2001 to January 2005, Secretary Thompson served as the nation's leading advocate for
 the health and welfare of all Americans. Secretary Thompson was a partner in the law firm of Akin Gump Strauss Hauer & Feld LLP, or
 Akin Gump, from March 2005 to January 2012, when he resigned to run for the United States Senate. Secretary Thompson served as an Independent
 Chairman of the Deloitte Center for Health Solutions, a healthcare consulting company, from March 2005 to May 2009. At the Deloitte Center
 for Health Solutions and at Akin Gump, Secretary Thompson built on his efforts at HHS to work toward developing solutions to the healthcare
 challenges facing American families, businesses, communities, states, and the nation as a whole. Secretary Thompson has also served as
 the President of Logistics Health, Inc., a provider of medical readiness and homeland security solutions, from February 2005 to January
 2011. Secretary Thompson has served as a Senior Fellow for the Bipartisan Policy Center, a non-profit organization focused on bipartisan
 advocacy and policymaking, since July 2013. Secretary Thompson also serves as a member of the board of directors for United Therapeutics
 Corporation [NASDAQ: UTHR] and Healthpeak Properties, Inc. (f/k/a Physicians Realty Trust) [NYSE: DOC]. Secretary Thompson also served
 as a member of the boards of directors of Tyme Technologies, Inc. [NASDAQ: TYMI] from August 2017 to February 2020, Centene Corporation
 [NYSE: CNC] from April 2005 to January 2022 and Scilex Holding Company [NASDAQ: SCLX] from 2022 to 2023, and has historically served on
 the boards of directors of other public companies.

 Key Qualifications and Experience

 We believe Secretary Thompson's experience in public service
 and on the boards of directors of numerous public companies, particularly his services and knowledge related to the healthcare industry
 as a whole, makes him well suited to serve on our Board of Directors. Secretary Thompson received both his B.S. and J.D. from the University
 of Wisconsin-Madison.

 COOPER C. COLLINS

 Director Since: 2012

 Age: 45

 Committees:

 Audit

 Biographical Information

 Cooper C. Collins has served as a director of our company since February
 2012. Mr. Collins has served as Chief Executive Officer of Fortis BioPharma LLC since June 2015. Mr. Collins served as Chief Strategy
 Officer of Pernix Therapeutics Holdings, Inc. [NASDAQ: PTX], or Pernix, from May 2013 until April 2014, as its President and Chief Executive
 Officer from March 2010 until May 2013, and as a director from March 2010 until February 2014. Mr. Collins joined Pernix Therapeutics,
 Inc., a predecessor of Pernix, in 2002, where he was appointed as a director in January 2007, its President in December 2007 and its Chief
 Executive Officer in June 2008, serving in those three capacities until March 2010. From December 2005 to December 2007, Mr. Collins served
 as Vice President of Business and Product Development of Pernix Therapeutics, Inc. and as its Territory Manager from December 2003 to
 December 2005. Mr. Collins was employed for three years by the National Football League franchise, the New Orleans Saints, in its media
 relations department.

 Key Qualifications and Experience

 We believe Mr. Collins' specialty pharmaceutical company knowledge
 and executive experience provide the requisite qualifications, skills, perspectives, and experience that make him well qualified to serve
 on our Board of Directors. While on a football scholarship, Mr. Collins received a B.A. from Nicholls State University, where he later
 received an M.B.A.

 GAIL K. NAUGHTON,

 PH.D.

 Director Since: 2020

 Age: 69

 Committee:

 Biographical Information

 Gail K. Naughton, Ph. D. has served as a director of our company since
 March 2020. Dr. Naughton has served as the Chief Scientific Officer and Chief Business Development Officer of Histogen, a company she
 founded which is focused on the development of novel solutions based on the products of cells grown under simulated embryonic conditions,
 since April 2017. Dr. Naughton served as the Chairman and Chief Executive Officer of Histogen from June 2007 until April 2017. Prior to
 Histogen, Dr. Naughton was the Vice Chairman of Advanced Tissue Sciences, Inc., a human-based tissue engineering company, from March 2002
 to October 2002, President from August 2000 to March 2002, President and Chief Operating Officer from 1995 to 2000 and Executive Vice
 President, Chief Operating Officer from 1991 to 1995. Dr. Naughton also served as Dean of the College of Business Administration at San
 Diego State University from August 2002 to June 2011. She has spent over 30 years extensively researching the tissue engineering process,
 holds over 105 U.S. and foreign patents, and has founded two regenerative medicine companies. Dr. Naughton has brought several tissue
 engineered products to market including a product for severe burns (TransCyte), a dermal replacement for diabetic ulcers (Dermagraft),
 an aesthetic dermal filler (Cosmederm/Cosmeplast), and SkinMedica's TNS product for skin care. Dr. Naughton has been extensively
 published and a frequent speaker in the field of tissue engineering. In 2000, Dr. Naughton received the 27th Annual National Inventor
 of the Year award by the Intellectual Property Owners Association in honor of her pioneering work in the field of tissue engineering.
 Dr. Naughton previously served as a member of several public company boards of directors since 1988, including Cytori Therapeutics, Inc.
 [NASDAQ: CYTX] from July 2014 until January 2018 and CEL-SCI Corporation [NYSE American: CVM] from August 2022 until April 2024.

 Key Qualifications and Experience

 We believe Dr. Naughton's extensive executive experience, her
 in-depth knowledge of the healthcare industry and regenerative medicine technology, her experience developing FDA-approved products, and
 her service on other public company boards and committees, provide the requisite qualifications, skills, perspectives, and experience
 that make her well qualified to serve on our Board of Directors. Dr. Naughton received her B.S. in Biology from St. Francis College, her
 M.S. in Histology and her Ph. D. in Hematology from the New York University Medical Center and her E.M.B.A. from UCLA.

 JUSTIN ROBERTS

 Director Since: 2022

 Age: 42

 Committees:

 Audit

 Biographical Information

 Mr. Roberts is a Partner at Rubric Capital Management LP, a role he has held since the formation of the company in 2016. He currently
serves as a Non-Executive Director of Mereo BioPharma Group plc [NASDAQ: MREO]. Before Rubric he spent seven years at Point72 Asset Management.
Mr. Roberts has also held roles at ZS Associates, Moore Capital Management, and began his career at Lehman Brothers as an investment banker
in their M&A practice.

 Key Qualifications and Experience

 We believe Mr. Roberts' extensive executive experience, his finance
 background, and his service on other public company boards and committees, provide the requisite qualifications, skills, perspectives,
 and experience that make him well qualified to serve on our Board of Directors. Mr. Roberts graduated with honors from Johns Hopkins University.

 Executive Officers

 The following table sets forth certain information regarding our current
executive officers:

 Name

 Age

 Position

 Chief Executive Officer

 Joseph Ziegler

 Principal Financial and Accounting Officer

 Listed below are biographical descriptions of our current executive
officers.

 Marlan Walker has served as Chief Executive Officer of our company
since December 2022. Previously he served as General Counsel of our company from March 2016. Mr. Walker previously also served as Chief
Development Officer from April 2018 to December 2019 and as our Corporate and Intellectual Property Counsel from June 2013 until he became
our General Counsel. Mr. Walker's experience is focused in management of legal issues and risk in the life science industries across
a variety of disciplines. His legal practice prior to his time at TherapeuticsMD included long-term portfolio strategy and management,
patent preparation and prosecution, contract negotiation and drafting, life-cycle management, and Hatch-Waxman matters. After law school,
he took a position at Greenberg Traurig, LLP in August 2005. In March of 2009, he moved to Luce Forward Hamilton & Scripps. Mr. Walker
accepted an in-house position as Intellectual Property Counsel for Medicis Pharmaceutical Corp. in June 2011, which was acquired by Valeant
Pharmaceutical International, Inc. in December 2012. In February 2013, Mr. Walker accepted a position at Kilpatrick Townsend & Stockton,
but chose to move in-house again in June 2013, when he accepted a position at our company. Mr. Walker graduated from Arizona State University
Sandra Day O'Connor College of Law with his J.D. in 2004, and an LL.M. in Intellectual Property Law at The George Washington University
Law School in 2005. He holds a Master's Degree in Molecular Biology and a B.S. degree, both earned from Brigham Young University.

