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 utr:sqft

 UNITED
STATES

 SECURITIES
AND EXCHANGE COMMISSION

 WASHINGTON,
DC 20549

 FORM

ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For
the fiscal year ended December 31, 2024

 OR

 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 For
the transition period from to

 Commission
File No. 001-41245

 (Exact
name of registrant as specified in its charter)

 Delaware

 87-3272543

 (State
 or other jurisdiction

 of
 incorporation or organization)

 (I.R.S.
 Employer

 Identification
 Number)

 4581
 Tamiami Trail North, Suite 200

 Naples,
 Florida

 34103

 (Address
 of principal executive offices)

 (Zip
 Code)

 Registrant's
telephone number, including area code:

 (646) - 491-9132

 Securities
registered pursuant to Section 12(b) of the Act:

 Title
 of each class

 Trading
 Symbol

 Name
 of each exchange on which registered

 Common
 Stock, par value $0.0001 per share

 CDT

 The
 Nasdaq Stock Market LLC

 Redeemable
 Warrants, each whole warrant exercisable for one share of Common Stock at an exercise price of $1,150

 CDTTW

 The
 Nasdaq Stock Market LLC

 Securities
registered pursuant to Section 12(g) of the Act:

 None

by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes No

by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act. Yes
 No

by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)
has been subject to such filing requirements for the past 90 days. Yes No

by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule
405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant
was required to submit such files). Yes No

by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer,"
"smaller reporting company" and "emerging growth company" in Rule 12b-2 of the Exchange Act.

 Large
 accelerated filer

 Accelerated
 filer

 Non-accelerated
 filer

 Smaller
 reporting company

 Emerging
 growth company

 If
an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying
with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness
of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered
public accounting firm that prepared or issued its audit report.

 If
securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant
included in the filing reflect the correction of an error to previously issued financial statements.

by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation
received by any of the registrant's executive officers during the relevant recovery period pursuant to §240.10D-1(b).

by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes No

 As
of March 28, 2025, there were 6,662,755 shares of common stock, $ 0.0001 par value, of the Registrant issued and outstanding. The aggregate
market value of the common stock held by non-affiliates of the registrant as of June 28, 2024, the last business day of the registrant's
most recently completed second fiscal quarter, was $ 41,401,162 based upon the closing price reported for such date on The Nasdaq Global
Market.

 On
January 25, 2025, the Registrant effected a 1-for-100 reverse stock split of its authorized shares of common stock, accompanied by a
corresponding decrease in its issued and outstanding shares of common stock. All references to numbers of shares of common stock and
per-share information in this Annual Report on Form 10-K have been adjusted retroactively, as appropriate, to reflect the reverse stock
split.

 TABLE
OF CONTENTS

 Item
 1.

 Business

 Item
 1A.

 Risk Factors

 Item
 1B.

 Unresolved Staff Comments

 Item
 IC.

 Cybersecurity

 Item
 2.

 Properties

 Item
 3.

 Legal Proceedings

 Item
 4.

 Mine Safety Disclosures

 Item
 5.

 Market For Registrant's Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

 Item
 6.

 Reserved

 Item
 7.

 Management's Discussion and Analysis of Financial Condition and Results of Operations

 Item
 7A.

 Quantitative and Qualitative Disclosures About Market Risk

 Item
 8.

 Financial Statements and Supplementary Data

 Item
 9.

 Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

 Item
 9A.

 Controls and Procedures

 Item
 9B.

 Other Information

 Item
 9C.

 Disclosure Regarding Foreign Jurisdictions that Prevent Inspections

 Item
 10.

 Directors, Executive Officers and Corporate Governance

 Item
 11.

 Executive Compensation

 Item
 12.

 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 Item
 13.

 Certain Relationships and Related Transactions, and Director Independence

 Item
 14.

 Principal Accountant Fees and Services

 Item
 15.

 Exhibits and Financial Statement Schedules

 Item
 16.

 Form 10-K Summary.

 Signatures.

 i

 CAUTIONARY
NOTE REGARDING FORWARD-LOOKING STATEMENTS

 This
Annual Report on Form 10-K (this "Annual Report") and the information incorporated herein by reference contain forward-looking
statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only
on the Company's current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies,
projections, anticipated events and trends, the economy, and other future conditions. This includes, without limitation, statements regarding
the financial position and the plans and objectives of management for our future operations. Such statements can be identified by the
fact that they do not relate strictly to historical or current facts. When used in this Annual Report, words such as "anticipate,"
"believe," "continue," "could," "estimate," "expect," "intend,"
"may," "might," "plan," "possible," "potential," "predict," "project,"
"should," "strive," "would" and similar expressions may identify forward-looking statements,
but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements in this Annual Report
and in any document incorporated by reference in this Annual Report may include, for example, statements about:

 the
 ability to maintain the listing of our securities on The Nasdaq Global Market and The Nasdaq Capital Market of The Nasdaq Stock Market
 LLC ("Nasdaq"), and the potential liquidity and trading of our securities;

 the
 risk of disruption to our current plans and operations;

 the
 ability to recognize the anticipated benefits of our business and the business combination completed in September 2023 (the "Business
 Combination"), which may be affected by, among other things, competition and the ability to grow, manage growth profitably,
 and retain key employees;

 costs
 related to our business;

 changes
 in applicable laws or regulations;

 our
 ability to meet future capital requirements to fund our operations, which may involve debt and/or equity financing, and to obtain
 such debt and/or equity financing on favorable terms, and our sources and uses of cash;

 our
 ability to execute our plans to develop and commercialize our current clinical assets, as well as any future clinical assets that
 we license, and the timing of any such commercialization;

 our
 ability to maintain existing license agreements;

 our
estimates regarding expenses, future revenue, capital requirements, and needs for additional financing;

 our
 ability to use artificial intelligence to enhance our decision-making processes and maximize the value of our pharmaceutical asset
 portfolio;

 the
 occurrence of any event, change or other circumstances, including the outcome of any legal proceedings that may be instituted against
 us; and

 other
 factors disclosed under the section entitled "Risk Factors" in this Annual Report.

 These
forward-looking statements are based on information available as of the date of this Annual Report and current expectations, forecasts,
and assumptions, and involve a number of judgments, risks, and uncertainties. Accordingly, forward-looking statements should not be relied
upon as representing our views as of any subsequent date, and we do not undertake any obligation to update forward-looking statements
to reflect events or circumstances after the date they were made, whether as a result of new information, future events, or otherwise,
except as may be required under applicable securities laws.

 ii

 TRADEMARKS

 This
document contains references to trademarks and service marks belonging to other entities. Solely for convenience, trademarks and trade
names referred to in this Annual Report may appear without the or symbols, but such references are not intended to indicate,
in any way, that the applicable licensor will not assert, to the fullest extent under applicable law, its rights to these trademarks
and trade names. We do not intend our use or display of other companies' trade names, trademarks, or service marks to imply a relationship
with, or endorsement or sponsorship of it by, any other companies.

 SUMMARY
OF RISK FACTORS

 The
following is a summary of the principal risks that could adversely affect our business, financial condition, operating results, cash
flows and/or stock price. Discussion of the risks listed below, and other risks that we face, are discussed in the section titled "Risk
Factors" in Part I, Item 1A of this Annual Report.

 Risks
Related to Our Business and Industry

 Our
 business is dependent on the successful development, regulatory approval, and commercialization of our clinical assets, in particular
 a glucokinase activator which we believe is active in a range of autoimmune disorders, which we refer to as AZD1656, and a potent,
 irreversible inhibitor of human Myeloperoxidase that has the potential to treat idiopathic male infertility, which we refer to as
 AZD5904.

 Preclinical
 drug development for our clinical assets is expensive, time-consuming, and uncertain. Our preclinical trials may fail to adequately
 demonstrate pharmacologic activity in therapeutic areas of interest; cause unintended short- or long-term effects in other bodily
 systems; or produce unexpected toxicity that may alter or risk benefit assessment.

 It
 is difficult to accurately predict the time and cost of development and of subsequently obtaining regulatory approval for AZD1656
 as it employs newly developed technology.

 We
 may not be successful in our efforts to use and expand our research and development platform to build a pipeline of clinical assets.

 drug development for our clinical assets is very expensive, time-consuming, difficult to design and implement, and uncertain. Our
 clinical trials may fail to adequately demonstrate the safety and efficacy of our clinical assets, which could prevent or delay regulatory
 approval and commercialization.

 We
 may be unable to obtain regulatory approval for our early-stage clinical assets under applicable regulatory requirements. The U.S. Food and Drug Administration (the "FDA")
 and foreign regulatory bodies have substantial discretion in the approval process, including the ability to delay, limit, or deny
 approval of clinical assets. The delay, limitation, or denial of any regulatory approval would adversely impact commercialization,
 our potential to generate revenue, our business, and our operating results.

 We
 may face product liability exposure, and if successful claims are brought against us, we may incur substantial liability if our insurance
 coverage for those claims is inadequate.

 We
 currently rely on, and expect to continue to rely on, third-party contract research organizations ("CROs") and other third parties to conduct and oversee our clinical
 trials and other aspects of product development. If these third parties do not meet our requirements or otherwise conduct the trials
 as required, we may not be able to satisfy our contractual obligations or obtain regulatory approval for, or commercialize, our clinical
 assets when expected or at all.

 We
 currently rely on agreements with a related party and third parties for the purpose of licensing our clinical assets. In the near-term,
 we intend to rely on third parties for the licensing of clinical assets and those which may arise through future partnerships.

 Manufacturing
 and supply of the active pharmaceutical ingredients ("APIs") and other substances and materials used in our clinical assets is a complex and technically challenging undertaking,
 and there is potential for failure at many points in the manufacturing, testing, quality assurance, and distribution supply chain,
 as well as the potential for latent defects after products have been manufactured and distributed.

 Risks
Related to Intellectual Property

 Failure
 to adequately protect our intellectual property could adversely affect our business, financial condition, and operating results.

 We
 may not be able to protect our intellectual property rights throughout the world.

 Our
 intellectual property rights throughout the world may be challenged by third parties, on prospectively a correct or incorrect basis

 Risks
Related to Securities Markets and Investment in Our Stock

 Claims
 for indemnification by our directors and officers may reduce our available funds to satisfy successful third-party claims against
 us and may reduce the amount of money available to us.

 Risks
Related to Finances and Capital Requirements

 There
 is substantial doubt regarding our ability to continue as a going concern. We will need to raise additional funding, which may not
 be available on acceptable terms, or at all. Failure to obtain this necessary capital when needed may force us to delay, limit or
 terminate our commercial programs, product development efforts or other operations, all of which could have a material adverse effect
 on the Company and its financial results.

 We
 may issue additional shares of common stock or preferred stock, including under an employee incentive plan, which would dilute the
 interest of our stockholders.

 iii

 PART
I

 Item
1. Business

 Overview

 On
September 22, 2023, a merger transaction (the "Business Combination") between Conduit Pharmaceuticals Limited ("Old
Conduit"), Murphy Canyon Acquisition Corp ("MURF") and Conduit Merger Sub, Inc., a Cayman Islands exempted company
and a wholly owned subsidiary of MURF ("Merger Sub"), was completed pursuant to the Agreement and Plan of Merger, dated November
8, 2022, as amended, (the "Merger Agreement"). Pursuant to the terms of the Merger Agreement, at the closing, (i) Merger
Sub merged with and into Old Conduit, with Old Conduit surviving the Business Combination as a wholly-owned subsidiary of MURF, and (ii)
MURF changed its name from Murphy Canyon Acquisition Corp. to Conduit Pharmaceuticals Inc. ("Conduit" or the "Company").

has developed a unique business model that allows it to act as a conduit to bring clinical assets from pharmaceutical companies and
develop new treatments for patients. Our novel approach addresses unmet medical needs and lengthens the intellectual property for
our existing assets through cutting-edge solid-form technology and then commercializing these products with life science companies.
We continue to evaluate novel artificial intelligence ("AI") and cybernetics approaches to drug re-purposing,
intellectual property and asset selection to give Conduit a competitive advantage.

 We
are led by highly experienced pharmaceutical executives: Dr. Freda Lewis-Hall, former Chief Medical Officer of Pfizer Inc., the Chair
of our Board of Directors, and Dr. David Tapolczay, former Chief Executive Officer of the United Kingdom-based medical research charity
LifeArc, our Chief Executive Officer. Our management team includes active senior scientists who have an extensive understanding of the
pharmaceuticals market, which supports our strategy of developing clinical assets in a cost-efficient manner while focusing on therapeutic
efficacy and patient safety.

 Simultaneously,
Conduit leverages the capabilities of our Cambridge laboratory facility and highly experienced team of solid-form experts to extend or
develop proprietary solid-form intellectual property for our existing and future clinical assets. Our own intellectual property portfolio
comprises pending patent applications in several international jurisdictions describing a solid-form compound, including the AZD1656
Cocrystal (a HK-4 Glucokinase Activator), targeting a wide range of autoimmune disorders. Our pipeline research includes a number of
compounds that serve as promising alternatives to existing clinical assets currently marketed and sold by large pharmaceutical companies,
which we have identified as having an opportunity to develop further intellectual property positions through solid-form technology.

 In
connection with the funding and development of clinical assets, we evaluate and select the specific molecules to be developed and collaborate
with external CROs and Key Opinion Leaders ("KOLs") to run clinical trials
that are managed, funded, and overseen by us. We intend to leverage our comprehensive clinical and scientific expertise in order to facilitate
development of clinical assets through Phase II trials in an efficient manner by using CROs and third-party service providers. We will
also collaborate closely with disease specific KOLs to collectively assess and determine the most appropriate indications for all our
current and forthcoming assets.

 We
believe that successful Phase II trials of the clinical assets in our pipeline will increase the value of our assets. There is no assurance
that any clinical trials on the assets owned or licensed by us will be successful, however, following a successful Phase II clinical
trial, we would look to licensing opportunities with large biotech or pharmaceutical companies, typically for up-front milestone payments
and royalty income streams for the life of the asset patent. We anticipate using any future royalty income stream to develop our asset
portfolio in combination with other potential sources of financing, including debt or equity financing.

 Outside
of our proprietary owned patented clinical assets, AstraZeneca agreed to grant a license to the Company under certain intellectual property
rights controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor
AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male infertility. The Company will be responsible for the development
and commercialization of the relevant products licensed under the related License Agreement (the "Licensed Products"). The
Company is required to use commercially reasonable efforts to develop and commercialize the Licensed Products.

 AstraZeneca
has conducted initial pre-clinical and, in some instances, clinical trials on these assets, but has decided to license them for further
development. As the clinical assets have undergone initial pre-clinical and clinical testing conducted by AstraZeneca, we are able to
use the safety data generated in these clinical trials to assess which clinical assets to further develop and for which indications.

 Through
this relationship, there are considerable APIs that were manufactured by AstraZeneca
(prior to conducting its clinical trials) available to Conduit. As a result, Conduit may not have to develop the APIs, which is often
a time consuming and expensive process, and the APIs already produced were subject to rigorous quality control measures.

 In
collaboration with SARBORG Limited ("Sarborg"), Conduit intends to leverage an advanced
artificial intelligence (AI) and cybernetics platform to evaluate key deliverables across multiple areas of the Company's
operations, including drug repurposing, drug discovery, solid-form identification, and clinical trial monitoring.

 The
Sarborg Agreement (defined and described below) is designed to address longstanding challenges in the pharmaceutical sector, in
particular by reducing human error in critical decision-making processes in both clinical development and asset identification. By
integrating Sarborg's algorithmic AI/cybernetics technology, Conduit aims to enhance efficiency, lower costs, and accelerate
timelines by minimizing human intervention, ultimately optimizing the drug development cycle and giving Conduit a competitive
advantage in the sector.

 Through
this relationship, Conduit will gain access to cutting-edge predictive models and dashboards, enabling the Company to evaluate drug candidates,
streamline clinical trials, and optimize asset management with real-time data. These tools will drive faster, more accurate decisions,
improving efficiency and reducing costs. By leveraging these insights, Conduit to differentiate itself in a competitive sector and gain
unique data-driven insights that position the Company for success across both its current and future asset portfolio.

 In
addition, Conduit will retain a perpetual, non-exclusive, royalty-free, and assignable right to use any platform or technology developed
by Sarborg in association with the deliverables. Ongoing support from Sarborg will ensure these systems evolve with Conduit's needs,
driving long-term innovation in areas like IP creation, regulatory strategy, and clinical trial monitoring. This partnership reinforces
Conduit's commitment to leveraging AI-driven solutions to accelerate growth, deliver value to stockholders, and maintain a competitive
edge in the pharmaceutical sector.

 Sarborg is considered to
be a related party of conduit, as Dr. Andrew Regan, a stockholder of Conduit and member of Conduit's board of directors,
also sits on the board of directors of Sarborg. Refer to Note 16 to our financial statements included elsewhere in this Annual Report
for additional details on the relationship between Conduit and Sarborg.

 This
strategic move reaffirms Conduit's commitment to adopting forward-thinking solutions to stay at the forefront of innovation in
the pharmaceutical industry. By reducing reliance on traditional, labor-intensive methods and harnessing the power of AI-driven technology,
Conduit is well-positioned to lead in areas such as drug repurposing, clinical trial monitoring, and IP creation, ensuring the Company's
long-term growth and market leadership.

Conduit believes that it is well positioned to pursue, and intends to pursue, additional relationships and/or partnerships with
third parties for the licensing of further assets which are currently deprioritized. We plan to focus our efforts on developing
clinical assets to address disorders that impact a large population where there is no present treatment or the present treatment,
carries significant unwanted side effects.

 Our
Initial Pipeline: HK-4 Glucokinase Activator Cocrystal, AZD1656, and its metabolite AZD5658 and AZD5904

 We
wholly own the intellectual property and the rights to further develop the solid-form Cocrystals of AZD1656 (AZD1656 Cocrystal–
pending international patent applications, which, if granted should expire no earlier than 2042) that we intend to target a wide range
of autoimmune disorders.

 In
addition, we currently have the exclusive rights to develop clinical assets, AZD1656 and AZD5658 in all human indications and AZD5904
in idiopathic male infertility which are licensed to us by AstraZeneca.

 Outside
of our proprietary owned patented clinical assets, AstraZeneca granted a license to the Company of certain intellectual property rights
controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor
AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male infertility. The Company will be responsible for the development
and commercialization of the Licensed Products. The Company is required to use commercially reasonable efforts to develop and commercialize
the Licensed Products.

 Due
to our relationship with AstraZeneca, we intend to leverage the data generated from these historical trials in order to investigate the
efficacy and safety to AZD1656 to potentially treat Lupus and ANCA Vasculitis patients, and the efficacy and safety of AZD5904 to treat
IMI. AZD1656 has undergone testing in a total of 20 Phase I clinical trials and five Phase II clinical trials conducted by AstraZeneca
since 2008 and 19 of which were conducted in the U.S. Additional information about those clinical trials is available at the U.S. National
Library of Medicine's website at www.clinicaltrials.gov (however, the information contained on or otherwise accessible through
such website is not part of this annual report). AZD5904 has undergone testing in five Phase I clinical trials conducted by AstraZeneca,
one of which was conducted in the U.S. While a significant amount of clinical trial data has already been generated for both AZD1656
and AZD5904, some of this data was generated outside of the U.S. and accordingly may not be accepted by the FDA. In the event that such
data is not accepted by the FDA, additional clinical trials may be required to commercialize these assets in the United States, which
would result in additional costs and time to develop these clinical assets.

underwent Phase I and Phase II clinical trials consisting of 23 studies in 526 subjects, 446 of whom were dosed with AZD1656. Other
than for the intended effect of lowering glucose, there were no difference identified between the AZD1656-treated and
placebo-treated subjects relating to adverse events. All of the cases where low glucose levels were identified were managed by the
patients and resolved. Based on these clinical trials, no safety signals were identified regarding vital signs, safety laboratory
values or electrocardiogram data. No deaths occurred in any studies with healthy volunteers or patients. AZD1656 was also subject to
Phase II clinical trials consisting of two studies where AZD1656 was given to patients with Type 2 Diabetes Mellitus for four months
or longer. In total, there were 754 randomized patients, 516 of whom were exposed to AZD1656 (316 men and 200 women). There were no
clinically important differences in the adverse effects profile between the AZD1656 treatment group and the AZD1656 placebo group
and there were no deaths in either of the Phase II studies. The efficacy of AZD1656 as a potential treatment for diabetes was also
assessed during the Phase II clinical trials, including whether the efficacy was statistically significant. Clinically relevant and
statistically significant reductions in HbA1c were seen after four months; however, the initial improvement in glucose control
deteriorated over time and the change in HbA1c levels after four months were not statistically different than the placebo. This
decreasing efficacy over time was seen in both Phase II studies.

was subject to a randomized, single-blind, placebo-controlled, single-center, Phase I study to assess the safety, tolerability, pharmacokinetics,
pharmacodynamics and the effect of fasting after single ascending oral doses of AZD5658 in Type 2 Diabetes Mellitus patients. There were
six dose levels with eight patients in each cohort, six receiving AZD5658 and two receiving placebo. The effect of fasting on the pharmacokinetics
of AZD5658 was also studied for two dose levels. Each patient treated with metformin received a maximum of two single oral suspension
doses (one on a low dose of AZD5658/placebo and one on a high dose of AZD5658/placebo under fed conditions), except for patients participating
in the evaluation of the effect of fasting, who received a maximum of three single oral suspension doses. For each patient the study
included a pre-entry visit (Visit 1), two or three clinic-based treatment visits (Visit 2, 3, and 4) and a follow-up visit (Visit 5).
Hence, the total duration of the study for each patient was approximately two and one-half months, assuming three weeks between dose
levels. There were no deaths, serious adverse events, discontinuations due to adverse events, or adverse events of severe intensity during
the study. Overall, there were 13 (61.9%) AZD5658-treated patients with adverse events compared to 2 (28.6%) patients who received placebo.
There were no trends noted with increasing dose in the number of adverse events overall or within any preferred term. The most frequently
occurring adverse events were hypoglycemia and diarrhea, each occurring in three AZD5658-treated patients. One adverse event of ear
pain (30 mg AZD5658 fed) was assessed by the study investigator as moderate in intensity; all other adverse events were of mild intensity.
Five adverse events in AZD5658- treated patients were assessed by the investigator as causally related to investigational product, including
hypoglycemia in three patients (100 mg, 200 mg fasted, and 400 mg AZD5658), diarrhea in one patient (200 mg AZD5658 fasted), and headache
in one patient (30 mg AZD5658). No adverse events in placebo-treated patients were assessed as causally related to investigational product.
The three patients who experienced hypoglycemia adverse events were treated with intake of food or orange juice and the episodes resolved
in less than one hour.

was subject to five Phase I clinical studies, with a total of 1,181 subjects being exposed to AZD5904. Single doses of up to 1200 mg
and multiple doses of up to 325 mg for up to three times per day for 21 days have been administered as an oral solution in the completed
clinical studies. In addition, single doses of up to 1,400 mg and multiple doses of up to 600 mg for 10 days have been administered as
an "extended release" formulation. The data from these studies did not identify any expected adverse drug reactions for AZD5904
and no adverse effects were reported as related to AZD5904. In addition, the data revealed no clinically significant changes in blood
pressure or pulse rate related to AZD5904 and electrocardiogram data was within the physiological range for the population studied. The
effect of AZD5904 on human myeloperoxidase, which we refer to as MPO, activity was evaluated by determination in an ex vivo assay of
MPO activity in plasma. The correlation between MPO activity and plasma concentrations was assessed for single and multiple doses of
AZD5904. A relationship between plasma concentrations of AZD5904 and MPO activity was demonstrated, which indicates that AZD5904 may
be an effective inhibitor of MPO activity in humans. However, Phase I trials do not assess statistical significance so additional Phase
II trials are necessary to determine if the inhibition of MPO activity as a result of AZD5904 is statistically significant.

 Asset
Development

 Our
initial development plan is to conduct a Phase II clinical trial on AZD1656 in Lupus (including Lupus Nephritis) and ANCA Vasculitis
(AAV). Should we choose to develop AZD1656, AZD5658, or AZD5904, that development would be subject to the terms of the License Agreement,
described in more detail below. We anticipate developing our Initial Pipeline (which has already undergone pre-clinical and clinical
trials) through the Phase II stage and then monetizing such clinical assets through a license, royalty, or other transaction at this
stage. At this time, we do not expect that we will commercialize any clinical assets or seek marketing approval from the FDA (or similar
organizations) as we intend to enter into agreements with third parties following Phase II clinical trials for each such clinical asset
that would provide that such third party would pursue the further development, commercialization, and marketing of such assets.

 To
enable us to monetize our clinical assets, we, in partnership with CROs and KOLs, intend to conduct additional clinical trials on our
clinical assets in order to generate clinical data to support the further development of our clinical assets beyond the Phase II stage.
In the event successful clinical trial data is generated for a clinical asset with a particular indication, at that point, we will seek
to enter into a license, royalty, or other transaction with a third party whereby the third party would continue to pursue the development
of the clinical asset in Phase III clinical trials. There is no assurance that any clinical trials on the assets owned or licensed by
us will be successful.

 We
intend to use the income received from licensing clinical assets in our pipeline to fund the development of additional clinical assets,
which will allow us to use the existing income stream from clinical assets that have been licensed to fund our on-going operations, including
the development and commercialization of additional clinical assets, without having to rely solely on debt and/or equity financing.

 Our
Development Strategy

 Our
strategy is to generate value through the development of new medicines, or clinical assets, for patients where our research
indicates that there are not effective pharmaceutical treatments available or such existing pharmaceutical treatments are not
adequate due to, among other things, cost of such pharmaceuticals and side effects. We are working to develop new medicines in
disorders where competitive treatments carry a high incidence of unacceptable side effects resulting in tolerability and compliance
issues. We aim to extend and develop solid-form intellectual property on assets which are licensed from pharmaceutical companies or
generated within our facility in Cambridge, United Kingdom (the"UK"). We believe that our Cambridge facility positions us at the nexus of scientific
advancement, providing an environment to drive cutting-edge research and development initiatives.

 There
is evidence that promising solid-form candidates can supersede original pharmaceutical products. We are currently in the process of developing
new solid-form intellectual property on clinical assets which we believe will serve as promising alternatives for existing products on
the market. We believe that our expertise and utilization of solid-form technology can potentially enhance the efficacy, bioavailability,
solubility and delivery of existing products on the market. Once a candidate has been identified and patented, we will fund and conduct
clinical trials through CROs.

 As
previously indicated, our strategy also involves establishing strategic collaborations with globally recognized KOLs. We will collaborate
closely with disease specific KOLs to collectively assess and determine the most appropriate indications for all our current and forthcoming
assets. This approach ensures that the selection of indications aligns with the KOLs' insights, in addition to our internal expertise,
optimizing the development and success of Conduit's diverse portfolio.

 Our
unique relationships allow us to bypass certain traditional hurdles for the development of clinical assets. Through our relationship
with AstraZeneca, our Initial Pipeline has already undergone initial pre-clinical, and, in some instances, clinical testing conducted
by AstraZeneca, which enables us to use the safety data generated in the prior trials in order to assess which assets to continue to
develop. We regularly assess our asset portfolio to identify potential risks and take steps to mitigate those risks, such as the repurposing
of assets, which reduces development costs and timelines, as the clinical asset has already undergone safety and toxicity testing in
humans, as well as extending the remaining patent life by up to 20 years on all assets which are licensed.

 The
prior preclinical and clinical studies conducted by AstraZeneca allow us to reduce the costs, expenses, and time in the development of
these assets by allowing us to continue the Phase Ib or Phase II stage, rather than the preclinical or Phase I stage, even if we are
investigating the assets for a new indication. For example, if a clinical asset was subject to a Phase I trial, such clinical asset may
be advanced to a Phase II trial even if the clinical asset is being investigated for a different indication. In addition, we have access
to API manufactured by AstraZeneca and as a result, should we use their formulation, we do not have to develop a route of manufacture
for the API, which is time consuming and expensive.

 Principal
Strategic Partnerships

 License
Agreement – Conduit and AstraZeneca

 On
August 7, 2024, the Company and AstraZeneca entered into the License Agreement. Pursuant to such License Agreement, AstraZeneca agreed
to grant a license to the Company under certain intellectual property rights controlled by AstraZeneca related to HK-4 Glucokinase activators
AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor AZD5904 for the treatment, prevention, and prophylaxis of idiopathic
male infertility. The Company will be responsible for the development and commercialization of the Licensed Products under the
related License Agreement. The Company is required to use commercially reasonable efforts to develop
and commercialize the Licensed Products.

 As
consideration for the grant of the license, the Company (i) granted AstraZeneca common stock pursuant to the Issuance Agreement (as further
set out below), (ii) paid AstraZeneca an up-front payment of $1.5 million, and (iii) is obligated to pay AstraZeneca a percentage (on
a tiered basis) of any amounts it may receive in connection with a grant of a sublicense (subject to various customary exceptions).

 AstraZeneca
has been granted a right of first negotiation to develop, manufacture, and commercialize a Licensed Product if the Company receives an
offer for, or solicits, a transaction where a third party would obtain the right to develop, manufacture, or commercialize a Licensed
Product. If AstraZeneca exercises such right, the parties would negotiate in good faith for an agreed period of time on an exclusive
basis.

 Either
party may terminate the License Agreement for material breach (subject to a cure period) or insolvency of the other party. The Company
may terminate the License Agreement for convenience (in its entirety or on a Licensed Product-by-Licensed Product basis). In addition,
AstraZeneca may terminate the License Agreement in certain circumstances, including (but not limited to) the Company ceasing development
of all Licensed Products (subject to certain exceptions for normal pauses or gaps between clinical studies).

 In
addition, in connection with the execution of the License Agreement, the Company and AstraZeneca entered into the Issuance Agreement,
whereby the Company issued AstraZeneca 95,044 shares of the Company's Common Stock. The Issuance Agreement provides
AstraZeneca with resale registration rights for such shares.

 Services
Agreement – Conduit and Sarborg Limited

 On
December 12, 2024, the Company entered into a Services Agreement (the "Sarborg Agreement") with Sarborg, a Cayman
Islands company and related party of the Company. Under the terms of the Sarborg Agreement, Sarborg will provide algorithmic and cybernetic technology services to
Conduit, including the development of decision-support tools and advanced cybernetic systems tailored to enhance Conduit's
decision-making processes and maximize the value of its pharmaceutical asset portfolio.

will perform the services to Conduit comprised of three phases: the Initial Phase (0-24 weeks) focuses on establishing a foundation for
collaboration and aligning Sarborg's services with Conduit's strategic goals; the Development Phase (24-36 weeks) involves
building technological infrastructure, including dashboards and predictive models; and the Ongoing Services Phase (36-52 weeks) ensures
the sustained functionality and relevance of Sarborg's deliverables while supporting Conduit's growth through iterative improvements
and updates. Sarborg will create specific deliverables, including reports, computer programs, software applications, APIs, mobile applications,
source code, written technical specifications and designs, operating and maintenance manuals, and other recorded data and information
arising from or relating to the services. Sarborg will provide all necessary resources to perform the services and deliver the deliverables
in accordance with the Sarborg Agreement.

 To
date, Conduit has successfully completed the Initial Phase of its collaboration with Sarborg, establishing a strong foundation for integrating
AI-driven solutions into our operations. This phase focused on identifying key inputs for the algorithmic approach and ensuring alignment
between Sarborg's services and Conduit's strategic goals. As part of this effort, Sarborg has successfully delivered three
key milestones. First, they conducted detailed teach-in sessions with Conduit's management team to gain a deeper understanding
of our objectives, challenges, and operational workflows, resulting in documented meeting agendas, minutes, and action plans. Second,
they finalized and validated a set of proprietary inputs essential for their cybernetic models, tailored specifically to Conduit's
portfolio and R&D pipeline. Finally, they completed an in-depth market analysis of potential cocrystal candidates, assessing the
patent landscape, competitive positioning, and market size. The insights from this Annual Report are now informing Conduit's ongoing
strategic decision-making. With these key milestones delivered, we are now progressing to the next phase of development.

has now commenced Phase II: The Development Phase, which focuses on building the technological infrastructure necessary to integrate
AI into Conduit's operations. As part of this, Sarborg has successfully completed the first milestone, Dashboard Creation and Refinement,
delivering personalized dashboards that provide Conduit's key personnel with real-time access to critical data related to deliverables,
clinical trials, and drug discovery. These initial dashboards, along with user interface mock-ups and a dashboard user guide, will serve
as the foundation for further refinements. Moving forward, the platform will continue to be optimized to maximize efficiency and ensure
seamless integration into Conduit's workflows.

 Master
Service Agreement – Conduit and Charles River Laboratories

 On
February 7, 2025, Conduit and Charles River Laboratories ("Charles River") entered into a Master Services Agreement (the
"Charles River MSA"). Under the Charles River MSA, Charles River agreed to provide preclinical testing and research
services to Conduit, including the evaluation of compounds in animal models and other related services. The services are defined in
individual Statements of Work ("SOWs") or Protocols, which outline the specific scope, design, and timelines for each
study. To date, one SOW, dated February 11, 2025, has been entered into. Charles River will conduct the studies in compliance with
applicable laws and industry standards, and Conduit will provide necessary test articles and materials. The Charles River MSA
includes provisions for confidentiality, intellectual property ownership, indemnification, and dispute resolution. The Charles River
MSA has a term of five years and can be terminated by either party under specified conditions.

 Market
Overview

 Global
Biotechnology Industry

 The
global biotechnology industry comprises a large range of companies engaged in diverse activities, such as biopharmaceutical development.
The industry companies also span across a wide spectrum of operational models. Some small, dedicated biotechnology companies are research
and development ("R&D") intensive and operate primarily with venture capital, grants, initial public offerings and collaborative
agreements. Conversely, large, diversified companies hold significant in-house R&D resources and well-established production, commercialization,
and distribution processes.

believes that the global biotechnology market was valued at $1.68 trillion in 2024 and is projected to grow at a compound annual growth
rate ("CAGR") of 9.18% from 2024 to 2033. 1 The market is driven by strong government support through initiatives
aimed at the modernization of regulatory framework, improvements in approval processes and reimbursement policies, as well as standardization
of clinical studies.

 Global
investor confidence has fallen during the period, which served to somewhat subdue revenue growth. However, global investment in R&D
has grown strongly and consistently in recent years, with much of this funding funneled into medical biotechnology development, aimed
at providing better care for the aging global population, thus bolstering industry revenue.

 Global
Pharmaceutical Industry

 Over
the previous five years, pharmaceutical companies have benefited from an aging population in developed economies and a growing middle
class in emerging economies. Many companies have also tapped into regional demand for pharmaceuticals that may differ from developed
markets and have expanded their global presence to tap into regional market needs.

 Patent
cliffs have continued to hamper industry revenue during the current period. When drugs lose patent exclusivity, the market is inundated
with low-cost generic drugs. As manufacturers contend with more price-based competition from generics, many operators respond by lowering
their R&D expenditures, which limits the industry's drug pipelines. Additionally, many governments and health insurance organizations
have reduced their drug reimbursements to control healthcare costs, such as implementing incentives for patients to use generic drugs.

 Moving
forward, revenue is forecast to grow an annualized 3.2% to $1.3 trillion over the next five years amid an anticipated persistence of
global demand for industry products. 2

 Our
Initial Pipeline: AZD1656, AZD5658 and AZD5904

 We
wholly own the intellectual property and the rights to further develop the solid-form Cocrystals of AZD1656 (AZD1656 Cocrystal–
pending international patent applications if granted should expire no earlier than 2042) which we intend to target a wide range of autoimmune
disorders.