 Joseph Ziegler has served as Principal Financial and Accounting Officer of our company since August 2023 and has served as founder and chief executive
officer of JZ Advisory Group, a consulting company largely focused on providing fractional CFO and outsourced accounting services to middle-market
and entrepreneurial businesses, since January 2022. He previously served as the Chief Financial Officer of DAS Health, a private equity
owned provider of IT Services to healthcare providers, from April 2021 to December 2021 and as the Chief Financial Officer of Encompass
Onsite, a provider of end-to-end property solutions, from November 2018 to February 2021. Prior to joining Encompass, he held multiple
roles as a CFO in the healthcare industry, including private equity backed specialty pharmacy Biomatrix and Novis Pharmaceuticals. Mr.
Ziegler served as a director of Progressive Care Inc. from December 2021 until December 2024. He earned his B.S. in Finance and an M.B.A.
from Florida Atlantic University.

 CORPORATE GOVERNANCE

 Director Independence

 Since October 9, 2017, our common stock has been listed on the Nasdaq
Global Select Market of the Nasdaq Stock Market LLC, or Nasdaq, under the symbol "TXMD." From April 23, 2013 to October 6,
2017, our common stock was listed on the NYSE American under the symbol "TXMD." Under the rules of Nasdaq, independent directors
must comprise a majority of a listed company's board of directors.

 Our Board of Directors has affirmatively determined, after considering
all the relevant facts and circumstances, that each of Dr. Gail Naughton, and Messrs. Tommy G. Thompson, Cooper C. Collins and Justin
Roberts is an independent director, as "independence" is defined under the applicable rules and regulations of the SEC and
the listing standards of Nasdaq, and does not have a relationship with us (either directly or as a partner, stockholder, or officer of
an organization that has a relationship with us) that would interfere with their exercise of independent judgment in carrying out their
responsibilities as directors. Accordingly, a majority of our directors are independent, as required under the applicable Nasdaq rules.
There are no family relationships among any of our directors or officers.

 Committee Charters, Corporate Governance, and Code of Ethics

 Our Board of Directors has adopted charters for the Audit and Compensation
Committees describing the authority and responsibilities delegated to each committee by our Board of Directors. Our Board of Directors
has also adopted Corporate Governance Guidelines, a Code of Conduct and Ethics, and a Code of Ethics for the Chief Executive Officer and
senior financial officers of our company. We post on our website, at www.therapeuticsmd.com, the charters of our Audit and Compensation
Committees; our Corporate Governance Guidelines, Code of Conduct and Ethics, and Code of Ethics for the Chief Executive Officer and senior
financial officers, and any amendments or waivers thereto; and any other corporate governance materials contemplated by the SEC or Nasdaq.
These documents are also available in print to any stockholder requesting a copy in writing from our corporate secretary at our executive
offices.

 Executive Sessions

 We regularly schedule executive sessions in which non-employee directors
will meet without the presence or participation of management, with at least one of such sessions including only independent directors.
Mr. Thompson, as the Chairman of our Board of Directors, chairs the executive sessions.

 Board Committees

 Our Board of Directors has an Audit Committee and a Compensation Committee,
each consisting entirely of independent directors.

 Given the relatively small size of our Board of Directors and the desire
to involve the entire Board of Directors in nominating decisions, we have elected to no longer have a separate Nominating Committee. Since
we do not have a Nominating Committee, our independent directors, who currently constitute all of the Board of Directors, determine the
director nominees. Our Board of Directors may employ a variety of methods for identifying and evaluating director nominees. If vacancies
are anticipated or arise, our Board of Directors considers various potential candidates who may come to their attention through current
Board members, professional search firms, stockholders or other persons. These candidates may be evaluated by our Board of Directors at
any time during the year.

 In evaluating a director candidate, our Board of Directors will review
their qualifications including capability, availability to serve, conflicts of interest, general understanding of business, understanding
of our business and technology, educational and professional background, personal accomplishments and other relevant factors. Our Board
of Directors has not established any specific qualification standards for director nominees, and we do not have a formal diversity policy
relating to the identification and evaluation of nominees for director, although from time to time the Board of Directors may identify
certain skills or attributes as being particularly desirable to help meet specific needs that have arisen. Our Board of Directors may
also interview prospective nominees in person or by telephone. After completing this evaluation, the Board of Directors will determine
the nominees. The Board has not adopted a formal process for considering director candidates who may be recommended by stockholders. However,
our policy is to give due consideration to any and all such candidates.

 Audit Committee

 Members

 Cooper C. Collins, Chair

 Tommy G. Thompson

 The purpose of the Audit Committee is to oversee our financial and
 reporting processes and the audits of our financial statements and to provide assistance to our Board of Directors with respect to its
 oversight of the integrity of our financial statements, our company's compliance with legal and regulatory matters, the independent
 registered public accountant's qualifications and independence, and the performance of our independent registered public accountant.
 The primary responsibilities of the Audit Committee are set forth in its charter and include various matters with respect to the oversight
 of our accounting and financial reporting process and audits of our financial statements on behalf of our Board of Directors. The Audit
 Committee also selects the independent registered public accountant to conduct the annual audit of our financial statements; reviews the
 proposed scope of such audit; reviews accounting and financial controls with the independent registered public accountant and our financial
 accounting staff; and reviews and approves any transactions between us and our directors, officers, and their affiliates.

 The Audit Committee currently consists of Messrs. Collins, Thompson
 and Roberts, each an independent director of our company under the listing standards of Nasdaq as well as under applicable rules and regulations
 of the SEC, with Mr. Collins serving as Chair. Our Board of Directors has determined that Mr. Thompson (whose background is detailed above)
 qualifies as an "audit committee financial expert" in accordance with applicable rules and regulations of the SEC.

 Compensation Committee

 Members

 Gail Naughton, Chair

 Cooper C. Collins

 The purpose of the Compensation Committee includes, among other things, determining, or recommending to our Board of Directors for determination, the compensation of our Chief Executive Officer and other executive officers and directors, and discharging the responsibilities of our Board of Directors relating to our compensation programs. Pursuant to its charter, the Compensation Committee may delegate any of its responsibilities to a subcommittee comprised of one or more members of the Compensation Committee. The Compensation Committee currently consists of Dr. Naughton and Messrs. Collins and Roberts, each an independent director of our company under the listing standards of Nasdaq as well as under applicable rules and regulations of the SEC, with Dr. Naughton serving as Chair.

 Board's Role in Risk Oversight

 Risk is inherent in every business. As is the case in virtually all
businesses, we face a number of risks, including operational, economic, financial, legal, regulatory, and competitive risks. Our management
is responsible for the day-to-day management of the risks we face. Our Board of Directors, as a whole and through its committees, has
responsibility for the oversight of risk management.

 Our Board of Directors' involvement in our business strategy
and strategic plans plays a key role in its oversight of risk management, its assessment of management's risk appetite, and its
determination of the appropriate level of enterprise risk. Our Board of Directors receives updates at least quarterly from senior management
and periodically from outside advisors regarding the various risks we face, including operational, cybersecurity and information technology,
economic, financial, legal, regulatory, and competitive risks. Our Board of Directors also reviews the various risks we identify in our
filings with the SEC as well as risks relating to various specific developments, such as debt and equity issuances.

 The committees of our Board of Directors assist our Board of Directors
in fulfilling its oversight role in certain areas of risks. The Audit Committee oversees the financial and reporting processes of our
company and the audit of the financial statements of our company and provides assistance to our Board of Directors with respect to the
oversight and integrity of the financial statements of our company, our company's compliance with legal and regulatory matters,
the independent auditor's qualification and independence, and the performance of our independent auditor. The Audit Committee also
receives reports regarding our compliance program and our cybersecurity and information technology programs. The Compensation Committee
considers the risks that our compensation policies and practices may have in attracting, retaining, and motivating valued employees and
endeavors to assure that it is not reasonably likely that our compensation plans and policies would create undue risk or have a material
adverse effect on our company.

 Director Attributes

 We seek diversity in experience, viewpoint, education, skill, and other
individual qualities and attributes to be represented on our Board of Directors. We believe directors should have various qualifications,
including individual character and integrity; business experience and leadership ability; strategic planning skills, ability, and experience;
requisite knowledge of our industry and finance, accounting, and legal matters; communications and interpersonal skills; and the ability
and willingness to devote time to our company. We also believe the skill sets, backgrounds, and qualifications of our directors, taken
as a whole, should provide a significant mix of personal and professional experience, background, viewpoints, perspectives, knowledge,
and abilities. Nominees are not to be discriminated against on the basis of race, religion, national origin, sex, sexual orientation,
disability, or any other basis prohibited by law. The assessment of directors is made in the context of the perceived needs of our Board
of Directors from time to time.

 All of our directors have held high-level positions in business or
professional service firms and have experience in dealing with complex issues. We believe that all of our directors are individuals of
high character and integrity, are able to work well with others, and have committed to devote sufficient time to the business and affairs
of our company. In addition to these attributes, the description of each director's background sets forth above indicates the specific
experience, qualifications, and skills necessary to conclude that each individual should continue to serve as a director of our company.

 Board Leadership Structure

 We believe that effective board leadership structure depends on the
experience, skills, and personal interaction among persons in leadership roles as well as the needs of our company at any point in time.
We currently maintain separate roles between the Chief Executive Officer and the Chairman of the Board of Directors in recognition of
the differences between the two responsibilities. Our Chief Executive Officer is responsible for setting our strategic direction and day-to-day
leadership and performance of our company. The Chairman of the Board of Directors provides input to the Chief Executive Officer, sets
the agenda for board meetings, and presides over meetings of the full Board of Directors as well as executive sessions of our Board of
Directors. Our Board of Directors believes that our current leadership structure provides the most effective leadership model for our
company, as it promotes balance between the Board of Directors' independent authority to oversee our business and the Chief Executive
Officer and his management team, which manage the business on a day-to-day basis.

 Compensation Recovery Policy

 In 2023, we adopted a policy on recoupment of incentive compensation,
or clawback policy, which provides for recoupment of compensation in certain circumstances in the event of a restatement of our financial
results, in accordance with the requirements of SEC rules and Nasdaq listing standards implementing the requirement of Section 954 of
the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (the "Dodd-Frank Act").

 Insider Trading Policy

 We have adopted an insider trading policy that governs transactions
in our securities by our directors, officers, employees and their respective family members and affiliates that that we believe is reasonably
designed to promote compliance with insider trading laws, rules and regulations, and applicable Nasdaq listing standards. In addition,
it is our policy to comply with Federal securities laws and applicable stock exchange listing standards regarding trading in our own securities.

 Anti-Hedging and Anti-Pledging Policy

 In April 2020, the Board of Directors amended the Company's Code
of Conduct and Ethics to include a policy regarding hedging and pledging transactions. Pursuant to the policy, directors, officers, and
employees are prohibited from: (1) directly or indirectly engaging in any hedging transactions with respect to any directly or indirectly
owned securities of the company, which includes the purchase of any financial instrument (including puts, calls, equity swaps, forward
contracts, collars, exchange funds or other derivative securities) on an exchange or in any other market in order to hedge or offset any
decrease in the market value of such securities; (2) engaging in short sale transactions or forward sale transactions or any short-term
or speculative transactions in the company's securities or in other transactions in the company's securities that may lead
to inadvertent violations of insider trading laws; and (3) pledging securities of the company as collateral for a loan or otherwise using
securities of the company to secure a debt, including through the use of traditional margin accounts with a broker.

 Board and Committee Meetings

 Our Board of Directors held a total of seven meetings during the
fiscal year ended December 31, 2024. No director attended fewer than 75% of the aggregate of (i) the total number of meetings of our
Board of Directors and (ii) the total number of meetings held by all committees of our Board of Directors on which such director was
a member.

 During the fiscal year ended December 31, 2024, the Audit Committee
held five meetings and the Compensation Committee held zero meetings.

 Annual Meeting Attendance

 We encourage our directors to attend each annual meeting of stockholders.
Two of our directors virtually attended the 2024 annual meeting of stockholders.

 Communications with Directors

 Stockholders may communicate with our Board of Directors or specific
members of our Board of Directors, including our independent directors and the members of our various board committees, by submitting
a letter addressed to our Board of Directors of TherapeuticsMD, Inc. at the address set forth in this annual report c/o any specified
individual director or directors. Any such letters are forwarded to the indicated directors. In addition, at the request of the Board
of Directors, communications that do not directly relate to our Board of Directors' duties and responsibilities as directors will
be excluded from distribution. Such excluded items include, among others, "spam," advertisements, mass mailings, form letters,
and email campaigns that involve unduly large numbers of similar communications; solicitations for goods, services, employment or contributions;
and surveys. Additionally, communications that appear to be unduly hostile, intimidating, threatening, illegal or similarly inappropriate
will also be screened for omission. Any excluded communication will be made available to any director upon his or her request.

 Item 11. Executive Compensation

 As a smaller reporting company, the rules of the U.S. Securities and
Exchange Commission permit us to omit the Compensation Discussion and Analysis section and to report the compensation of our principal
executive officer, each of our two other most highly compensated executive officers who were serving at the end of our last completed
fiscal year, and up to two additional former executive officers for whom disclosure would have been provided but for the fact that the
individual was not serving as an executive officer at the end of our last completed fiscal year (collectively, our NEOs).

 For 2024, our NEOs were:

 Marlan Walker, CEO

 Joseph Ziegler, Principal Financial
and Accounting Officer

 As of December 31, 2024, we employed one full-time employee primarily
engaged in an executive position- Mr. Marlan Walker, our Chief Executive Officer. Mr. Ziegler serves as our Principal Financial and Accounting
Officer pursuant to a master services agreement (the "Master Services Agreement") with JZ Advisory Group ("JZ Advisory").
See "Ziegler Master Services Agreement" below.

 Fiscal Year 2024 Summary Compensation Table

 The following table lists the compensation of our NEOs for the years
provided. The following information includes the dollar value of salaries, bonus awards, the number of awards granted, non-equity incentive
plan compensation, and certain other compensation, if any.

 Name and Principal Position

 Year

 Salary

 Bonus
 ($)

 Stock

 Awards (1)
 ($)

 Option

 Awards ($)

 Non-Equity

 Incentive Plan

 Compensation (2)

 ($)

 All Other

 ($)

 Total
 ($)

 2024

 500,000

 -

 -

 -

 250,000

 9,174
 (6)

 759,174

 Chief Executive Officer

 2023

 476,462

 176,535
 (4)

 358,400
 (5)

 -

 -

 8,420
 (6)

 1,019,817

 Joseph Ziegler (3)

 2024

 120,000
 (7)

 -

 -

 -

 -

 -

 120,000

 Principal Financial and Accounting Officer

 2023

 52,900
 (7)

 -

 30,000
 (8)

 -

 -

 -

 82,900

 (1)
 Represents
the grant date fair value of restricted stock units (RSUs) and performance restricted stock units (PSUs) granted. The number of PSUs
represents the maximum number of PSUs that may vest. The actual number of PSUs that will vest will depend on the Company's achievement
of certain performance goals.