 In
addition, we currently have the exclusive rights to develop clinical assets, AZD1656 and AZD5658 in all human indications and AZD5904
in idiopathic male infertility which are licensed to us by AstraZeneca.

 Outside
of our proprietary owned patented clinical assets, AstraZeneca granted a license to the Company of certain intellectual property rights
controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor
AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male infertility. The Company will be responsible for the development
and commercialization of the Licensed Products. The Company is required to use commercially reasonable efforts to develop and commercialize
the Licensed Products.

 Due
to our relationship with AstraZeneca, we intend to leverage the data generated from these historical trials in order to investigate the
efficacy and safety to AZD1656 to potentially treat Lupus and ANCA Vasculitis patients, and the efficacy and safety of AZD5904 to treat
IMI. AZD1656 has undergone testing in a total of 20 Phase I clinical trials and five Phase II clinical trials conducted by AstraZeneca
since 2008 and 19 of which were conducted in the U.S. Additional information about those clinical trials is available at the U.S. National
Library of Medicine's website at www.clinicaltrials.gov (however, the information contained on or otherwise accessible through
such website is not part of this annual report). AZD5904 has undergone testing in five Phase I clinical trials conducted by AstraZeneca,
one of which was conducted in the U.S. While a significant amount of clinical trial data has already been generated for both AZD1656
and AZD5904, some of this data was generated outside of the U.S. and accordingly may not be accepted by the FDA. In the event that such
data is not accepted by the FDA, additional clinical trials may be required, which would result in additional costs and time to develop
these clinical assets.

 1 (2025,
January 8). Biotechnology Market Size to Worth Around USD 3.54 Trillion by 2033. BioSpace.com.

 2 IBISWorld Industry Report L6724-GL – Global Biotechnology, May 2021

 The
table below sets forth the pre-clinical or clinical trials that have been conducted by or at the direction of AstraZeneca to date on
the particular clinical asset. All of these pre-clinical or clinical trials were conducted by AstraZeneca prior to Conduit entering into
the License Agreement with AstraZeneca. None of the pre-clinical or clinical trials that have taken place to date were conducted by or
at the direction of the Company.

 Asset

 Therapeutic
 Area

 Stage
 of Development

 Location
 of Trials

 Type
 2 Diabetes

 Phase I and Phase II

 Kingdom; United States

 Renal
 Transplant Patients with Type II Diabetes

 Phase I and Phase II

 Kingdom

 Covid-19

 Phase I

 Kingdom

 Idiopathic
 Male Infertility

 Phase I

 European
 Union; United States

 Type
 2 Diabetes

 Phase I

 States

 The
following table sets forth the current asset development stage for each of AZD1656 and AZD5904 for the indications noted below.

 Asset

 Therapeutic
 Area

 Assets
 at Their Present Stage of Readiness (1)

 Next
 Stage of Development to be Conducted by Conduit

 Anticipated
 Exit Stage for Monetization (3)

 Phase
 I

 Phase
 II

 Phase
 III

 Lupus
 & ANCA Vasculitis

 Phase
 II

 completion of Phase II

 Idiopathic
 Male Infertility

 Phase
 II

 completion of Phase II

 Further
 Autoimmune Disorders

 Phase
 II

 completion of Phase II

 Covid-19,
 Long Covid

 N/A (2)

 N/A (2)

 (1)

 Indicates
 that the asset is considered ready for this Phase. For example, if an asset is listed under Phase II, this means that the asset has
 already completed Phase I trials and is therefore considered Phase II ready.

 (2)

 We
 do not intend to provide additional funding to develop AZD1656 for Covid-19, which is principally owned by third parties. However,
 we are entitled to a portion of the revenues in the event that AZD1656 is further developed by a third party and is monetized, whether
 through a sale, license agreement, or otherwise.

 (3)

 Reflects
 the stage at which we currently anticipate that we will seek to monetize such assets through a license, royalty, or other transaction
 with a third party, who would then seek to continue the development of such clinical asset until its potential commercialization
 after Phase III clinical trials were completed. There is no assurance that we will be able to monetize such assets by entering into
 a license, royalty, or other transaction with a third party. In addition, there is no assurance that any of the clinical assets licensed
 or owned by us will successfully complete Phase II or Phase III clinical trials or obtain regulatory approvals, or that such assets
 will be monetized or commercialized.

was subject to Phase I and Phase II clinical trials consisting of 23 studies in 526 subjects, 446 of whom were dosed with AZD1656.
Other than for the intended effect of lowering glucose, there were no difference identified between the AZD1656-treated and
placebo-treated subjects relating to adverse events. All of the cases where low glucose levels were identified were managed by the
patients and resolved. Based on these clinical trials, no safety signals were identified regarding vital signs, safety laboratory
values or electrocardiogram data. No deaths occurred in any studies with healthy volunteers or patients. AZD1656 was also subject to
Phase II clinical trials consisting of two studies where AZD1656 was given to patients with Type 2 Diabetes Mellitus for four months
or longer. In total, there were 754 randomized patients, 516 of whom were exposed to AZD1656 (316 men and 200 women). There were no
clinically important differences in the adverse effects profile between the AZD1656 treatment group and the AZD1656 placebo group
and there were no deaths in either of the Phase II studies. The efficacy of AZD1656 as a potential treatment for diabetes was also
assessed during the Phase II clinical trials, including whether the efficacy was statistically significant. Clinically relevant and
statistically significant reductions in HbA1c were seen after four months; however, the initial improvement in glucose control
deteriorated over time and the change in HbA1c levels after four months were not statistically different than the placebo. This
decreasing efficacy over time was seen in both Phase II studies.

was subject to a randomized, single-blind, placebo-controlled, single-center, Phase I study to assess the safety, tolerability, pharmacokinetics,
pharmacodynamics and the effect of fasting after single ascending oral doses of AZD5658 in Type 2 Diabetes Mellitus patients. There were
six dose levels with eight patients in each cohort, six receiving AZD5658 and two receiving placebo. The effect of fasting on the pharmacokinetics
of AZD5658 was also studied for two dose levels. Each patient treated with metformin received a maximum of two single oral suspension
doses (one on a low dose of AZD5658/placebo and one on a high dose of AZD5658/placebo under fed conditions), except for patients participating
in the evaluation of the effect of fasting, who received a maximum of three single oral suspension doses. For each patient the study
included a pre-entry visit (Visit 1), two or three clinic-based treatment visits (Visit 2, 3, and 4) and a follow-up visit (Visit 5).
Hence, the total duration of the study for each patient was approximately two and one-half months, assuming three weeks between dose
levels. There were no deaths, serious adverse events, discontinuations due to adverse events, or adverse events of severe intensity during
the study. Overall, there were 13 (61.9%) AZD5658-treated patients with adverse events compared to 2 (28.6%) patients who received placebo.
There were no trends noted with increasing dose in the number of adverse events overall or within any preferred term. The most frequently
occurring adverse events were hypoglycemia and diarrhea, each occurring in three AZD5658-treated patients. One adverse event of ear pain
(30 mg AZD5658 fed) was assessed by the study investigator as moderate in intensity; all other adverse events were of mild intensity.
Five adverse events in AZD5658- treated patients were assessed by the investigator as causally related to investigational product, including
hypoglycemia in three patients (100 mg, 200 mg fasted, and 400 mg AZD5658), diarrhea in one patient (200 mg AZD5658 fasted), and headache
in one patient (30 mg AZD5658). No adverse events in placebo-treated patients were assessed as causally related to investigational product.
The three patients who experienced hypoglycemia adverse events were treated with intake of food or orange juice and the episodes resolved
in less than one hour.

was subject to five Phase I clinical studies, with a total of 1,181 subjects being exposed to AZD5904. Single doses of up to 1,200 mg and
multiple doses of up to 325 mg for up to three times per day for 21 days have been administered as an oral solution in the completed
clinical studies. In addition, single doses of up to 1,400 mg and multiple doses of up to 600 mg for 10 days have been administered as
an "extended release" formulation. The data from these studies did not identify any expected adverse drug reactions for AZD5904
and no adverse effects were reported as related to AZD5904. In addition, the data revealed no clinically significant changes in blood
pressure or pulse rate related to AZD5904 and electrocardiogram data was within the physiological range for the population studied. The
effect of AZD5904 on human myeloperoxidase, which we refer to as MPO, activity was evaluated by determination in an ex vivo assay of
MPO activity in plasma. The correlation between MPO activity and plasma concentrations was assessed for single and multiple doses of
AZD5904. A relationship between plasma concentrations of AZD5904 and MPO activity was demonstrated, which indicates that AZD5904 may
be an effective inhibitor of MPO activity in humans. However, Phase I trials do not assess statistical significance so additional Phase
II trials are necessary to determine if the inhibition of MPO activity as a result of AZD5904 is statistically significant.

 AZ1656
in Autoimmune Disorders

 Autoimmune
disorders refers to a broad group of disorders and conditions that arise from an abnormal immune response to a functioning body part.
For example, autoimmune disorders may arise from an abnormal immune response of major organs (i.e., the heart, kidneys, bladder, liver,
lungs, and skin), glands (i.e., the adrenal gland, pancreas, thyroid, or reproductive organs), digestive system, and tissue (i.e., blood,
connective tissue, muscle, eyes, ears, or vascular system). Management believes that there are over 80 types of autoimmune disorders
that have been identified, including lupus, celiac disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel
disease. Autoimmune disorders are often difficult to diagnose and often the cause of the disorders is not known.

 It
is estimated by the American Autoimmune Related Diseases Association ("AARDA") that as many as 50 million Americans are living
with an autoimmune disease – at a cost of $86 billion a year and there is presently no totally effective treatment known to management.
The currently available treatments for autoimmune disorders include non-steroidal anti-inflammatory drugs ("NSAIDS") or immune
suppressants. These treatments often improve the symptoms but ultimately do not cure the disease and often involve side effects.

is a highly specific glucokinase activator; originally developed by AstraZeneca for use in diabetes mellitus. It has now been tested
in over 1,000 patients with both type I and II diabetes and no significant safety concerns have been raised. It was most recently tested
in the ARCADIA Phase II trial in diabetic patients hospitalized with Covid-19 on the basis of new research into immunometabolic modulation.
We believe that AZD1656 may be used to activate a patient's own immune system in order to limit harmful inflation. We have identified
several autoimmune disorders, which reflects good market potential, with a high level of need that may be treatable using AZD1656. We
believe that our clinical assets have the potential to treat numerous autoimmune disorders. We intend to initially focus on the indications
below in order to maximize the commercial potential of our clinical assets.

 Lupus
Nephritis

 Lupus
Nephritis ("LN") is a severe progression of Systemic Lupus Erythematosus ("SLE") where the immune system attacks
the kidneys, often resulting in renal failure. There is currently no cure or long-term remission treatment available. LN is clinically
evident in 50-60% of patients with SLE, and is histologically evident in most SLE patients, even those without clinical manifestations
of kidney disease. LN is the main cause of SLE related mortality. Current therapy is based on long-term corticosteroid or immunosuppressive
therapy, with clinical efficacy of biological drugs not yet proven in LN. Side effect issues of all current therapies demonstrate an
unmet need for a safer, patient compliant therapy in LN.

 The
Company believes that LN presents a lucrative opportunity given the potential oversight of two conditions, as a Phase IIa trial can be
designed to allow readouts on the wider characteristics of SLE as well as the nephritis aspects, allowing assessment of the potential
of AZD1656 in the field of SLE as a whole. Additionally, LN is an orphan disease that the Company believes has around 80,000 to 100,000
patients in the U.S., and one million patients worldwide, thereby offering additional incentives for investors.

 The
Company believes the global LN market was valued at $3.3 billion in 2022 and is projected to grow from $3.6 billion in 2023 to $6.78
billion by 2032, exhibiting a CAGR of 10.3% during the forecast period.

 SLE
is characterized by dysregulation and a hyperactivity of immune response. In LN, Teff subtype (TH17) has shown significant hyperactivation
leading to skewed T cell differentiation resulting in continued proinflammatory environment, leading to prolonged inflammation and subsequent
tissue damage and organ function loss. TH17/Treg dysregulation has been characterized in lupus patients compared to healthy individuals. 1

a study in mice, findings showed that the IL2/CD25 fusion protein that selectively targets IL-2 on Treg cells induced immune suppression
in a preclinical LN model demonstrating inhibition of LN based on levels of proteinuria, autoantibody titers and kidney histology scores. 2

 ANCA
Vasculitis

 ANCA
Vasculitis ("AAV") is an orphan status autoimmune disease affecting small blood vessels which can lead to multiple organ
injury, especially the kidneys, lungs and peripheral nerves. Undiagnosed AAV has a 90% mortality rate within two years. 3

 Current
maintenance therapies rely on combination of corticosteroid and rituximab, both known for long term use side effects. Recently approved
drugs target specific subpopulations of AAV and have tolerability and side effect issues which demonstrate an unmet need for safer long-term
therapies applicable to all AAV sufferers.

 An
imbalance of Th17/activated Treg cells has been shown in AAV and this has been correlated with renal involvement (with a positive correlation
in creatinine and BUN levels). 4

 Low
dose IL2 therapy in AAV patients, the Company believes, resulted in rebalance of Th17/Treg ration. The levels of Erythrocyte Sedimentation
Rate (ESR) and C-Reactive Protein (CSR) were also significantly decreased, which the Company believes indicates an improvement in disease
activity.

 The
Company believes the seven major AAV markets reached a value of $339.0 million in 2023 and is expected to reach $534.3 million by 2034,
exhibiting a CAGR of 4.22% during 2024 to 2034.

 Paquissi FC et al. Front Med (Lausanne). 2021 Sep; 8: 654912 (

 Wang et al. Mol Immunol. 2020; 118: 19-29 (

 Hunter et al. BMJ. 2020;369 (

 Wang et al. Mol Immunol. 2020; 118: 19-29 (

was previously subject to preclinical and clinical trials, including Phase I and Phase II trials, conducted by AstraZeneca relating to
its potential to treat type 2 diabetes. As of the date hereof, no preclinical or clinical trials have been conducted on the use of AZD1656
to treat autoimmune disorders.

 We
intend to conduct further trials on AZD1656 relating to autoimmune disorders. We plan to conduct further research on AZD1656 to investigate
if AZD1656 is a treatment option, including investigating any negative side effects in the use of AZD1656 as compared to the currently
available treatment options.

in Idiopathic Male Infertility

 Idiopathic
Male Infertility ("IMI") is defined as failure of a couple to conceive after one year of regular sexual intercourse where
the physical examination and endocrine laboratory testing of the male are normal, but semen analysis reveals sperm abnormalities. Approximately
15% of couples globally, or 48.5 million couples globally, are infertile and that 30% of infertility cases can be attributed solely to
the female, 30% can be attributed solely to the male, 30% can be attributed to a combination of both partners, and 10% of cases have
an unknown cause. 5 According to the National Library of Medicine, male infertility accounts for 30% of infertility cases
and its prevalence in the general population approximately ranges between 9 to 15%. 6 Our management believes that male
sperm counts have declined in Western men and will continue to decline due, in part, to increasing rates of disorders such as obesity
and diabetes that can reduce fertility.

 IMI
affects families worldwide and is inherent in problems of reproduction. Currently, there are no specific treatments for male infertility,
and we are not aware of any other company that is developing a treatment for male infertility. There are no approved pharmacotherapies
for idiopathic male infertility. Lifestyle medicine and unproven supplements are often used. Intracytoplasmic sperm injection, a form
of in vitro fertilization, is the only treatment currently available for male infertility. This process is not a treatment of male infertility
but rather is an alternative means of fertilizing the egg. In vitro fertilization places a significant burden on the woman as it requires
the induction of egg production and harvesting of eggs. In vitro fertilization is costly and time consuming and has modest success rates.
Management believes that the male infertility market size is expected to grow from $3.72 billion in 2023 to $4.42 billion by 2028, at
a CAGR of 3.54% during the period 2023-2028.

 Damaged
sperm are unable to successfully fertilize eggs due to factors including impaired motility, impaired ability to penetrate and/or DNA
damaged sperm that is unable to form a viable fetus. Our development pipeline for AZD5904 includes a potent, irreversible inhibitor of
human myeloperoxidase, which we refer to as MPO, that has the potential to treat idiopathic male infertility.

was investigated by AstraZeneca for the treatment of idiopathic male infertility in Phase I trials, which confirmed the suitability to
progress to Phase II trials. While AZD5904 is Phase II ready, our management intends to conduct a Phase Ib "proof of mechanism"
trial to verify AZD5904 has the intended biological effect in semen (as well as in blood) prior to commencing a Phase II trial for the
use of AZD5904 to treat idiopathic male infertility. Specifically, our management intends to conduct the Phase Ib study in order to see
if the trial will provide evidence that AZD5904 has its intended effect of inhibiting myeloperoxidase and reduce oxidative stress in
semen. We believe that AZD5904 has the potential to be used to create a tablet that could treat IMI and would be the first drug developed
to directly treat IMI. We, in connection with a CRO, have prepared clinical trial protocols relating to the use of AZD5904 to treat IMI
in a Phase Ib clinical trial: a Phase Ib, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety,
tolerability and preliminary efficacy of AZD5904 in adult men with IMI with an anticipated enrollment of 60 patients, and a Phase II
clinical trial: a Phase II, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of AZD5904
in the treatment of IMI with an anticipated enrollment of 200 patients. There can be no assurances that the clinical trials that we intend
to conduct on AZD5904 to treat idiopathic male infertility will be successful.

 Future
Clinical Assets

 As
part of our strategic planning process, we intend to explore the efficacy of using AZD1656 and AZD5658 to treat other disorders.
Specifically, we intend to conduct research on whether AZD1656 and AZD5658 may be effective treating other autoimmune disorders,
include rheumatoid arthritis, multiple sclerosis, motor neuron disease, and amyotrophic lateral sclerosis. As part of our strategic
planning process, we intend to explore the efficacy of using AZD1656 to treat other disorders. We also plan to further develop the
co-crystals that we own from our prior development work on AZD1656, including to research the ability of the co-crystals developed
from AZD1656 to treat psoriasis, Crohn's disease, lupus, sarcoidosis, diabetic wound healing, idiopathic pulmonary fibrosis,
and non-alcoholic steatohepatitis. In addition, we currently intend to explore the use of AZD5904 for the treatment of glioma. We
expect to seek to develop other clinical assets and determine based on pre-clinical and clinical data which clinical assets in order
to determine which assets in our pipeline to continue to develop. Accordingly, we believe that our management team will be able to
effectively allocate resources to the development of clinical assets that we believe show the most promise. However, there can be no
guarantee that the clinical trials conducted by us of our clinical assets will be successful. If we are unable to commercialize our
clinical assets or experience significant delays in doing so, our business will be materially harmed.

 Manufacturing

 We
do not currently own or operate any facilities to formulate, manufacture, test, store, package, or distribute any of the clinical assets
that we are developing or may seek to develop and do not currently have the capabilities to conduct such activities. We currently rely
on third parties to manufacture, store, and test the clinical assets that we seek to develop, including material manufactured originally
by AstraZeneca. We will depend on third-party suppliers and manufacturing organizations for all our required raw materials and drug substance
and to formulate, manufacture, test, store, package, and distribute clinical trial quantities of clinical assets that we may seek to
develop. We plan to continue to use third-party suppliers and manufacturing organizations and we anticipate expanding our network of
third-party suppliers and manufacturing organizations as our operations expand.

 "A unique view on male infertility around the globe," by Ashok Agarwal, Aditi Mulgund, Alaa Hamada, and Michelle Renee
Chyatte (Link:

 We
have internal personnel and utilize consultants with extensive technical, manufacturing, analytical, and quality experience to oversee
our contract manufacturing and testing activities. Manufacturing is subject to extensive regulations that impose procedural and documentation
requirements, including, but not limited to, record-keeping, manufacturing processes and controls, personnel, quality control, and quality
assurance. Our systems, procedures, and contractors are required to be in compliance with these regulations and are assessed through
regular monitoring and formal audits.

and Development

 Our
research and development activities have included developing co-crystals of AZD1656 to increase patent life. Most of this work is conducted
in our laboratories based in Cambridge, UK, but parts of this work is completed by third-party CROs but all intellectual property is
retained by us. The successful completion of clinical trials increases the value of clinical assets and may lead to the commercialization
and/or licensing of such assets to other pharmaceutical companies. There is no assurance that any clinical trials on the assets owned
or licensed by us will be successful or any assurance our co-crystal development will be successful.

 We
do not intend to further fund the research and development of the use of AZD1656 in Covid; however, we retain an economic interest in
the AZD1656 in the indication of Covid and if AZD1656 is further developed in Covid through funding provided by other third parties,
then we may be entitled to receive compensation from those development activities conducted by third parties due to its economic interest
in AZD1656 in Covid.

 Sales
and Marketing

 We
do not currently have marketing, sales, or distribution capabilities. In order to commercialize any clinical asset that is approved for
commercial sale, we must either develop our own sales, marketing, and distribution infrastructure or collaborate with third parties that
have such commercial infrastructure and relevant marketing and sales experience. We anticipate relying on licensing, co-sale, co-promotion,
and distribution agreements with strategic partners for the commercialization of our products. We do not currently anticipate that we
would develop our own internal sales force organization.

 Competition

 We
operate in the highly competitive pharmaceutical and biotechnology industry. Our competitors may include public and private companies,
universities, governmental agencies, and other research organizations actively engaged in the research and development of clinical assets
and biopharmaceutical products. Our competitors may have greater financial, technical, and human resources than we currently have and/or
may be better equipped to develop, manufacture, and market their products. Our competitors may be developing clinical assets for products
for similar indications. However, we believe that we have an unprecedented advantage in novelty. As discussed above, AZD1656 is an activator
(not an inhibitor) of a metabolic process. We anticipate that the number of companies seeking to develop clinical assets, biopharmaceutical
products, and therapies will continue to increase. As a result, the competition we face may also increase. However, both in the treatment
of autoimmune disease and idiopathic male infertility the competition is currently expected to come in years, even if biopharmaceutical
products that we develop and/or commercialize were not to compete with products of our competitors based on the product efficacy, safety,
ease of use, price, demonstrated cost-effectiveness, marketing effectiveness, service, reputation, and access to technical information.
However, we believe that our ability to focus on clinical assets that have been deprioritized by larger pharmaceutical companies is a
competitive advantage.

 Intellectual
Property

 We
hold exclusive rights to develop AZD1656, AZD5658, and AZD5904 through our License Agreement with AstraZeneca and we also own the intellectual
property and the rights to further develop co-crystals resulting from our prior research and development work on AZD1656.

 On December 18, 2024, Conduit UK Management Limited ("Conduit") received a notification from the UK Intellectual
Property Office ("UK IPO") notifying the company that St George Street Capital had initiated patent entitlement proceedings
with respect to patent application PCT/IB2022/00775 ("Patent Application"). Conduit refutes the claims made by St George Street
Capital and filed a counterstatement on February 26, 2025 with the UK IPO. In addition, each of the three inventors named in the Patent
Application filed simultaneous counterstatements fully supporting Conduit's position, and assertions that the claims are without
merit. Further updates will be made following notification by the UK IPO.

 We
currently have eight pending patent applications in several international jurisdictions. Even though we have filed patent applications,
there is no guarantee that the validity of the patents will be upheld if challenged by a third party, that patents will be granted on
the applications filed in the respective jurisdictions, or that once granted, the patents will contain claims that encompass our commercial
products. There can be no assurance that any of our intellectual property rights will afford us any protection from competition.

 The
following patent applications are relevant to the operation of our business:

 Related
 Clinical Asset

 Mechanism
 of Action

 Patent
 Information and Number

 Patent

 Ownership/Licensing

 Status;
 Patent Status

 Jurisdictions
 Protected

 Expiration

 Composition
 of Matter Patent; 101901 (family number)

 Licensed
 to Conduit from AstraZeneca for use in all human indications. Granted and in force.

 Brazil,
 Canada, Switzerland, China, Germany, European Procedure, Spain, France, United Kingdom, Hong Kong, India, Japan, South Korea, Mexico,
 Netherlands, Russian Federation, Sweden, Turkey, United States. Granted in Australia

 July 3, 2026.

 Polymorph
 Patent; 103631 (family number)

 Licensed
 to Conduit from AstraZeneca for use in human applications. Granted and in force.

 China
 and United States

 February 2030.

 Co-crystal
 PCT/IB2022/00075

 Owned
 by Conduit Pharmaceuticals.

 Filed
 September 2, 2022.

 Global

 Filing
 date September 2, 2022. If granted, will expire September 2, 2042.

 Co-crystal
 JP2022-176753

 Owned
 by Conduit Pharmaceuticals.

 Filed
 November 2, 2022.

 Granted:
 Japan

 November 2, 2042.

 MPO
 Inhibitor

 Idiopathic
 Male Infertility; AZD5904 use patent; 200644 (family number)

 [WO/2019/016074]

 Licensed
 to Conduit from AstraZeneca.

 International
 Description

 July 12, 2038.

 Composition
 of Matter Patent; 101901 (family number)

 Licensed
 to Conduit from AstraZeneca for use in all human indications. Granted and in force.

 Australia,
 Brazil, Canada, Switzerland, China, Germany, European Procedure, Spain, France, United Kingdom, Hong Kong, India, Japan, South Korea,
 Mexico, Netherlands, Russian Federation, Sweden, Turkey, United States

 July 3, 2026

 We
have not filed any applications for trademark protection of any names or logos for products or technologies in development. We plan to
seek trademark protection inside and outside of the United States where and when appropriate and if available. We intend to use these
registered marks in connection with our pharmaceutical research and development, including proprietary technologies, as well as our clinical
assets.

 We
expect to protect our products and technologies through a combination of patents, regulatory exclusivity, and potentially confidential
and proprietary know-how. We intend to actively seek to obtain, where appropriate, the broadest commercially reasonable intellectual
property protection possible for our clinical assets and technologies, including any future clinical assets and technologies under development,
our proprietary information, and our proprietary technology through a combination of contractual arrangements and patents, in the United
States and abroad. However, we cannot guarantee that patent protection will provide complete protection against competitors who seek
to circumvent our patents.

 Government
Regulation and Product Approval

 Government
authorities in the United States, at the federal, state, and local level, and in other countries, extensively regulate, among other things,
the research, development, clinical trials, testing, manufacture, including any manufacturing changes, authorization, pharmacovigilance,
adverse event reporting, recalls, packaging, storage, recordkeeping, labeling, advertising, promotion, distribution, marketing, import
and export of pharmaceutical products and clinical assets, including clinical assets such as those we are developing. The processes for
obtaining regulatory approvals in the United States and in foreign countries, along with subsequent compliance with applicable statutes
and regulations have no guaranteed outcomes and require the expenditure of substantial time and financial resources.

 Our
development plan for each of AZD1656, AZD5658 and AZD5904 is to conduct clinical trials and if those trials are successful, we will then
seek to enter into a transaction with a third party with respect to AZD1656, AZD5658 orAZD5904, as applicable, for the particular indication.
We do not intend to continue development of such clinical assets beyond Phase II clinical trials. Accordingly, we anticipate developing
clinical assets, which we own or license from third parties, that have undergone pre-clinical and clinical trials through the Phase II
stage and then monetizing such clinical assets through a license, royalty, or other transaction. We do not expect that we will commercialize
any clinical assets or seek marketing approval from the FDA (or similar organizations) as we intend to enter into agreements with third
parties following Phase II clinical trials for each such clinical asset that would provide that such third party would pursue the further
development, commercialization, and marketing of such assets.

 The
following description of the process relating to obtaining regulatory approvals in the United States and in foreign countries is intended
for informational purposes only as we do not expect to continue the development of any of the clinical assets beyond the Phase II stage.
There is no assurance that any clinical trials on the assets owned or licensed by us will be successful.

States Government Regulation

 In
the United States, the FDA regulates drugs under the Federal Food, Drug, and Cosmetic
Act ("FDCA") and implementing regulations. Failure to comply with the applicable United States requirements at any time during
the product development process, approval process or after approval, may subject an applicant to a variety of administrative or judicial
sanctions, such as the FDA's refusal to approve pending New Drug Applications ("NDAs"), withdrawal of an approval,
imposition of a clinical hold, issuance of warning letters, product recalls, product seizures, total or partial suspension of production
or distribution, injunctions, fines, refusals of government contracts, restitution, disgorgement or civil and/or criminal penalties.

 The
process required by the FDA before a drug may be marketed in the United States generally involves the following steps, each of which
requires the expenditure of substantial time and financial resources:

 completion
 of preclinical laboratory tests, animal studies and formulation studies in compliance with good laboratory practices ("GLPs")
 and other applicable regulations;

 submission
 to the FDA of an Investigational New Drug Application ("IND"), which must become effective before human clinical trials
 may begin;

 approval
 by an independent institutional review board ("IRB") at each clinical site before each trial may be initiated;

 performance
 of well-controlled human clinical trials in accordance with good clinical practices ("GCPs"), which may include placebo
 controls, to establish the safety and efficacy of the proposed drug product for each indication;

 submission
 to the FDA of an NDA and payment of fees;

 satisfactory
 completion of an FDA advisory committee review, if applicable;

 satisfactory
 completion of an FDA pre-approval inspection of the manufacturing facility or facilities at which the product is produced to assess
 compliance with current good manufacturing practices ("cGMPs") and to assure that the facilities, methods and controls
 are adequate to preserve the drug's identity, strength, quality and purity;

 satisfactory
 completion of audits of clinical trial sites conducted by FDA to assure compliance with GCPs and the integrity of clinical data;
 and

 FDA
 review and approval of the NDA.

 Preclinical
Studies

 Preclinical
studies include laboratory evaluation of product chemistry, toxicity, and formulation, as well as animal studies to assess potential
safety and efficacy. Preclinical tests intended for submission to the FDA to support the safety of a clinical asset must be conducted
in compliance with GLP regulations and the U.S. Department of Agriculture's Animal Welfare Act. A drug sponsor must submit the
results of the preclinical tests, together with manufacturing information, analytical data and any available ex-U.S. clinical data or
relevant literature, among other things, to the FDA as part of an IND. Some nonclinical testing may continue even after the IND is submitted.
An IND automatically becomes effective 30 days after receipt by the FDA, unless before that time the FDA raises concerns or questions
related to one or more proposed clinical trials and places the clinical trial on a clinical hold. In such a case, the IND sponsor and
the FDA must resolve any outstanding concerns before the clinical trial can begin. As a result, submission of an IND may not result in
the FDA allowing clinical trials to commence. A clinical hold may occur at any time during the life of an IND and may affect one or more
specific studies or all studies conducted under the IND.

the FDA or the sponsor may suspend or terminate a clinical trial at any time on various grounds, including a finding that the research
subjects are being exposed to an unacceptable health risk. Similarly, an IRB can suspend or
terminate approval of a clinical trial at its institution if the clinical trial is not being conducted in accordance with the IRB's
requirements or if the drug candidate has been associated with unexpected serious harm to patients.

Trials

trials involve the administration of the investigational new drug to human subjects under the supervision of qualified investigators
in accordance with GCP requirements, which include the requirement that all research subjects provide their informed consent in writing
for their participation in any clinical trial along with the requirement to ensure that the data and results reported from the clinical
trials are credible and accurate. Clinical trials are conducted under protocols detailing, among other things, the objectives of the
trial, the criteria for determining subject eligibility, the dosing plan, the parameters to be used in monitoring safety, the procedure
for timely reporting of adverse events, and the effectiveness criteria to be evaluated. A protocol for each clinical trial and any subsequent
protocol amendments must be submitted to the FDA as part of the IND. In addition, an IRB at each institution participating in the clinical
trial must review and approve the plan for any clinical trial before it commences at that institution.

 Information
about certain clinical trials and clinical trial results must be submitted within specific timeframes to the National Institutes of Health
for public dissemination on the Clinicaltrials.gov registry. Failure to timely register a covered clinical study or to submit study results
as provided for in the law can give rise to civil monetary penalties and prevent the non-compliant party from receiving future grant
funds from the federal government. The government has begun enforcing these registration and results reporting requirements
against non-compliant clinical trial sponsors.

 Human
clinical trials are typically conducted in at least three sequential phases and occasionally four or more, which may require repetition,
or overlap or be combined:

 Phase
I: The drug candidate is initially introduced into healthy human subjects or patients with the target disease or condition and
tested for safety, dosage tolerance, absorption, metabolism, distribution, excretion and, if possible, to gain an early indication of
its effectiveness. During Phase I clinical trials, sufficient information about the investigational drug's pharmacokinetics and
pharmacological effects may be obtained to permit the design of well-controlled and scientifically valid Phase II clinical trials.

 Phase
II: The drug candidate is administered to a larger, but still limited patient population to identify possible adverse effects
and safety risks, to preliminarily evaluate the efficacy of the product for specific targeted indications and to determine dosage tolerance
and optimal dosage. Phase II clinical trials are typically well-controlled and closely monitored.

 Phase
III: The drug candidate is administered to an expanded patient population, generally at geographically dispersed clinical trial
sites, in well-controlled clinical trials to generate enough data to statistically evaluate the efficacy and safety of the product for
approval, to establish the overall risk-benefit profile of the product, and to provide adequate information for the labeling of the product.
Phase III clinical trials usually involve a larger number of participants than a Phase II clinical trial.

 There
is no guarantee that a clinical asset will successfully complete any such clinical trials. There is no assurance that any clinical trials
on the assets owned or licensed by Conduit will be successful.

 Interactions
with FDA During the Clinical Development Program

the clearance of an IND and the commencement of clinical trials, the sponsor of such trial will continue to have interactions with the
FDA. Progress reports detailing the results of clinical trials must be submitted at least annually to the FDA and more frequently if
serious adverse events occur. In addition, IND safety reports must be submitted to the FDA for any of the following: serious and unexpected
suspected adverse reactions; findings from other studies or animal or in vitro testing that suggest a significant risk in humans exposed
to the product; and any clinically important increase in the occurrence of a serious suspected adverse reaction over that listed in the
protocol or investigator brochure.

 In
addition, sponsors are given opportunities to meet with the FDA at certain points in the clinical development program. Specifically,
sponsors may meet with the FDA prior to the submission of an IND ("pre-IND meeting"), at the end of Phase II clinical trial
("EOP2" meeting) and before an NDA is submitted ("pre-NDA meeting"). Meetings at other times may also be requested.
These meetings provide an opportunity for the sponsor to share information about the data gathered to date with the FDA and for the FDA
to provide advice on the next phase of development. For example, at an EOP2, a sponsor may discuss its Phase II clinical results and
present its plans for the pivotal Phase III clinical trial(s) that it believes will support the approval of the new product. Such meetings
may be conducted in person, via teleconference/videoconference or written response only with minutes reflecting the questions that the
sponsor posed to the FDA and the agency's responses. The FDA has indicated that its responses, as conveyed in meeting minutes and
advice letters, only constitute recommendations and/or advice made to a sponsor and, as such, sponsors are not bound by such recommendations
and/or advice. Nonetheless, from a practical perspective, a sponsor's failure to follow the FDA's recommendations for design
of a clinical program may put the program at significant risk of failure.

 Acceptance
of NDAs

 Assuming
successful completion of the required clinical testing, the results of the preclinical studies and clinical trials, along with information
relating to the product's chemistry, manufacturing, controls, safety updates, patent information, abuse information and proposed
labeling, are submitted to the FDA as part of an application requesting approval to market the clinical asset for one or more indications.
Data may come from company-sponsored clinical trials intended to test the safety and efficacy of a product's use or from a number
of alternative sources, including studies initiated by investigators. To support marketing approval, the data submitted must be sufficient
in quality and quantity to establish the safety and efficacy of a drug product. The fee required for the submission and review of an
application under the Prescription Drug User Fee Act ("PDUFA") is substantial, and the sponsor of an approved application
is also subject to an annual program fee assessed based on eligible prescription drug products. These fees are typically adjusted annually,
and exemptions and waivers may be available under certain circumstances, such as where a waiver is necessary to protect the public health,
where the fee would present a significant barrier to innovation, or where the applicant is a small business submitting its first human
therapeutic application for review.