 (2)

 Amounts in this column represent the amounts earned and payable under our annual performance-targeted
incentive plan, which were earned and payable during the indicated fiscal year but portions of which may not have been paid until after
the end of indicated fiscal year.

 (3)

 On August 17, 2023, Mr. Ziegler began serving as Principal Financial and Accounting Officer of
the Company.

 (4)

 Amounts represent retention bonuses.

 (5)

 For 2023, the amount represents 70,000 RSUs with a grant date fair value of $358,400.

 (6)

 Other compensation paid was related to (i) employer match to 401(k) plan of $2,000, and (ii) health and welfare benefits paid by the Company.

 (7)

 The amounts represent the fixed fee paid to JZ Advisory in accordance with the Master Services Agreement.

 (8)

 For 2023, the amount represents 7,500 RSUs with a grant date fair value of $30,000.

 Outstanding Equity Awards at Fiscal Year-End
2024

 The following tables set forth information with respect to outstanding
equity-based awards held by our NEOs at December 31, 2024.

 Option Awards

 Number of Securities
 Underlying Unexercised Options

 Option

 Name

 Equity Award
 Date

 Exercisable
 (#)

 Unexercisable
 (#)

 Exercise
 Price
 ($)

 Option
 Expiration
 Date

 07/30/2019

 4,000

 -

 109.00

 07/30/2029

 Joseph Ziegler

 -

 -

 -

 -

 -

 Stock Awards

 Equity Incentive Plan Awards

 Name

 Equity
 Award Date

 Number
 of Shares
 or Units
 of Stock
 That Have
 Not
 Vested
 (#)

 Market
 Value of
 Shares or
 Units of
 Stock
 That Have
 Not
 Vested (1)
 ($)

 Number
 of Shares
 or Units
 of Stock
 That Have
 Not
 Vested
 (#)

 Market
 Value of
 Shares or
 Units of
 Stock
 That Have
 Not
 Vested (1)
 ($)

 3/23/2022

 1,733
 (2)

 1,490

 -

 -

 3/31/2022

 5,200
 (3)

 4,472

 Joseph Ziegler

 -

 -

 -

 -

 -

 (1)
 The amounts in this column
are based on the closing price of our common stock on December 31, 2024 of $0.86.

 (2)
 The amount reflects 1,733 RSUs that vested on March 23, 2025.

 (3)
 The amount reflects 5,200 PSUs
that vested on April 5, 2025.

 Post-Employment Compensation

 Pension Benefits

 We do not offer any defined benefit pension plans for any of our employees.
We have a 401(k) plan in which employees may participate.

 Other Compensation

 Mr. Walker is eligible to participate in our employee benefit plans,
including medical and dental plans. Should we decide to hire other employees, these plans do not discriminate in favor of executive officers
and would be available to any potential employee. It is generally our policy to not extend significant perquisites to executives that
are not broadly available to our other employees. In designing these elements, we seek to provide an overall level of benefits that is
competitive with that offered by similarly situated companies in the markets in which we operate based upon our general understanding
of industry practice. These benefits are not considered in determining the compensation of our executive officers.

 Employment Agreement

 Marlan D. Walker has an amended and restated employment agreement (as
amended, the "Walker Employment Agreement"), with the Company that commenced on December 18, 2018, and was amended effective
October 15, 2021, December 30, 2022, February 21, 2023 and December 17, 2024. The Walker Employment Agreement provides that we will continue
to employ Mr. Walker, and Mr. Walker will continue to serve the Company, unless sooner terminated pursuant to the terms of the Walker
Employment Agreement.

 The Walker Employment Agreement provides for: (i) a base salary of
$428,000 per year until April 15, 2023; thereafter, a base salary of $500,000 per year and a lump-sum bonus payment of $20,909, which
was paid in April 2023, (ii) an annual short-term incentive compensation of 50% of salary, at the discretion of our Board of Directors,
and (iii) 70,000 RSUs which vested on June 30, 2023. Mr. Walker will receive employee benefits, vacation, and other perquisites as may
be determined from time to time.

 Conditions of termination call for (i) termination immediately upon
death, (ii) termination upon a disability in which Mr. Walker is unable to perform his duties for more than six (6) consecutive months,
(iii) voluntary termination without good reason by Mr. Walker with prior notice, (iv) involuntary termination by our Company without good
cause, (v) termination for good cause, and (vi) termination for good reason wherein Mr. Walker will have ninety (90) days from the date
of occurrence of a condition giving rise to good reason to provide a notice of termination of his employment with the Company, which will
be effective thirty-one (31) days after we receive notice and the criteria remains uncorrected.

 Ziegler Master Services Agreement

 We entered into the Master Services Agreement with JZ Advisory that
commenced on August 15, 2023, pursuant to which, among other things, JZ Advisory will serve as an independent consultant for the purpose
of providing the Company with certain support services, including the services of Mr. Ziegler as the Company's Principal Financial
Officer.

 The Company agreed to pay JZ Advisory $10,000 a month for the services
provided under the Master Services Agreement during the third quarter of 2023, which monthly rate will continue until the parties negotiate
a future retainer amount. Mr. Ziegler was also granted 7,500 restricted stock units, which vested on August 17, 2024.

 The Master Services Agreement will continue through the third anniversary
of the Effective Date, unless earlier terminated (the "Term"). The Term will automatically be extended for successive one-year
periods unless either party provides written notice of non-extension no less than thirty (30) days in advance. The Master Services Agreement
may be terminated pursuant to its terms.

 The Master Services Agreement contains certain covenants and agreements
of the parties, including certain indemnification obligations of each party.

 Potential Payments Upon Termination or Change in Control

 We have employment agreements with certain of our executive officers
as described above. The arrangements reflected in these employment agreements are designed to encourage the officers' full attention
and dedication to our Company currently and, in the event of any proposed change in control, provide these officers with individual financial
security. The employment agreements provide for specified payments and benefits by us to our executive officers only upon a qualifying
termination of employment as described below.

 Termination by Us Without Good Cause or by Executive with Good Reason
- No Change in Control

 Under the Walker Employment Agreement, for Mr. Walker, in the event
of termination of the executive's employment without "cause" (referred to as "good cause" in the Walker
Employment Agreement) or resignation by the executive for "good reason" (as each term is defined in the Walker Employment
Agreement), he would be entitled to, subject to his signing and not revoking a full and complete release of all claims against the Company
and its affiliates, (i) the sum of his salary, payable on a biweekly basis ratably over eighteen (18) months, and one and one half times
(1.5x) his target annual incentive compensation for the fiscal year in which such termination of employment occurs, (ii) a continuation
of welfare benefits for a period of two years after such termination, (iii) COBRA benefits for a period of twenty-four (24) months following
such termination, (iv) payment for any annual short-term incentive compensation earned for the calendar year immediately preceding the
calendar year of such termination, (v) unpaid accrued base salary and unused vacation pay through the termination date, and (vi) amounts
accrued but unpaid at the time of termination. Furthermore, the above obligations of the Company are subject to the executive complying
with a non-solicitation agreement of employees and customers, and a non-competition agreement.

 Termination or Resignation in Connection with a Change in Control

 In the event of termination of Mr. Walker's employment without
"good cause" or resignation by the executive for "good reason" in the twelve (12) months following a change in
control, Mr. Walker would be entitled to, subject to his signing and not revoking a full and complete release of all claims against the
Company and its affiliates, (i) the sum of his salary, payable on a biweekly basis ratably over eighteen (18) months, and one and one
half times (1.5x) his target annual incentive compensation for the fiscal year in which such termination of employment occurs, (ii) payment
for any annual short-term incentive compensation earned for the calendar year immediately preceding the calendar year of such termination,
(iii) unpaid accrued base salary and unused vacation pay through the termination date, and (iv) amounts accrued but unpaid at the time
of termination. Furthermore, the above obligations of the Company are subject to the executive complying with a non-solicitation agreement
of employees and customers, and a non-competition agreement.