 The
FDA conducts a preliminary review of all applications within 60 days of receipt and must inform the sponsor at that time or before whether
an application is sufficiently complete to permit substantive review. In pertinent part, the FDA's regulations provide that the
agency may refuse to file an application if the application does not include all pertinent information and data necessary for review
by the FDA. In the event that the FDA determines that an application does not satisfy this standard, it will issue a Refuse to File ("RTF")
determination to the applicant. Typically, an RTF will be based on administrative incompleteness, such as clear omission of information
or sections of required information; scientific incompleteness, such as omission of critical data, information or analyses needed to
evaluate safety and efficacy or provide adequate directions for use; or inadequate content, presentation, or organization of information
such that substantive and meaningful review is precluded. The FDA may request additional information rather than accept an application
for filing. In this event, the application must be resubmitted with the additional information. The resubmitted application is also subject
to review before the FDA accepts it for filing.

 Review
of NDAs

 After
the submission is accepted for filing, the FDA begins an in-depth substantive review of the application. The FDA reviews the application
to determine, among other things, whether the proposed product is safe and effective for its intended use, whether it has an acceptable
purity profile and whether the product is being manufactured in accordance with cGMP.

 Under
the goals and policies agreed to by the FDA under PDUFA, the FDA has 10 months from the filing date in which to complete its initial
review of a standard application that is a new molecular entity, and six months from the filing date for an application with "priority
review." The review process may be extended by the FDA for three additional months to consider new information or in the case of
a clarification provided by the applicant to address an outstanding deficiency identified by the FDA following the original submission.
Despite these review goals, the NDA review process can be very lengthy, and it is not uncommon for FDA review of an application to extend
beyond the PDUFA target action date. Most innovative drug products (other than biological products) obtain FDA marketing approval pursuant
to an NDA submitted under Section 505(b)(1) of the FDCA, commonly referred to as a traditional or "full NDA." In 1984, with
passage of the Drug Price Competition and Patent Term Restoration Act, informally known as the Hatch-Waxman Act, that established an
abbreviated regulatory scheme authorizing the FDA to approve generic drugs based on an innovator or "reference" product,
Congress also enacted Section 505(b)(2) of the FDCA, which provides a hybrid pathway combining features of a traditional NDA and a generic
drug application. Section 505(b)(2) enables the applicant to rely, in part, on the FDA's prior findings of safety and efficacy
data for an existing product, or published literature, in support of its application. Section 505(b)(2) NDAs may provide an alternate
path to FDA approval for new or improved formulations or new uses of previously approved products that would require new clinical data
to demonstrate safety or effectiveness. Section 505(b)(2) permits the filing of an NDA in which the applicant relies, at least in part,
on information from studies made to show whether a drug is safe or effective that were not conducted by or for the applicant and for
which the applicant has not obtained a right of reference or use. A Section 505(b)(2) applicant may eliminate or reduce the need to conduct
certain preclinical or clinical studies, if it can establish that reliance on studies conducted for a previously approved product is
scientifically appropriate. The FDA may also require companies to perform additional studies or measurements, including nonclinical and
clinical studies, to support the change from the approved product. The FDA may then approve the new clinical asset for all or some of
the labeled indications for which the referenced product has been approved, as well as for any new indication for which the Section 505(b)(2)
NDA applicant has submitted data.

 In
connection with its review of an application, the FDA will typically submit information requests to the applicant and set deadlines for
responses thereto. The FDA will also conduct a pre-approval inspection of the manufacturing facilities for the new product to determine
whether the manufacturing processes and facilities comply with cGMPs. The FDA will not approve the product unless it determines that
the manufacturing processes and facilities are in compliance with cGMP requirements and are adequate to assure consistent production
of the product within required specifications.

 The
FDA also may inspect the sponsor and one or more clinical trial sites to assure compliance with IND and GCP requirements and the integrity
of the clinical data submitted to the FDA. To ensure cGMP and GCP compliance by its employees and third-party contractors, an applicant
may incur significant expenditure of time, money and effort in the areas of training, record keeping, production and quality control.
The FDA generally accepts data from foreign clinical trials in support of an NDA if the trials were conducted under an IND. If a foreign
clinical trial is not conducted under an IND, the FDA nevertheless may accept the data in support of an NDA if the study was conducted
in accordance with GCPs and the FDA is able to validate the data through an on-site inspection, if deemed necessary. Although the FDA
generally requests that marketing applications be supported by some data from domestic clinical trials, the FDA may accept foreign data
as the sole basis for marketing approval if (1) the foreign data are applicable to the United States population and United States medical
practice, (2) the studies were performed by clinical investigators with recognized competence, and (3) the data may be considered valid
without the need for an on-site inspection or, if the FDA considers the inspection to be necessary, the FDA is able to validate the data
through an on-site inspection or other appropriate means.

 The
FDA may also refer an application, including applications for novel clinical asset which present difficult questions of safety or efficacy,
to an advisory committee for review, evaluation and recommendation as to whether the application should be approved and under what conditions.
Typically, an advisory committee is a panel of independent experts, including clinicians and other scientific experts, that reviews,
evaluates and provides a recommendation as to whether the application should be approved and under what conditions. The FDA is not bound
by the recommendation of an advisory committee, but it considers such recommendations when making final decisions on approval.

 Data
from clinical trials are not always conclusive, and the FDA or its advisory committee may interpret data differently than the sponsor
interprets the same data. The FDA may also re-analyze the clinical trial data, which could result in extensive discussions between the
FDA and the applicant during the review process or delay, limit or prevent regulatory approval. The FDA may not grant approval on a timely
basis or at all.

 The
FDA also may require submission of a risk evaluation and mitigation strategy ("REMS") if it determines that a REMS is necessary
to ensure that the benefits of the drug product outweigh its risks and to assure the safe use of the product. The REMS could include
medication guides, physician communication plans, assessment plans and/or elements to assure safe use, such as restricted distribution
methods, patient registries or other risk minimization tools. The FDA determines the requirement for a REMS, as well as the specific
REMS provisions, on a case-by-case basis. If the FDA concludes a REMS is needed, the sponsor of the application must submit a proposed
REMS and the FDA will not approve the application without a REMS.

 Decisions
on NDAs

 The
FDA reviews an application to determine, among other things, whether the product is safe and whether it is effective for its intended
use(s), with the latter determination being made on the basis of substantial evidence. The term "substantial evidence" is
defined under the FDCA as "evidence consisting of adequate and well-controlled investigations, including clinical investigations,
by experts qualified by scientific training and experience to evaluate the effectiveness of the drug involved, on the basis of which
it could fairly and responsibly be concluded by such experts that the drug will have the effect it purports or is represented to have
under the conditions of use prescribed, recommended, or suggested in the labeling or proposed labeling thereof."

 The
FDA has interpreted this evidentiary standard to require at least two adequate and well-controlled clinical investigations to establish
effectiveness of a new product. Under certain circumstances, however, the FDA has indicated that a single trial with certain characteristics
and additional information may satisfy this standard. This approach was subsequently endorsed by Congress in 1998 with legislation providing,
in pertinent part, that "If [the FDA] determines, based on relevant science, that data from one adequate and well-controlled clinical
investigation and confirmatory evidence (obtained prior to or after such investigation) are sufficient to establish effectiveness, the
FDA may consider such data and evidence to constitute substantial evidence." This modification to the law recognized the potential
for the FDA to find that one adequate and well controlled clinical investigation with confirmatory evidence, including supportive data
outside of a controlled trial, is sufficient to establish effectiveness. In December 2019, the FDA issued draft guidance further explaining
the studies that are needed to establish substantial evidence of effectiveness, and in September 2023 it issued a draft guidance that
complements the 2019 draft guidance. The FDA has not yet finalized either guidance.

 After
evaluating the application and all related information, including the advisory committee recommendations, if any, and inspection reports
of manufacturing facilities and clinical trial sites, the FDA will issue either a Complete Response Letter ("CRL") or an
approval letter. To approve the application, the FDA must determine that the drug is effective and that its expected benefits outweigh
its potential risks to patients. This "benefit-risk" assessment is informed by the extensive body of evidence about the product's
safety and efficacy in the NDA. This assessment is also informed by other factors, including: the severity of the underlying condition
and how well patients' medical needs are addressed by currently available therapies; uncertainty about how the premarket clinical
trial evidence will extrapolate to real-world use of the product in the post-market setting; and whether risk management tools are necessary
to manage specific risks. In connection with this assessment, the FDA review team will assemble all individual reviews and other documents
into an "action package," which becomes the record for FDA review. The review team then issues a recommendation, and a senior
FDA official makes a decision.

 A
CRL indicates that the review cycle of the application is complete, and the application will not be approved in its present form. A CRL
generally outlines the deficiencies in the submission and may require substantial additional testing or information in order for the
FDA to reconsider the application. The CRL may require additional clinical or other data, additional pivotal Phase III clinical trial(s)
and/or other significant and time-consuming requirements related to clinical trials, preclinical studies or manufacturing. If a CRL is
issued, the applicant will have one year to respond to the deficiencies identified by the FDA, at which time the FDA can deem the application
withdrawn or, in its discretion, grant the applicant an additional six-month extension to respond. The FDA has committed to reviewing
resubmissions in response to an issued CRL in either two or six months depending on the type of information included. Even with the submission
of this additional information, however, the FDA ultimately may decide that the application does not satisfy the regulatory criteria
for approval.

 An
approval letter, on the other hand, authorizes commercial marketing of the product with specific prescribing information for specific
indications. That is, the approval will be limited to the conditions of use ( e.g., patient population, indication) described in
the FDA-approved labeling. Further, depending on the specific risk(s) to be addressed, the FDA may require that contraindications, warnings
or precautions be included in the product labeling, require that post-approval trials, including Phase 4 clinical trials, be conducted
to further assess a product's safety after approval, require testing and surveillance programs to monitor the product after commercialization
or impose other conditions, including distribution and use restrictions or other risk management mechanisms under a REMS which can materially
affect the potential market and profitability of the product. The FDA may prevent or limit further marketing of a product based on the
results of post-marketing trials or surveillance programs. After approval, some types of changes to the approved product, such as adding
new indications, manufacturing changes and additional labeling claims, are subject to further testing requirements and FDA review and
approval.

 Special
FDA Expedited Review Programs

 The
FDA is authorized to designate certain products for expedited development or review if they are intended to address an unmet medical
need in the treatment of a serious or life-threatening disease or condition. These programs include fast track designation, breakthrough
therapy designation, and priority review designation. The purpose of these programs is to provide important new drugs to patients earlier
than under standard FDA review procedures.

 To
be eligible for a fast-track designation, the FDA must determine, based on the request of a sponsor, that a product is intended to treat
a serious or life-threatening disease or condition and demonstrates the potential to address an unmet medical need. The FDA will determine
that a product will fill an unmet medical need if it will provide a therapy where none exists or provide a therapy that may be potentially
superior to existing therapy based on efficacy or safety factors. Fast track designation provides additional opportunities for interaction
with the FDA's review team and may allow for a rolling review of NDA components before the completed application is submitted,
if the sponsor provides a schedule for the submission of the sections of the NDA, the FDA agrees to accept sections of the NDA and determines
that the schedule is acceptable, and the sponsor pays any required user fees upon submission of the first section of the NDA. In addition,
fast track designation may be withdrawn by the sponsor or rescinded by the FDA if the designation is no longer supported by data emerging
in the clinical trial process.

 In
addition, with the enactment of the FDA Safety and Innovation Act ("FDASIA") in 2012, Congress created a new regulatory program
for therapeutic candidates designated by FDA as "breakthrough therapies" upon a request made by the IND sponsors. A breakthrough
therapy is defined as a drug that is intended, alone or in combination with one or more other drugs, to treat a serious or life-threatening
disease or condition, and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing
therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development.
The FDA must take certain actions with respect to breakthrough therapies, such as holding timely meetings with and providing advice to
the product sponsor, intended to expedite the development and review of an application for approval of a breakthrough therapy.

 Finally,
the FDA may designate a product for priority review if it is a drug that treats a serious condition and, if approved, would provide a
significant improvement in safety or effectiveness. The FDA determines at the time that the marketing application is submitted, on a
case-by-case basis, whether the proposed drug represents a significant improvement in treatment, prevention or diagnosis of disease when
compared with other available therapies. Significant improvement may be illustrated by evidence of increased effectiveness in the treatment
of a condition, elimination or substantial reduction of a treatment-limiting drug reaction, documented enhancement of patient compliance
that may lead to improvement in serious outcomes, or evidence of safety and effectiveness in a new subpopulation. A priority review designation
is intended to direct overall attention and resources to the evaluation of such applications, and to shorten the FDA's goal for
taking action on a marketing application from ten months to six months for an NDA for a new molecular entity from the date of filing.

 Even
if a product qualifies for one or more of these programs, the FDA may later decide that the product no longer meets the conditions for
qualification or decide that the time period for FDA review or approval will not be shortened. Furthermore, fast track designation, breakthrough
therapy designation and priority review do not change the standards for approval and may not ultimately expedite the development or approval
process.

 Accelerated
Approval Pathway

 In
addition, a product studied for its safety and effectiveness in treating serious or life-threatening illnesses and that provide meaningful
therapeutic benefit over existing treatments may receive accelerated approval, meaning that it may be approved on (i) the basis of adequate
and well-controlled clinical trials establishing that the drug product has an effect on a surrogate endpoint that is reasonably likely
to predict clinical benefit, or (ii) on an intermediate clinical endpoint that can be measured earlier than irreversible morbidity or
mortality ("IMM") and that is reasonably likely to predict an effect on IMM or other clinical benefits, taking into account
the severity, rarity or prevalence of the condition and the availability or lack of alternative treatments. As a condition of approval,
the FDA may require a sponsor of a drug receiving accelerated approval to perform post-marketing studies to verify and describe the predicted
effect on IMM or other clinical endpoints, and the drug may be subject to expedited withdrawal procedures. Drugs granted accelerated
approval must meet the same statutory standards for safety and effectiveness as those granted traditional approval.

 The
accelerated approval pathway is usually contingent on a sponsor's agreement to conduct, in a diligent manner, additional
post-approval confirmatory studies to verify and describe the drug's clinical benefit. As a result, a therapeutic candidate
approved on this basis is subject to rigorous post-marketing compliance requirements, including the completion of Phase 4 or
post-approval clinical trials to confirm the effect on the clinical endpoint. Failure to conduct required post-approval studies, or
to confirm the predicted clinical benefit of the product during post-marketing studies, would allow the FDA to withdraw approval of
the drug. All promotional materials for drug products being considered and approved under the accelerated approval program are
subject to prior review by the FDA. Lawmakers, FDA officials, and other stakeholders continually evaluate the accelerated approval
program which may lead to legislative and/or administrative changes in the future.

 Post-Approval
Requirements

 Drugs
manufactured or distributed pursuant to FDA approvals are subject to pervasive and continuing regulation by the FDA, including, among
other things, requirements relating to recordkeeping, periodic reporting, product sampling and distribution, advertising and promotion
and reporting of adverse experiences with the product. After approval, most changes to the approved product, such as adding new indications
or other labeling claims, are subject to prior FDA review and approval. Certain modifications to the product, including changes in indications
or manufacturing processes or facilities, may require the applicant to develop additional data or conduct additional preclinical studies
and clinical trials to support the submission to FDA. As previously noted, there also are continuing, annual user fee requirements for
any marketed products, as well as new application fees for supplemental applications with clinical data.

 The
FDA may impose a number of post-approval requirements as a condition of approval of an NDA. For example, the FDA may require post-marketing
testing, including Phase 4 clinical trials, and surveillance to further assess and monitor the product's safety and effectiveness
after commercialization.

 In
addition, FDA regulations require that products be manufactured in specific approved facilities and in accordance with cGMPs. The cGMP
regulations include requirements relating to the organization of personnel, buildings and facilities, equipment, control of components
and drug product containers and closures, production and process controls, packaging and labeling controls, holding and distribution,
laboratory controls, records and reports and returned or salvaged products. Drug manufacturers and other entities involved in the manufacture
and distribution of approved drugs are required to register their establishments with the FDA and some state agencies and are subject
to periodic unannounced inspections by the FDA for compliance with cGMP requirements and other laws. Changes to the manufacturing process
are strictly regulated and, depending on the significance of the change, may require prior FDA approval before being implemented. FDA
regulations also require investigation and correction of any deviations from cGMP and impose reporting and documentation requirements
upon the sponsor and any third-party manufacturers. Accordingly, manufacturers must continue to expend time, money, and effort in production
and quality control to maintain compliance with cGMP and other aspects of quality control and quality assurance.

 The
FDA strictly regulates the marketing, labeling, advertising and promotion of drug products that are placed on the market. A product cannot
be commercially promoted before it is approved, and approved drugs may generally be promoted only for their approved indications and
for use in patient populations described in the product's approved labeling. Promotional claims must also be consistent with the
product's FDA-approved label, including claims related to safety and effectiveness. The government closely scrutinizes the promotion
of prescription drugs in specific contexts such as direct-to-consumer advertising, industry-sponsored scientific and educational activities,
and promotional activities involving the Internet and social media. Although physicians may prescribe legally available products for
off-label uses, manufacturers may not market or promote such uses.

 Later
discovery of previously unknown problems with a product, including adverse events of unanticipated severity or frequency, or with manufacturing
processes, or failure to comply with regulatory requirements, may result in mandatory revisions to the approved labeling to add new safety
information; imposition of post-market studies or clinical trials to assess new safety risks; or imposition of distribution or other
restrictions under a REMS program. Other potential consequences of regulatory non-compliance include, among other things:

 restrictions
 on, or suspensions of, the marketing or manufacturing of the product, complete withdrawal of the product from the market or product
 recalls;

 interruption
 of production processes, including the shutdown of manufacturing facilities or production lines or the imposition of new manufacturing
 requirements;

 fines,
 warning letters or other enforcement letters or clinical holds on post-approval clinical trials;

 mandated
 modification of promotional materials and labeling and the issuance of corrective information;

 refusal
 of the FDA to approve pending NDAs or supplements to approved NDAs, or suspension or revocation of product approvals;

 product
 seizure or detention, or refusal to permit the import or export of products;

 injunctions
 or the imposition of civil or criminal penalties; or

 consent
 decrees, corporate integrity agreements, debarment, or exclusion from federal healthcare programs.

 In
addition, the distribution of prescription pharmaceutical products is subject to the Prescription Drug Marketing Act ("PDMA")
which regulates the distribution of drugs and drug samples at the federal level and sets minimum standards for the registration and regulation
of drug distributors by the states. Both the PDMA and state laws limit the distribution of prescription pharmaceutical product samples
and impose requirements to ensure accountability in distribution. The Drug Supply Chain Security Act (the "DSCSA"),
was enacted with the aim of building an electronic system to identify and trace certain prescription drugs distributed in the United
States. The DSCSA mandated phased-in and resource-intensive obligations for pharmaceutical
manufacturers, wholesale distributors and dispensers by November 2023, but, so as not to disrupt supply chains, the FDA has granted certain
exemptions from enhanced drug distribution security requirements for eligible trading partners for particular periods of time. From time to time, new legislation and regulations
may be implemented that could significantly change the statutory provisions governing the approval, manufacturing and marketing of products
regulated by the FDA. For example, the FDA released proposed regulations in February 2022 to amend the national standards for licensing
of wholesale drug distributors by the states; establish new minimum standards for state licensing third-party logistics providers; and
create a federal system for licensure for use in the absence of a state program, each of which is mandated by the DSCSA. It is impossible
to predict whether further legislative or regulatory changes will be enacted, or FDA regulations, guidance or interpretations will be
changed or what the impact of such potential changes, if any, may be.

 Regulatory
Exclusivity and Approval of Follow-on Products

 Hatch-Waxman
Exclusivity

 In
addition to enacting Section 505(b)(2) of the FDCA as part of the Hatch-Waxman Amendments to the FDCA, Congress also established an abbreviated
regulatory scheme authorizing the FDA to approve generic drugs that are shown to contain the same active ingredients as, and to be bioequivalent
to, drugs previously approved by the FDA pursuant to NDAs. To obtain approval of a generic drug, an applicant must submit an abbreviated
new drug application ("ANDA") to the agency. An ANDA is a comprehensive submission that contains, among other things, data
and information pertaining to the active pharmaceutical ingredient, bioequivalence, drug product formulation, specifications and stability
of the generic drug, as well as analytical methods, manufacturing process validation data and quality control procedures. ANDAs are "abbreviated"
because they cannot include preclinical and clinical data to demonstrate safety and effectiveness. Instead, in support of such applications,
a generic manufacturer must rely on the preclinical and clinical testing previously conducted for a drug product previously approved
under an NDA, known as the reference listed drug ("RLD").

 In
order for an ANDA to be approved, the FDA must find that the generic version is identical to the RLD with respect to the active ingredients,
the route of administration, the dosage form, the strength of the drug and the conditions of use of the drug. At the same time, the FDA
must also determine that the generic drug is "bioequivalent" to the innovator drug. Under the statute, a generic drug is
bioequivalent to an RLD if "the rate and extent of absorption of the drug do not show a significant difference from the rate and
extent of absorption of the listed drug." Unlike the 505(b)(2) NDA pathway that permits a follow-on applicant to conduct and submit
data from additional clinical trials or nonclinical studies in order to support the proposed change(s) to the reference product, the
ANDA regulatory pathway does not allow applicants to submit new clinical data other than bioavailability or bioequivalence data.

 Upon
approval of an ANDA, the FDA indicates whether the generic product is "therapeutically equivalent" to the RLD in its publication
"Approved Drug Products with Therapeutic Equivalence Evaluations," also referred to as the "Orange Book." Physicians
and pharmacists consider a therapeutic equivalent generic drug to be fully substitutable for the RLD. In addition, by operation of certain
state laws and numerous health insurance programs, the FDA's designation of therapeutic equivalence often results in substitution
of the generic drug without the knowledge or consent of either the prescribing physician or patient.

 As
part of the NDA review and approval process, applicants are required to list with the FDA each patent that has claims that cover the
applicant's product or method of therapeutic use. Upon approval of a new drug, each of the patents listed in the application for
the drug is then published in the Orange Book. Drugs listed in the Orange Book can, in turn, be cited by potential follow-on competitors
in support of approval of an ANDA or 505(b)(2) NDA.

 When
an ANDA applicant submits its application to the FDA, it is required to certify to the FDA concerning any patents listed for the reference
product in the FDA's Orange Book. Specifically, the applicant must certify that: (i) the required patent information has not been
filed; (ii) the listed patent has expired; (iii) the listed patent has not expired but will expire on a particular date and approval
is sought after patent expiration; or (iv) the listed patent is invalid or will not be infringed by the new product. Moreover, to the
extent that the Section 505(b)(2) NDA applicant is relying on studies conducted for an already approved product, the applicant also is
required to certify to the FDA concerning any patents listed for the NDA-approved product in the Orange Book to the same extent that
an ANDA applicant would.

 If
the follow-on applicant does not challenge the innovator's listed patents, the FDA will not approve the ANDA or 505(b)(2) application
until all the listed patents claiming the referenced product have expired. A certification that the new product will not infringe the
already approved product's listed patents, or that such patents are invalid, is called a Paragraph IV certification. If the follow-on
applicant has provided a Paragraph IV certification to the FDA, the applicant must also send notice of the Paragraph IV certification
to the NDA and patent holders once the ANDA has been accepted for filing by the FDA. The NDA and patent holders may then initiate a patent
infringement lawsuit in response to the notice of the Paragraph IV certification. The filing of a patent infringement lawsuit within
45 days of the receipt of a Paragraph IV certification automatically prevents the FDA from approving the ANDA or 505(b)(2) NDA until
the earlier of 30 months, expiration of the patent, settlement of the lawsuit, or a decision in the infringement case that is favorable
to the ANDA or 505(b)(2) applicant.

 An
ANDA or 505(b)(2) application also will not be approved until any applicable non-patent exclusivities listed in the Orange Book for the
referenced product have expired. The Hatch-Waxman Amendments to the FDCA provided a five-year period of non-patent data exclusivity within
the United States to the first applicant to gain approval of an NDA for a new chemical entity ("NCE"). For the purposes of
this provision, an NCE is a drug that contains no active moiety that has previously been approved by the FDA in any other NDA. An active
moiety is the molecule or ion responsible for the physiological or pharmacological action of the drug substance. In cases where such
NCE exclusivity has been granted, an ANDA or 505(b)(2) NDA may not be filed with the FDA until the expiration of five years unless the
submission is accompanied by a Paragraph IV certification, in which case the applicant may submit its application four years following
the original product approval.

 The
FDCA also provides for a period of three years of data exclusivity if an NDA or NDA supplement includes reports of one or more new clinical
investigations, other than bioavailability or bioequivalence studies, that were conducted or sponsored by the applicant are deemed by
the FDA to be essential to the approval of the application. This three-year exclusivity period often protects changes to a previously
approved drug product, such as new indications, dosage forms, route of administration or combination of ingredients. Three-year exclusivity
would be available for a drug product that contains a previously approved active moiety, provided the statutory requirement for a new
clinical investigation is satisfied. Unlike five-year NCE exclusivity, an award of three-year exclusivity does not block the FDA from
accepting ANDAs or 505(b)(2) NDAs seeking approval for generic versions of the drug as of the date of approval of the original drug product;
rather, this three-year exclusivity covers only the conditions of use associated with the new clinical investigations and, as a general
matter, does not prohibit the FDA from approving follow-on applications for drugs containing the original active ingredient.

 Five-year
and three-year exclusivity also will not delay the submission or approval of a traditional NDA filed under Section 505(b)(1) of the FDCA;
however, an applicant submitting a traditional NDA would be required to conduct or obtain a right of reference to all of the preclinical
studies and adequate and well-controlled clinical trials necessary to demonstrate safety and effectiveness.

 Orphan
Drug Designation and Exclusivity

 Under
the Orphan Drug Act, the FDA may grant orphan drug designation to a drug intended to treat a rare disease or condition, which is generally
a disease or condition that affects either (i) fewer than 200,000 individuals in the United States, or (ii) more than 200,000 individuals
in the United States and for which there is no reasonable expectation that the cost of developing and making available in the United
States a drug for this type of disease or condition will be recovered from sales in the United States for that drug. Legislative proposals
are currently being considered that would revise or revoke the second option available for a drug candidate to receive an orphan designation,
the so-called "cost recovery" pathway. Orphan drug designation must be requested before submitting an NDA. After the FDA
grants orphan drug designation, the identity of the therapeutic agent and its potential orphan use will be disclosed publicly by the
FDA; the posting will also indicate whether a drug is no longer designated as an orphan drug.

 More
than one clinical asset may receive an orphan drug designation for the same indication, and the same clinical asset can be designated
for more than one qualified orphan indication. The benefits of orphan drug designation include research and development tax credits and
exemption from FDA prescription drug user fees. Orphan drug designation does not convey any advantage in or shorten the duration of the
regulatory review and approval process if or when an NDA for the drug candidate is filed.

 If
a product that has orphan drug designation subsequently receives the first FDA approval for the indication for which it has such designation,
the product is entitled to orphan product exclusivity, which means that for seven years, the FDA may not approve any other marketing
applications for the same drug for the same indication, except under limited circumstances described further below. Orphan exclusivity
does not block the approval of a different drug for the same rare disease or condition, nor does it block the approval of the same drug
for different conditions. As a result, the FDA can still approve different drugs for use in treating the same indication or disease.
Additionally, if a drug designated as an orphan product receives marketing approval for an indication broader than what was designated,
it may not be entitled to orphan drug exclusivity.

 Orphan
exclusivity will not bar approval of another product with the same drug for the same condition under certain circumstances, including
if a subsequent product with the same drug for the same condition is shown to be clinically superior to the approved product on the basis
of greater efficacy or safety or a major contribution to patient care, or if the company with orphan drug exclusivity cannot assure the
availability of sufficient quantities of the drug to meet the needs of persons with the disease or condition for which the drug was designated.
The FDA is now required to publish a summary of the clinical superiority findings when a drug is eligible for orphan product exclusivity
on the basis of a demonstration of clinical superiority.

 Patent
Term Extension

 A
patent claiming a prescription drug for which FDA approval is granted may be eligible for a limited patent term extension under the FDCA,
which permits a patent restoration of up to five years for patent term lost during product development and the FDA regulatory review
provided that certain statutory and regulatory requirements are met. The length of the patent term extension is related to the length
of time the drug is under regulatory review while the patent is in force. The restoration period granted on a patent covering a new FDA-regulated
medical product is typically one-half the time between the date a clinical investigation on human beings is begun and the submission
date of an application for premarket approval of the product, plus the time between the submission date of an application for approval
of the product and the ultimate approval date. Patent term restoration cannot be used to extend the remaining term of a patent past a
total of 14 years from the product's approval date. Only one patent applicable to an approved drug product is eligible for the
extension, and the application for the extension must be submitted prior to the expiration of the patent in question. A patent that covers
multiple products for which approval is sought can only be extended in connection with one of the marketing approvals. The USPTO reviews
and approves the application for any patent term extension or restoration in consultation with the FDA.

 Other
U.S. Healthcare Laws and Regulations

 Manufacturing,
sales, promotion, and other activities following product approval may also be subject to regulation by other regulatory authorities in
the United States in addition to the FDA. Depending on the nature of the product, those authorities may include the Centers for Medicare
and Medicaid Services ("CMS"), other divisions of the Department of Health and Human Services ("HHS"), the Department
of Justice, the Drug Enforcement Administration, the Federal Trade Commission, the Occupational Safety and Health Administration, and
state and local governments.

 For
example, in the United States, sales and marketing for prescription biopharmaceutical products must comply with state and federal fraud
and abuse laws. These laws include the federal Anti-Kickback Statute, which makes it illegal for any person, including a prescription
drug manufacturer (or a party acting on its behalf), to knowingly and willfully solicit, receive, offer or pay any remuneration that
is intended to induce or reward referrals, including the purchase, recommendation, order or prescription of a particular drug, for which
payment may be made under a federal healthcare program, such as Medicare or Medicaid. Violations of this law are punishable by up to
ten years in prison, criminal fines, administrative civil money penalties and exclusion from participation in federal healthcare programs.
In addition, the Patient Protection and Affordable Care Act, or ACA, among other things, amended the intent requirement of the federal
Anti-Kickback Statute and two of the five criminal healthcare fraud statutes created by the Health Insurance Portability and Accountability
Act of 1996, or HIPAA. A person or entity no longer needs to have actual knowledge of these two provisions in the statute or specific
intent to violate them; specifically with respect to the prohibition on executing or attempting to execute a scheme or artifice to defraud
or to fraudulently obtain money or property of any healthcare benefit program and the prohibition on disposing of assets to enable a
person to become eligible for Medicaid. Moreover, the government may now assert that a claim including items or services resulting from
a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the False Claims Act.

 Pricing
and rebate programs must comply with the Medicaid rebate requirements of the U.S. Omnibus Budget Reconciliation Act of 1990 and more
recent requirements in the ACA. If products are made available to authorized users of the Federal Supply Schedule of the General Services
Administration, additional laws and requirements apply. There also are federal transparency requirements under the Physician Payments
Sunshine Act that require manufacturers of FDA-approved drugs, devices, biologics and medical supplies covered by Medicare or Medicaid
to report, on an annual basis, to CMS information related to payments and other transfers of value to physicians, teaching hospitals,
and certain advanced non-physician healthcare practitioners and physician ownership and investment interests. Prescription drug products
also must meet applicable child-resistant packaging requirements under the U.S. Poison Prevention Packaging Act.

 Manufacturing,
sales, promotion, and other activities also are potentially subject to federal and state consumer protection and unfair competition laws.
Some state laws require pharmaceutical companies to comply with the pharmaceutical industry's voluntary compliance guidelines,
or the relevant compliance guidance promulgated by the federal government, in addition to requiring drug manufacturers to report information
related to payments to physicians and other healthcare providers or marketing expenditures to the extent that those laws impose requirements
that are more stringent than the Physician Payments Sunshine Act. State and foreign laws also govern the privacy and security of health
information in some circumstances, many of which differ from each other in significant ways and often are not preempted by HIPAA, thus
complicating compliance efforts.

 The
failure to comply with any of these laws or regulatory requirements subjects firms to possible legal or regulatory action. Depending
on the circumstances, failure to meet applicable regulatory requirements can result in criminal prosecution, fines or other penalties,
injunctions, requests for recall, seizure of products, total or partial suspension of production, denial or withdrawal of product approvals
or refusal to allow a firm to enter into supply contracts, including government contracts.

 Government
Regulation Outside the U.S.

 In
addition to regulations in the United States, we will be subject to a variety of foreign regulations that govern, among other things,
clinical trials and any commercial sales and distribution of our products, if approved, either directly or through distribution partners.
Whether or not we obtain FDA approval for a product candidate, we must obtain the requisite approvals from regulatory authorities in
foreign countries or economic areas, such as the European Union and the United Kingdom, among other foreign countries, before we may
commence clinical trials or market products in those countries or areas. The foreign regulatory approval process includes all of the
risks associated with the FDA approval described above, and the time required to obtain approval in other countries and jurisdictions
might differ from and be longer than that required to obtain FDA approval. Some foreign jurisdictions have a drug product approval process
similar to that in the U.S., which requires the submission of a clinical trial application much like the IND prior to the commencement
of clinical studies. In Europe, for example, a clinical trial application, or CTA, must be submitted to each country's national
health authority and an independent ethics committee, much like the FDA and IRB, respectively. Once the CTA is approved in accordance
with a country's requirements, clinical trial development may proceed. To obtain regulatory approval of a medicinal product candidate
under European Union regulatory systems, we would be required to submit a Marketing Authorisation Application, or MAA, which is similar
to the NDA, except that, among other things, there are country-specific document requirements. For countries outside of the European
Union, such as countries in Eastern Europe, Latin America or Asia, and recently the United Kingdom, the requirements governing the conduct
of clinical trials, product approval, pricing and reimbursement vary from country to country. Regulatory approval in one country or jurisdiction
does not ensure regulatory approval in another, but a failure or delay in obtaining regulatory approval in one country or jurisdiction
may negatively impact the regulatory process in others. Moreover, some nations may not accept clinical studies performed for U.S. approval
to support approval in their countries or require that additional studies be performed on natives of their countries. In addition, in
certain foreign markets, the pricing of drug products is subject to government control and reimbursement may in some cases be unavailable
or insufficient. If we fail to comply with applicable foreign regulatory requirements, we may be subject to, among other things, fines,
suspension or withdrawal of regulatory approvals, product recalls, seizure of products, operating restrictions, and criminal prosecution.

 As
of January 31, 2020, the United Kingdom is no longer a member state of the European Union, and therefore a separate marketing authorization
application and approval will be required to market a medicinal product in the U.K. The Medicines and Healthcare products Regulatory
Agency, or the MHRA, is the U.K.'s standalone pharmaceutical regulator.

Trials and Regulation of Medicinal Products in Europe

 As
in the United States, medicinal products can be marketed in the European Union only if a marketing authorization from the competent regulatory
agencies has been obtained. Similar to the United States, the various phases of preclinical and clinical research in the European Union
are subject to significant regulatory controls.