 Termination by Reason of Death or Disability

 For Mr. Walker, in the event of termination of the executive's
employment by reason of his death or "disability" (as such term is defined in the Walker Employment Agreement), in addition
to those payments and benefits provided to salaried employees generally, including amounts accrued but unpaid at the time of termination,
he would be entitled to (i) pro-rated target annual incentive compensation for the fiscal year in which such termination of employment
occurs, payable in a lump sum, subject to the executive's signing and not revoking a full and complete release of all claims against
the company and its affiliates in the event of a disability, (ii) immediate vesting of all outstanding equity awards that vest solely
on the passage of time, (iii) accrued but unused vacation pay through the termination date, payable in a lump sum, and (iv) all other
rights and benefits the executive is vested in, pursuant to other plans and programs of our company.

 Termination by the Executive Without Good Reason

 The table below reflects the amount of compensation to Marlan Walker,
the only NEO currently employed by the Company, assuming termination of such executive's employment without cause or for good reason
or following a change in control of our company on December 31, 2024. Other than as set forth below, no amounts will be paid to our NEOs
in the event of termination.

 Marlan Walker

 Executive Benefits and Payments

 Termination
 Without Good
 Cause
 or with Good
 Reason
 (Not in
 Connection
 with a Change
 in Control)
 ($)

 Termination
 Without
 Good Cause
 or with
 Good Reason
 Following a
 Change in Control
 ($)

 Termination by
 Reason of
 Death or
 Disability
 ($)

 Cash severance

 1,178,362
 (1)

 1,176,575
 (2)

 250,000
 (3)

 Equity awards (4)

 5,962

 5,962

 5,962

 (1)

 Consists of payments due to executive for (i) eighteen (18) months of his then current salary, (ii) 150% target annual incentive compensation, (iii) health and welfare benefits for twenty-four (24) months, (iv) unused PTO, and (v) any annual short-term incentive compensation earned from the prior year that had not yet been paid by the Company.

 (2)

 Consists of payments due to executive for (i) eighteen (18) months of his then current salary, (ii) 150% target annual incentive compensation, (iii) unused PTO, and (iv) any annual short-term incentive compensation earned from the prior year that had not yet been paid by the Company.

 (3)

 Represents full annual incentive compensation that would be prorated based on termination date.

 (4)

 Represents the value of unvested equity awards that would become fully vested. The value is calculated by multiplying the number of shares underlying each accelerated award by the per share closing price of the common stock on December 31, 2024.

 Nonqualified Defined Contribution and Nonqualified Deferred Compensation

 We do not offer any nonqualified defined contribution plans or nonqualified
deferred compensation plans for any of our NEOs.

 Limitation of Directors' Liability; Indemnification of Directors,
Officers, Employees, and Agents

 Our Amended and Restated Articles of Incorporation and bylaws, each
as amended, provide that we may indemnify to the full extent of our power to do so, all directors, officers, employees, and/or agents.
The effect of this provision in the Amended and Restated Articles of Incorporation, as amended, is to eliminate the rights of our company
and our stockholders, either directly or through stockholders' derivative suits brought on behalf of our company, to recover monetary
damages from a director for breach of the fiduciary duty of care as a director except in those instances described under Nevada law.

 Insofar as indemnification by our company for liabilities arising under
the Securities Act of 1933, as amended (the "Securities Act"), may be permitted to officers and directors of our company pursuant
to the foregoing provisions or otherwise, we are aware that in the opinion of the SEC, such indemnification is against public policy as
expressed in the Securities Act and is, therefore, unenforceable.

 DIRECTOR COMPENSATION

 We compensate our non-employee directors with a combination of cash
and equity. Our Board of Directors receives the following cash compensation for their service: each director receives an annual cash retainer
of $57,500; the chairperson of the Board receives an additional $22,500 annual cash retainer; the chairperson of our Audit Committee receives
an annual cash retainer of $30,000 and the other members of the Audit Committee receive an annual cash retainer of $15,000; the chairperson
of the Compensation Committee receives an annual cash retainer of $20,000 and the other members of the Compensation Committee receive
an annual cash retainer of $12,000; and the chairperson of each of our other committees receives an annual cash retainer of $12,500 and
the other members receive an annual cash retainer of $7,500. We also reimburse our directors for reasonable expenses related to attendance
at Board of Directors and committee meetings. No directors were granted equity awards during 2024. We do not pay our directors per meeting
fees.

 The following table and accompanying footnotes detail compensation
paid to our directors for services rendered for the year ended December 31, 2024. Mr. Roberts is entitled to receive compensation in the
same manner as our other non-employee directors, but he has elected not to receive any compensation for his service as a non-employee
director at this time.

 Name (1)

 Fees Earned
 or Paid in Cash
 ($)

 Stock
 Awards
 ($)

 All Other
 ($)

 Total
 ($)

 Tommy G. Thompson

 101,758
 (2)

 -

 -

 101,758

 Cooper C. Collins

 99,500

 -

 -

 99,500

 Gail Naughton, Ph. D.

 77,500

 -

 -

 77,500

 -

 -

 -

 -

 (1)

 As of December 31, 2024, each of the directors listed in the "Director Compensation" table had the following awards outstanding:

 Name

 Option
 Awards
 (#)

 Stock
 Awards
 (#)

 Tommy G. Thompson

 7,250

 8,500

 Cooper C. Collins

 5,000

 8,500

 Gail Naughton, Ph. D.

 -

 8,500

 -

 -

 The stock awards listed above include 8,500 restricted stock units
that were vested but not settled as of December 31, 2024, for each of Mr. Thompson, Mr. Collins and Dr. Naughton, respectively.

 (2)

 Reflects proration of Executive Chairman retainer for the portion of 2024 that Mr. Thompson served as Executive Chairman.

 Item 12. Security Ownership of Certain Beneficial Owners and Management
and Related Stockholder Matters

 SECURITY OWNERSHIP OF PRINCIPAL STOCKHOLDERS, DIRECTORS, AND OFFICERS

 The following table sets forth information regarding the beneficial
ownership of our common stock as of April 18, 2025, by the following:

 each of our directors and named
executive officers;

 all of our directors and executive
officers as a group; and

 each person, or group of affiliated
persons, who is known by us to beneficially own more than 5% of our common stock.

 Beneficial ownership is determined according to the rules of the SEC
and generally means that a person has beneficial ownership of a security if he, she, or it possesses sole or shared voting or investment
power of that security, including options and warrants that are currently exercisable or exercisable within sixty (60) days of April 18,
2025. Shares issuable pursuant to stock options, warrants, and convertible securities are deemed outstanding for computing the percentage
of the person holding such options, warrants, or convertible securities but are not deemed outstanding for computing the percentage of
any other person. Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the persons named
in the table below have sole voting and investment power with respect to all shares of common stock shown that they beneficially own,
subject to community property laws where applicable. The information does not necessarily indicate beneficial ownership for any other
purpose.

 Unless otherwise indicated, the address of each beneficial owner listed
in the table below is c/o TherapeuticsMD, Inc., 951 Yamato Road, Suite 220, Boca Raton, Florida 33431.