 Pursuant
to the European Clinical Trials Directive, a system for the approval of clinical trials in the European Union has been implemented through
national legislation of the member states. Under this system, an applicant must obtain approval from the competent national authority
of a European Union member state in which the clinical trial is to be conducted. Furthermore, the applicant may only start a clinical
trial after a competent ethics committee has issued a favorable opinion. Clinical trial applications must be accompanied by an investigational
medicinal product dossier with supporting information prescribed by the European Clinical Trials Directive and corresponding national
laws of the member states and further detailed in applicable guidance documents. In April 2014, the new Clinical Trials Regulation, (EU)
No 536/2014 (Clinical Trials Regulation) was adopted and became effective on January 31, 2022. The Clinical Trials Regulation is directly
applicable in all the European Union Member States, repealing the prior Clinical Trials Directive 2001/20/EC. The extent to which ongoing
clinical trials will be governed by the Clinical Trials Regulation will depend on the duration of the individual clinical trial; if a
clinical trial continues for more than three years from the day on which the Clinical Trials Regulation becomes applicable the Clinical
Trials Regulation will at that time begin to apply to the clinical trial.

 The
new Clinical Trials Regulation aims to simplify and streamline the approval of clinical trials in the European Union. The main characteristics
of the regulation include: a streamlined application procedure via a single entry point; a single set of documents to be prepared and
submitted for the application as well as simplified reporting procedures for clinical trial sponsors; and a harmonized procedure for
the assessment of applications for clinical trials.

 To
obtain marketing approval of a drug in the European Union, an applicant must submit a MAA either under a centralized or decentralized
procedure. The centralized procedure provides for the grant of a single marketing authorization by the European Commission that is valid
for all European Union member states, Iceland, Lichtenstein and Norway. The centralized procedure is compulsory for specific products,
including for medicines produced by certain biotechnological processes, products designated as orphan medicinal products, advanced therapy
products (such as gene-therapy, somatic cell-therapy or tissue-engineered medicines) and products with a new active substance indicated
for the treatment of certain disorders. For products with a new active substance indicated for the treatment of certain disorders and
products that are highly innovative or for which a centralized process is in the interest of patients, the centralized procedure may
be optional. Under the centralized procedure the maximum timeframe for the evaluation of an MAA by the European Medicines Agency ("EMA")
is 210 days, excluding clock stops, when additional written or oral information is to be provided by the applicant in response to questions
asked by the Committee for Medicinal Products for Human Use ("CHMP"). Accelerated assessment might be granted by the CHMP
in exceptional cases, when a medicinal product is expected to be of a major public health interest, particularly from the point of view
of therapeutic innovation. The timeframe for the evaluation of an MAA under the accelerated assessment procedure is of 150 days, excluding
stop-clocks.

 The
decentralized procedure is available to applicants who wish to market a product in specific European Union member states where such product
has not received marketing approval in any European Union member states before. The decentralized procedure provides for an applicant
to apply to one-member state to assess the application (the reference member state) and specifically list other member states in which
it wishes to obtain approval (concerned member states).

 In
the European Union, only products for which marketing authorizations have been granted may be promoted. A marketing authorization is
valid for five years in principle and the marketing authorization may be renewed after five years on the basis of a re-evaluation of
the risk-benefit balance by the EMA or by the competent authority of the authorizing member state. To this end, the marketing authorization
holder must provide the EMA or the competent authority with a consolidated version of the file in respect of quality, safety and efficacy,
including all variations introduced since the marketing authorization was granted, at least six months before the marketing authorization
ceases to be valid. Once renewed, the marketing authorization is valid for an unlimited period, unless the European Commission or the
competent authority decides, on justified grounds relating to pharmacovigilance, to proceed with one additional five-year renewal. Any
authorization which is not followed by the actual placing of the drug on the European Union market (in case of centralized procedure)
or on the market of the authorizing member state within three years after authorization ceases to be valid (the so-called sunset clause).

 Moreover,
even if authorized to be marketed in the European Union, prescription medicines may only be promoted to healthcare professionals, not
the general public. All promotion should be in accordance with the particulars listed in the summary of product characteristics. Promotional
materials must also comply with various laws, and codes of conduct developed by pharmaceutical industry bodies in the European Union
which govern (among other things) the training of sales staff, promotional claims and their justification, comparative advertising, misleading
advertising, endorsements, and (where permitted) advertising to the general public. Failure to comply with these requirements could lead
to the imposition of penalties by the competent authorities of the European Union member states. The penalties could include warnings,
orders to discontinue the promotion of the drug product, seizure of promotional materials, fines and possible imprisonment.

 Regulation
of New Drugs in the United Kingdom

 The
United Kingdom left the European Union on January 31, 2020 (commonly referred to as "Brexit"), with a transitional period
that expired on December 31, 2020. The United Kingdom and the European Union entered into a trade agreement known as the Trade and Cooperation
Agreement, which went into effect on January 1, 2021. We are currently evaluating the potential
impacts on our business of the Trade and Cooperation Agreement and guidance issued to date by the United Kingdom's MHRA regarding
the requirements for licensing and marketing medicinal products in the United Kingdom.

 Since
the regulatory framework for pharmaceutical products in the United Kingdom covering the quality, safety and efficacy of pharmaceutical
products, clinical trials, marketing authorization, commercial sales and distribution of medicinal products has only recently changed,
it is difficult to draw comparisons about the impact of the new regulatory regime and impact on the approval of product candidates in
the United Kingdom. In addition, even if a drug is licensed in the UK by the MHRA, it must further be approved by the National Institute
for Health & Care Excellence to ensure use within the UK's National Health Service (NHS).

 Pharmaceutical
Coverage, Pricing and Reimbursement, and Healthcare Reform

 Sales
of our products, if approved for marketing, will depend, in part, on the availability and extent of coverage and reimbursement by third-party
payors, such as government health programs, including Medicare and Medicaid, commercial insurance and managed healthcare organizations.
These third-party payors are increasingly challenging the price and limiting the coverage and reimbursement amounts for medical products
and services. There may be significant delays in obtaining coverage and reimbursement for approved products, and coverage may be more
limited than the purposes for which the product is approved by the FDA or regulatory authorities in other countries. It is time-consuming
and expensive to seek reimbursement from third-party payors. Moreover, eligibility for reimbursement does not imply that any product
will be paid for in all cases or at a rate that covers our costs, including research, development, manufacture, sale and distribution.
Interim payments for new products, if applicable, may also not be sufficient to cover our costs and may not be made permanent. Payment
rates may vary according to the use of the product and the clinical setting in which it is used, may be based on payments allowed for
lower-cost products that are already reimbursed and may be incorporated into existing payments for other services. Net prices for products
may be reduced by mandatory discounts or rebates required by third-party payors and by any future relaxation of laws that presently restrict
imports of products from countries where they may be sold at lower prices than in the United States. In the United States, third-party
payors often rely upon Medicare coverage policy and payment limitations in setting their own reimbursement policies, but they also have
their own methods and approval process apart from Medicare coverage and reimbursement determinations. Accordingly, one third-party payor's
determination to provide coverage for a product does not assure that other payors will also provide coverage for the product.

 In
addition, the containment of healthcare costs has become a priority for federal and state governments, and the prices of drugs have been
a focus in this effort. The U.S. government, state legislatures and foreign governments have shown significant interest in implementing
cost-containment programs, including price controls, restrictions on coverage and reimbursement, and requirements for substitution of
generic products. Adoption of price controls and cost-containment measures, and adoption of more restrictive policies in jurisdictions
with existing controls and measures, could further limit our net revenue and results. Decreases in third-party reimbursement for our
clinical assets or a decision by a third-party payor to not cover our clinical assets could reduce physician usage of the clinical asset
and have a material adverse effect on our sales, results of operations and financial condition. Moreover, there has been heightened governmental
scrutiny over the manner in which manufacturers set prices for their marketed products, which has resulted in several Congressional inquiries
and proposed and enacted federal and state legislation designed to, among other things, bring more transparency to product pricing, review
the relationship between pricing and manufacturer patient programs, and reform government program reimbursement methodologies for drug
products. Individual states in the United States have also increasingly passed legislation and implemented regulations designed to control
pharmaceutical product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access
and marketing cost disclosure and transparency measures, and, in some cases, designed to encourage importation from other countries and
bulk purchasing. In December 2020, the U.S. Supreme Court held unanimously that federal law does not preempt the states' ability
to regulate pharmaceutical benefit managers ("PBMs") and other members of the healthcare and pharmaceutical supply chain,
an important decision that has led to further and more aggressive efforts by states in this area.

 On August 16, 2022, President
Biden signed into the law the Inflation Reduction Act of 2022, or the IRA. Among other things, the IRA has multiple provisions that can
impact the prices of drug products that are both sold into the Medicare program and throughout the United States. Beginning in 2023, a
manufacturer of drugs covered by Medicare Parts B or D must pay a rebate to the federal government if their drug product's price
increases faster than the rate of inflation. This calculation is made on a drug product by drug product basis and the amount of the rebate
owed to the federal government is directly dependent on the volume of a drug product that is paid for by Medicare Parts B or D. Additionally,
starting for payment year 2026, CMS will negotiate drug prices annually for a select number of single source Part D drugs without generic
or biosimilar competition. CMS will also negotiate drug prices for a select number of Part B drugs starting for payment year 2028. If
a drug product is selected by CMS for negotiation, it is expected that the revenue generated from such drug will decrease.

 In
addition, in some foreign countries, the proposed pricing for a drug must be approved before it may be lawfully marketed. The requirements
governing drug pricing vary widely from country to country. For example, in the European Union, the sole legal instrument at the European
Union level governing the pricing and reimbursement of medicinal products is Council Directive 89/105/EEC (the "Price Transparency
Directive"). The aim of the Price Transparency Directive is to ensure that pricing and reimbursement mechanisms established in
the European Union Member States are transparent and objective, do not hinder the free movement of and trade in medicinal products in
the European Union, and do not hinder, prevent or distort competition on the market. The Price Transparency Directive does not provide
any guidance concerning the specific criteria on the basis of which pricing and reimbursement decisions are to be made in the individual
European Union Member States, nor does it have any direct consequence for pricing or reimbursement levels in the individual European
Union Member States. The European Union Member States are free to restrict the range of medicinal products for which their national health
insurance systems provide reimbursement, and to control the prices and/or reimbursement levels of medicinal products for human use. A
European Union Member State may approve a specific price or level of reimbursement for the medicinal product, or alternatively adopt
a system of direct or indirect controls on the profitability of the company responsible for placing the medicinal product on the market,
including volume-based arrangements, caps and reference pricing mechanisms.

 Health
Technology Assessment ("HTA") of medicinal products is becoming an increasingly common part of the pricing and reimbursement
procedures in some European Union Member States, including France, Germany, Ireland, Italy and Sweden. The HTA process in the European
Union Member States is governed by the national laws of these countries. HTA is the procedure according to which the assessment of the
public health impact, therapeutic impact, and the economic and societal impact of the use of a given medicinal product in the national
healthcare systems of the individual country is conducted. HTA generally focuses on the clinical efficacy and effectiveness, safety,
cost, and cost-effectiveness of individual medicinal products as well as their potential implications for the healthcare system. Those
elements of medicinal products are compared with other treatment options available on the market. The outcome of HTA regarding specific
medicinal products will often influence the pricing and reimbursement status granted to these medicinal products by the competent authorities
of individual European Union Member States. The extent to which pricing and reimbursement decisions are influenced by the HTA of the
specific medicinal product vary between the European Union Member States. For example, European Union Member States that have not yet
developed HTA mechanisms could rely to some extent on the HTA performed in countries with a developed HTA framework when adopting decisions
concerning the pricing and reimbursement of a specific medicinal product.

 Separately
from cost containment efforts, in the United States and some foreign jurisdictions, there also have been, and continue to be, several
legislative and regulatory changes and proposed changes regarding the healthcare system that could prevent or delay marketing approval
of product candidates or restrict or regulate post-approval activities. The FDA's and other regulatory authorities' policies
may change, and additional government regulations may be enacted that could prevent, limit or delay regulatory approval of our current
or future product candidates.

 Data
Privacy and the Protection of Personal Information

 We
are subject to laws and regulations governing data privacy and the protection of personal information including health information. The
legislative and regulatory landscape for privacy and data protection continues to evolve, and there has been an increasing focus on privacy
and data protection issues which will continue to affect our business. In the United States, we may be subject to state security breach
notification laws, state laws protecting the privacy of health and personal information and federal and state consumer protections laws
that regulate the collection, use, disclosure and transmission of personal information. These laws overlap and often conflict and each
of these laws is subject to varying interpretations by courts and government agencies, creating complex compliance issues. If we fail
to comply with applicable laws and regulations we could be subject to penalties or sanctions, including criminal penalties. Our customers
and research partners must comply with laws governing the privacy and security of health information, including HIPAA and state health
information privacy laws. If we knowingly obtain health information that is protected under HIPAA, called "protected health information,"
our customers or research collaborators may be subject to enforcement, and we may have direct liability for the unlawful receipt of protected
health information or for aiding and abetting a HIPAA violation.

 State
laws protecting health and personal information are becoming increasingly stringent. For example, California has implemented the California
Confidentiality of Medical Information Act that imposes restrictive requirements regulating the use and disclosure of health information
and other personally identifiable information, and California has recently adopted the California Consumer Privacy Act of 2018 ("CCPA").
The CCPA mirrors a number of the key provisions of the EU General Data Protection Regulation ("GDPR") described below. The
CCPA establishes a new privacy framework for covered businesses by creating an expanded definition of personal information, establishing
new data privacy rights for consumers in the State of California, imposing special rules on the collection of consumer data from minors,
and creating a new and potentially severe statutory damages framework for violations of the CCPA and for businesses that fail to implement
reasonable security procedures and practices to prevent data breaches. Since passage of the CCPA, several other states (Connecticut,
Colorado, Virginia, and Utah) have also enacted comprehensive consumer privacy laws that include key differences from California's
law, further complicating compliance by industry and other stakeholders. Other states in the U.S. are considering privacy laws similar
to the CCPA.

 In
Europe, the GDPR went into effect in May 2018, implementing a broad data protection framework that expanded the scope of European Union
data protection law, including to non- European Union entities that process, or control the processing of, personal data relating to
individuals located in the European Union, including clinical trial data. The GDPR sets out a number of requirements that must be complied
with when handling the personal data of European Union-based data subjects including: providing expanded disclosures about how their
personal data will be used; higher standards for organizations to demonstrate that they have obtained valid consent or have another legal
basis in place to justify their data processing activities; the obligation to appoint data protection officers in certain circumstances;
new rights for individuals to be "forgotten" and rights to data portability, as well as enhanced current rights (e.g. access
requests); the principal of accountability and demonstrating compliance through policies, procedures, training and audit; and a new mandatory
data breach regime. In particular, medical or health data, genetic data and biometric data where the latter is used to uniquely identify
an individual are all classified as "special category" data under the GDPR and afforded greater protection and require additional
compliance obligations. Further, European Union member states have a broad right to impose additional conditions – including restrictions
– on these data categories. This is because the GDPR allows European Union member states to derogate from the requirements of the
GDPR mainly in regard to specific processing situations (including special category data and processing for scientific or statistical
purposes). As the European Union states continue to reframe their national legislation to harmonize with the GDPR, we will need to monitor
compliance with all relevant European Union member states' laws and regulations, including where permitted derogations from the
GDPR are introduced. We will also be subject to evolving European Union laws on data export, if we transfer data outside the European
Union to ourselves or third parties outside of the European Union.

 The EU GDPR is an EU Regulation
and it no longer applies to the UK. If you operate inside the UK, you need to comply with the Data Protection Act 2018 (DPA 2018). The
provisions of the EU GDPR have been incorporated directly into UK law as the UK GDPR. On 28 June 2021, the EU approved adequacy decisions
for the EU GDPR and the Law Enforcement Directive (LED). This means data can continue to flow freely from the EU to the UK, in the majority
of cases.

 The
Cayman Islands Government enacted the Data Protection Act on May 18, 2017 (as amended, the "DPA"). The DPA regulates the
processing of personal data in the Cayman Islands. Under the DPA, the Company is a "data controller" and the Company's
affiliates and/or its delegates may be "data processors" (or, in some circumstances, data controllers in their own right),
in respect of such personal data.

 U.S.
Foreign Corrupt Practices Act and Anti-bribery Regulations

 In
general, the Foreign Corrupt Practices Act of 1977, as amended, or the FCPA, prohibits offering to pay, paying, promising to pay, or
authorizing the payment of money or anything of value to a foreign official in order to influence any act or decision of the foreign
official in his or her official capacity or to secure any other improper advantage in order to obtain or retain business for or with,
or in order to direct business to, any person. The prohibitions apply not only to payments made to "any foreign official,"
but also to those made to "any foreign political party or official thereof," to "any candidate for foreign political
office" or to any person, while knowing that all or a portion of the payment will be offered, given, or promised to anyone in any
of the foregoing categories. "Foreign officials" under the FCPA include officers or employees of a department, agency, or
instrumentality of a foreign government. The term "instrumentality" is broad and can include state-owned or state-controlled
entities. Importantly, United States authorities deem most healthcare professionals and other employees of foreign hospitals, clinics,
research facilities and medical schools in countries with public healthcare and/or public education systems to be "foreign officials"
under the FCPA. When we interact with foreign healthcare professionals and researchers in testing and marketing our products abroad,
should any of our product candidates receive foreign regulatory approval in the future, we must have policies and procedures in place
sufficient to prevent us and agents acting on our behalf from providing any bribe, gift or gratuity, including excessive or lavish meals,
travel or entertainment in connection with marketing our products and services or securing required permits and approvals. The FCPA also
obligates companies whose securities are listed in the United States to comply with accounting provisions requiring us to maintain books
and records that accurately and fairly reflect all transactions of the corporation, including international subsidiaries, and to devise
and maintain an adequate system of internal accounting controls for international operations.

 We
are also subject to U.K. Bribery Act of 2010, which prohibits both domestic and international bribery, as well as bribery across both
private and public sectors. In addition, an organization that "fails to prevent bribery" committed by anyone associated with
the organization can be charged under the U.K. Bribery Act unless the organization can establish the defense of having implemented "adequate
procedures" to prevent bribery. As we expand our operations, we are likely to be subject to additional laws and restrictions relating
to anti-bribery.

 Environmental,
Health, and Safety Regulation

 We
are subject to numerous federal, state, and local environmental, health, and safety ("EHS") laws and regulations relating
to, among other matters, safe working conditions, product stewardship, environmental protection, and handling or disposition of products,
including those governing the generation, storage, handling, use, transportation, release, and disposal of hazardous or potentially hazardous
materials, medical waste, and infectious materials that may be handled by our partner research laboratories. Some of these laws and regulations
also require us to obtain licenses or permits to conduct our operations. If we fail to comply with such laws or obtain and comply with
the applicable permits, we could face substantial fines or possible revocation of our permits or limitations on our ability to conduct
our operations. Certain of our development and manufacturing activities may involve, from time to time, use of hazardous materials, and
we believe we are in compliance with the applicable environmental laws, regulations, permits, and licenses. However, we cannot ensure
that EHS liabilities will not develop in the future. EHS laws and regulations are complex, change frequently and have tended to become
more stringent over time. Although the costs to comply with applicable laws and regulations, have not been material, we cannot predict
the impact on our business of new or amended laws or regulations or any changes in the way existing and future laws and regulations are
interpreted or enforced, nor can we ensure we will be able to obtain or maintain any required licenses or permits.

 Employees

 As
of December 31, 2024, we had a total of six full-time employees.

 We
currently rely on several consultants who provide services to our Company. None of our employees are represented by a labor union or
covered by collective bargaining agreements. We consider our relationship with our employees to be good. We anticipate that the number
of employees will increase as we continue to develop the assets in our pipeline and other clinical assets that we seek to develop. Additionally,
we utilize and expect to continue to utilize clinical research organizations and third parties to perform our pre-clinical studies, clinical
studies, and manufacturing.

 Corporate
Information

 We
were incorporated under the name "Murphy Canyon Acquisition Corp." in October 2021 under the laws of the State of Delaware
for the purpose of effecting a merger, capital stock exchange, asset acquisition, stock purchase, reorganization or similar business
combination with one or more businesses. We changed our name to "Conduit Pharmaceuticals Inc." in connection with the completion
of the Business Combination in September 2023.

 Our
principal executive offices are located at 4581 Tamiami Trail North, Suite 200 Naples, Florida. Our telephone number is +1 (646)-491-9132,
and our website can be found at

 Item
1A. Risk Factors

 An
investment in our securities involves a high degree of risk. Investors should carefully consider the risks described below before making
an investment decision. Our business, prospects, financial condition, or operating results could be harmed by any of these risks, as
well as other risks not currently known to us or that we currently consider immaterial. The trading price of our securities could decline
due to any of these risks, and, as a result, stockholders may lose all or part of their investment. Certain statements in "Risk
Factors" are forward-looking statements. See "Cautionary Statement Regarding Forward-Looking Statements."

 Risks
Related to Our Business and Industry

 We
have incurred significant net losses since our inception and we anticipate future losses and negative cash flow. It is uncertain if or
when we will become profitable.

 We
have incurred net losses since our inception. Our net losses were $17.8 million for the year ended December 31, 2024 and $0.5 million
for the year ended December 31, 2023. As of December 31, 2024, we had an accumulated deficit of $29.1 million. We do not expect to generate
any significant revenues, if any, until we successfully complete adequate development of our first clinical asset. As of December 31,
2024, our clinical assets are still in development and have not been approved by the FDA or any other regulatory body.

 We
have not yet demonstrated our ability to generate revenue, and we may never be able to produce revenues or operate on a profitable basis.
We expect to experience operating losses and negative cash flow for the foreseeable future. Even if we are able to commercialize our
technology, which may include licensing, we may never recover our research and development expenses.

 Our
business is dependent on the successful development, regulatory approval, and commercialization of our clinical assets, in particular
a glucokinase activator which we believe is active in a range of autoimmune disorders, which we refer to as AZD1656, and a potent, irreversible
inhibitor of human Myeloperoxidase that has the potential to treat idiopathic male infertility, which we refer to as AZD5904.

 The
success of our business, including our ability to finance our operations and generate any revenue in the future, will primarily depend
on the successful development, regulatory approval, and commercialization or partnering of our clinical assets. In the future, we may
also become dependent on just one of our clinical assets or any future clinical assets that we may in-license, acquire, or develop. The
preclinical, clinical and commercial success of our clinical assets will depend on a number of factors, including the following:

 the
 ability to raise additional capital to fund our current pre-clinical and clinical plans on acceptable terms, or at all;

 the
 timely completion of our clinical trials, which may be significantly slower or cost more than we currently anticipate and will depend
 substantially upon the performance of third-party contractors;

 we are required by the FDA or similar foreign regulatory agencies to conduct additional preclinical or clinical trials beyond those
 planned to support the approval and commercialization of our clinical assets or any future clinical assets;

 the
 acceptance of our proposed indications and primary endpoint assessments relating to the proposed indications of our clinical assets
 by the FDA or similar foreign regulatory authorities;

 our
 ability to demonstrate the safety and efficacy of our clinical assets or any future clinical assets to the satisfaction of the FDA
 and similar foreign regulatory authorities;

 the
 prevalence, duration, and severity of potential side effects experienced in connection with our clinical assets or future approved
 products, if any;

 the
 timely receipt of necessary marketing approvals from the FDA and similar foreign regulatory authorities;

 achieving
 and maintaining, and, where applicable, ensuring that our third-party contractors achieve and maintain, compliance with our contractual
 obligations and with all regulatory requirements applicable to our clinical assets or any future clinical assets or approved products,
 if any;

 the
 ability of third parties with whom we contract to manufacture clinical trial and commercial supplies of our clinical assets or any
 future clinical assets, remain in good standing with regulatory agencies, and develop, validate, and maintain commercially viable
 manufacturing processes that are compliant with cGMP;

 a
 continued acceptable safety profile during preclinical and clinical development and following approval of our clinical assets or
 any future clinical assets;

 our
 ability to successfully commercialize our clinical assets or any future clinical assets in the U.S. and internationally, if approved
 for marketing, sale, and distribution in such countries and territories, whether alone or in collaboration with others;

 the
 acceptance by physicians, patients, and payors of the benefits, safety, and efficacy of our clinical assets or any future clinical
 assets, if approved, including relative to alternative and competing treatments;

 our
 ability to comply with numerous post-approval regulatory requirements;

 our
 and our partners' ability to establish and enforce intellectual property rights in and to our clinical assets or any future
 clinical assets;

 our
 and our partners' ability to avoid third-party patent interference or intellectual property infringement claims; and

 our
 ability to in-license or acquire additional clinical assets or commercial-stage products that we believe that we can successfully
 develop and commercialize.

 If
we are unable to achieve one or more of the above factors, many of which are beyond our control, in a timely manner or at all, we could
experience significant delays and increased costs or an inability to obtain regulatory approvals or commercialize our clinical assets.
Even if regulatory approvals are obtained, we may never be able to successfully commercialize any of our clinical assets. Accordingly,
we cannot assure investors that we will be able to generate sufficient revenue through the sale of our clinical assets or any future
clinical assets to continue operations.

 There is substantial
doubt regarding our ability to continue as a going concern. We will need to raise additional funding, which may not be available on acceptable
terms, or at all. Failure to obtain this necessary capital when needed may force us to delay, limit or terminate our commercial programs,
product development efforts or other operations.

 The report of our independent registered public accounting
firm on the Company's financial statements as of and for the year ended December 31, 2024, includes an explanatory paragraph indicating
that there is substantial doubt about our ability to continue as a going concern for at least one year from the date of filing. Through
the date of the Business Combination, Old Conduit financed its working capital requirements by raising capital through private placements
of its ordinary shares and issuing of short-term and convertible notes. The Company has financed its working capital requirements since
the Business Combination primarily through the PIPE Financing (the "PIPE Financing") completed in September 2023, and through
issuing of short-term and convertible notes.

 We will need to raise additional funding, which may
not be available on acceptable terms, or at all. Failure to obtain this necessary capital when needed may force us to delay, limit or
terminate our commercial programs, product development efforts or other operations. We do not expect to generate meaningful product revenues
in the foreseeable future. Based on our current business plan as of the date of our consolidated financial statements appearing elsewhere
in this Annual Report on Form 10-K, there is substantial doubt regarding our ability to continue as a going concern. We will need to raise
additional funding in order to execute on our current business plans and strategy, including prior to becoming profitable.

 Our efforts to raise additional funding may divert
our management from their day-to-day activities, which may adversely affect our ability to develop our products. In addition, we cannot
guarantee that financing will be available in sufficient amounts or on terms acceptable to us, if at all. Moreover, the terms of any financing
may adversely affect the holdings or the rights of our stockholders and the issuance of additional securities, whether equity or debt,
by us, or the possibility of such issuance, may cause the market price of our shares to decline. The sale of additional equity or convertible
securities would dilute all of our stockholders. The incurrence of indebtedness would result in increased fixed payment obligations, and
we may be required to agree to certain restrictive covenants, such as limitations on our ability to incur additional debt, limitations
on our ability to acquire, sell or license intellectual property rights and other operating restrictions that could adversely impact our
ability to conduct our business. We could also be required to seek funds through arrangements with collaborative partners or otherwise
at an earlier stage than otherwise would be desirable and we may be required to relinquish rights to some of our technologies or product
candidates or otherwise agree to terms unfavorable to us, any of which may have a material adverse effect on our business, operating results
and prospects.

 Moreover, as a result of recent volatile market conditions,
the cost and availability of capital has been and may continue to be adversely affected. Concern about the stability of the banking sector
has generally led many lenders and institutional investors to reduce, and in some cases, cease to provide credit to businesses and consumers.
Continued turbulence in the U.S. market and economy may adversely affect our liquidity and financial condition, including our ability
to access the capital markets to meet liquidity needs.

 If we are unable to obtain funding on a timely basis,
or if revenues from collaboration arrangements are less than we have projected, we may be required to further revise our business plan
and strategy, which may result in us significantly curtailing, delaying or discontinuing one or more of our research or development programs
or may result in our being unable to expand our operations or otherwise capitalize on our business opportunities. As a result, our business,
financial condition and results of operations could be materially affected.

 As
a result of our limited operating history, we may not be able to correctly estimate, operating expenses, need for investment capital,
or stability of operations, which could lead to cash shortfalls.

 We
have a limited operating history from which to evaluate our business. As a result, our historical financial data is of limited value
in estimating future operating expenses. We have not obtained regulatory approvals for any of our clinical assets. Therefore, our budgeted
operating expense levels are based in part on our expectations concerning the FDA approval process and expenses related to development
of other clinical assets. Failing to reach our short-term developmental milestones within anticipated timelines due to serious adverse or unacceptable side effects caused by our clinical assets, or other events, many of which
may be beyond our control, may cause our financial condition and operating results to continue to fluctuate significantly from quarter
to quarter and year to year.

 Preclinical
drug development for our clinical assets (AZD1656 and AZD5904) is expensive, time-consuming, and uncertain. Our preclinical trials may
fail to adequately demonstrate pharmacologic activity in therapeutic areas of interest; cause unintended short- or long-term effects
in other bodily systems; or produce unexpected toxicity that may alter or risk benefit assessment.

 The
scientific discoveries that form the basis for our efforts to generate and develop our clinical assets are relatively recent. AZD1656
is a glucokinase activator that is in a number of Phase II ready autoimmune disorders including uveitis, Hashimoto's thyroiditis,
preterm labor, and renal transplant, and the successful development of AZD1656 may require additional studies and efforts to optimize
its therapeutic potential. In addition, our development pipeline includes what we believe to be a potent irreversible inhibitor of human
Myeloperoxidase (MPO) that has the potential to treat idiopathic male infertility, which we refer to as AZD5904. AZD5904 may not demonstrate
in patients the therapeutic properties ascribed to it in the laboratory or preclinical studies, and may interact with human biological
systems in unforeseen, ineffective, or even harmful ways. If we are not able to successfully develop and commercialize our clinical assets,
including AZD1656 and AZD5904, we may never become profitable and the value of our capital stock may decline.

 It
is difficult to predict the time and cost of development and of subsequently obtaining regulatory approval for AZD1656 as it employs
newly developed technology.

uses a novel mechanism to reduce inflammation in many of the immune pathways. We have concentrated our research and development efforts
of AZD1656 on a limited number of initial targeted disease indications for AZD1656. There can be no assurance that we will not experience
problems or delays in developing our current or future indications for AZD1656 and that such problems or delays will not cause unanticipated
costs, or that any such development problems can be solved. Moreover, AZD1656 would also represent a novel approach for the treatment
of uveitis as steroids are currently the most common treatment for uveitis even though there are numerous side effects associated with
the use of steroids. The clinical development of these novel technologies will require review and allowance by the FDA under an Investigational
New Drug Application.

 We
may not be successful in our efforts to use and expand our development platform to build a pipeline of clinical assets.

 A
key element of our strategy is to use our experienced management and scientific team to build a pipeline of clinical assets that address
a broad range of human diseases in order to treat unmet medical needs. Our current clinical assets and pipeline address the areas of
autoimmune disease and idiopathic male infertility. Although our research and development efforts to date have resulted in potential
clinical assets, we may not be able to continue to identify and develop additional clinical assets. Even if we are successful in continuing
to build our pipeline, the potential clinical assets that we identify may not be suitable for clinical development. For example, these
potential clinical assets may be shown to have harmful side effects or other characteristics that indicate that they are unlikely to
receive marketing approval and achieve market acceptance. If we do not successfully develop and commercialize clinical assets based upon
our approach, we will not be able to obtain product revenue in future periods, which likely would result in significant harm to our financial
position. There is no assurance that we will be successful in our preclinical and clinical development of our current or future clinical
assets, and the process of obtaining regulatory approvals will, in any event, require the expenditure of substantial time and financial
resources.

drug development for our clinical assets is very expensive, time-consuming, difficult to design and implement, and uncertain. Our clinical
trials may fail to adequately demonstrate the safety and efficacy of our clinical assets, which could prevent or delay regulatory approval
and commercialization.

drug development for our clinical assets is very expensive, time-consuming, difficult to design and implement, and its outcome is inherently
uncertain. Before obtaining regulatory approval for the commercial sale of a clinical asset, we must demonstrate through clinical trials
that a clinical asset is both safe and effective for use in the target indication, which is impossible to predict. Most clinical assets
that commence clinical trials are never approved by regulatory authorities for commercialization. Our clinical assets are in various
stages of development and a failure of one more clinical trial can occur at any stage of testing or at any time during the trial process.
We expect that clinical trials for these clinical assets will continue for several years but may take significantly longer than expected
to complete. Not all of our clinical assets have been tested in humans and the first use in humans may reveal unexpected effects. We
have not completed all clinical trials for the approval of any of our clinical assets.

 We
may experience delays in ongoing and future clinical trials for our clinical assets and we do not know if future clinical trials, if
any, will begin on time, need to be redesigned, enroll adequate number of patients on time or be completed on schedule, if at all. In
addition, the Company, any partner with which we currently or may in the future collaborate, the FDA, an IRB or other regulatory authorities, including state and local agencies and counterpart agencies in foreign countries, may suspend,
delay, require modifications to, or terminate our clinical trials at any time, for various reasons, including:

 discovery
 of safety or tolerability concerns, such as serious or unexpected toxicities or side effects or exposure to otherwise unacceptable
 health risks, experienced by study participants or other safety issues;

 lack
 of effectiveness of any clinical asset during clinical trials or the failure of our clinical assets to meet specified endpoints;

 slower
 than expected rates of subject recruitment and enrollment rates or inability to enroll a sufficient number of patients in clinical
 trials resulting from numerous factors, including the prevalence of other companies' clinical trials for their clinical assets
 for the same indication, or clinical trials for indications for which patients do not as commonly seek treatment;

 in retaining subjects who have initiated a clinical trial but may withdraw at any time due to adverse side effects from the therapy,
 insufficient efficacy, fatigue with the clinical trial process, or for any other reason;

 in obtaining IRB approval for studies to be conducted at each clinical trial site;

 delays
 in manufacturing or obtaining, or inability to manufacture or obtain, sufficient quantities of materials for use in clinical trials;

 inadequacy
 of or changes in our manufacturing process or the product formulation or method of delivery;

 changes
 in applicable laws, regulations, and regulatory policies;

 delays
 or failure in reaching agreement on acceptable terms in clinical trial contracts or protocols with prospective CROs, clinical trial sites, and other third-party contractors;

 inability
 to add a sufficient number of clinical trial sites;

 uncertainty
 regarding proper formulation and dosing;

 failure
 by us, our employees, our CROs or their employees, or other third-party contractors to comply with contractual and applicable regulatory
 requirements or to perform their services in a timely or acceptable manner;

 failure
 by us, our employees, our CROs or their employees, or any partner with which we may collaborate or their employees to comply with
 applicable FDA or other regulatory requirements relating to the conduct of clinical trials or the handling, storage, security, and
 recordkeeping for drug and biologic products;

 scheduling
 conflicts with participating clinicians and clinical institutions;

 failure
 to design appropriate clinical trial protocols;

 insufficient
 data to support regulatory approval;

 inability
 or unwillingness of medical investigators to follow our clinical trial protocols; or

 in maintaining contact with subjects during or after treatment, which may result in incomplete data.

 We
or any partner with which we may collaborate may suffer significant setbacks in their clinical trials similar to the experience of a
number of other companies in the pharmaceutical and biotechnology industries, even after receiving promising results in earlier trials.
In the event that we or our potential partners abandon or are delayed in the clinical development efforts related to our clinical assets,
we may not be able to execute on our business plan effectively and our business, financial condition, operating results, and prospects
would be harmed.

 We
may be unable to obtain regulatory approval for our early-stage clinical assets under applicable regulatory requirements. The FDA and
foreign regulatory bodies have substantial discretion in the approval process, including the ability to delay, limit, or deny approval
of clinical assets. The delay, limitation, or denial of any regulatory approval would adversely impact commercialization, our potential
to generate revenue, our business, and our operating results.

 We
currently have no products approved for sale, and we may never obtain regulatory approval to commercialize any of our current or future
clinical assets. The research, testing, manufacturing, safety surveillance, efficacy, quality control, recordkeeping, labeling, packaging,
storage, approval, sale, marketing, distribution, import, export, and reporting of safety and other post-market information related to
our drug products are subject to extensive regulation by the FDA and other regulatory authorities in the U.S. and in foreign countries,
and such regulations differ from country to country. We are not permitted to market any of our current clinical assets in the U.S. until
we receive approval of an NDA, Biologics License Application (a "BLA"), or other applicable regulatory filing from the FDA.
We are also not permitted to market any of our current clinical assets in any foreign countries until we or our partners receive the
requisite approval from the applicable regulatory authorities of such countries. To gain approval to market a new drug such as AZD1656
and AZD5904, the FDA and/or foreign regulatory authorities must receive, among other things, preclinical and clinical data that adequately
demonstrate the safety, purity, potency, efficacy, and compliant manufacturing of the drug product for the intended indication applied
for in a NDA, BLA, or other applicable regulatory filing. The development and approval of new drug products involves a long, expensive,
and uncertain process, and delay or failure can occur at any stage. A number of companies in the pharmaceutical and biopharmaceutical
industry have suffered significant setbacks in nonclinical development, clinical trials, including in Phase III clinical development,
even after promising results in earlier preclinical studies or clinical trials. These setbacks have been caused by, among other things,
findings made while clinical trials were underway and safety or efficacy observations made in clinical trials, including previously unreported
adverse events. Success in clinical trials does not ensure that later clinical trials will be successful, or that nonclinical studies
will be successful. The results of clinical trials by other parties may not be indicative of the results in trials that we or our partners
may conduct.

 The
FDA and foreign regulatory bodies have substantial discretion in the drug development and approval process, including the ability to
delay, limit drug development, or limit or deny approval of clinical assets for many reasons. The FDA or the applicable foreign regulatory
body may:

 disagree
 with the design or implementation of one or more clinical trials;

 not
 deem a clinical asset safe and effective for its proposed indication, or may deem a clinical asset's safety or other perceived
 risks to outweigh its clinical or other benefits;

 not
 find the data from preclinical studies and clinical trials sufficient to support approval, or the results of clinical trials may
 not meet the level of statistical or clinical significance required by the FDA or the applicable foreign regulatory body for approval;

 disagree
 with our interpretation of data from preclinical studies or clinical trials performed by us or third parties, or with the interpretation
 of any partner with which we may collaborate;

 determine
 the data collected from preclinical or clinical trials may not be sufficient to support the submission of an Investigational New
 Drug Application ("IND") or NDA, or other applicable regulatory filing;

 require
 additional preclinical studies or clinical trials;

 identify
 deficiencies in the formulation, quality control, labeling, or specifications of our current or future clinical assets;

 require
 clinical trials in pediatric patients in order to establish pharmacokinetics or safety for this more drug-sensitive population;

 grant
 approval contingent on the performance of costly additional post-approval clinical trials;

 approve
 our current or any future clinical assets for a more limited indication or a narrower patient population than we originally requested
 or with strong warnings that may affect marketability;

 not
 approve the labeling that we believe is necessary or desirable for the successful commercialization of our clinical assets;

 not
 approve of the manufacturing processes, controls, or facilities of third-party manufacturers or testing labs with which we contract;

 consider
 our products a device instead of a drug requiring a different approval process and manufacturing needs;

 consider
 one of our products a combination product instead of a singular drug requiring additional clinical trials or increased number of
 patients per study; or

 change
 its approval policies or adopt new regulations in a manner rendering our clinical data or regulatory filings insufficient for approval.

 Any
delay, limitation, or denial in any applicable regulatory approval for any of our clinical assets would delay or adversely impact commercialization
of our clinical assets and would harm our business, financial condition, operating results, and prospects.

 We
have identified material weaknesses in our internal control over financial reporting. If we fail to remedy these weaknesses or maintain
an effective system of internal controls, then our ability to produce timely and accurate financial statements or comply with applicable
regulations could be adversely affected. We may identify additional material weaknesses in our internal controls over financing reporting
which we may not be able to remedy in a timely manner.

 In
connection with the preparation and audit of the financial statements as of and for the fiscal years ended December 31, 2024 and 2023,
material weaknesses were identified in our internal control over financial reporting. A material weakness is a deficiency, or a combination
of deficiencies, in internal control over financial reporting such that there is a reasonable possibility that a material misstatement
of annual or interim financial statements will not be prevented or detected on a timely basis. These material weaknesses primarily relate
to the following matters that are relevant to the preparation of our financial statements:

 We
 have limited segregation of duties. For the periods under audit, the Company did not have any internal personnel in the financial
 accounting and reporting department, instead relied upon third party consultants to perform these activities.

 We
 lack a formal process for review and approval of financial statements. For the periods under audit, especially prior to the business
 combination, numerous, recurring errors in account balances and disclosures were detected in the financial statements that resulted
 in a reasonable possibility that a material misstatement would not have been detected on a timely basis.

 We
 did not design adequate and appropriate internal controls, including monitoring controls, to review and evaluate the accounting implications
 of all material transactions that occurred in the audit period.

 If
these material weaknesses are not remediated, it could result in a misstatement of account balances or disclosures that would result
in a material misstatement to the annual or interim financial statements that would not be prevented or detected. We are reviewing measures
designed to improve our internal control over financial reporting to remediate these material weaknesses, although they have not been
fully remediated as of the date of this filing. As a part of these measures, we also expect to engage an external advisor to assist with
evaluating and documenting the design and operating effectiveness of internal controls and assisting with the remediation of deficiencies
when funding and additional liquidity becomes available, as necessary. The primary costs associated with such measures are corresponding
recruiting and additional salary and consulting costs, which are difficult to estimate but which may be significant. These additional
resources and procedures are intended to enable us to broaden the scope and quality of our internal review of underlying information
related to financial reporting and to formalize and enhance our internal control procedures.

 The
material weaknesses will not be considered remediated until a remediation plan has been fully implemented, the applicable controls
operate for a sufficient period of time, and we have concluded, through testing, that the newly implemented and enhanced controls are
operating effectively. A failure to implement and maintain effective internal control over financial reporting could result
in errors in our financial statements that could result in a restatement of our financial statements and could cause us to fail to meet
our reporting obligations, any of which could diminish investor confidence in us and cause a decline in the price of our common stock.

 Our
independent registered public accounting firm will not be required to formally attest to the effectiveness of our internal control over
financial reporting until after we are no longer an "emerging growth company," as defined in the JOBS Act. At such time,
our independent registered public accounting firm may issue a report that is adverse in the event it is not satisfied with the level
at which our internal control over financial reporting is documented, designed, or operating.

 There
is a risk that we will fail to maintain an effective system of internal controls and our ability to produce timely and accurate financial
statements or comply with applicable regulations could be adversely affected. We may identify material weaknesses in our internal controls
over financing reporting which we may not be able to remedy in a timely manner.

 As
a public company, we operate in an increasingly demanding regulatory environment, which requires us to comply with the Sarbanes-Oxley
Act, the regulations of Nasdaq, the rules and regulations of the SEC, expanded disclosure requirements, accelerated reporting requirements,
and more complex accounting rules. Responsibilities required by the Sarbanes-Oxley Act include establishing corporate oversight and adequate
internal control over financial reporting and disclosure controls and procedures. Effective internal controls are necessary for us to
produce reliable financial reports and are important to help prevent financial fraud.

 We
may discover additional weaknesses in our system of internal financial and accounting controls and procedures that could result in a
material misstatement of our financial statements. Our internal control over financial reporting will not prevent or detect all errors
and all fraud. A control system, no matter how well designed and operated, can provide only reasonable, not absolute, assurance that
the control system's objectives will be met. Because of the inherent limitations in all control systems, no evaluation of controls
can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud
will be detected.

 If
we are not able to comply with the requirements of Section 404 of the Sarbanes-Oxley Act in a timely manner, or if we are unable to maintain
proper and effective internal controls, we may not be able to produce timely and accurate financial statements. If we cannot provide
reliable financial reports or prevent fraud, our business and results of operations could be harmed, investors could lose confidence
in our reported financial information, and we could be subject to sanctions or investigations by Nasdaq, the SEC, or other regulatory
authorities.

 If
we do not develop and implement all required accounting practices and policies, we may be unable to provide the financial information
required of a U.S. publicly traded company in a timely and reliable manner.

 If
we fail to develop and maintain effective internal controls and procedures and disclosure procedures and controls, we may be unable to
provide financial information and required SEC reports that a U.S. publicly traded company is required to provide in a timely and reliable
fashion. Any such delays or deficiencies could penalize us, including by limiting our ability to obtain financing, either in the public
capital markets or from private sources and hurt our reputation and could thereby impede our ability to implement our growth strategy.
In addition, any such delays or deficiencies could result in our failure to meet the requirements for continued listing of our shares
of common stock on a national securities exchange.

 We
may face product liability exposure, and if successful claims are brought against us, we may incur substantial liability if our insurance
coverage for those claims is inadequate.

 We
face an inherent risk of product liability as a result of the clinical testing of our clinical assets and will face an even greater risk
if we commercialize any products. This risk exists even if a product is approved for commercial sale by the FDA and manufactured in facilities
licensed and regulated by the FDA or an applicable foreign regulatory authority. Our products and clinical assets are designed to affect
important bodily functions and processes. Any side effects, manufacturing defects, misuse, or abuse associated with our clinical assets
could result in injury to a patient or even death. We cannot offer any assurance that we will not face product liability suits in the
future, nor can we assure investors that our insurance coverage will be sufficient to cover our liability under any such cases. In addition,
a liability claim may be brought against us even if our clinical assets merely appear to have caused an injury. Product liability claims
may be brought against us by consumers, health care providers, pharmaceutical companies, or others selling or otherwise coming into contact
with our clinical assets, among others. If we cannot successfully defend ourselves against product liability claims, we will incur substantial
liabilities and reputational harm.

 We
currently rely on, and expect to continue to rely on, third-party CROs and other third parties to conduct and oversee our clinical trials
and other aspects of product development. If these third parties do not meet our requirements or otherwise conduct the trials as required,
we may not be able to satisfy our contractual obligations or obtain regulatory approval for, or commercialize, our clinical assets when
expected or at all.

 We
have in the past relied and expect to continue to rely on third-party CROs to conduct and oversee our clinical trials and other aspects
of product development. We also rely upon various medical institutions, clinical investigators, and contract laboratories to conduct
our trials in accordance with our clinical trial protocols and all applicable regulatory requirements, including the FDA's regulations
and GCPs, which are an international standard meant to protect the rights and health of patients and to define the roles of clinical
trial sponsors, administrators and monitors, and state regulations governing the handling, storage, security, and recordkeeping for drug
and biologic products. These CROs and other third parties play a significant role in the conduct of these trials and the subsequent collection
and analysis of data from the clinical trials. We rely heavily on these parties for the execution of our clinical trials and preclinical
studies, and control only certain aspects of their activities. We, our CROs, and other third-party contractors are required to comply
with GCP, GLP, and GACP requirements, which are regulations and guidelines enforced by the FDA and comparable foreign regulatory authorities
for products in clinical development. Regulatory authorities enforce these GCP, GLP, and GACP requirements through periodic inspections
of trial sponsors, principal investigators, and trial sites. If we or any of these third parties fail to comply with applicable GCP,
GLP, or GACP requirements, the clinical data generated in our clinical trials may be deemed unreliable and the FDA or other regulatory
authority may require us to perform additional clinical trials before approving our or our partners' marketing applications. We
cannot assure investors that upon inspection by a given regulatory authority, such regulatory authority will determine that any of our
clinical or preclinical trials complies with applicable GCP and GLP requirements. In addition, our clinical trials must generally be
conducted with product produced under cGMP regulations. Our failure to comply with these regulations and policies may require us to repeat
clinical trials, which would delay the regulatory approval process.

 Our
CROs are not our employees, and we do not control whether or not they devote sufficient time and resources to our clinical trials. Our
CROs may also have relationships with other commercial entities, including our competitors, for whom they may also be conducting clinical
trials, or other drug development activities, which could harm our competitive position. We face the risk of potential unauthorized disclosure
or misappropriation of our intellectual property by CROs, which may reduce our trade secret protection and allow potential competitors
to access and exploit our proprietary technology. If our CROs do not successfully carry out their contractual duties or obligations,
fail to meet expected deadlines, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to
adhere to our clinical trial protocols or regulatory requirements or for any other reason, our clinical trials may be extended, delayed,
or terminated, and we may not be able to obtain regulatory approval for, or successfully commercialize any clinical asset that we develop.
As a result, our financial results and the commercial prospects for any clinical asset that we develop would be harmed, our costs could
increase, and our ability to generate revenue could be delayed.

 If
any of our CROs or clinical trial sites terminate their involvement in one of our clinical trials for any reason, we may not be able
to enter into arrangements with alternative CROs or clinical trial sites or do so on commercially reasonable terms. In addition, if our
relationship with clinical trial sites is terminated, we may experience the loss of follow-up information on patients enrolled in our
ongoing clinical trials unless we are able to transfer the care of those patients to another qualified clinical trial site. In addition,
principal investigators for our clinical trials may serve as scientific advisors or consultants to us from time to time and could receive
cash or equity compensation in connection with such services. If these relationships and any related compensation result in perceived
or actual conflicts of interest, the integrity of the data generated at the applicable clinical trial site may be questioned by the FDA.

 We
rely completely on third-party contractors to supply, manufacture, and distribute clinical drug supplies for our clinical assets, including
certain sole-source suppliers and manufacturers. We intend to rely on third parties for commercial supply, manufacturing, and distribution
if any of our clinical assets receive regulatory approval and we expect to rely on third parties for supply, manufacturing, and distribution
of preclinical, clinical, and commercial supplies of any future clinical assets.

 We
do not currently have, nor do we plan to acquire, the infrastructure or capability to supply, manufacture, or distribute preclinical,
clinical, or commercial quantities of drug substances or products. Our ability to develop our clinical assets depends and our ability
to commercially supply our products will depend, in part, on our ability to successfully obtain the raw materials and APIs and other
substances and materials used in our clinical assets from third parties and to have finished products manufactured by third parties in
accordance with regulatory requirements and in sufficient quantities for preclinical and clinical testing and commercialization. If we
fail to develop and maintain supply relationships with these third parties, we may be unable to continue to develop or commercialize
our clinical assets.

 We
rely and will continue to rely on certain third parties as the sole source of the materials they supply or the finished products they
manufacture. Any of our existing suppliers or manufacturers may:

 fail
 to supply us with product on a timely basis or in the requested amount due to unexpected damage to or destruction of facilities or
 equipment or otherwise;

 fail
 to increase manufacturing capacity and produce drug product and components in larger quantities and at higher yields in a timely
 or cost-effective manner, or at all, to sufficiently meet our commercial needs;

 be
 unable to meet our production demands due to issues related to their reliance on sole-source suppliers and manufacturers;

 supply
 us with product that fails to meet regulatory requirements;

 become
 unavailable through business interruption or financial insolvency;

 lose
 regulatory status as an approved source;

 be
 unable or unwilling to renew current supply agreements when such agreements expire on a timely basis, on acceptable terms or at all;
 or

 discontinue
 production or manufacturing of necessary drug substances or products.

 In
the event of any of the foregoing, if we do not have an alternative supplier or manufacturer in place, we would be required to expend
substantial management time and expense to identify, qualify, and transfer processes to alternative suppliers or manufacturers. Transferring
technology to other sites may require additional processes, technologies, and validation studies, which are costly, may take considerable
amounts of time, may not be successful and, in most cases, require review and approval by the FDA. Any need to find and qualify new suppliers
or manufacturers could significantly delay production of our clinical assets, adversely impact our ability to market our clinical assets,
and adversely affect our business. Replacements may not be available to us on a timely basis, on acceptable terms, or at all. Additionally,
we and our manufacturers do not currently maintain significant inventory of drug substances and other materials. Any interruption in
the supply of a drug substance or other material or in the manufacture of our clinical assets could have a material adverse effect on
our business, financial condition, operating results, and prospects.

 We
do not have direct control over the ability of our contract suppliers and manufacturers to maintain adequate capacity and capabilities
to serve our needs, including quality control, quality assurance, and qualified personnel. Although we are ultimately responsible for
ensuring compliance with regulatory requirements such as cGMPs and GACP, we are dependent on our contract suppliers and manufacturers
for day-to-day compliance with cGMPs or GACP for production of raw materials, APIs, and finished products. Facilities used by our contract
suppliers and manufacturers to produce the APIs and other substances and materials or finished products for commercial sale must pass
inspection and be approved by the FDA and other relevant regulatory authorities. Our contract suppliers and manufacturers must comply
with cGMP and GACP requirements enforced by the FDA through its facilities inspection program and review of submitted technical information.
If the safety of any product or clinical asset or component is compromised due to a failure to adhere to applicable laws or for other
reasons, we may not be able to successfully commercialize or obtain regulatory approval for the affected product or clinical asset, and
we may be held liable for injuries sustained as a result. Any of these factors could cause a delay or termination of preclinical studies,
clinical trials, or regulatory submissions or approvals of our clinical assets, and could entail higher costs or result in us being unable
to effectively commercialize our approved products on a timely basis, or at all.

 In
addition, these contract manufacturers are engaged with other companies to supply and manufacture materials or products for such companies,
which also exposes our suppliers and manufacturers to regulatory risks for the production of such materials and products. As a result,
failure to meet the regulatory requirements for the production of those materials and products may also affect the regulatory clearance
of a contract supplier's or manufacturer's facility. If the FDA or a comparable foreign regulatory agency does not approve
these facilities for the supply or manufacture of our clinical assets, or if it withdraws its approval in the future, we may need to
find alternative supply or manufacturing facilities, which would negatively impact our ability to develop, obtain regulatory approval
of, or market our clinical assets, if approved.

 If
any of our third-party contractors terminate their involvement in the supply, manufacture, or distribution of clinical drug supplies
for us for any reason, we may not be able to enter into arrangements with alternative third party-contractors, or do so on commercially
reasonable terms. In addition, if our relationship with such third-party contractors is terminated, we may experience a negative impact
to the respective licenses on which we rely and, therefore, on our ability to obtain regulatory approval for, or commercialize, our clinical
assets when expected or at all.

 Our
reliance on contract manufacturers and suppliers further exposes us to the possibility that they, or third parties with access to their
facilities, will have access to and may misappropriate our trade secrets or other proprietary information.

 In
addition, the manufacturing facilities of certain of our suppliers are located outside of the U.S. This may give rise to difficulties
in importing our products or clinical assets or their components into the U.S. or other countries as a result of, among other things,
regulatory agency approval requirements or import inspections, incomplete or inaccurate import documentation, or defective packaging.

 We
currently rely on agreements with third parties for the purpose of licensing our clinical assets. In the near-term, we intend to rely
on third parties for the licensing of clinical assets and those which may arise through future partnerships.

 We
currently rely on agreements with third parties for the purpose of licensing clinical assets from large pharmaceutical companies. For
example, we have agreements with AstraZeneca pursuant to which we license clinical assets from AstraZeneca. If we are in breach of the
agreements, the termination of such agreement(s) could materially adversely affect our business, financial condition, operating results,
and prospects. Our business strategy heavily depends on our ability to commercialize our clinical assets and our ability to enter into
license agreements relating to such clinical assets is critical to the success of our operations

 We
may choose not to continue developing or commercializing any of our clinical assets at any time during development or after approval,
which would reduce or eliminate our potential return on investment for those clinical assets.

 We
may decide to discontinue the development of any of our clinical assets or not to continue commercializing one or more of our approved
clinical assets for a variety of reasons, including the appearance of new technologies that make a product obsolete, competition from
a competing product, or changes in or failure to comply with applicable regulatory requirements at any time. If we terminate a program
in which we have invested significant resources, we will not receive any return on our investment and we will have missed the opportunity
to have allocated those resources to potentially more productive uses.

 If
we fail to attract and retain management and other key personnel, we may be unable to continue to successfully develop or commercialize
our clinical assets or otherwise implement our business plan.

 Our
ability to compete in the highly competitive pharmaceuticals industry depends upon our ability to attract and retain highly qualified
managerial, scientific, medical, sales, marketing, and other personnel. We are highly dependent on our management, including our Chief
Executive Officer, David Tapolczay. The loss of the services of any of these individuals could impede, delay, or prevent the successful
development of our product pipeline, completion of our planned clinical trials, commercialization of our clinical assets, or in-licensing
or acquisition of new assets and could negatively impact our ability to successfully implement our business plan. If we lose the services
of any of these individuals, we might not be able to find suitable replacements on a timely basis or at all, and our business could be
harmed as a result. We do not maintain "key man" insurance policies on the lives of these individuals or the lives of any
of our other employees. In order to retain valuable employees, in addition to salary and cash incentives, we provide stock options that
vest over time.

 We
might not be able to attract or retain qualified management and other key personnel in the future due to the intense competition for
qualified personnel among biotechnology, pharmaceutical, and other businesses. We could have difficulty attracting experienced personnel
to the Company and may be required to expend significant financial resources in our employee recruitment and retention efforts. Many
of the other pharmaceutical companies with whom we compete for qualified personnel have greater financial and other resources, different
risk profiles, and longer histories in the industry than we do. They also may provide more diverse opportunities and better chances for
career advancement. If we are not able to attract and retain the necessary personnel to accomplish our business objectives, we may experience
constraints that will harm our ability to implement our business strategy and achieve our business objectives.

 In
addition, we have scientific and clinical advisors who assist us in formulating our development and clinical strategies. These advisors
are not our employees and may have commitments to, or consulting or advisory contracts with, other entities that may limit their availability
to us. In addition, our advisors may have arrangements with other companies to assist those companies in developing products or technologies
that may compete with those of the Company.

 We
currently have limited marketing capabilities and no sales organization. If we do not establish sales and marketing capabilities on our
own or through third parties, we will be limited in our commercialization to license deals with third parties following successful Phase
II trials.

 We
currently have limited marketing capabilities and no sales organization. If we do not establish sales and marketing capabilities on our
own or through third parties, we will be limited in our commercialization to license deals with third parties following successful Phase
II trials. To commercialize our clinical assets, if approved, in the U.S., Canada, the European Union, and other jurisdictions that we
seek to enter, we must build our marketing, sales, distribution, managerial, and other non-technical capabilities or make arrangements
with third parties to perform these services, and we may not be successful in doing so. Although our management team has experience in
the marketing, sale, and distribution of pharmaceutical products from prior employment at other companies, we as a company have no prior
experience in the marketing, sale, and distribution of pharmaceutical products and there are significant risks involved in building and
managing a sales organization, including our ability to hire, retain, and incentivize qualified individuals, generate sufficient sales
leads, provide adequate training to sales and marketing personnel, and effectively manage a geographically dispersed sales and marketing
team. Any failure or delay in the development of our internal sales, marketing, and distribution capabilities would adversely impact
the commercialization of these products. We may choose to collaborate with additional third parties that have direct sales forces and
established distribution systems, either to augment our own sales force and distribution systems or in lieu of its own sales force and
distribution systems. If we are unable to enter into such arrangements on acceptable terms or at all, we may not be able to successfully
commercialize our clinical assets. If we are unable to successfully commercialize our clinical assets, either on our own or through collaborations
with one or more third parties, our business, financial condition, operating results, and prospects would suffer.

 Our
failure to successfully in-license, acquire, develop, and market additional clinical assets or approved products would impair our ability
to grow our business.

 We
intend to in-license, acquire, develop, and market additional products and clinical assets and we may in-license or acquire commercial-stage
products or engage in other strategic transactions. Because our internal research and development capabilities are limited, we may be
dependent upon pharmaceutical companies, academic scientists, and other researchers to sell or license products or technology to us.
The success of this strategy depends partly upon our ability to identify and select promising pharmaceutical clinical assets and products,
negotiate licensing or acquisition agreements with their current owners, and finance these arrangements.

 The
process of proposing, negotiating, and implementing a license or acquisition of a clinical asset or approved product is lengthy and complex.
Other companies, including some with substantially greater financial, marketing, sales, and other resources, may compete with us for
the license or acquisition of clinical assets and approved products. We have limited resources to identify and execute the acquisition
or in-licensing of third-party products, businesses, and technologies and integrate them into our current infrastructure. Moreover, we
may devote resources to potential acquisitions or licensing opportunities that are never completed, or we may fail to realize the anticipated
benefits of such efforts. We may not be able to acquire the rights to additional clinical assets on terms that we find acceptable, or
at all.

 Further,
any clinical asset that we acquire may require additional development efforts prior to commercial sale, including preclinical or clinical
testing and approval by the FDA and applicable foreign regulatory authorities. All clinical assets are prone to risks of failure typical
of pharmaceutical product development, including the possibility that a clinical asset will not be shown to be sufficiently safe and
effective for approval by regulatory authorities. In addition, we cannot provide assurance that any approved products that we acquire
will be manufactured or sold profitably or achieve market acceptance.

 Additional
potential transactions that we may consider include a variety of different business arrangements, including spin-offs, strategic partnerships,
joint ventures, restructurings, divestitures, business combinations, and investments. Any such transaction may require us to incur non-recurring
or other charges, may increase our near- and long-term expenditures, and may pose significant integration challenges or disrupt our management
or business, which could adversely affect our operations and financial results. For example, these transactions entail numerous potential
operational and financial risks, including:

 exposure
 to unknown liabilities;

 disruption
 of our business and diversion of our management's time and attention in order to develop acquired products, clinical assets,
 or technologies;

 incurrence
 of substantial debt or dilutive issuances of equity securities to pay for acquisitions;

 substantial
 acquisition and integration costs;

 write-downs
 of assets or impairment charges;

 increased
 amortization expenses;

 and cost in combining the operations and personnel of any acquired businesses with our operations and personnel;

 impairment
 of relationships with key suppliers, partners, or customers of any acquired businesses due to changes in management and ownership;
 and

 inability
 to retain our key employees or those of any acquired businesses.

 Accordingly,
there can be no assurance that we will undertake or successfully complete any transactions of the nature described above, and any transaction
that we do complete could harm our business, financial condition, operating results, and prospects.

 Manufacturing
and supply of the APIs and other substances and materials used in our clinical assets is a complex and technically challenging undertaking,
and there is potential for failure at many points in the manufacturing, testing, quality assurance, and distribution supply chain, as
well as the potential for latent defects after products have been manufactured and distributed.

 Manufacturing
and supply of APIs, other substances, and materials and finished drug products is technically challenging. Changes beyond our direct
control can impact the quality, volume, price, and successful delivery of our clinical assets and can impede, delay, limit, or prevent
the successful development and commercialization of our clinical assets. Mistakes and mishandling are not uncommon and can affect successful
production and supply. Some of these risks include:

 failure
 of our manufacturers to follow cGMP or GACP requirements or mishandling of product while in production or in preparation for transit;

 inability
 of our contract suppliers and manufacturers to efficiently and cost-effectively increase and maintain high yields and batch quality,
 consistency, and stability;

 our
 inability to develop an FDA-approved bioassay for release of any future product;

 in establishing optimal drug delivery substances and techniques, production, and storage methods and packaging and shipment processes;

 transportation
 and import/export risk, particularly given the global nature of our supply chain;

 delays
 in analytical results or failure of analytical techniques that we depend on for quality control and release of any future product;

 natural
 disasters, pandemics, labor disputes, financial distress, lack of raw material supply, issues with facilities and equipment, or other
 forms of disruption to business operations of our contract manufacturers and suppliers; and

 latent
 defects that may become apparent after the product has been released and which may result in recall and destruction of product.

 Any
of these factors could result in delays or higher costs in connection with our clinical trials, regulatory submissions, required approvals,
or commercialization of our clinical assets, which could harm our business, financial condition, operating results, and prospects.

 Our
operating results may fluctuate significantly, which makes our future operating results difficult to predict and could cause our operating
results to fall below expectations.

 The
operations of the Company since the Business Combination and of Old Conduit prior to the Business Combination have been primarily limited
to researching and developing our clinical assets and undertaking preclinical studies and clinical trials of our clinical assets. We
have not yet obtained regulatory approvals for any of our clinical assets. Consequently, any predictions investors make about our future
success or viability may not be as accurate as they could be if we had a longer operating history or approved products on the market.
Furthermore, our operating results may fluctuate due to a variety of other factors, many of which are outside of our control and may
be difficult to predict, including the following:

 delays
 in the commencement, enrollment, and the timing of clinical testing for our clinical assets;

 the
 timing and success or failure of clinical trials for our clinical assets or competing clinical assets, or any other change in the
 competitive landscape of our industry, including consolidation among our competitors or partners;

 any
 delays in regulatory review and approval of clinical assets in clinical development;

 the
 timing and cost of, and level of investment in, research and development activities relating to our clinical assets, which may change
 from time to time;

 the
 cost of manufacturing our clinical assets, which may vary depending on FDA guidelines and requirements, and the quantity of production;

 our
 ability to obtain additional funding to develop our clinical assets;

 expenditures
 that we will or may incur to acquire or develop additional clinical assets and technologies;

 the
 level of demand for our clinical assets, should they receive approval, which may vary significantly;

 potential
 side effects of our clinical assets that could delay or prevent commercialization or cause an approved drug to be taken off the market;

 the
 ability of patients or healthcare providers to obtain coverage of or sufficient reimbursement for our clinical assets, if approved;

 our
 dependency on third-party manufacturers to supply or manufacture our clinical assets;

 our
 ability to establish an effective sales, marketing, and distribution infrastructure in a timely manner;

 market
 acceptance of our clinical assets, if approved, and our ability to forecast demand for those clinical assets;

 our
 ability to receive approval and commercialize our clinical assets outside of the U.S.;

 our
 ability to establish and maintain collaborations, licensing, or other arrangements;

 our
 ability and third parties' abilities to protect intellectual property rights;

 costs
 related to and outcomes of potential litigation or other disputes;

 our
 ability to adequately support future growth;

 our
 ability to attract and retain key personnel to manage our business effectively;

 potential
 liabilities associated with hazardous materials;

 our
 ability to maintain adequate insurance policies; and

 future
 accounting pronouncements or changes in our accounting policies.

 Fluctuations
in foreign currency could have an effect on our reported results of operations.

 Our
exposure to fluctuations in foreign currency rates results primarily from the translation exposure associated with the preparation of
our consolidated financial statements, as well as from transaction exposure associated with transactions in currencies other than our
functional currency. While our consolidated financial statements are reported in U.S. dollars, our financial statements of foreign subsidiaries
are prepared using the British pound sterling as the functional currency and then translated into U.S. dollars. We cannot accurately
predict the nature or extent of future exchange rate variability of the British pound sterling or the exchange rate relative to the U.S.
dollar. Foreign exchange rates are sensitive to factors beyond our control. In addition, Brexit has caused, and may continue to cause,
significant volatility in currency exchange rates, especially between the U.S. dollar and the British pound sterling. These fluctuations
in foreign currency exchange rates could negatively affect our results of operations and impact reported financial results.

 Our
operating results and liquidity needs could be negatively affected by market fluctuations and economic downturn.

 Our
operating results and liquidity could be negatively affected by economic conditions generally, both in the U.S. and elsewhere around
the world. The market for discretionary medical products and procedures may be particularly vulnerable to unfavorable economic conditions.
Some patients may consider certain of our clinical assets to be discretionary, and if full reimbursement for such products is not available,
demand for these products may be tied to the discretionary spending levels of our targeted patient populations. Domestic and international
equity and debt markets have experienced and may continue to experience heightened volatility and turmoil based on domestic and international
economic conditions and concerns. In the event these economic conditions and concerns continue or worsen and the markets continue to
remain volatile, our operating results and liquidity could be adversely affected by those factors in many ways, including weakening demand
for certain of our products and making it more difficult for us to raise funds if necessary. Additionally, although we plan to market
our products primarily in the U.S., we could in the future have partners with extensive global operations, indirectly exposing us to
risk.

 We
maintain our cash and cash equivalents with high quality, accredited financial institutions. However, some of these accounts exceed the
government-insured limits, and, while we believe that we are not exposed to significant credit risk due to the financial strength of
these depository institutions or investments, the failure or collapse of one or more of these depository institutions or default on these
investments could materially adversely affect our ability to recover these assets and/or materially harm our financial condition.

 We
are increasingly dependent on information technology, and our systems and infrastructure face certain risks, including cybersecurity
and data leakage risks.

 Significant
disruptions to our information technology systems or breaches of information security could adversely affect our business. In the ordinary
course of business, we collect, store, and transmit large amounts of confidential information, and it is critical that we do so in a
secure manner to maintain the confidentiality and integrity of such confidential information. The size and complexity of our information
technology systems, and those of our third-party vendors with whom we contract, make such systems potentially vulnerable to service interruptions
and security breaches from inadvertent or intentional actions by our employees, partners, or vendors, from attacks by malicious third
parties, or from intentional or accidental physical damage to our systems infrastructure maintained by us or by third parties. Maintaining
the secrecy of this confidential, proprietary, or trade secret information is important to our competitive business position. While we
have taken steps to protect such information and invested in information technology, there can be no assurance that our efforts will
prevent service interruptions or security breaches in our systems or the unauthorized or inadvertent wrongful use or disclosure of confidential
information that could adversely affect our business operations or result in the loss, dissemination, or misuse of critical or sensitive
information. A breach of our security measures or the accidental loss, inadvertent disclosure, unapproved dissemination, misappropriation
or misuse of trade secrets, proprietary information, or other confidential information, whether as a result of theft, hacking, fraud,
trickery, or other forms of deception, or for any other reason, could enable others to produce competing products, use our proprietary
technology or information, or adversely affect our business or financial condition. Further, any such interruption, security breach,
loss, or disclosure of confidential information could result in financial, legal, business, and reputational harm to us and could have
a material adverse effect on our business, financial position, results of operations, or cash flow.

 Our
business and operations would suffer in the event of failures in our internal computer systems.

 Despite
the implementation of security measures, our computer systems and those of our current and any future partners, contractors, and consultants
are vulnerable to damage from computer viruses, unauthorized access, natural disasters, terrorism, war, and telecommunication and electrical
failures. While we have not experienced any such material system failure, accident, or security breach to date, if such an event were
to occur and cause interruptions in our operations, it could result in a material disruption of our manufacturing activities, development
programs, and business operations. For example, the loss of manufacturing records or clinical trial data from completed or future clinical
trials could result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce the data.
If we experienced a security breach, our online sources were hacked, or we experienced a data leak, it could result in confidential clinical
trial data being leaked to competitors and the market. To the extent that any disruption or security breach were to result in a loss
of, or damage to, our data or applications, or inappropriate disclosure of confidential or proprietary information, we could incur liability
and the further commercialization and development of our products and clinical assets could be delayed.

 Risks
Related to Intellectual Property

 Failure
to adequately protect our intellectual property could adversely affect our business, financial condition, and operating results.