 Shares Beneficially Owned

 Name of Beneficial Owners

 Number

 Percent (1)

 Executive Officers and Directors:

 Marlan D. Walker (2)

 84,572

 *

 Tommy G. Thompson (3)

 36,362

 *

 Cooper C. Collins (4)

 65,516

 *

 Gail K. Naughton, Ph. D. (5)

 8,500

 *

 -

 -

 Joseph Ziegler (6)

 7,500

 *

 All executives and directors as a group (6 persons)

 202,450

 1.7
 %

 5% Stockholders:

 Rubric Capital Management LP (7)

 2,946,908

 25.5
 %

 Clearline Capital LP (8)

 635,222

 5.5
 %

 *

 Represents less than 1% of the outstanding shares of our common stock.

 (1)

 Based on 11,574,362 shares outstanding as of April 18, 2025.

 (2)

 Includes (i) 73,639 shares held by Mr. Walker directly, (ii) 1,733 shares issuable to Mr. Walker underlying vested but unsettled restricted stock units, (iii) 5,200 shares issuable to Mr. Walker underlying vested but unsettled performance stock units and (iv) 4,000 shares issuable to Mr. Walker upon the exercise of vested stock options.

 (3)

 Includes (i) 14,312 shares held by Thompson Family Investments, LLC, an entity solely owned by Thompson Family Holdings, LLC, an entity solely owned by Mr. Thompson, (ii) 14,779 shares held by Mr. Thompson directly, (iii) 21 shares held indirectly by Thompson Family Holdings, LLC and (iv) 7,250 shares issuable to Mr. Thompson upon the exercise of vested stock options.

 (4)

 Includes (i) 60,516 shares held by Mr. Collins directly and (ii) 5,000 shares issuable to Mr. Collins upon the exercise of vested stock options.

 (5)

 Includes 8,500 shares held by Dr. Naughton directly.

 (6)

 Includes 7,500 shares held by Mr. Ziegler directly.

 (7)

 Based solely on the Form 4 filed with the SEC by Rubric Capital Management LP on November 17, 2023. The address of Rubric Capital Management LP is 155 East 44th Street, Suite 1630, New York, NY 10017.

 (8)

 Based solely on a Schedule 13G filed with the SEC by Clearline Capital LP on February 12, 2025. Clearline Capital LP has shared voting and shared dispositive power over 635,222 shares. The address of Clearline Capital LP is 950 Third Avenue, 23rd Floor, New York, NY 10022.

 EQUITY COMPENSATION PLAN INFORMATION

 As of December 31, 2024, the following table shows the number of securities
to be issued upon exercise of outstanding options under equity compensation plans approved by our stockholders, which plans do not provide
for the issuance of warrants or other rights.

 (a)

 Number of Securities to be Issued Upon

 (b)

 (c)

 Number of
 Securities
 Remaining
 Available For
 Future

 Issuance

 Under Equity

 Plan
 Name

 Exercise
 of
 Outstanding
 Options
 (#)

 Vesting
 and
 Settlement of
 Restricted
 Stock Units
 ("RSUs")
 (#)

 Vesting
 and
 Settlement of
 Performance
 Stock Units
 ("PSUs")
 (#)

 Weighted-

 Average
 Exercise
 Price of
 Outstanding
 Options
 ($)

 Plans
 (Excluding

 Securities
 Reflected in
 Columns (a))
 (#)

 Equity Compensation Plans Approved by Stockholders

 2019 Plan

 19,820

 1,733

 5,200

 120.71

 411,000

 2012 Plan

 7,300

 -

 -

 309.77

 -

 2009 Plan

 29,410

 -

 -

 361.37

 -

 Equity Compensation Plans Not Approved by Stockholders

 None

 -

 -

 -

 -

 -

 Item 13. Certain Relationships and Related Transactions, and Director
Independence

 Policy Relating to Related Party Transactions

 We have a policy that we will not enter into any material transaction
in which a director or officer has a direct or indirect financial interest unless the transaction is determined by our Board of Directors
to be fair to us or is approved by a majority of our disinterested directors or by our stockholders, as provided for under Nevada law.
Generally, our Board of Directors as a whole, other than an affected director, if applicable, determines whether a director or officer
has a direct or indirect ( i.e., any) financial interest in a transaction deemed material based upon our Code of Conduct and Ethics
and Nevada law. From time to time, our Audit Committee, in accordance with its charter, will also review potential conflict of interest
transactions involving members of our Board of Directors and our executive officers. The policy with respect to such transactions is provided
in our company's Code of Conduct and Ethics.

 Related Party Transactions

 Other than compensation arrangements, we describe below transactions
and series of similar transactions, since January 1, 2023, to which we were a party or will be a party, in which:

 the amounts involved exceeded or will exceed $120,000; and

 any of our directors, executive officers, or holders of more than 5% of our voting securities, or any member of the immediate family of the foregoing persons, had or will have a direct or indirect material interest.

 Compensation arrangements for our directors and NEOs are described
elsewhere in this annual report.

 Agreements with Rubric Capital Management LP

 On August 23, 2022, we appointed Mr. Justin Roberts as a director to
fill a newly created vacancy on the Board of Directors. As a director of the Company, Mr. Roberts is entitled to receive compensation
in the same manner as our other non-employee directors, but he has elected not to receive any compensation for his service as a non-employee
director at this time. Mr. Roberts currently serves as a Partner of Rubric. On July 29, 2022, September 30, 2022, October 28, 2022 and
May 1, 2023, we entered into subscription agreements with Rubric. On December 30, 2022, and in accordance with the terms of the Certificate
of Designation, the Company redeemed all 29,000 outstanding shares of the Company's Series A Preferred Stock from Rubric at a purchase
price of $1,333 per share. The Company also paid certain affiliates of Rubric approximately $3.0 million as a make-whole payment pursuant
to the subscription agreements previously entered into between the Company and Rubric. On June 29, 2023, we issued and sold 312,525 shares
of Common Stock to Rubric at a price per share equal to $3.6797 pursuant to the subscription agreement and received gross proceeds of
$1.15 million before expenses. On November 15, 2023, Rubric drew down an additional 877,192 shares of Common Stock at a price per share
equal to $2.2761. We received gross proceeds of $2.0 million from the drawdown before expenses.

 Independence

 See Item 10 - Directors, Executive Officers and Corporate Governance
above for a discussion on director independence.

 Item 14. Principal Accountant Fees and Services

 Aggregate fees billed to our company for the fiscal year ended December
31, 2024 and 2023 by Berkowitz Pollack Brant, Advisors + CPAs were as follows:

 2024

($)

 2023

($)

 Audit fees

 201,345

 186,575

 Audit-related fees

 -

 -

 Tax fees

 -

 -

 All other fees

 -

 -

 Total

 201,345

 186,575

 Audit fees consist of fees associated with the annual audit, the reviews
of our annual and quarterly reports, and other filings with the SEC as well as comfort letters and consents.

 Audit Committee Pre-Approval Policies and Procedures

 The charter of our Audit Committee provides that the duties and responsibilities
of our Audit Committee include the pre-approval, or adopting procedures for pre-approval, of all audit, audit-related, tax, and other
services permitted by law or applicable SEC regulations (including fee and cost ranges) to be performed by our independent auditor. Any
pre-approved services that will involve fees or costs exceeding pre-approved levels will also require specific pre-approval by the Audit
Committee. Unless otherwise specified by the Audit Committee in pre-approving a service, the pre-approval will be effective for the 12-month
period following pre-approval. The Audit Committee will not approve any non-audit services prohibited by applicable SEC regulations or
any services in connection with a transaction initially recommended by the independent auditor, the purpose of which may be tax avoidance
and the tax treatment of which may not be supported by the Internal Revenue Code and related regulations.

 To the extent deemed appropriate, the Audit Committee may delegate
pre-approval authority to the Chairperson of the Audit Committee or any one or more other members of the Audit Committee provided that
any member of the Audit Committee who has exercised any such delegation must report any such pre-approval decision to the Audit Committee
at its next scheduled meeting. The Audit Committee will not delegate to management the pre-approval of services to be performed by the
independent auditor.

 Our Audit Committee requires that our independent auditor, in conjunction
with our Chief Financial Officer, be responsible for seeking pre-approval for providing services to us and that any request for pre-approval
must inform the Audit Committee about each service to be provided and must provide detail as to the particular service to be provided.

 All of the services provided by our independent registered public accounting
firm described above were approved by our Audit Committee pursuant to our Audit Committee's pre-approval policies.

 Item 15. Exhibits and Financial Statement Schedules

 (a)
 Financial statements and
financial statements schedules

 (1) All financial statements are omitted for the
reason that they are not required, or the information is otherwise supplied in Item 8. "Financial Statements and Supplementary Data"
in the Original Form 10-K.

 (2) No financial statement schedules are included
because such schedules are not applicable, are not required, or because required information is included in the consolidated financial
statements or notes thereto contained in the Original Form 10-K.

 (b)
 Exhibits

 Exhibit No.

 Description

 2.1

 Agreement and Plan of Reorganization, dated July 6, 2009, among Croff Enterprises, Inc., AMHN Acquisition Corp., America's Minority Health Network, Inc., and the Major Shareholders(1)

 2.2

 Agreement and Plan of Reorganization, dated June 11, 2010, among AMHN, Inc., SHN Acquisition Corp., Spectrum Health Network, Inc., and the Sole Shareholder of Spectrum Health Network, Inc.(2)

 2.3

 Croff Enterprises, Inc. Plan of Corporate Division and Reorganization, dated October 25, 2007 (3)

 2.4

 Agreement and Plan of Merger, dated July 18, 2011, among vitaMedMD, LLC, AMHN, Inc., and vitaMed Acquisition, LLC(4)

 2.5***+

 Stock Purchase Agreement, dated March 6, 2022, by and between TherapeuticsMD, Inc. and GoodRx, Inc. (5)

 3.1

 Articles of Conversion of AMHN, Inc. filed in the State of Nevada, dated July 20, 2010 (6)

 3.2

 Articles of Incorporation of AMHN, Inc. filed in the State of Nevada, dated July 20, 2010 (6)

 3.3

 Composite Amended and Restated Articles of Incorporation of the Company, as amended (7)

 3.4

 Bylaws of the AMHN, Inc. (8)

 3.5

 First Amendment to Bylaws of the Company, dated December 17, 2015 (9)

 3.6

 Second Amendment to Bylaws of the Company, adopted May 27, 2022 (10)

 3.7

 Third Amendment to Bylaws of the Company, dated July 29, 2022 (11)

 3.8

 Certificate of Change to Articles of Incorporation of the Company (12)

 3.9

 Certificate of Designation, Preferences and Rights of Series A Preferred Stock (11)

 3.10

 Fourth Amendment to Bylaws of the Company, dated June 29, 2023 (13)

 4.1

 Form of Certificate of Common Stock (14)

 4.2

 Description of Securities of the Company (15)

 10.1

 Form of Common Stock Purchase Warrant (16)

 10.2*

 Form of Non-Qualified Stock Option Agreement (16)

 10.3*

 TherapeuticsMD, Inc. 2019 Stock Incentive Plan (17)

 10.4*

 First Amendment to the TherapeuticsMD, Inc. 2019 Stock Incentive Plan (18)

 10.5*

 Amended and Restated 2012 Stock Incentive Plan (19)

 10.6*

 2009 Long Term Incentive Compensation Plan, as amended (20)

 10.7*

 TherapeuticsMD, Inc. 2020 Employee Stock Purchase Plan (21)

 10.8

 Form of Common Stock Purchase Warrant, dated February 24, 2012 (22)

 10.9

 Common Stock Purchase Warrant, issued to Plato & Associates, LLC, dated January 31, 2013 (23)

 10.10

 Form of Warrant to Purchase Common Stock, dated August 5, 2020 (24)

 10.11

 Amendment to Company Warrant issued by the Company to the Subscribers party to that certain Subscription Agreement, dated as of August 5, 2020, dated November 8, 2020 (25)

 10.12

 Second Amendment to Company Warrant issued by the Company to the Subscribers party to that certain Subscription Agreement, dated as of August 5, 2020 (26)

 10.13

 Warrant issued by the Company to Robert Finizio (26)

 10.14

 Amendment to Warrant issued by the Company to Robert Finizio (26)

 10.15*

 Warrant issued by the Company to John C.K. Milligan, IV (26)

 10.16*

 Amendment to Warrant issued by the Company to John C.K. Milligan, IV (26)

 10.17

 Subscription Agreement, dated August 5, 2020, by and among TherapeuticsMD, Inc. and the Subscribers identified on the Schedule of Subscribers attached thereto (24)

 10.18***

 License Agreement, dated July 30, 2018, by and between TherapeuticsMD, Inc. and The Population Council, Inc. (27)

 10.19***

 Lease, dated October 5, 2018, by and between 951 Yamato Acquisition Company, LLC and TherapeuticsMD, Inc. (28)

 10.20***

 License and Supply Agreement, dated June 6, 2019, by and between TherapeuticsMD, Inc. and Theramex HQ UK Limited (29)

 10.21*

 Form of Indemnification Agreement between TherapeuticsMD, Inc. and each of its executive officers and directors (25)

 10.22*

 2022 Executive Retention and Performance Bonus Plan. (ERB-Plan) (30)

 10.23

 Subscription Agreement between TherapeuticsMD, Inc. and Rubric Capital Management LP, dated July 29, 2022 (11)

 10.24

 Subscription Agreement by and among TherapeuticsMD, Inc., Sixth Street Specialty Lending, Inc., TOP IV Talents, LLC and TOA Talents, LLC, dated July 29, 2022 (11)

 10.25

 Subscription Agreement between TherapeuticsMD, Inc. and Rubric Capital Management LP, dated September 30, 2022 (31)

 10.26

 Subscription Agreement by and among TherapeuticsMD, Inc., Sixth Street Specialty Lending, Inc., TOP IV Talents, LLC and TAO Talents, LLC, dated September 30, 2022 (31)

 10.27

 Subscription Agreement between TherapeuticsMD, Inc. and Rubric Capital Management LP, dated October 28, 2022 (32)

 10.28

 Subscription Agreement by and among TherapeuticsMD, Inc., Sixth Street Specialty Lending, Inc., TOP IV Talents, LLC and TAO Talents, LLC, dated October 28, 2022 (32)

 10.29***+

 License Agreement by and between TherapeuticsMD, Inc. and Mayne Pharma LLC, dated December 4, 2022 (33)

 10.30***+

 Transaction Agreement by and between TherapeuticsMD, Inc. and Mayne Pharma LLC, dated December 4, 2022 (33)

 10.31**

 Amendment No. 1 to the License Agreement between TherapeuticsMD, Inc. and Mayne Pharma LLC, dated as of December 30, 2022 (15)

 10.32

 Amendment No. 1 to the Transaction Agreement between TherapeuticsMD, Inc. and Mayne Pharma LLC, dated as of December 30, 2022 (15)

 10.33*

 Amended and Restated Employment Agreement, dated as of December 18, 2018, by and between TherapeuticsMD, Inc. and Marlan Walker (15)

 10.34*

 Amendment, effective October 15, 2021, to the Employment Agreement, dated as of December 18, 2018, by and between TherapeuticsMD, Inc. and Marlan Walker (15)

 10.35*

 Amendment, dated February 21, 2023, to the Employment Agreement, dated as of December 18, 2018, as extended effective October 15, 2021, by and between TherapeuticsMD, Inc. and Marlan Walker (34)

 10.36*

 Amendment, dated December 17, 2024, to the Employment Agreement, dated as of December 18, 2018,
 as extended effective February 21, 2023, by and between TherapeuticsMD, Inc. and Marlan Walker (38)

 10.37*

 General Consulting and Services Agreement by and between TherapeuticsMD, Inc. and MCD Consulting Management Services, LLC, dated February 21, 2023 (34)

 10.38

 Subscription Agreement, dated May 1, 2023, between TherapeuticsMD, Inc. and Rubric Capital Management LP (35)

 10.39*

 Master Services Agreement, dated August 15, 2023, between TherapeuticsMD, Inc. and JZ Advisory Group (36)

 Insider Trading Policy (38)

 21.1

 Subsidiaries of the Company (38)

 23.1

 Consent of Berkowitz Pollack Brant (38)

 31.1

 Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a)

 31.2

 Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and Rule 15d-14(a)

 32.1

 Section 1350 Certification of Chief Executive Officer (38)

 32.2

 Section
 1350 Certification of Chief Financial Officer (38)

 97.1

 TherapeuticsMD, Inc. Policy on Recoupment of Incentive Compensation (37)

 *

 Indicates a contract with management or compensatory plan or arrangement.