 Our
business depends on our intellectual property and proprietary technology, the protection of which is crucial to the success of our business.
We rely on a combination of trademark, copyright, and trade secret laws, license agreements, intellectual property assignment agreements,
and confidentiality procedures to protect our intellectual property. Additionally, we rely on proprietary information (such as trade
secrets, know-how, and confidential information) to protect intellectual property that may not be patentable, or that we believe is best
protected by means that do not require public disclosure. We generally attempt to protect our intellectual property, technology, and
confidential information by requiring our employees and consultants who develop intellectual property on our behalf to enter into confidentiality
and invention assignment agreements and third parties that we share information with to enter into nondisclosure agreements. These agreements
may not effectively prevent unauthorized use or disclosure of our confidential information, intellectual property, or technology and
may not provide an adequate remedy in the event of unauthorized use or disclosure of our confidential information or technology, or infringement
of our intellectual property. For example, we may fail to enter into the necessary agreements, and even if entered into, these agreements
may be willfully breached or may otherwise fail to prevent disclosure, third-party infringement, or misappropriation of our proprietary
information, may be limited as to their term, and may not provide an adequate remedy in the event of unauthorized disclosure or use of
proprietary information. In addition, our proprietary information may otherwise become known or be independently developed by our competitors
or other third parties. To the extent that our employees, consultants, contractors, and other third parties use intellectual property
owned by others in their work for us, disputes may arise as to the rights in related or resulting know-how and inventions. Costly and
time-consuming litigation could be necessary to enforce and determine the scope of our intellectual property rights and other proprietary
rights, and failure to obtain or maintain protection for our proprietary information could adversely affect our competitive business
position.

 Despite
our efforts to protect our proprietary rights, other parties may unintentionally or willfully disclose, obtain, or use our technologies
or systems, which may allow unauthorized parties to copy aspects of our platform or other software, technology, and functionality or
obtain and use information that we consider proprietary. In addition, unauthorized parties may also attempt, or successfully endeavor,
to obtain our intellectual property, confidential information, and trade secrets through various methods, including through scraping
of public data or other content from our website or mobile applications, cybersecurity attacks, and legal or other methods of protecting
this data may be inadequate. Monitoring unauthorized use and disclosures of our intellectual property, proprietary technology, or confidential
information can be difficult and expensive and we cannot be sure that the steps we have taken will prevent misappropriation or infringement
of our intellectual property or proprietary rights.

 We
have registered the domain name for the website that we use in our business, which is www.conduitpharma.com. The inclusion of the website
address in this Annual Report does not include or incorporate by reference the information on the Company's website into this document.

 Competitors
have and may continue to adopt service names similar to ours, thereby harming our ability to build brand identity and possibly leading
to user confusion. In addition, there could be potential trade name or trademark infringement claims brought by owners of other trademarks
that are similar to our trademarks. Further, litigation or proceedings before the U.S. Patent and Trademark Office or other governmental
authorities and administrative bodies in the U.S. and abroad may be necessary in the future to enforce our intellectual property rights
and to determine the validity and scope of the proprietary rights of others. Any litigation initiated by us concerning the violation
by third parties of our intellectual property rights is likely to be expensive and time-consuming and could lead to the invalidation
of, or render unenforceable, our intellectual property, or could otherwise have negative consequences for us. Even when we sue other
parties for such infringement, that suit may have adverse consequences for our business. In addition, we may not timely or successfully
apply for a patent or register our trademarks or otherwise secure our intellectual property, which could result in negative effects to
our market share, financial condition, and results of operations. Our efforts to protect, maintain, or enforce our proprietary rights
may not be respected in the future or may be invalidated, circumvented, or challenged, and could result in substantial costs and diversion
of resources, which could adversely affect our business, financial condition, and operating results.

 We
may be unable to continue to use the domain name that we use in our business or prevent third parties from acquiring and using domain
names that infringe on, are similar to, or otherwise decrease the value of our brand, trademarks, or service marks.

 We
have registered the domain name that we use in our business. If we lose the ability to use that domain name, whether due to trademark
claims, failure to renew the applicable registration, or any other cause, we may be forced to market our business under a new domain
name, which could cause us substantial harm, or to incur significant expense in order to purchase rights to the domain name in question.
We may not be able to obtain preferred domain names outside the U.S. due to a variety of reasons, including because they are already
held by others. In addition, our competitors and others could attempt to capitalize on our brand recognition by using domain names similar
to our domain name. We may be unable to prevent third parties from acquiring and using domain names that infringe on, are similar to,
or otherwise decrease the value of our brand or our trademarks or service marks. Protecting, maintaining, and enforcing our rights in
our domain names may require litigation, which could result in substantial costs and diversion of resources, which could in turn adversely
affect our business, financial condition, and operating results.

 We
may not be able to protect our intellectual property rights throughout the world.

 Filing,
prosecuting, and defending patents on our clinical assets in all countries throughout the world would be prohibitively expensive. The
requirements for patentability may differ in certain countries, particularly developing countries. In addition, the laws of some foreign
countries do not protect intellectual property rights to the same extent as laws in the U.S. Consequently, we may not be able to prevent
third parties from practicing our inventions in all countries outside the U.S. Competitors may use our technologies in jurisdictions
where we have not obtained patent protection to develop their own products and, further, may export otherwise infringing products to
territories where we have patent protection, but enforcement on infringing activities is inadequate. These products may compete with
our products, and our patents or other intellectual property rights may not be effective or sufficient to prevent them from competing.

 Many
companies have encountered significant problems in protecting and defending intellectual property rights in foreign jurisdictions. The
legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents and other intellectual
property protection, particularly those relating to pharmaceuticals, which could make it difficult for us to stop the infringement of
our patents or marketing of competing products in violation of our proprietary rights generally. Proceedings to enforce our patent rights
in foreign jurisdictions could result in substantial costs and divert our efforts and attention from other aspects of our business, could
put our patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing, and could provoke
third parties to assert claims against us. We may not prevail in any lawsuits that we initiate, and the damages or other remedies awarded,
if any, may not be commercially meaningful. In addition, certain countries in Europe and certain developing countries have compulsory
licensing laws under which a patent owner may be compelled to grant licenses to third parties. In those countries, we may have limited
remedies if our patents are infringed or if we are compelled to grant a license to our patents to a third party, which could materially
diminish the value of those patents. This could limit our potential revenue opportunities. Accordingly, our efforts to enforce our intellectual
property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual property that we
own or license. Our ability to protect and enforce our intellectual property rights may also be adversely affected by unforeseen changes
in foreign intellectual property laws.

 Obtaining
and maintaining our patent protection depends on compliance with various procedural, document submission, fee payment, and other requirements
imposed by governmental patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.

 Periodic
maintenance and annuity fees on any issued patent are due to be paid to the United States Patent and Trademark Office ("USPTO")
and foreign patent agencies in several stages over the lifetime of the patent. The USPTO and various foreign governmental patent agencies
require compliance with a number of procedural, documentary, fee payment, and other similar provisions during the patent application
process. While an inadvertent lapse can in many cases be cured by payment of a late fee or by other means in accordance with the applicable
rules, there are situations in which noncompliance can result in abandonment or lapse of the patent or patent application, resulting
in partial or complete loss of patent rights in the relevant jurisdiction. Non-compliance events that could result in abandonment or
lapse of a patent or patent application include failure to respond to official actions within prescribed time limits, non-payment of
fees, and failure to properly legalize and submit formal documents. If we or our licensors fail to maintain the patents and patent applications
covering our clinical assets, our competitors might be able to enter the market, which would have an adverse effect on our business.

 If
we fail to comply with our obligations under our intellectual property license agreements, we could lose license rights that are important
to our business.

 We
are a party to certain license agreements that impose various diligence, milestone, royalty, insurance, and other obligations on us.
If we fail to comply with these obligations, the respective licensors may have the right to terminate the license, in which event we
may not be able to develop or market the affected clinical asset. Our business strategy depends on our ability to commercialize our
clinical assets and our ability to enter into license agreements relating to such clinical assets is critical to the success of our
operations. The loss of such rights could materially adversely affect our business, financial condition, operating results, and
prospects. For more information about these license arrangements, see "Business — Principal Strategic Partnerships."

 If
we are sued for infringing intellectual property rights of third parties, it will be costly and time-consuming, and an unfavorable outcome
in that litigation could have a material adverse effect on our business.

 Our
commercial success depends upon its ability to develop, manufacture, market, and sell our clinical assets and use our proprietary technologies
without infringing the proprietary rights of third parties. We cannot guarantee that marketing and selling such candidates and using
such technologies will not infringe existing or future patents. Numerous U.S. and foreign issued patents and pending patent applications
owned by third parties exist in the fields relating to our clinical assets. As the biotechnology and pharmaceutical industries expand
and more patents are issued, the risk increases that others may assert that our clinical assets, technologies, or methods of delivery
or use infringe their patent rights. Moreover, it is not always clear to industry participants, including us, which patents cover various
drugs, biologics, drug delivery systems, or their methods of use, and which of these patents may be valid and enforceable. Thus, because
of the large number of patents issued and patent applications filed in our fields, there may be a risk that third parties may allege
they have patent rights encompassing our clinical assets, technologies, or methods.

 In
addition, there may be issued patents of third parties that are infringed or are alleged to be infringed by our clinical assets or proprietary
technologies. We cannot be certain that others have not filed patent applications for technology covered by our own and in-licensed issued
patents or our pending applications because some patent applications in the U.S. may be maintained in secrecy until the patents are issued,
patent applications in the U.S. and many foreign jurisdictions are typically not published until eighteen months after filing, and publications
in the scientific literature often lag behind actual discoveries. Our competitors may have filed, and may in the future file, patent
applications covering our clinical assets or technology similar to ours. Any such patent application may have priority over our own and
in-licensed patent applications or patents, which could further require us to obtain rights to issued patents covering such technologies.
If another party has filed a U.S. patent application on inventions similar to those owned or in-licensed to us, we or, in the case of
in-licensed technology, the licensor may have to participate, in the U.S., in an interference proceeding to determine priority of invention.

 We
may be exposed to, or threatened with, future litigation by third parties having patent or other intellectual property rights alleging
that our clinical assets or proprietary technologies infringe such third parties' intellectual property rights, including litigation.
These lawsuits could claim that there are existing patent rights for such drug and this type of litigation can be costly and could adversely
affect our operating results and divert the attention of managerial and technical personnel, even if we do not infringe such patents
or the patents asserted against us are ultimately established as invalid. There is a risk that a court would decide that we are infringing
the third party's patents and would order us to stop the activities covered by the patents. In addition, there is a risk that a
court will order us to pay the other party damages for having violated the other party's patents.

 As
a result of patent infringement claims, or to avoid potential claims, we may choose or be required to seek licenses from third parties.
These licenses may not be available on commercially acceptable terms, or at all. Even if we are able to obtain a license, the license
would likely obligate us to pay license fees or royalties or both, and the rights granted to us might be nonexclusive, which could result
in our competitors gaining access to the same intellectual property, or such rights might be restrictive and limit our present and future
activities. Ultimately, we or a licensee could be prevented from commercializing a product or be forced to cease some aspect of our business
operations, if, as a result of actual or threatened patent infringement claims, we are unable to enter into licenses on acceptable terms.

 In
addition to possible infringement claims against us, we may become a party to other patent litigation and other proceedings, including
interference, derivation, re-examination, or other post-grant proceedings declared or granted by the USPTO, and similar proceedings in
foreign countries, regarding intellectual property rights with respect to our current or future products.

 There
is a substantial amount of litigation involving patent and other intellectual property rights in the biotechnology and pharmaceutical
industries generally. To date, no litigation asserting infringement claims has ever been brought against us. If a third-party claims
that we infringe its intellectual property rights, we may face a number of issues, including:

 infringement
 and other intellectual property claims which, regardless of merit, may be expensive and time-consuming to litigate and may divert
 our management's attention from our core business;

 substantial
 damages for infringement, which we may have to pay if a court decides that the product or technology at issue infringes or violates
 the third party's rights, and if the court finds that the infringement was willful, we could be ordered to pay treble damages
 and the patent owner's attorneys' fees;

 a
 court prohibiting us from selling or licensing the product or using the technology unless the third party licenses its intellectual
 property rights to us, which it is not required to do;

 if
 a license is available from a third party, we may have to pay substantial royalties or upfront fees or grant cross-licenses to intellectual
 property rights for our products or technologies; and

 redesigning
 our products or processes so they do not infringe, which may not be possible or may require substantial monetary expenditures and
 time.

 Some
of our competitors may be able to sustain the costs of complex patent litigation more effectively than we can because they have substantially
greater resources. In addition, any uncertainties resulting from the initiation and continuation of any litigation could harm our ability
to raise additional funds or otherwise adversely affect our business, financial condition, operating results, and prospects.

 Because
we rely on certain third-party licensors and partners, and will continue to do so in the future, if one of our licensors or partners
is sued for infringing a third party's intellectual property rights, our business, financial condition, operating results, and
prospects could suffer in the same manner as if we were sued directly. In addition to facing litigation risks, we have agreed to indemnify
certain third-party licensors and partners against claims of infringement caused by our proprietary technologies, and we have entered
or may enter into cost-sharing agreements with some our licensors and partners that could require us to pay some of the costs of patent
litigation brought against those third parties whether or not the alleged infringement is caused by our proprietary technologies. In
certain instances, these cost-sharing agreements could also require us to assume greater responsibility for infringement damages than
would be assumed just on the basis of our technology.

 The
occurrence of any of the foregoing could adversely affect our business, financial condition, or operating results.

 We
may become involved in lawsuits to protect or enforce our patents or other intellectual property or the patents of our licensors, or
other claims may be made against us, which could be expensive and time-consuming.

 Competitors
may infringe our intellectual property, including our patents or the patents of our licensors. As a result, we may be required to file
infringement claims to stop third-party infringement or unauthorized use. This can be expensive and time-consuming, particularly for
a company of our size. In addition, in an infringement proceeding, a court may decide that a patent of ours is not valid or is unenforceable
or may refuse to stop the other party from using the technology at issue on the grounds that our patent claims do not cover its technology
or that the factors necessary to grant an injunction against an infringer are not satisfied. An adverse determination of any litigation
or other proceedings could put one or more of our patents at risk of being invalidated, interpreted narrowly, or amended such that they
do not cover our clinical assets. Moreover, such adverse determinations could put our patent applications at risk of not issuing or issuing
with limited and potentially inadequate scope to cover our clinical assets or to prevent others from marketing similar products.

 Interference,
derivation, or other proceedings brought at the USPTO may be necessary to determine the priority or patentability of inventions with
respect to our patent applications or those of our licensors or potential partners. Litigation or USPTO proceedings brought by us may
fail or may be invoked against us by third parties. Even if we are successful, domestic or foreign litigation or USPTO or foreign patent
office proceedings may result in substantial costs and distraction to our management. We may not be able, alone or with our licensors
or potential partners, to prevent misappropriation of our proprietary rights, particularly in countries where the laws may not protect
such rights as fully as in the U.S.

because of the substantial amount of discovery required in connection with intellectual property litigation or other proceedings, there
is a risk that some of our confidential information could be compromised by disclosure during this type of litigation or other proceedings.
In addition, during the course of this kind of litigation or proceedings, there could be public announcements of the results of hearings,
motions, or other interim proceedings or developments or public access to related documents.

 In
addition, in August 2023, prior to the Business Combination, our now wholly-owned subsidiary, Conduit Pharmaceuticals Limited, received
a letter from Strand Hanson Limited ("Strand") claiming it was owed advisory fees pursuant to a previously executed letter.
Conduit rejected and disputed the substance of the letter in full. Following such rejection, on September 7, 2023, Strand filed a claim
in the Business and Property Courts of England and Wales claiming it is entitled to be paid the sum of $2 million and, as a result of
the event the Business Combination is completed, to be issued 65 thousand shares of common stock. We intend to vigorously defend against
these claims. Regardless of its outcome, the litigation may impact our business due to, among other things, defense legal cost and the
diversion of the attention of our management.

 Our
reliance on third parties requires us to share our trade secrets, which increases the possibility that our trade secrets will be misappropriated
or disclosed, and confidentiality agreements with employees and third parties may not adequately prevent disclosure of trade secrets
and protect other proprietary information.

 We
consider proprietary trade secrets or confidential know-how and unpatented know-how to be important to our business. We may rely on trade
secrets or confidential know-how to protect our technology, especially where we believe that patent protection is of limited value.

 To
protect this type of information against disclosure or appropriation by competitors, our policy is to require our employees, consultants,
collaborators, contractors, and advisors to enter into confidentiality agreements and, if applicable, material transfer agreements, consulting
agreements, or other similar agreements with us prior to beginning research or disclosing proprietary information. These agreements typically
limit the rights of the third parties to use or disclose our confidential information, including our trade secrets. However, current
or former employees, consultants, collaborators, contractors, and advisors may unintentionally or willfully disclose our confidential
information to competitors, and confidentiality agreements may not provide an adequate remedy in the event of unauthorized disclosure
of confidential information. The need to share trade secrets and other confidential information increases the risk that such trade secrets
become known by our competitors, are inadvertently incorporated into the technology of others, or are disclosed or used in violation
of these agreements. Given that our proprietary position is based, in part, on our know-how and trade secrets, a competitor's discovery
of our trade secrets or other unauthorized use or disclosure would impair our competitive position and may have an adverse effect on
our business and results of operations. Enforcing a claim that a third party obtained illegally and is using trade secrets or confidential
know-how is expensive, time consuming, and unpredictable. The enforceability of confidentiality agreements may vary from jurisdiction
to jurisdiction.

 In
addition, these agreements typically restrict the ability of our employees, consultants, collaborators, contractors, and advisors to
publish data potentially relating to our trade secrets, although our agreements may contain certain limited publication rights. Despite
our efforts to protect our trade secrets, our competitors may discover our trade secrets, either through breach of our agreements with
third parties, independent development, or publication of information by any of our third-party collaborators. A competitor's discovery
of our trade secrets would impair our competitive position and have an adverse impact on our business.

 We
may be subject to claims that our employees, consultants, or independent contractors have wrongfully used or disclosed to us alleged
trade secrets of their former employers or their former or current customers.

 As
is common in the biotechnology and pharmaceutical industries, certain of our employees were formerly employed by other biotechnology
or pharmaceutical companies, including our competitors or potential competitors. Moreover, we engage the services of consultants to assist
it in the development of our products and clinical assets, many of whom were previously employed at or may have previously been or are
currently providing consulting services to, other biotechnology or pharmaceutical companies, including our competitors or potential competitors.
We may be subject to claims that these employees and consultants or we have inadvertently or otherwise used or disclosed trade secrets
or other proprietary information of their former employers or their former or current customers. Although we have no knowledge of any
such claims being alleged to date, if such claims were to arise, litigation may be necessary to defend against any such claims. Even
if we are successful in defending against any such claims, any such litigation could be protracted, expensive, a distraction to our management
team, not viewed favorably by investors and other third parties, and may potentially result in an unfavorable outcome.

 If
our trademarks and trade names are not adequately protected, then we may not be able to build name recognition in our markets of interest
and our business may be adversely affected.

 Our
unregistered trademarks or trade names may be challenged, infringed, circumvented, or declared generic or determined to be infringing
on other marks. We may not be able to protect our rights to these trademarks and trade names, which we need to build name recognition
among potential collaborators or customers in our markets of interest. At times, competitors may adopt trade names or trademarks similar
to those of ours, thereby impeding our ability to build brand identity and possibly leading to market confusion. In addition, there could
be potential trade name or trademark infringement claims brought by owners of other registered trademarks or trademarks that incorporate
variations of our unregistered trademarks or trade names. Over the long term, if we are unable to successfully register its trademarks
and trade names and establish name recognition based on its trademarks and trade names, then we may not be able to compete effectively,
and our business may be adversely affected. Our efforts to enforce or protect our proprietary rights related to trademarks, trade secrets,
domain names, copyrights, or other intellectual property may be ineffective and could result in substantial costs and diversion of resources
and could adversely impact our financial condition or results of operations.

 Our
proprietary information may be lost, or we may suffer security breaches.

 In
the ordinary course of our business, we collect and store sensitive data, including intellectual property, clinical trial data, proprietary
business information, personal data, and personally identifiable information of our clinical trial subjects and employees, in our data
centers and on our networks. The secure processing, maintenance, and transmission of this information is critical to our operations.
Despite our security measures, our information technology and infrastructure may be vulnerable to attacks by hackers or breached due
to employee error, malfeasance, or other disruptions. Although, to our knowledge, we have not experienced any such material security
breach to date, any such breach could compromise our networks and the information stored there could be accessed, publicly disclosed,
lost, or stolen. Any such access, disclosure, or other loss of information could result in legal claims or proceedings, liability under
laws that protect the privacy of personal information, significant regulatory penalties, disrupt our operations, damage our reputation,
and cause a loss of confidence in us and our ability to conduct clinical trials, which could adversely affect our reputation and delay
our clinical development of our clinical assets.

 We
use artificial intelligence technology in our business, specifically, in relation to our service agreement with Sarborg and
challenges with properly managing such technology could result in reputational harm, competitive harm and legal liability, and
adversely affect our business, financial condition and results of operations.

 On
December 12, 2024, we entered into the Sarborg Agreement with Sarborg. Under the terms of the Sarborg Agreement, Sarborg will provide
algorithmic and cybernetic technology services to Conduit, including the development of decision-support tools and advanced cybernetic
systems tailored to enhance Conduit's decision-making processes and maximize the value of its pharmaceutical asset portfolio.

will perform the services to Conduit comprised of three phases: the Initial Phase (0-24 weeks) focuses on establishing a foundation for
collaboration and aligning Sarborg's services with Conduit's strategic goals; the Development Phase (24-36 weeks) involves
building technological infrastructure, including dashboards and predictive models; and the Ongoing Services Phase (36-52 weeks) ensures
the sustained functionality and relevance of Sarborg's deliverables while supporting Conduit's growth through iterative improvements
and updates. Sarborg will create specific deliverables, including reports, computer programs, software applications, APIs, mobile applications,
source code, written technical specifications and designs, operating and maintenance manuals, and other recorded data and information
arising from or relating to the services. Sarborg will provide all necessary resources to perform the services and deliver the deliverables
in accordance with the Sarborg Agreement.

 To
date, Conduit has successfully completed the Initial Phase of its collaboration with Sarborg, establishing a strong foundation for
integrating AI-driven solutions into our operations. This phase focused on identifying key inputs for the algorithmic approach and
ensuring alignment between Sarborg's services and Conduit's strategic goals. As part of this effort, Sarborg has
successfully delivered three key milestones. First, they conducted detailed teach-in sessions with Conduit's management team
to gain a deeper understanding of our objectives, challenges, and operational workflows, resulting in documented meeting agendas,
minutes, and action plans. Second, they finalized and validated a set of proprietary inputs essential for their cybernetic models,
tailored specifically to Conduit's portfolio and R&D pipeline. Finally, they completed an in-depth market analysis of
potential cocrystal candidates, assessing the patent landscape, competitive positioning, and market size. The insights from this
market analysis are now informing Conduit's ongoing strategic decision-making. With these key milestones delivered, we are now
progressing to the next phase of development.

has now commenced Phase II: The Development Phase, which focuses on building the technological infrastructure necessary to integrate
AI into Conduit's operations. As part of this, Sarborg has successfully completed the first milestone, Dashboard Creation and Refinement,
delivering personalized dashboards that provide Conduit's key personnel with real-time access to critical data related to deliverables,
clinical trials, and drug discovery. These initial dashboards, along with user interface mock-ups and a dashboard user guide, will serve
as the foundation for further refinements. Moving forward, the platform will continue to be optimized to maximize efficiency and ensure
seamless integration into Conduit's workflows.

 As
with many developing technologies, AI presents risks and challenges that could affect its further development, adoption, and use, and
therefore our business. AI algorithms may be flawed or biased. Datasets used to train or develop AI systems may be insufficient, of inferior
quality, or contain biased information. Additionally, the laws and regulations concerning the use of AI continue to evolve. If the use
or integration of AI systems, or the outputs generated by such systems, were determined to be non-compliant (e.g., in relation to intellectual
property or data privacy rights), this may result in liability, including legal liability, or adversely affect our business, reputation,
brand, financial condition and results of operations. It is possible that emerging regulations may limit or block the use of AI in our
business and solutions or otherwise impose other restrictions that may affect or impair the usability or efficiency of our business or
services for an extended period of time or indefinitely. Our competitors or other third parties may incorporate AI into their product
development, technology and infrastructure more quickly or more successfully than us, which could impair our ability to compete effectively
and adversely affect our business, financial condition and results of operations.

 Risks
Related to Securities Markets and Investment in Our Stock

 If we do not maintain
our trading market's listing requirements, Nasdaq may delist our securities from trading on its exchange.

 In August 2024, the Company
received deficiency letters from Nasdaq notifying the Company that it was not in compliance with Listing Rule 5450(a)(1) (the "Bid
Price Rule"), Listing Rule 5450(b)(2)(C) (the "MVPHS Rule") and Listing Rule 5450(b)(2)(A) (the "MVLS Rule",
together with the Bid Price Rule and the MVPHS Rule, the "Rules"). The Company had until February 10, 2025, and February
11, 2025, to regain compliance with the Rules. On December 17, 2024, Nasdaq issued a letter to the Company that as of December 17, 2024,
it determined that the Company's securities had a closing bid price of $0.10 or less for ten consecutive trading days. As a result,
Nasdaq had determined to delist the Company's common stock and redeemable warrants from The Nasdaq Global Market, on December 27,
2024. The Company subsequently requested and received a hearing (the "Nasdaq Hearing") from the Nasdaq Hearings Panel (the
"Panel"). The Company submitted a written plan of compliance to cure its Rule deficiencies to Nasdaq on January 22, 2025,
and attended the Nasdaq Hearing for the Company on February 11, 2025. On March 5, 2025, the Company received a written notification (the
"Notice") from the Panel confirming it has granted the Company such an extension for the Company to regain compliance with
the MVPHS and MVLS rules, provided that the Company, (i) on or before March 12, 2025, files an application to transfer to the Nasdaq
Capital Market, which application was submitted on March 7, 2025, and (ii) on or before March 31, 2025, demonstrates compliance with all Nasdaq listing rules,
which it intends to do, and believes it will satisfy. Additionally, the Company was also notified in the Notice that as of February
26, 2025, it had regained compliance with the Bid Price Rule.

the transfer to the Nasdaq Capital Market, the Company's current MVPHS will be compliant with the MVPHS continued listing
standard of greater than $1.0 million and the Company believes it will be able to demonstrate its compliance with the Equity
Standard of Stockholder's Equity greater than $2.5 million prior to the March 31, 2025, deadline to the satisfaction of
Nasdaq, although no such assurance can be given. The inability to comply with Nasdaq's continued requirements or standards
could result in the delisting of our common stock, which could have a material adverse effect on our financial condition and could
cause the value of the common stock to decline.

 If
our common stock were to be delisted from trading on The Nasdaq Global Market and the trading price of our common stock were below $5.00
per share on the date the common stock is delisted, trading in our common stock would also be subject to the requirements of certain
rules promulgated under the Exchange Act. These rules require additional disclosure by broker-dealers in connection with any trades involving
a stock defined as a "penny stock" and impose various sales practice requirements on broker-dealers who sell penny stocks
to persons other than established customers and accredited investors, generally institutions. These additional requirements may discourage
broker-dealers from effecting transactions in securities that are classified as penny stocks, which could severely limit the market price
and liquidity of such securities and the ability of purchasers to sell such securities in the secondary market. A penny stock is defined
generally as any non-exchange listed equity security that has a market price of less than $5.00 per share, subject to certain exceptions.

 We
do not anticipate paying any dividends in the foreseeable future.

 The
current expectation is that we will retain our future earnings to fund the development and growth of our business. As a result, capital
appreciation, if any, of the shares of our common stock will stockholders' sole source of gain, if any, for the foreseeable future.

 Our
Second Amended and Restated Certificate of Incorporation (the "Certificate of Incorporation") provides, subject to limited
exceptions, that the Court of Chancery of the State of Delaware will be the sole and exclusive forum for certain stockholder litigation
matters, which could limit our stockholders' ability to obtain a chosen judicial forum for disputes with us or our directors, officers,
employees, or stockholders.

 Our
Certificate of Incorporation requires to the fullest extent permitted by law, that derivative actions brought in our name, actions against
directors, officers and employees for breach of fiduciary duty and other similar actions may be brought in the Court of Chancery in the
State of Delaware or, if that court lacks subject matter jurisdiction, another federal or state court situated in the State of Delaware.
Any person or entity purchasing or otherwise acquiring any interest in shares of our capital stock shall be deemed to have notice of
and consented to the forum provisions in our Certificate of Incorporation. In addition, our Certificate of Incorporation and Bylaws provide
that the federal district courts of the United States shall be the exclusive forum for the resolution of any complaint asserting a cause
of action under the Securities Act and the Exchange Act. Neither the exclusive forum provisions nor the federal securities laws (and
the rules and regulations thereunder) may be waived by a stockholder.

 In
March 2020, the Delaware Supreme Court issued a decision in Salzburg et al. v. Sciabacucchi, which found that an exclusive forum
provision providing for claims under the Securities Act to be brought in federal court is facially valid under Delaware law. We intend
to enforce this provision, but we do not know whether courts in other jurisdictions will agree with this decision or enforce it.

 This
choice of forum provision may limit a stockholder's ability to bring a claim in a judicial forum of its choosing for disputes with
us or any of our directors, officers, other employees or stockholders, which may discourage lawsuits with respect to such claims and,
if a stockholder were to bring such a claim, the choice of forum provision may result in the stockholder incurring increased costs in
connection with bring such a claim as such stockholder will be required to bring the claim in the state or federal courts located in
the State of Delaware. Alternatively, if a court were to find the choice of forum provision contained in our Certificate of Incorporation
to be inapplicable or unenforceable in an action, we may incur additional costs associated with resolving such action in other jurisdictions,
which could harm its business, operating results, and financial condition.

 Our
charter documents and Delaware law could prevent a takeover that stockholders consider favorable and could also reduce the market price
of our common stock.

 Our
Certificate of Incorporation and Bylaws contain provisions that could delay or prevent a change in control of the Company. These provisions
could also make it more difficult for stockholders to elect directors and take other corporate actions. These provisions include:

 authorizing
 our board of directors to issue preferred stock with voting or other rights or preferences that could discourage a takeover attempt
 or delay changes in control;

 prohibiting
 cumulative voting in the election of directors;

 providing
 that vacancies on our board of directors may be filled only by a majority of directors then in office, even though less than a quorum;

 prohibiting
 stockholder action by written consent;

 limiting
 the persons who may call special meetings of stockholders; and

 requiring
 advance notification of stockholder nominations and proposals.

 These
provisions may frustrate or prevent any attempts by our stockholders to replace or remove our current management by making it more difficult
for stockholders to replace members of our board of directors, which is responsible for appointing the members of our management. These
and other provisions in our Certificate of Incorporation and Bylaws and under Delaware law could discourage potential takeover attempts,
reduce the price investors might be willing to pay in the future for shares of common stock and result in the market price of common
stock being lower than it would be without these provisions.

 If
securities or industry analysts do not publish or cease publishing research or reports about us, our business, or our market, or if they
adversely change their recommendations or publish negative reports regarding our business or our common stock, our share price and trading
volume could decline.

 The
trading market for our common stock will depend on the research and reports that securities or industry analysts publish about us, our
business, or our market. Currently, we do not have any analyst coverage and may not obtain analyst coverage in the future. In the event
we obtain analyst coverage, we will not have any control over such analysts. If one or more of the analysts who cover us downgrade the
common stock or change their opinion of such shares, the share price of the common stock would likely decline. If one or more of these
analysts cease coverage of the Company or fail to regularly publish reports on the Company, we could lose visibility in the financial
markets, which could cause the share price or trading volume of the common stock to decline.

 We
are an "emerging growth company" and we cannot be certain if the reduced disclosure requirements applicable to emerging growth
companies will make our securities less attractive to investors.

 We
are an "emerging growth company," as defined in the JOBS Act. Emerging growth companies can delay adopting new or revised
accounting standards until such time as those standards apply to private companies. As an emerging growth company, we are not required
to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act, we have reduced disclosure obligations
regarding executive compensation in our periodic reports and proxy statements, and we are exempt from the requirements of holding a nonbinding
advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously approved. We cannot
predict if investors will find our stock less attractive because we may rely on these provisions. If some investors find our stock less
attractive as a result, there may be a less active trading market for our shares and our stock price may be more volatile.

 We
will remain an emerging growth company until the earliest of (i) the end of the fiscal year in which the market value of our common stock
that is held by non-affiliates exceeds $700 million as of the end of the second fiscal quarter, (ii) the end of the fiscal year in which
we have total annual gross revenues of $1.235 billion or more during such fiscal year, (iii) the date on which we issue more than $1
billion in non-convertible debt in a three-year period, or (iv) the end of the fiscal year following the fifth anniversary of the date
of the first sale of our common stock pursuant to an effective registration statement filed under the Securities Act.

 Claims
for indemnification by our directors and officers may reduce our available funds to satisfy successful third-party claims against us
and may reduce the amount of money available to us.

 Our
Certificate of Incorporation and Bylaws provides that we will indemnify our directors and officers, in each case to the fullest extent
permitted by Delaware law.

 In
addition, as permitted by Section 145 of the DGCL, our Bylaws and our indemnity agreements that we entered into with our directors and
officers provide that:

 We
 will indemnify our directors and officers for serving us in those capacities or for serving other business enterprises at our request,
 to the fullest extent permitted by Delaware law. Delaware law provides that a corporation may indemnify such person if such person
 acted in good faith and in a manner such person reasonably believed to be in or not opposed to the best interests of the registrant
 and, with respect to any criminal proceeding, had no reasonable cause to believe such person's conduct was unlawful;

 We
 may, in our discretion, indemnify employees and agents in those circumstances where indemnification is permitted by applicable law;

 We
 will be required to advance expenses, as incurred, to our directors and officers in connection with defending a proceeding, except
 that such directors or officers shall undertake to repay such advances if it is ultimately determined that such person is not entitled
 to indemnification;

 We
 will not be obligated pursuant to our Bylaws to indemnify a person with respect to proceedings initiated by that person against us
 or our other indemnitees, except with respect to proceedings authorized by our board of directors;

 the
 rights conferred in our Bylaws are not exclusive, and we are authorized to enter into indemnification agreements with our directors,
 officers, employees and agents and to obtain insurance to indemnify such persons; and

 we
 may not retroactively amend our Bylaw provisions to reduce our indemnification obligations to directors, officers, employees and
 agents.

 Risks
Related to Finances and Capital Requirements

 We
will require substantial additional funding in the future, which may not be available to us on acceptable terms, or at all, and, if not
so available, may require us to delay, limit, reduce, or cease our operations.

 Our
operations have consumed substantial amounts of cash since our inception. As of December 31, 2024, we had an accumulated deficit of $29.1
million and our net loss was $17.8 million for the fiscal year ended December 31, 2024. We expect to continue to incur significant expenses
and increasing operating losses for the foreseeable future. Our business will require substantial additional capital for implementation
of our long-term business plan and development of clinical assets. Our ability to raise additional funds may be adversely impacted by
potential worsening global economic conditions and the recent disruptions to, and volatility in, the credit and financial markets in
the U.S. As we require additional funds, we may seek to fund our operations through the sale of additional equity securities, debt financing,
and/or strategic collaboration agreements. We cannot be sure that additional financing from any of these sources will be available when
needed or that, if available, the additional financing will be obtained on favorable terms.

 Our
future funding requirements will depend on many factors, including, but not limited to:

 the
 progress, timing, scope, and costs of our clinical trials, including the ability to timely enroll patients in our potential future
 clinical trials;

 the
 outcome, timing, and cost of regulatory approvals by the FDA and comparable regulatory authorities, including the potential that
 the FDA or comparable regulatory authorities may require that we perform more studies than those that we currently expect;

 the
 amount of revenues, if any, from our current clinical assets or any future clinical assets;

 the
 terms and timing of any potential future collaborations, licensing, or other arrangements that we may establish;

 cash
 requirements of any future acquisitions and/or the development of other clinical assets;

 the
 costs of operating as a public company;

 the
 time and cost necessary to respond to technological and market developments;

 any
 disputes which may occur between us, employees, collaborators, or other prospective business partners; and

 the
 costs of filing, prosecuting, defending, and enforcing any patent claims and other intellectual property rights

 If
we raise additional funds by selling shares of our common stock or other equity-linked securities, the ownership interest of our current
stockholders will be diluted. We may seek to access the public or private capital markets whenever conditions are favorable, even if
we do not have an immediate need for additional capital at that time. If we raise additional funds through collaborations, strategic
alliances or marketing, distribution, or licensing arrangements with third parties, we may have to relinquish valuable rights to our
technologies, future revenue streams, or clinical assets or to grant licenses on terms that may not be acceptable to us. If we raise
additional funds through debt financing, we may have to grant a security interest on our assets to the future lenders, our debt service
costs may be substantial, and the lenders may have a preferential position in connection with any future bankruptcy or liquidation involving
the Company.