 **

 Certain confidential material contained in the document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been granted with respect to this omitted information.

 ***

 Portions of this exhibit have been redacted in compliance with Regulation S-K Item 601(b)(2). The omitted information is not material and would likely cause competitive harm to the Company if publicly disclosed.

 +

 Certain of the exhibits and schedules to this exhibit have been omitted in accordance with Item 601(a)(5) of Regulation S-K. The Company agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request.

 Filed herewith.

 Furnished herewith.

 (1)

 Filed as an exhibit to Form 8-K filed with the Commission on July 10, 2009 and incorporated herein by reference (SEC File No. 000-16731).

 (2)

 Filed as an exhibit to Form 8-K filed with the Commission on June 14, 2010 and incorporated herein by reference (SEC File No. 000-16731).

 (3)

 Filed as an exhibit to Form 10-K for the year ended December 31, 2007 filed with the Commission on May 1, 2008 and incorporated herein by reference (SEC File No. 000-16731).

 (4)

 Filed as an exhibit to Form 8-K filed with the Commission on July 21, 2011 and incorporated herein by reference (SEC File No. 000-16731).

 (5)

 Filed as an exhibit to Form 8-K filed with the Commission on March 10, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (6)

 Filed as an exhibit to Form 10-Q for the quarter ended June 30, 2010 filed with the Commission on August 3, 2010 and incorporated herein by reference (SEC File No. 000-16731).

 (7)

 Filed as an exhibit to Form 10-Q for the quarter ended June 30, 2023 filed with the Commission on August 14, 2023 and incorporated herein by reference (SEC File No. 001-00100).

 (8)

 Filed as an exhibit to Definitive 14C Information Statement filed with the Commission on June 29, 2010 and incorporated herein by reference (SEC File No. 000-16731).

 (9)

 Filed as an exhibit to Form 8-K filed with the Commission on December 22, 2015 and incorporated herein by reference (SEC File No. 001-00100).

 (10)

 Filed as an exhibit to Form 8-K filed with the Commission on June 3, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (11)

 Filed as an exhibit to Form 8-K filed with the Commission on August 1, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (12)

 Filed as an exhibit to Form 8-K filed with the Commission on May 9, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (13)

 Filed as an exhibit to Form 8-K filed with the Commission on July 6, 2023 and incorporated herein by reference (SEC File No. 001-00100).

 (14)

 Filed as an exhibit to Form S-3 filed with the Commission on January 25, 2013 and incorporated hereby by reference (SEC File No. 333-186189).

 (15)

 Filed as an exhibit to Form 10-K for the year ended December 31, 2022 filed with the Commission on April 7, 2023 and incorporated herein by reference (SEC File No. 001-00100).

 (16)

 Filed as an exhibit to Form 8-K filed with the Commission on October 11, 2011 and incorporated herein by reference (SEC File No. 000-16731).

 (17)

 Filed as an exhibit to Form S-8 filed with the Commission on June 21, 2019 and incorporated herein by reference (SEC File No. 333-232268).

 (18)

 Filed as an appendix to the Definitive Proxy Statement filed with the Commission on April 14, 2021 and incorporated herein by reference (SEC File No. 001-00100).

 (19)

 Filed as an exhibit to Form 8-K filed with the Commission on August 22, 2013 and incorporated herein by reference (SEC File No. 001-00100).

 (20)

 Filed as an exhibit to Registration Statement on Form S-8 filed with the Commission on October 15, 2013 and incorporated herein by reference (SEC File No. 333-191730).

 (21)

 Filed as an appendix to the Definitive Proxy Statement filed with the Commission on May 4, 2020 and incorporated herein by reference (SEC File No. 001-00100).

 (22)

 Filed as an exhibit to Form 8-K filed with the Commission on February 24, 2012 and incorporated herein by reference (SEC File No. 000-16731).

 (23)

 Filed as an exhibit to Form 8-K filed with the Commission on February 6, 2013 and incorporated herein by reference (SEC File No. 000-16731).

 (24)

 Filed as an exhibit to Form 10-Q for the quarter ended June 30, 2020 filed with the Commission on August 7, 2020 and incorporated herein by reference (SEC File No. 001-00100).

 (25)

 Filed as an exhibit to Form 10-Q filed with the Commission on November 9, 2020 and incorporated herein by reference (SEC File No. 001-00100).

 (26)

 Filed as an exhibit to Form 10-K for the year ended December 31, 2020 filed with the Commission on March 4, 2021 and incorporated herein by reference (SEC File No. 001-00100).

 (27)

 Filed as an exhibit to Form 10-Q for the quarter ended
 September 30, 2018 filed with the Commission on November 8, 2018 and incorporated herein by reference (SEC File No. 001-00100).

 (28)

 Filed as an exhibit to Form 10-Q for the quarter ended
 September 30, 2019 filed with the Commission on November 8, 2019 and incorporated herein by reference (SEC File No. 001-00100).

 (29)

 Filed as an exhibit to Form 10-Q for the quarter ended
 June 30, 2019 filed with the Commission on August 9, 2019 and incorporated herein by reference (SEC File No. 001-00100).

 (30)

 Filed as an exhibit to Form 10-K for the year ended
 December 31, 2021, filed with the Commission on March 23, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (31)

 Filed as an exhibit to Form 8-K filed with the Commission
 on October 3, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (32)

 Filed as an exhibit to Form 8-K filed with the Commission
 on October 31, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (33)

 Filed as an exhibit to Form 8-K filed with the Commission
 on December 5, 2022 and incorporated herein by reference (SEC File No. 001-00100).

 (34)

 Filed as an exhibit to Form 8-K filed with the Commission
 on February 27, 2023 and incorporated herein by reference (SEC File No. 001-00100).

 (35)

 Filed as an appendix to the Definitive Proxy Statement
 filed with the Commission on May 17, 2023 and incorporated herein by reference (SEC File No. 001-00100).

 (36)

 Filed as an exhibit to Form 10-Q for the quarter ended
 September 30, 2023, filed with the Commission on November 14, 2023 and incorporated herein by reference (SEC File No. 001-00100).

 (37)

 Filed as an exhibit to Form 10-K for the year ended
 December 31, 2023 filed with the Commission on March 29, 2024 and incorporated herein by reference (SEC File No. 001-00100).

 (38)

 Filed as an exhibit to Form 10-K for the year ended
 December 31, 2024 filed with the Commission on March 27, 2025 and incorporated herein by reference (SEC File No. 001-00100).

 SIGNATURES

 Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized,
on April 30, 2025.

 THERAPEUTICSMD, INC.

 /s/ Marlan D. Walker

 Chief Executive Officer

 0000025743

 2024-01-01
 2024-12-31

 0000025743

 2024-06-30

 0000025743

 2025-04-18