 On
March 27, 2025, the last quoted sale price for our common stock as reported on Nasdaq was $0.77 per share. Currently, the exercise
prices of the Company's warrants are significantly greater than the current market price of our common stock. Accordingly,
such warrants are unlikely to be exercised and therefore the Company does not expect to receive any proceeds from such exercise of
the warrants in the near term. Whether any holders of Warrants determine to exercise such warrants, which would result in cash
proceeds to the Company, will likely depend upon the market price of our common stock at the time of any such holder's
determination.

 If
we are unable to raise additional capital when needed, we may be required to curtail the development of our technology or materially
curtail or reduce our operations. We could be forced to sell or dispose of our rights or assets. Any inability to raise adequate funds
on commercially reasonable terms could have a material adverse effect on our business, results of operations, and financial condition,
including the possibility that a lack of funds could cause our business to fail and our Company to dissolve and liquidate with little
or no return to investors.

 We
will continue to incur significant increased costs as a result of operating as a public company, and our management will be required
to devote substantial time to new compliance initiatives.

 As
a publicly traded company, we will incur significant legal, accounting, and other expenses under the Exchange Act, the Sarbanes-Oxley
Act, and other applicable securities rules and regulations. In addition, new and changing laws, regulations, and standards relating to
corporate governance and public disclosure, including the Dodd Frank Wall Street Reform and Consumer Protection Act and the rules and
regulations promulgated and to be promulgated thereunder, as well as under the Sarbanes-Oxley Act, the JOBS Act, and the rules and regulations
of the SEC and national securities exchanges have created uncertainty for public companies and increased the costs and the time that
our board of directors and management must devote to complying with these rules and regulations. We expect these rules and regulations
to increase our legal and financial compliance costs and will divert management time and attention from revenue generating activities.

the need to establish the corporate infrastructure demanded of a public company may divert management's attention from implementing
our growth strategy, which could prevent us from improving our business, results of operations, and financial condition. We have made,
and will continue to make, changes to our internal controls and procedures for financial reporting and accounting systems to meet our
reporting obligations as a publicly traded company. However, the measures we take may not be sufficient to satisfy our obligations as
a publicly traded company.

 For
as long as we remain an "emerging growth company" as defined in the JOBS Act, we may take advantage of certain exemptions
from various reporting requirements that are applicable to other public companies that are not "emerging growth companies."
We may remain an "emerging growth company" until the earliest of (i) the last day of our fiscal year following February 7,
2027 (the fifth anniversary of the consummation of the SPAC IPO), (ii) the last day of the fiscal year in which the market value of our
shares of common stock that are held by non-affiliates exceeds $700 million as of June 30 of that fiscal year, (iii) the last day of
the fiscal year in which we have total annual gross revenue of $1.235 billion or more during such fiscal year (as indexed for inflation)
or (iv) the date on which we have issued more than $1.0 billion in non-convertible debt in the prior three-year period. Further, there
is no guarantee that the exemptions available to us under the JOBS Act will result in significant savings. To the extent we choose not
to use exemptions from various reporting requirements under the JOBS Act, we will incur additional compliance costs, which may impact
earnings.

 We
may issue additional shares of common stock or preferred stock under an employee incentive plan or under our existing at the market offering program, which would dilute the interest of
our stockholders.

 We
may issue a substantial number of additional shares of common or preferred stock under an employee incentive plan or under our ongoing at the market offering program. The issuance of
additional shares of common or preferred stock:

 may
 significantly dilute the equity interest of investors;

 may
 subordinate the rights of holders of common stock if preferred stock is issued with rights senior to those afforded our common stock;

 could
 cause a change of control if a substantial number of shares of our common stock are issued, which may affect, among other things,
 our ability to use our net operating loss carry forwards, if any, and could result in the resignation or removal of our present officers
 and directors; and

 may
 adversely affect prevailing market prices for the common stock.

 Item
1B. Unresolved Staff Comments

 None.

 Item
1C. Cybersecurity

 We
operate in the biotechnology sector, which is subject to various cybersecurity risks that could adversely affect our business,
financial condition, and results of operations, including intellectual property theft; fraud; extortion; harm to employees or
customers; violation of privacy laws and other litigation and legal risk; and reputational risk. We have implemented a risk-based
approach to identify and assess the cybersecurity threats that could affect our business and information systems. We
have implemented a risk-based approach to identify and assess cybersecurity threats that could impact our business and information
systems. As part of this strategy, the Company has engaged a third-party service provider to implement comprehensive IT and
cybersecurity policies, including Guardz, Cyber Essentials, and others. These initiatives are supported by detailed policies, staff
training programs, and the use of advanced tools such as firewalls and VPNs to prevent cybersecurity incidents. Additionally,
consultation with third-party experts has further strengthened the Company's IT framework and improved overall compliance. We
require third-party service providers with access to personal, confidential or proprietary information to implement and
maintain comprehensive cybersecurity practices consistent with applicable legal standards and industry best practices.

 The Company has engaged a third-party service provider
to implement comprehensive IT and cybersecurity policies, including Guardz, Cyber Essentials, and others. These initiatives are supported
by detailed policies and staff training programs, which have strengthened the Company's IT framework and improved compliance.

 In
light of the pervasive and increasing threat from cyberattacks, the Company's Board
of Directors and the Audit Committee, with input from management, assess the Company's cybersecurity threats and the
measures implemented by the Company to mitigate and prevent cyberattacks. The Audit
Committee consults with management regarding ongoing cybersecurity initiatives, and requests management to report to the
Audit Committee or the full Board regularly on their assessment of the Company's cybersecurity program and risks.

 As
of the date of this Annual Report, the Company is not aware of any risks from cybersecurity threats that have materially affected or
are reasonably likely to materially affect the Company, including its business strategy, results of operations, or financial condition.

 Item
2. Properties

 We
currently operate as a virtual company, but also lease property in the United Kingdom. On March 7, 2024, we entered into a lease for
laboratory space at Cambridge Science Park. Rent is 92,925 per annum, the equivalent of approximately $10,000 per month. The lease
runs until January of 2027, and the laboratory space is intended to provide us with the ability to extend or develop proprietary solid-form
intellectual property for existing and future clinical assets.

 Item
3. Legal Proceedings

 Other
than as set forth below, we are not currently party to or aware of being subject to any material legal proceedings. However, we may from
time to time become a party to various legal proceedings arising in the ordinary course of our business, which could have a material
adverse effect on our business, financial condition, or results of operations. Regardless of outcome, litigation could impact our business
due to defense and settlement costs, diversion of management resources and other factors.

 In
August 2023, prior to the Business Combination, our now wholly-owned subsidiary, Conduit Pharmaceuticals Limited, received a letter from
Strand Hanson Limited ("Strand") claiming it was owed advisory fees pursuant to a previously executed letter. Conduit rejected
and disputes the substance of the letter in full. Following such rejection, on September 7, 2023, Strand filed a claim in the Business
and Property Courts of England and Wales claiming it is entitled to be paid the sum of $2 million and, as a result of the completion
of the Business Combination, to be issued 6.5 million shares of common stock. As of December 31, 2024, the potential contingency is considered
probable and reasonably estimable and as such, the Company accrued an estimated liability of $0.4 million in the accompanying financial
statements. We intend to vigorously defend against these claims. Regardless of its outcome, the litigation may impact our business due
to, among other things, defense legal cost and the diversion of the attention of our management.

 On December 18, 2024, Conduit UK Management Limited
("Conduit") received a notification from the UK Intellectual Property Office ("UK IPO") notifying the company
that St George Street Capital had initiated patent entitlement proceedings with respect to patent application PCT/IB2022/00775 ("Patent
Application"). Conduit refutes the claims made by St George Street Capital and filed a counterstatement on February 26, 2025 with
the UK IPO. In addition, each of the three inventors named in the Patent Application filed simultaneous counterstatements fully supporting
Conduit's position, and assertions that the claims are without merit. Further updates will be made following notification by the
UK IPO.

 Item
4. Mine Safety Disclosures

 Not
applicable.

 PART
II

 Item
5. Market for Registrant's Common Equity, Related Stockholder Matters, and Issuer Purchases of Equity Securities

 (a)
Market Information

 Our
common stock and warrants are traded on The Nasdaq Global Market and The Nasdaq Capital Market, respectively, under the symbols "CDT"
and "CDTTW", respectively. Prior to the completion of the Business Combination, the securities of MURF were listed on The
Nasdaq Global Market under the symbols "MURFU," "MURF," and "MURFW", all of which are no longer listed
on The Nasdaq Global Market.

 On
March 27, 2025, the last quoted sale price for our common stock as reported on Nasdaq was $0.77 per share.

 (b)
Holders

 As
of March 28, 2025, there were approximately 400 holders of record of our common stock. Such numbers do not include beneficial owners
holding our securities through nominee names.

 (c)
Dividends

 We
have never declared or paid any cash dividends on our capital stock, and we do not currently intend to pay any cash dividends for the
foreseeable future. We expect to retain future earnings, if any, to fund the development and growth of our business. Any future determination
to pay dividends on our common stock will be at the discretion of our board of directors and will depend upon, among other factors, our
financial condition, operating results, current and anticipated cash needs, plans for expansion, and other factors that our board of
directors may deem relevant.

 (d)
Securities Authorized for Issuance Under Equity Compensation Plans

 Reference
is made to the information contained in the Equity Compensation Plan table contained in Item 11 of this Annual Report.

 (e)
Recent Sales of Unregistered Securities

 There were no unregistered sales of equity securities which have not been
previously disclosed in a quarterly report on Form 10-Q or a current report on Form 8-K since January 1, 2024.

 (f)
Use of Proceeds from Registered Offerings

 None.

 (g)
Purchases of Equity Securities by the Issuer and Affiliated Purchasers

 None.

 Item
6. [Reserved].

 Item
7. Management's Discussion and Analysis of Financial Condition and Results of Operations

 The
following discussion and analysis of our financial condition and results of operations should be read together with the other sections
of this Annual Report on Form 10-K, including our audited financial statements for the year ended December 31, 2024, together with related
notes thereto, included elsewhere in this Annual Report. The following discussion contains forward-looking statements based upon current
expectations that involve risks, uncertainties, and assumptions. Our actual results may differ materially from those anticipated in these
forward-looking statements as a result of various factors, including those set forth under the section titled "Risk Factors"
or in other parts of this Annual Report and our other filings with the SEC. Our historical results are not necessarily indicative of
the results that may be expected for any period in the future. Conduit Pharmaceuticals Limited entered into an Agreement and Plan of
Merger (the "Merger Agreement") with Murphy Canyon Acquisition Corp. ("MURF") on November 8, 2022. The transaction
contemplated by the terms of the Merger Agreement was completed on September 22, 2023, in conjunction with which MURF changed its name
to Conduit Pharmaceuticals Inc. (hereafter referred to, collectively with is subsidiaries as "Conduit", the "Company",
"we", "us" or "our", unless the context otherwise requires. All dollar amounts are expressed in thousands
of United States dollars ("$"), unless otherwise indicated.

 Overview

 On
September 22, 2023, a merger transaction (the "Business Combination") between Conduit Pharmaceuticals Limited ("Old
Conduit"), Murphy Canyon Acquisition Corp ("MURF") and Conduit Merger Sub, Inc., a Cayman Islands exempted company
and a wholly owned subsidiary of MURF ("Merger Sub"), was completed pursuant to the Agreement and Plan of Merger, dated November
8, 2022, as amended, (the "Merger Agreement"). Pursuant to the terms of the Merger Agreement, at the closing, (i) Merger
Sub merged with and into Old Conduit, with Old Conduit surviving the Business Combination as a wholly-owned subsidiary of MURF, and (ii)
MURF changed its name from Murphy Canyon Acquisition Corp. to Conduit Pharmaceuticals Inc.

has developed a unique business model that allows it to act as a conduit to bring clinical assets from pharmaceutical companies and develop
new treatments for patients. Our novel approach addresses unmet medical needs and lengthens the intellectual property for our existing
assets through cutting-edge solid-form technology and then commercializing these products with life science companies. We continue to
evaluate novel artificial intelligence and cybernetics approaches to drug re-purposing, intellectual property and asset selection to
give Conduit a competitive advantage.

 We
are led by highly experienced pharmaceutical executives: Dr. Freda Lewis-Hall, former Chief Medical Officer of Pfizer Inc., the Chair
of our Board of Directors, and Dr. David Tapolczay, former Chief Executive Officer of the United Kingdom-based medical research charity
LifeArc, our Chief Executive Officer. Our management team includes active senior scientists who have an extensive understanding of the
pharmaceuticals market, which supports our strategy of developing clinical assets in a cost-efficient manner while focusing on therapeutic
efficacy and patient safety.

 Simultaneously,
Conduit leverages the capabilities of our Cambridge laboratory facility and highly experienced team of solid-form experts to extend or
develop proprietary solid-form intellectual property for our existing and future clinical assets. Our own intellectual property portfolio
comprises pending patent applications in several international jurisdictions describing a solid-form compound, including the AZD1656
Cocrystal (a HK-4 Glucokinase Activator), targeting a wide range of autoimmune disorders. Our pipeline research includes a number of
compounds that serve as promising alternatives to existing clinical assets currently marketed and sold by large pharmaceutical companies,
which we have identified as having an opportunity to develop further intellectual property positions through solid-form technology.

 In
connection with the funding and development of clinical assets, we expect to evaluate and select the specific molecules to be
developed and collaborate with external CROs and Key Opinion Leaders
("KOLs") to run clinical trials that are managed, funded, and overseen by us. We intend to leverage our comprehensive
clinical and scientific expertise in order to facilitate development of clinical assets through Phase II trials in an efficient
manner by using CROs and third-party service providers. We will also collaborate closely with disease specific KOLs to collectively
assess and determine the most appropriate indications for all our current and forthcoming assets.

 We
believe that successful Phase II trials of the clinical assets in our pipeline will increase the value of our assets. There is no assurance
that any clinical trials on the assets owned or licensed by us will be successful, however, following a successful Phase II clinical
trial, we would look to licensing opportunities with large biotech or pharmaceutical companies, typically for up-front milestone payments
and royalty income streams for the life of the asset patent. We anticipate using any future royalty income stream to develop our asset
portfolio in combination with other potential sources of financing, including debt or equity financing.

 Outside
of our proprietary owned patented clinical assets, AstraZeneca agreed to grant a license to the Company under certain intellectual property
rights controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656 and AZD5658 in all indications and myeloperoxidase inhibitor
AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male infertility. The Company will be responsible for the development
and commercialization of the Licensed Products under the related License Agreement. The
Company is required to use commercially reasonable efforts to develop and commercialize the Licensed Products.

 AstraZeneca
has conducted initial pre-clinical and, in some instances, clinical trials on these assets, but has decided to license them for further
development. As the clinical assets have undergone initial pre-clinical and clinical testing conducted by AstraZeneca, we are able to
use the safety data generated in these clinical trials to assess which clinical assets to further develop and for which indications.

 Through
this relationship, there are considerable APIs that were manufactured by AstraZeneca
(prior to conducting its clinical trials) available to Conduit. As a result, Conduit may not have to develop the APIs, which is often
a time consuming and expensive process, and the APIs already produced were subject to rigorous quality control measures.

 In
collaboration with SARBORG Limited ("Sarborg"), a related party, Conduit intends to leverage an advanced AI and cybernetics platform to evaluate key deliverables across multiple areas of the Company's operations,
including drug repurposing, drug discovery, solid-form identification, and clinical trial monitoring.

 The
Sarborg Agreement is designed to address longstanding challenges in the pharmaceutical sector, in particular by reducing human error
in critical decision-making processes in both clinical development and asset identification. By integrating Sarborg's
algorithmic AI/cybernetics technology, Conduit aims to enhance efficiency, lower costs, and accelerate timelines by minimizing human
intervention, ultimately optimizing the drug development cycle and giving Conduit a competitive advantage in the sector.

 Through
this relationship, Conduit will gain access to cutting-edge predictive models and dashboards, enabling the Company to evaluate drug candidates,
streamline clinical trials, and optimize asset management with real-time data. These tools will drive faster, more accurate decisions,
improving efficiency and reducing costs. By leveraging these insights, Conduit can differentiate itself in a competitive sector and gain
unique data-driven insights that position the Company for success across both its current and future asset portfolio.

 In
addition, Conduit will retain a perpetual, non-exclusive, royalty-free, and assignable right to use any platform or technology developed
by Sarborg in association with the deliverables. Ongoing support from Sarborg will ensure these systems evolve with Conduit's needs,
driving long-term innovation in areas like IP creation, regulatory strategy, and clinical trial monitoring. This partnership reinforces
Conduit's commitment to leveraging AI-driven solutions to accelerate growth, deliver value to shareholders, and maintain a competitive
edge in the pharmaceutical sector.

 This
strategic move reaffirms Conduit's commitment to adopting forward-thinking solutions to stay at the forefront of innovation in
the pharmaceutical industry. By reducing reliance on traditional, labor-intensive methods and harnessing the power of AI-driven technology,
Conduit is well-positioned to lead in areas such as drug repurposing, clinical trial monitoring, and IP creation, ensuring the Company's
long-term growth and market leadership.

Conduit is well positioned to pursue, and intends to pursue, additional relationships and/or partnerships with third parties for the
licensing of further assets which are currently deprioritized. We plan to focus our efforts on developing clinical assets to address
disorders that impact a large population where there is no present treatment or the present treatment, carries significant unwanted side
effects.

 Reverse
Stock Split

 On
January 22, 2025, we filed a certificate of amendment to the Company's Second Amended and Restated Certificate of Incorporation
(the "Amendment") with the Secretary of State of the State of Delaware to effectuate a 1-for-100 reverse stock split (the
"Reverse Stock Split") of the outstanding shares of our common stock. Our stockholders previously approved the Reverse Stock
Split and granted the board of directors the authority to determine the exact split ratio and when to proceed with the Reverse Stock
Split at our annual meeting of stockholders held on December 18, 2024. The Reverse Stock Split became effective on January 24, 2025,
and the common stock begin trading on The Nasdaq Global Market on a Reverse Stock Split-adjusted basis on January 27, 2025. The par value
and other terms of the common stock were not affected by the Reverse Stock Split.

 As
a result of the reverse stock split, every 100 shares of our common stock issued or outstanding were automatically reclassified into
and became one new share of common stock, and the number of our issued and outstanding shares of common stock was reduced to 1,384,801
and 738,295 as of December 31, 2024 and December 31, 2023, respectively. All references to numbers of shares of common stock and per-share
information in this Annual Report on Form 10-K have been adjusted retroactively, as appropriate, to reflect the reverse stock split.

 Nasdaq Stock Market Correspondence and Subsequent
Nasdaq Capital Market Listing

 We are compliant with the MVPHS
continued listing standard of Nasdaq Capital Market being greater than $1.0 million. The current MVPHS is $5,166,785 based on
the closing price of the common stock on March 27, 2025.

 On a pro-forma basis at March 31, 2025, we expect to satisfy compliance
with the Nasdaq Capital Market Equity Standard of Stockholder's Equity greater than $2.5 million, after anticipating all Q1
2025 expected losses. Through the date of the consolidated financial statements, Stockholder's Equity has increased significantly,
through (i) fundraising of an additional $8.332 million from the Sales Agreement with AGP, (ii) conversion of $1.785 million from the
Nirland Notes into 924,200 shares of common stock, and (iii) capitalization of certain invoices and fees. We expect to maintain
continued compliance with the Equity Standard through additional issuance under its Sales Agreement, additional conversions of outstanding
debt and capitalization of fees and a tight control of expenditure, although no such assurance can be given.

 Key
Component of Result of Operations

 Operating
Expenses

and Development Expenses

and development expenses consist primarily of costs incurred in connection with the research and development of our candidates and programs.
We expense research and development costs and intangible assets acquired that have no alternative future use as incurred. These expenses
include:

 personnel-related
 expenses, including salaries, bonuses, benefits and stock-based compensation for employees engaged in research and development functions;

 expenses
 incurred in connection with the clinical development and regulatory approval of our clinical assets, including under agreements with
 third parties, such as consultants, contractors and CROs;

 license
 fees with no alternative use; and

 other
 expenses related to research and development.

 We
expense research and development costs as incurred. Advance payments that we make for goods or services to be received in the future
for use in research and development activities are recorded as prepaid expenses. The prepaid amounts are expensed as the benefits are
consumed.

 Our research and development
activities have been wholly focused on developing co-crystals of AZD1656 to increase patent life. Some of this work was completed by
third-party CROs but all intellectual property is retained by us. We currently have one pending international patent application and
two pending national patent applications. The successful completion of clinical trials increases the value of clinical assets and may
lead to the commercialization and/or licensing of such assets to other pharmaceutical companies. There is no assurance that any clinical
trials on the assets owned or licensed by us will be successful.

and Administrative Expenses

and administrative expenses consist of salaries and other related costs, legal fees relating to intellectual property and corporate matters,
professional fees for accounting, auditing, tax and consulting services, insurance costs, travel, and other operating costs.

 We
anticipate that our general and administrative expenses will increase substantially for the foreseeable future as we increase our administrative
headcount to operate as a public company and as we advance clinical assets through clinical development. We also will incur additional
expenses as a result of operating as a public company, including expenses related to compliance with the rules and regulations of the
SEC and the Nasdaq listing rules, additional insurance expenses, investor relations activities and other administrative and professional
services. In addition, if regulatory approval is obtained for clinical assets, we expect to incur expenses associated with building a
sales and marketing team.

 Other
Income (Expenses)

 Other
income (expenses), net

 Other
income (expense), net consists of change in the fair value of options, change in fair value of convertible notes, and expense incurred
upon the issuance of warrants during the year.

 Interest
expense, net

 Interest
expense, net consists primarily of interest expense on convertible loan notes and promissory notes and interest expense on deferred commissions
payable to an advisor for fees related to the merger, as well as a small amount of interest income on cash and cash equivalents held
by the Company.

 Results
of Operations

 The
following table set forth our results of operations for the periods indicated:

 Change

 (Dollar amounts in thousands)

 2024

 2023

 %

 Research and development expenses

 $
 3,378

 $

 $
 3,288

 3,653
 %

and development expenses increased by approximately $3.3 million, or 3,653%, to approximately $3.4 million for the year ended December
31, 2024, as compared to approximately $90 thousand for the year ended December 31, 2023. The increase was primarily driven by a $3.1
million upfront payment to AstraZeneca in connection with the license agreement, comprised of $1.5 million cash and $1.6 million of our
common shares issued to AstraZeneca with no comparable activity in 2023.

and administrative expenses

 Change

 (Dollar amounts in thousands)

 2024

 2023

 %

 General and administrative expenses

 $
 12,041

 $
 5,173

 $
 6,868

 %

and administrative expenses increased by $6.9 million, or 133%, to approximately $12.0 million for the year ended December 31, 2024,
as compared to approximately $5.2 million for the year ended December 31, 2023. The increase was primarily driven by a $3.4 million increase
in salaries, stock-based compensation and payroll, a $1.3 million increase in other G&A expenses, a $1.1 million increase in D&O
insurance, a $0.5 million increase in professional fees including: legal fees, accounting and tax expense, listing fees and consulting
fees and a $0.5 million increase in travel expenses.

 Other
income (expense), net

 Change

 (Dollar amounts in thousands)

 2024

 2023

 %

 Other income (expense), net

 $
 (890
)

 $
 4,923

 $
 (5,813
)

 (118
)%

 Other
income (expense), net changed by $5.8 million, or 118%, to other expense of approximately $0.9 million for the year ended December
31, 2024, as compared to other income of $4.9 million for the year ended December 31, 2023. In 2024, other expense was driven by a
$2.7 million loss on the issuance of warrants, and a $0.7 million expense related to a net loss on extinguishments, offset by a $2.0
million gain on the change in fair value of convertible notes payable, a $0.3 million increase from an income tax refund and a $0.2
million increase in the gain on change in fair value of warrants. In 2023, other income was driven by a $1.5 million gain on the
derecognition of the Cizzle option in 2023, a $1.3 million gain on the change in fair value of the Cizzle option, a $2.8 million
gain on the derecognition of the deferred revenue for the Vela option prior to the exercise of the Vela option, and a $1.0 million
gain on the change in fair value of the Vela option. This was offset by a $1.0 million loss on issuance related to the Vela option,
$0.4 million change in the fair value of convertible notes payable and $0.3 million realized foreign currency transaction
loss.

 For
further details refer to Note 17 in the consolidated financial statements as of December 31, 2024 and 2023 included elsewhere in this
Annual Report.

 Interest
expense, net

 Change

 (Dollar amounts in thousands)

 2024

 2023

 %

 Interest expense, net

 $
 (1,506
)

 $
 (211
)

 $
 (1,295
)

 %

 Interest
expense, net changed by $1.3 million or 614%, to $1.5 million for the year ended December 31, 2024, from $0.2 million for the year
ended December 31, 2023. The change was driven by a $0.9 million increase in the amortization of debt issuance costs and debt
discounts and a $0.4 million increase in interest expense incurred on interest-bearing convertible promissory notes.

 Liquidity
and Capital Resources

assesses liquidity in terms of our ability to generate cash to fund operating, investing and financing activities. Since our inception,
and in line with our growth strategy, we have prepared our financial statements assuming we will continue as a going concern. Since our
inception, we have incurred net losses and experienced negative cash flows from operations. To date, our primary sources of capital have
been through private placements of equity securities and convertible debt and the Sales Agreement with A.G.P. During the years ended December
31, 2024 and 2023, we incurred operating losses of $15.4 million and $5.3 million, respectively.

 Our
primary uses of cash are to fund our operations as we continue to grow our business. We will require a significant amount of cash
for expenditures as we invest in ongoing research and development and business operations. Until such time we can generate
significant revenue from the successful approval and commercialization of a product candidate, we expect to finance our cash needs for
ongoing research and development and business operations through public or private equity or debt financings or other capital
sources, including strategic partnerships. However, we may be unable to raise additional funds or enter into such other
arrangements, when needed, on favorable terms or at all. To the extent that we raise additional capital through the sale of equity
or convertible debt securities, the ownership interest of our stockholders will be, or could be, diluted, and the terms of these
securities may include liquidation or other preferences that adversely affect the rights of our common stockholders. Debt financing
and equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take
specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we are unable to raise
additional funds through equity or debt financings when needed, we may be required to delay, limit, or substantially reduce research
and development efforts all of which could have a material adverse effect on the Company and its financial results.

 While
the Company believes in the viability of its ability to raise additional funds, there can be no assurances to that effect. We have based
our estimates on assumptions of operating costs that may prove to be wrong. As a result, we could deplete our capital resources sooner
than we currently expect. If, for any reason, our expenses differ materially from our assumptions or we utilize our cash more quickly
than anticipated, or if we are unable to obtain funding on a timely basis we may be required to revise our business plan and strategy,
which may result in significantly curtailing, delaying or discontinuing one or more of our research or development programs or the commercialization
of any product candidates or may result in our being unable to expand our operations or otherwise capitalize on our business opportunities.
As a result, our business, financial condition, and results of operations could be materially affected.

has concluded that there is substantial doubt regarding our ability to continue as a going concern for a period of at least 12 months
from the date of the filing of this Annual Report. This is based on our analysis under applicable accounting principles. These financial
statements have been prepared assuming the Company will continue as a going concern and do not include adjustments to reflect the possible
effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the
outcome of this uncertainty.

 Cash
Requirements

 Our
material cash requirements include the following contractual and other obligations.

 Loans
Payable

 In
May 2022, we entered into two loan agreements (the "Loans"), with an aggregate principal amount of $0.2 million, with
two lenders. The Loans were to mature and become payable in full two years from the date of the loan agreement and they bear no
interest. On October 9, 2024, the Company executed agreements to extend the loan maturity date for each loan to December 19, 2024.
As of December 31, 2024, the Loans are still outstanding and considered to be in default. The Company repaid the lenders in full during February 2025. Refer to Note 8 to our financial statements included elsewhere in this
Annual Report.

 Promissory
Convertible Note

 In
March 2023, we issued an aggregate principal amount of $0.8 million convertible promissory note (the "March 2023 Convertible Note")
payable to an investor.

 The
March 2023 Convertible Note originally was to mature and become payable in full, 18 months from the date of the March 2023 Convertible
Note. The March 2023 Convertible Note carries 20% interest per annum and interest is payable every six months from the date of the March
2023 Convertible Note until the maturity date. The March 2023 Convertible Note became convertible into Common Stock following the consummation
of the Merger.

 On
October 9, 2024, the Company and the loan holder signed an extension for the March 2023 Convertible Note to extend the maturity date
from September 20, 2024 to October 20, 2024 with the option for the Company to further extend the maturity date two times, each by
an additional 30-day period. The Company exercised both options to extend the maturity date to December 19, 2024. As of December 31,
2024, the March 2023 Convertible Note is still outstanding and considered to be in default. On March 6, 2025, the Company reached an agreement with the loan holder
to pay $0.7 million in order to settle the March 2023 Convertible Note in full. The Company repaid the loan holder the settlement amount
$0.7 million on March 13, 2025. Refer to Note 7 to our financial statements included elsewhere in this
Annual Report.

 A.G.P
Convertible Note

 On
November 25, 2024, the Company issued to A.G.P. a convertible promissory note (the "A.G.P. Convertible Note") in the principal
amount of $5.7 million to evidence the A.G.P.'s currently owed deferred commission payable. Unless earlier converted as specified
in the Convertible Note, the principal amount plus all accrued but unpaid interest is due on November 25, 2025 (the "Maturity Date").
The A.G.P. Convertible Note accrues interest at 5.5% per annum.

 At
any time prior to the full payment of the A.G.P. Convertible Note, provided that the A.G.P. has given at least three business days
written notice to the Company, A.G.P., in its sole discretion, may elect to have all or any portion of the outstanding principal amount
and all interest accrued converted into shares of the Company's common stock, at the lower of the Reverse Split price and the market
price per share at the time of the conversion date, but in no event less than $1.00, subject to adjustment as provided therein and to
take into account any future share splits or reverse splits. However, the conversion of the A.G.P. Convertible Note may not occur
prior to the Company having sufficiently authorized shares of common stock to permit the entire conversion of the convertible promissory
note. Refer to Note 8 to our financial statements included elsewhere in this Annual Report. Per the terms outlined in the agreement, we are required to undertake capital raises to paydown the A.G.P. Convertible
Note.

 August

 On
August 6, 2024, the Company entered into a Senior Secured Promissory Note (the "August 2024 Nirland Note") with Nirland,
a related party of the Company, pursuant to which the Company issued and sold to Nirland the August 2024 Note in the original principal
amount of $2,650,000, inclusive of a $500,000 original issuance discount. Refer to Note 8 to our financial statements included elsewhere
in this Annual Report.

 On
October 31, 2024, the Company and Nirland amended the August 2024 Nirland Note, whereby the August 2024 Nirland Note was amended to (i)
provide for the conversion of the August 2024 Nirland Note into shares of Common Stock, at Nirland's discretion, in a multiple
of any unpaid amounts, if not otherwise previously paid, pursuant to the conversion rate contained therein, (ii) remove Nirland's
Mandatory Prepayment Right, and (iii) remove Nirland's right of first refusal to participate in any future equity or debt offerings
of the Company. The number of shares of Common Stock issuable upon conversion of any Conversion Amount pursuant to shall be determined
by dividing (x) such conversion amount by (y) the conversion price. Conversion amount means two and one quarter times the sum of (x)
portion of the principal to be converted, redeemed or otherwise with respect to which this determination is being made and (y) all accrued
and unpaid interest with respect to such portion of the principal amount, if any. Conversion price means, as of any conversion date or
other date of determination, $10, subject to adjustment as provided within the amended agreement. Note 7 to our financial statements
included elsewhere in this Annual Report.

 On
November 22, 2024, the Company and Nirland entered into a Second Amendment to the August 2024 Nirland Note (the "Second
Amendment"). Pursuant to the Second Amendment, the Nirland Note may not be converted (other than partial conversions that may
be permitted pursuant to the rules and regulations of NASDAQ (or any successor entity)) prior to receipt of stockholder approval to
provide for such conversion of the Nirland Note, and subsequent issuance of the Company's Common Stock, pursuant to the
stockholder approval rules under the rules and regulations of The Nasdaq Stock Market. If the Company has not held a special meeting
of the stockholders to approve the full conversion of the August 2024 Nirland Note on or before January 9, 2025, then the Company
shall be obligated to pay Nirland a penalty of $100,000 per day until the special meeting is held. The special meeting was held on
January 9, 2025, in which stockholder approval was obtained. In addition, the existing conversion rate was amended to be two and one
half times the sum of (x) the portion of the principal to be converted, redeemed or otherwise with respect to which this
determination is being made and (y) all accrued and unpaid interest (including default interest) with respect to such portion of the
principal amount, if any divided by $0.10, pre-split in January 2025 (or following any reverse splits that may occur in a ratio greater than 10 to 1, the lower
of such reverse split price and the market price per share at the time of the conversion date, but in no event less than $1.00),
subject to adjustment as provided therein and to take into account any future share splits or reverse splits. On January 24, 2025, the Reverse Stock Split became effective, resulting in every 100 shares of our common stock
issued or outstanding becoming one new share of our common stock, resulting in the conversion price increasing to $6.86 as of December
31, 2024.

 On December 9, 2024, Nirland
exercised their conversion option and converted $0.1 million of principal for 23,000 shares of common stock pursuant to the rules and
regulations of the NASDAQ. As of December 31, 2024, $2.6 million of principal and accrued interest remains outstanding.

 October

 On
October 28, 2024, the Company issued a promissory note (the "October 2024 Nirland Note") to Nirland in the original
principal amount of $0.6 million in exchange for funds in such amount. The October 2024 Nirland Note bears interest at a rate of 12%
per annum, is due and payable semi-annually in arrears, and matures on October 31, 2025. If an event of default under and as defined
in the Nirland Note occurs, the interest rate will be increased to 18% per annum or to the maximum rate permitted by law. In
connection with the Nirland Note, the Company has agreed to pay Nirland a 1% arrangement fee, which will be included with the
principal and interest owed under the Nirland Note. The Company paid down $0.2 million of the October 2024 Nirland Note on December
11, 2024 and as of the date of filing this Annual Report, such note has been repaid in full. Refer to Note 8 and Note 20 to our
financial statements included elsewhere in this Annual Report.

 Working
Capital

 We
currently anticipate that cash required for working capital for the next 12 months is approximately $22.9 million, which includes forecasted
research and development costs of $6.0 million, forecasted operating expenses of $6.2 million, accrued expenses and other current liabilities
of $3.4 million, a convertible promissory note payable, if not converted prior to maturity of $6.0 million, a convertible promissory
note, if not converted prior to maturity, of $0.8 million and loans payable due within the next 12 months of $0.5 million. We do anticipate
being able to fund required working capital for the next 12 months with cash and cash equivalents on hand and current borrowings. Management
believes that we will be able to fund cash required for the next 12 months through borrowings and equity raises. We have historically
been able to access funds through the issuance of debt, and more recently the at the market offering program agreement, and believe we
can continue to obtain funding through such debt financing agreements and Sales agreement as needed to meet cash requirements
for the next 12 months.

 As
of December 31, 2024, we have raised $3.3 million (net of fees) out of the $23.9 million available to us
through the Sales agreement and expect to raise the additional $20.4 million over the next 12 months.

 Through the date of the issuance of the consolidated financial statements,
we have raised an additional $8.1 million, net of fees due to A.G.P., through the Sales Agreement. After considering the issuances subsequent
to December 31, 2024, we have $12.0 million available to us through the Sales Agreement.

 Cash
Flows

 The
following table set forth our cash flows for the period indicated (in thousands):

 2024

 2023

 Net cash (used in) provided by:

 Operating Activities

 $
 (9,682
)

 $
 (7,725
)

 Investing Activities

 (43
)

 Financing Activities

 6,067

 10,929

 Effect of exchange rate changes on cash and cash equivalents

 (16
)

 Net (decrease) increase in cash and cash equivalents

 $
 (3,674
)

 $
 4,228

 Cash
Flows Used in Operating Activities

 Net
cash used in operating activities for the year ended December 31, 2024 was $9.7 million, resulting primarily from a net loss of $17.8
million, a gain on the change in fair value of convertible notes payable of $2.0 million, a gain on change in fair value of warrant liabilities
of $0.2 million and a $0.1 million cash outflow from operating assets and liabilities. This was partially offset by a $2.7 million loss
on the issuance of warrants, $1.7 million of amortization of directors and officers insurance, a $1.6 million outflow attributable to
the purchase of licensing rights, $1.6 million of stock-based compensation, $0.9 million of debt discount amortization, a $0.7 million
loss on debt extinguishment, $0.5 million of non-cash interest expense, $0.4 million of amortization expense, a $0.2 million share issuance
for services and a $0.1 million of non-cash lease expense. The $0.1 million cash outflow from operating assets and liabilities is primarily
due to a $2.3 million cash outflow from prepaid expenses and other current assets and a $0.1 million cash outflow from lease liabilities,
partially offset by a cash inflow of $1.2 million from accounts payable and a cash inflow of $1.2 million from accrued expenses and other
current liabilities.

 Net
cash used in operating activities for the year ended December 31, 2023 was $7.7 million, resulting primarily from a net loss of $0.5
million, adjusted for non-cash items including a $4.3 million reduction of deferred income upon exercise of the Cizzle and Vela option,
a $2.5 million change in operating assets and liabilities, a $2.3 million gain on the change in fair value of the Vela and Cizzle options,
a $0.2 million change in the reserve for uncollectible loans and a $0.1 million gain on warrant remeasurement, partially offset by a
$1.0 million loss upon the issuance of the Vela option, a $0.5 million change in amortization on directors & officers insurance,
a $0.4 million loss on change in fair value of convertible notes and a $0.2 million increase in stock based compensation expense. The
$2.5 million cash outflow from operating assets and liabilities is primarily due to a $1.0 million cash outflow from prepaid expenses
and a $1.7 million cash outflow from accrued expenses and other current liabilities partially offset by a $0.2 million cash inflow from
accounts payable.

 Cash
Flows (Used) Provided by Investing Activities

 Net
cash used in investing activities for the year ended December 31, 2024 was $43 thousand, resulting from purchases
of short-term investments of $0.5 million and purchases of property, plant and equipment of $0.1 million, partially offset by sales of
short-term investments of $0.5 million.

 Net
cash provided by investing activities for the year ended December 31, 2023 was $0.7 million, resulting from $0.5 million in proceeds from
an option fee received from Vela and $0.6 million proceeds from the repayment of a loan from a related party, partially
offset by an issuance of a loan to a related party of $0.4 million.

 Cash
Flows Provided by Financing Activities

 Net
cash provided by financing activities for the year ended December 31, 2024 was $6.1 million, resulting from proceeds from the Sales Agreement
of $3.3 million, proceeds from the issuance of notes payable of $3.2 million, proceeds from the exercise of warrants of $0.2 million
and proceeds from the exercise of warrants of $0.1 million, partially offset by repayments of notes payable of $0.8 million.

 Net
cash provided by financing activities during the year ended December 31, 2023 was $11.0 million. resulting from the proceeds from the
Merger and related PIPE financing, net of transaction costs of $8.5 million, $2.3 million from issuance of convertible notes payable,
and $0.2 million capital contribution from a related party.

 Contractual
Obligations and Other Commitments

 Laboratory Lease

 As
of December 31, 2024, we are the lessee under one laboratory space lease for a term of two years. The annual rent payments
are $0.1 million for the years ending December 31, 2025 and December 31, 2026. The laboratory space lease has a remaining lease term
of approximately 1.2 years.

 Critical
Accounting Estimates

 The
preparation of financial statements in conformity with U.S. GAAP requires us to make estimates, judgments and assumptions that affect
the amounts reported in the Consolidated Financial Statements. These estimates, judgments and assumptions are evaluated on an ongoing
basis. We base our estimates on historical experience and on various other assumptions that we believe are reasonable at that time, the
results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent
from other sources. Actual results may differ materially from those estimates. The accounting policies that reflect our more significant
estimates, judgments and assumptions and which we believe are the most critical to aid in fully understanding and evaluating our reported
financial results include the following:

 Fair
Value of Convertible Notes

 The
Company has elected the fair value measurement option for convertible debt with embedded derivatives that would otherwise require bifurcation,
and has recorded the entire hybrid financial instrument at fair value under the guidance in ASC 825, Financial Instruments.
To value the convertible debt, the Company utilizes Binomial Lattice Pricing Models. The Binomial Lattice Pricing Models involve the
construction of various intermediate lattices: stock price tree, conversion value tree, conversion probability tree, and discount rate
tree. In doing so, we assume the holders act rationally to maximize return and minimize cost at each decision point. We computed the
notes payoff at maturity and at intermediate decision nodes based upon the better of (i) conversion or (ii) repayment of principal and
interest.

 The
significant inputs and assumptions used to estimate the fair value include: (i) the Company's stock price, (ii) the term of the
convertible debt, (iii) the sum of the notes' principal and unpaid accrued interest, (iv) expected volatility, (v) risk-free interest
rate, (vi) the corporate bond yield, (vii) the credit spread, (viii) probability of default, and (ix) the estimated recovery upon default.
Any change to the unobservable inputs to estimate fair value could produce significantly higher or lower fair value measurements and
result in a material change within the financial statements.

 The
convertible debt will subsequently be remeasured at fair value each reporting date until settled or converted.

 Fair
Value of Warrants

 The
Company has issued warrants to investors in our debt and equity offerings. The Company has also issued warrants to service providers
in relation to our financing offerings. We evaluate all warrants issued to determine the appropriate classification under ASC 480 and ASC
815.

 For
warrants that are determined to be equity-classified, we estimate the fair value at issuance and record the amounts to additional paid
in capital. For warrants that are determined to be liability-classified, we estimate the fair value at issuance and each subsequent reporting date.

 For
the Company's liability classified warrants, we estimate fair value using the Black-Scholes model. The significant inputs and assumptions
used to estimate the fair value include: (i) the Company's stock price, (ii) the risk-free rate, (iii) the expected volatility,
and (iv) the dividend yield. The use of these valuation models requires the input of highly subjective assumptions. Any change to these
inputs could produce significantly higher or lower fair value measurements and result in a material change within the financial statements.

 Contingencies

 In
the ordinary course of business, we are involved in various legal proceedings that are complex in nature and have outcomes that are difficult
to predict. We describe our legal proceedings and other matters that are significant or that we believe could become significant in Note
15 to the consolidated financial statements. We record accruals for loss contingencies to the extent that we conclude it is probable
that a liability has been incurred and the amount of the related loss can be reasonably estimated. We evaluate, on a quarterly basis,
developments in legal proceedings and other matters that could cause an increase or decrease in the amount of the liability that has
been accrued previously or modifications to contingency disclosures that are considered material.

 Stock-Based

 We
record stock compensation expense related to our 2023 Plan in accordance with ASC 718, Compensation - Stock Compensation
 which requires our stock-based awards, including restricted stock units ("RSUs") and stock options to be measured at
fair value.

 The
fair value of stock options is estimated on the grant date using the Black-Scholes option-valuation model. The calculation of stock-based
compensation expense requires that we make assumptions and judgments about the variables used in the Black- Scholes option-valuation
model, including the fair value of our common stock, expected term, expected volatility of the underlying common stock, and risk-free
interest rate.

 The
assumption inputs subject to significant estimation include:

 Expected
Term. The expected term represents the period that the Company's stock options are expected to be outstanding. Due to
limitations on the sale or transfer of the Company's common stock under the lock-up agreements and market standoff components of
the stock option agreements, the Company does not believe its historical exercise pattern is indicative of the pattern it will experience
after restricted periods expire. The Company uses the simplified method to calculate the expected term, which is the average of the contractual
term and vesting period.

 Volatility. We
determine the price volatility based on the historical volatilities of industry peers as we have limited trading history for our common
stock price. We intend to continue to consistently apply this process using the same or a similar peer group of public companies, until
a sufficient amount of historical information regarding the volatility of our own common stock price becomes available, or unless circumstances
change such that the identified peer companies are no longer similar, in which case other suitable peer companies whose common stock
prices are publicly available would be utilized in the calculation.

 Recent
Accounting Pronouncements

 A
discussion of recent accounting pronouncements is included in Note 1 - Nature of the Business and Basis of Presentation and Summary
of Significant Accounting Policies to our financial statements included elsewhere in this Annual Report.

 Emerging
Growth Company Status and Smaller Reporting Company Status

 The
Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the "JOBS Act"). Under
the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of
the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period
for complying with new or revised accounting standards that have different effective dates for public and private companies until the
earlier of the date that: (i) is no longer an emerging growth company or (ii) affirmatively and irrevocably opts out of the extended
transition period provided in the JOBS Act. As a result, these financial statements may not be comparable to companies that comply with
the new or revised accounting pronouncements as of public company effective dates.

 Upon
closing of the Merger, the surviving company remained an emerging growth company, as defined by the Jumpstart Our Business Startups act
of 2012, until the earliest of (i) the last day of the combined entity's first fiscal year following the fifth anniversary of the
completion of MURF's initial public offering, (ii) the last day of the fiscal year in which the combined entity has total annual
gross revenue of at least $1.235 billion, (iii) the last day of the fiscal year in which the combined entity is deemed to be a large
accelerated filer, which means the market value of the combined entity's common stock that is held by non-affiliates exceeds $700.0
million as of the prior December 31st or (iv) the date on which the combined entity has issued more than $1.0 billion in non-convertible
debt securities during the prior three year period.

 In
addition, Conduit is a smaller reporting company as defined in the Exchange Act. The Company may continue to be a smaller reporting company
even after we are no longer an emerging growth company. We may take advantage of certain of the scaled disclosures available to smaller
reporting companies and will be able to take advantage of these scaled disclosures for so long as (i) Conduit's voting and non-voting
common stock held by non-affiliates is less than $250.0 million measured on the last business day of our second fiscal quarter or (ii)
Conduit's annual revenue is less than $100.0 million during the most recently completed fiscal year and its voting and non-voting
common stock held by non-affiliates is less than $700.0 million measured on the last business day of its second fiscal quarter.

 Item
7A. Quantitative and Qualitative Disclosures about Market Risk

 As
a smaller reporting company, we are not required to provide the information required by this item.

 Item
8. Financial Statements and Supplementary Data

 This
information appears following Item 15 of this Annual Report and is included herein by reference.

 Item
9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

 None.

 Item
9A. Controls and Procedures

 Controls
and Procedures

 Disclosure
controls are procedures that are designed with the objective of ensuring that information required to be disclosed in our reports filed
under the Exchange Act, such as this Annual Report, is recorded, processed, summarized, and reported within the time period specified
in the SEC's rules and forms. Disclosure controls are also designed with the objective of ensuring that such information is accumulated
and communicated to our management, including the chief executive officer and chief financial officer, as appropriate to allow timely
decisions regarding required disclosure. Our management evaluated, with the participation of our current chief executive officer and
chief financial officer (our "Certifying Officers"), the effectiveness of our disclosure controls and procedures as of December
31, 2024, pursuant to Rule 13a-15(b) under the Exchange Act.

 We
do not expect that our disclosure controls and procedures will prevent all errors and all instances of fraud. Disclosure controls and
procedures, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the
disclosure controls and procedures are met. Further, the design of disclosure controls and procedures must reflect the fact that there
are resource constraints, and the benefits must be considered relative to their costs. Because of the inherent limitations in all disclosure
controls and procedures, no evaluation of disclosure controls and procedures can provide absolute assurance that we have detected all
our control deficiencies and instances of fraud, if any. The design of disclosure controls and procedures also is based partly on certain
assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated
goals under all potential future conditions.

 Management's
Report on Internal Controls Over Financial Reporting

 Our
management is responsible for establishing and maintaining adequate internal control over financial reporting, as such term is defined
in Exchange Act Rules 13a-15(f). Under the supervision and with the participation of our Management, including our Chief Executive Officer
and Chief Financial Officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting. In connection
with the preparation and audit of the financial statements as of and for the fiscal years ended December 31, 2024 and 2023, material
weaknesses were identified in our internal control over financial reporting. A material weakness is a deficiency, or a combination of
deficiencies, in internal control over financial reporting such that there is a reasonable possibility that a material misstatement of
annual or interim financial statements will not be prevented or detected on a timely basis. These material weaknesses primarily relate
to the following:

 The segregation of duties is limited and heavily reliant on interim personnel and third-party consultants to perform these activities.

 The Company lacks a formal process for review and approval of significant transactions and accounts on a contemporaneous basis and there have been numerous, recurring errors in account balances and disclosures.

 The Company has not designed adequate and appropriate internal controls
 under an appropriate internal control over financial reporting framework.

 The Company did not appropriately review and evaluate the accounting implications of all material transactions that occurred in the audit period which resulted in a restatement of previous periods.

 The review controls around certain related party transactions did no operate
consistently and the review of such transactions was not always contemporaneously documented.

 If
these material weaknesses are not remediated, it could result in a misstatement of account balances or disclosures that would result
in a material misstatement to the annual or interim financial statements that would not be prevented or detected. We are reviewing
measures designed to improve our internal control over financial reporting to remediate these material weaknesses, although they
have not been fully remediated as of the date of this filing. We anticipate hiring additional qualified accounting personnel with
experience with complex GAAP and SEC rules while, meanwhile, continuing to engage consultants to assist with our financial statement
close process, segregating duties among accounting personnel to enable adequate review controls, further developing and documenting
our accounting policies, and designing, implementing, and/or expanding IT systems and application controls in our systems relevant
to the preparation of the consolidated financial statements. We also expect to engage an external advisor to assist with evaluating
and documenting the design and operating effectiveness of internal controls and assisting with the remediation of deficiencies, as
necessary if sufficient capital resources become available.

 The ability to perform these remediation plans are dependent on
our ability to enhance funding and liquidity. The primary
costs associated with such measures are corresponding recruiting and additional salary and consulting costs, which are difficult to
estimate but which may be significant. These additional resources and procedures are intended to enable us to broaden the scope and
quality of our internal review of underlying information related to financial reporting and to formalize and enhance our internal
control procedures.

 The
material weaknesses will not be considered remediated until a remediation plan has been fully implemented, the applicable controls
operate for a sufficient period of time, and we have concluded, through testing, that the newly implemented and enhanced controls, provided we are able to obtain sufficient capital resources to cover
the cost of our remediation plan, are
operating effectively. A failure to implement and maintain effective internal control over financial reporting could result
in errors in our financial statements that could result in a restatement of our financial statements and could cause us to fail to meet
our reporting obligations, any of which could diminish investor confidence in us and cause a decline in the price of our common stock.

 Our
independent registered public accounting firm will not be required to formally attest to the effectiveness of our internal control over
financial reporting until after we are no longer an "emerging growth company," as defined in the JOBS Act. At such time,
our independent registered public accounting firm may issue a report that is adverse in the event it is not satisfied with the level
at which our internal control over financial reporting is documented, designed, or operating.

 Changes
in Internal Control over Financial Reporting

 There
have been a number of changes in our internal control over financial reporting (as such term is defined in Rules 13a-15(f) and 15d-15(f)
of the Exchange Act) during the most recent fiscal year that have materially affected, or are reasonably likely to materially affect,
our internal control over financial reporting. These changes include the implementation of enterprise resource planning accounting systems,
and increased accounting and financial reporting consulting resources.

 Item
9B. Other Information

the fiscal quarter ended December 31, 2024, none of the Company's directors or officers (as defined in Rule 16a-1(f) of the Exchange Act)
 adopted or terminated any contract, instruction or written plan for the purchase or sale of Company securities that was intended to satisfy
the affirmative defense conditions of Rule 10b5-1(c) or any "non-Rule 10b5-1 trading arrangement".

 Item
9C. Disclosure Regarding Foreign Jurisdictions that Prevent Inspections

 Not
applicable.

 PART
III

 Item
10. Directors, Executive Officers and Corporate Governance

 Executive
Officers and Directors

 The
following table sets forth certain information concerning our executive officers and directors as of March 28, 2025:

 Name

 Age

 Position

 David
 Tapolczay

 Chief
 Executive Officer and Director

 James
 Bligh

 Interim
 Chief Financial Officer and Director

 Freda
 Lewis-Hall

 Chairperson
 of the Board of Directors

 Faith
 L. Charles

 Chele
 Chiavacci Farley

 Simon
 Fry

 Andrew
 Regan

 Executive
Officers

 David
Tapolczay. Dr. Tapolczay has more than 20 years of experience in research and development management. He has served as our Chief
Executive Officer and a member of the board of directors since September 2023. He was a co-founder and served as the Chief Executive
Officer a member of the board of directors of Old Conduit from 2019 until the Business Combination in September 2023. He served as Chief
Executive Officer of St George Street Capital, a United Kingdom-based medical research charity that is a business partner to Conduit,
from July 2018 to September 2023. He also serves as Chief Executive Officer of Medeor Pharma Ltd, a pharmaceutical consultancy company,
a position which he has held since 2006.

 From
February 2008 to December 2018, he served as Chief Executive Officer at LifeArc (formerly the Medical Research Counsel Technology Group
(MRCT)), a United-Kingdom based charity advancing lab-based scientific discoveries to a point at which they can be developed into the
next generation of diagnostics, treatments and cures. He previously served as joint worldwide head of chemistry for Zeneca Agrochemicals,
a research and development unit of AstraZeneca, and as senior manager of chemical development for GlaxoSmithKlein plc, a pharmaceutical
and biotechnology company. Dr. Tapolczay served as Executive Vice President at Cambridge Discovery Chemistry, where he was responsible
for the rapid growth of Cambridge Discovery Chemistry and was a key figure in two successful sales of that company, the first to Oxford
Molecular and the second to Millennium Pharmaceuticals. After this last acquisition, Dr. Tapolczay was Senior Vice President of Pharmaceutical
Sciences at Millennium Pharmaceuticals, with responsibility for over 230 scientists. On leaving Millennium, Dr. Tapolczay was a founder
and Chairman of Pharmorphix Ltd., which was acquired by Sigma Aldrich Fine Chemicals in August 2006. He has also been involved with the
start-up of five companies, all of which are still trading and one of which has been AIM listed. He was VP of Technology Development
for GSK Pharmaceuticals from December 2005 to April 2007. He was awarded visiting Professorial Chair in Chemistry at Sussex University
from August 1999 to May 2007 and has previously held the position of visiting lecturer at Nottingham, Reading and Durham Universities
and a member of both the Technical Opportunities Panel and the User Panel of the EPSRC. He holds a BSc Hons and PhD in Chemistry from
the University of Southampton. Dr. Tapolczay also completed his Post-Doctoral Experience in Organic Chemistry from the University of
Oxford. Dr. Tapolczay was selected to serve on our board of directors following the Business Combination based on his deep knowledge
of Conduit, his extensive experience in research and development of clinical assets, and his in-depth knowledge of the pharmaceutical
industry.

 James
("Jamie") Bligh. Mr. Bligh has served as a member of our board of directors since September 2023, and also currently
serves as our Interim Chief Financial Officer. He was a co-founder of Conduit Pharmaceuticals Limited in 2019 and has served as a member
of its board of directors since its inception. From 2008 to 2019, Mr. Bligh worked closely with investment vehicle Corvus Capital Limited,
including as a Partner, where he led a number of reverse takeover transactions, stock market listings, initial public offerings, secondary
fundraisings, and merger transactions. Mr. Bligh's prior transaction experience includes advising several special purpose acquisition
vehicles in listing on the London Stock Exchange, including the listing of Bermele Plc, a special purpose acquisition vehicle, and the
subsequent acquisition of Bermele by East Imperial Pte. Ltd., a global purveyor of ultra-premium beverages, in June 2019; the listing
of Leverett Plc, which subsequently acquired Nuformix Plc, a pharmaceutical development company targeting unmet medical needs in fibrosis
and oncology via drug repurposing; and Cizzle Biotechnology Holdings PLC, a UK-based diagnostics developer. Jamie previously served as
a director of Bermele Plc from June 2021 through February 2022; Mertz Plc from January 2021 through March 2022; and East Imperial Pte.
Ltd. from September 2017 through April 2018. Jamie graduated from the University of Bristol with a BSc in Economics & Finance. Mr.
Bligh was selected to serve on our board of directors following the Business Combination based on his past experience with business development,
capital raising, financings, public offerings and other strategic transactions, including mergers and acquisitions.

 Directors

 Freda
Lewis-Hall, M.D., DFAPA. Dr. Lewis-Hall has served as a member of our Board since September 2023. She served as Senior Medical
Advisor to the CEO of Pfizer Inc., or Pfizer, from December 2019 until her retirement in March 2020. Before assuming that responsibility,
beginning January 2019, Dr. Lewis-Hall served as Chief Patient Officer and Executive Vice President of Pfizer. Dr. Lewis-Hall served
as Pfizer's Chief Medical Officer from 2009 to January 2019. Prior to joining Pfizer in 2009, Dr. Lewis-Hall held various senior
leadership positions including Chief Medical Officer and Executive Vice President, Medicines Development at Vertex Pharmaceuticals Incorporated
from June 2008 to May 2009; Senior Vice President, U.S. Pharmaceuticals, Medical Affairs for Bristol-Myers Squibb Company from 2003 until
May 2008; Vice President Research and Development at Pharmacia Corporation from 2002-2003; Product Team Leader at Pharmacia and Eli Lilly
and Company from 1998 to 2002; Director of Lilly Center for Women's Health from 1996-1999; and Clinical Research Physician at Eli
Lilly from 1994 through 1996. In October 2021, Dr. Lewis-Hall became a member of the board of directors for Pyxis Oncology (Nasdaq: PYXS),
(where she serves as a member of the Nominating and Corporate Governance Committee); she serves as a member of the board of directors
for Milliken & Company since July 2019, as a member of the Audit and HR and Compensation Committees; and as a member of the board
of directors of SpringWorks Therapeutics, Inc. (Nasdaq GS: SWTX) since 2017, where she serves as the chair of the Nominating and Governance
Committee and as a member of the audit committee. Dr. Lewis-Hall served as a member of the board of directors for Exact Sciences Corporation
(Nasdaq: EXAS) from April 2020 to June 2024 where she served as a member of the Human Capital and Innovation, Technology and Pipeline
Committees; a member of 1LifeHealthCare, Inc. (Nasdaq: ONEM) board from November 2019 to 2023, serving as a member of the Nominating
and Corporate Governance Committee; she also served as a member of the board of directors for Tenet Healthcare Corporation (NYSE: THC)
from 2014 to 2017.

 Dr.
Lewis-Hall holds an M.D. from Howard University College of Medicine and a B.A. in natural sciences from the Johns Hopkins University.
The Company believes Dr. Lewis-Hall is qualified to serve on the Board based on her expertise and experience in the biopharmaceutical
industry and her leadership experience as a senior executive at various biopharmaceutical companies.

 Faith
L. Charles. Ms. Charles has served as a member of our board of directors since September 2023. She has been a corporate
transactions and securities partner at the law firm of Thompson Hine LLP since 2010. She leads Thompson Hine's Life Sciences practice
and co-heads the securities practice, advising public and emerging biotech and pharmaceutical companies in the U.S. and internationally.
Ms. Charles negotiates complex private and public financing transactions, mergers and acquisitions, licensing transactions and strategic
collaborations. She serves as outside counsel to a myriad of life sciences companies and is known in the industry as an astute business
advisor, providing valuable insights into capital markets, corporate governance and strategic development. Ms. Charles has been a member
of the board of directors of: CNS Pharmaceuticals, Inc. (Nasdaq: CNSP), a biotechnology company developing novel treatments for cancers
of the brain and central nervous system, since December 2022; Avenue Therapeutics, Inc. (Nasdaq: ATXI), a specialty pharmaceutical company
specializing in developing and commercializing therapies for the treatment of the central nervous system, since May 2022; and Abeona
Therapeutics, Inc. (Nasdaq: ABEO), a fully integrated gene and cell therapy company, since March 2021. Ms. Charles serves as Chair of
CNS Pharmaceuticals, on the Audit Committee of Avenue Therapeutics and on the Audit Committee and as the Chair of the Nominating and
Governance Committee of Abeona Therapeutics. From 2018 until October 2021, Ms. Charles served on the Board of Directors and as a member
of the Audit Committee and Chair of the Compensation Committee of Entera Bio Ltd., a publicly-traded biotechnology company. Ms. Charles
founded the Women in Bio Metro New York chapter and chaired the chapter for five years. She also served on the national board of Women
in Bio. Ms. Charles is also a member of the board of Red Door Community (formerly Gilda's Club New York City.) She has been recognized
as a Life Sciences Star by Euromoney's LMG Life Sciences, has been named a BTI Client Service All-Star, and was named by Crain's
New York Business to the list of 2020 Notable Women in the Law. Ms. Charles holds a J.D degree from The George Washington University
Law School and a B.A. in Psychology from Barnard College, Columbia University. Ms. Charles is a graduate of Women in Bio's Boardroom
Ready Program, an Executive Education Program taught by The George Washington University School of Business. Ms. Charles' qualifications
to serve on our Board include her leadership skills and her vast legal experience representing companies in the biotech and pharmaceutical
field.

 Chele
Chiavacci Farley. Ms. Chiavacci Farley has served on our board of directors since the closing of our initial public offering.
She currently serves as a partner and managing director of Mistral Capital International ("Mistral"), a private equity firm,
that she has been a part of since 1995. In her role as Partner and Managing Director of Mistral, Ms. Farley originates, evaluates and
executes equity investment opportunities, creates and implements deal and financial structures, negotiates with banks for credit facilities,
and oversees management. Ms. Farley is the President and a member of the Board of Directors and Management Committee of Palmilla San
Jose Inmobiliaria, the Master Developer of the luxury Palmilla resort development in Cabo San Lucas, Mexico. Prior to Mistral, Ms. Farley
was Vice President of Tricap International from 1994 to 1995. From 1992 to 1994, Ms. Farley was an Associate at UBS Capital Corporation,
and analyzed and evaluated principal investment and financing opportunities for the firm's internal $1 billion fund. Ms. Farley
began her career as a Financial Analyst in the Global Finance department - Energy and Telecom Group of Goldman, Sachs & Co. Ms. Farley
has also had an active political career. In 2020, Ms. Farley ran for election to the U.S. House of Representatives to represent New York's
18th Congressional district. In 2018, Ms. Farley ran for election to the U.S. Senate to represent New York. Ms. Farley graduated from
Stanford University with a B.S. and M.S. in Industrial Engineering. She is a member of YPO - Young Presidents' Organization. Ms.
Farley was selected to serve on our board of directors following the Business Combination based on her past experience with business
development, capital raising, financings, and banking.

 Simon
Fry. Mr. Fry has served as a member of our board of directors since November 2024. Mr. Fry has over 30 years' experience
in investment banking having held senior executive positions at various top-tier institutions, such as Nomura and Credit Suisse First
Boston. In 2003, Mr. Fry was appointed as Chief Executive Officer at Crosby Asset Management. He previously worked at Nomura, where he
was Managing Director and European Board member, as well as a member of the risk committee and credit committee. During his time at Nomura,
Mr. Fry initiated and built the Company's Asset Investment Group, whose focus was to create specific product and strategy groups
within it to invest in mis-priced and undervalued credit and equity exposures. During this period, Mr. Fry was also responsible for building
Nomura's highly regarded International Markets Division, which was responsible for all the European capital market activity in
equity, fixed income and derivatives including primary origination. Prior to this, Mr. Fry spent 14 years at Credit Suisse First Boston
(CSFB) trading a variety of securities including both fixed income and equities. From 1990, Mr. Fry developed CSFB's Asset Trading
Group, and as Managing Director built a team that generated significant returns over a number of years for CSFB. Mr. Fry is based in
Los Angeles. His expertise in capital markets and strategic asset management is expected to contribute to Conduit's growth goals
as the company pursues development-ready assets and aims to enhance shareholder value.

 Andrew
Regan. Dr. Regan is a British born polar explorer and entrepreneur. He has served as a member of our board of directors since
September 2023. He was a co-founder of Conduit Pharmaceuticals Limited and has served as a board member of Old Conduit since 2019. Dr.
Regan also founded Corvus Capital Limited and has been its Chief Executive Officer since 2008. Corvus Capital is an investment vehicle
that was previously listed on the London Stock Exchange prior to being taken private in 2008. Corvus Capital continues to invest in a
number of industries and sectors. Dr. Regan also has experience as an investor in a number of public and private companies, including
ASOS.com Ltd, a global online fashion and beauty retailer, Virtual Internet, an IT services company that specializes in hosting infrastructure
such as VMWare cloud hosting and Managed and Dedicated Servers, and Imperial Energy Corporation plc, an upstream oil and gas exploration
and production company. Prior to that, Dr. Regan was the Chief Executive Officer of Hobson Plc, which was listed on the London Stock
Exchange, until its sale in 1996 through a cash takeover. Dr. Regan has a strong interest in the use of bio-inspired science to create
solutions for present day problems. In 2014, he was awarded a PhD from Oxford Brookes University for his research in writing and developing
a bio-inspired algorithm for forecasting the financial markets. He is passionate about the polar regions and is an accomplished polar
explorer having led a number of expeditions to both the Arctic and Antarctica. Dr. Regan was selected to serve on our board of directors
following the Business Combination based on his knowledge of Old Conduit and his extensive experience in investing, financing, overseeing
and developing companies.

 Board
Composition

 Our
business and affairs are organized under the direction of our board of directors. The board of directors will meet on a regular basis
and additionally as required. In accordance with the terms of the amended and restated certificate of incorporation, the board of directors
may establish the authorized number of directors from time to time by resolution. Our board of directors currently consists of seven
directors.

Independence

 Under
the Nasdaq listing standards, a majority of the members of our board of directors must qualify as "independent," as affirmatively
determined by the board of directors. The Company's board of directors affirmatively determined that all of the Company's
directors, except for Messrs. Bligh, Tapolczay, and Regan are independent directors within the meaning of the applicable Nasdaq listing
standards. A majority of the members of the board of directors and all members of the Audit Committee, Compensation Committee, and Nominating
and Corporate Governance Committee are independent directors under the applicable Nasdaq listing standards.

 Board
Leadership Structure

 The
board of directors is responsible for the control and direction of the Company. We separate the positions of Chairperson of the board
of directors and Chief Executive Officer of the Company. Dr. Lewis-Hall serves as the Chairperson of the board of directors and Dr. Tapolczay
serves as the Chief Executive Officer of the Company and as a member of the board of directors. The board of directors believe that this
structure serves us well by maintaining a link between management, through Dr. Tapolczay's membership on the board of directors,
and the non-executive directors led by Dr. Lewis-Hall in her role as a non-executive Chairperson.

 Board
Oversight of Risk

 One
of the key functions of our board of directors is to conduct informed oversight of our risk management process. The board of directors
does not anticipate having a standing risk management committee, but rather administers this oversight function directly through the
board of directors as a whole, as well as through various standing committees of the board of directors that address risks inherent in
their respective areas of oversight. In particular, the board of directors will be responsible for monitoring and assessing strategic
risk exposure and the Audit Committee will have the responsibility to consider and discuss the Company's major financial risk exposures
and the steps our management will take to monitor and control such exposures, including guidelines and policies to govern the process
by which risk assessment and management is undertaken. The Audit Committee also monitors compliance with legal and regulatory requirements.
The Compensation Committee assesses and monitors whether our compensation plans, policies, and programs comply with applicable legal
and regulatory requirements.

 Committees
of the Board of Directors

 The
board of directors has formed the committees described below. Each of the committees operates pursuant to a written charter adopted by
the committee or our board of directors. Each charter sets forth the committee's specific functions and responsibilities. The board
of directors of may from time to time establish other committees.

 Audit
Committee

 The
Audit Committee assists the board of directors with its oversight of the integrity of the financial statements; the compliance with legal
and regulatory requirements; the qualifications, independence and performance of the independent registered public accounting firm; the
design and implementation of the financial risk assessment and risk management. Among other things, the Audit Committee is responsible
for reviewing and discussing with management the adequacy and effectiveness of disclosure controls and procedures. The Audit Committee
also discusses with management and independent registered public accounting firm the annual audit plan and scope of audit activities,
scope, and timing of the annual audit of the financial statements, and the results of the audit, quarterly reviews of the financial statements
and, as appropriate, initiates inquiries into certain aspects of the financial affairs.

 The
Audit Committee is responsible for establishing and overseeing procedures for the receipt, retention, and treatment of any complaints
regarding accounting, internal accounting controls or auditing matters, as well as for the confidential and anonymous submissions by
employees of concerns regarding questionable accounting or auditing matters. In addition, the Audit Committee has direct responsibility
for the appointment, compensation, retention, and oversight of the work of the independent registered public accounting firm. The Audit
Committee has sole authority to approve the hiring and discharging of the independent registered public accounting firm, all audit engagement
terms and fees and all permissible non-audit engagements with the independent auditor. The Audit Committee reviews and oversees all related
party transactions in accordance with policies and procedures.

 The
Audit Committee is comprised of three members: Ms. Farley (Chairperson), Dr. Lewis-Hall and Mr. Fry. Each member of the Audit Committee
meets the requirements for independence under the current Nasdaq and SEC rules and regulations and each member is financially literate.
In addition, the board of directors has determined that each of Ms. Farley and Mr. Fry is an "audit committee financial expert"
as defined in Item 407(d)(5)(ii) of Regulation S-K promulgated under the Securities Act.

Committee

 The
Compensation Committee assists the board of directors with its oversight of the forms and amount of compensation for executive officers
(including officers reporting under Section 16 of the Exchange Act), the administration of equity and non-equity incentive plans for
employees and other service providers and certain other matters related to compensation programs. The Compensation Committee, among other
responsibilities, evaluates the performance of our Chief Executive Officer and, in consultation with the Chief Executive Officer, evaluates
the performance of other executive officers (including officers reporting under Section 16 of the Exchange Act).

 The
Compensation Committee is comprised of three members: Ms. Charles (Chairperson), Ms. Farley, and Mr. Fry. The composition of the Compensation
Committee meets the requirements for independence under the current Nasdaq and SEC rules and regulations. Each member of the Compensation
Committee is a "non-employee" director within the meaning of Rule 16b-3 promulgated under the Exchange Act.

 Nominating
and Governance Committee

 The
Nominating and Corporate Governance Committee assists the board of directors with its oversight of and identification of individuals
qualified to become members of the board of directors, consistent with criteria approved by the board of directors, and selects, or recommends
that the board of directors selects, director nominees; develops and recommends to the board of directors a set of corporate governance
guidelines; oversees the evaluation of the board of directors; and reviews the environmental, safety, sustainability, and corporate social
responsibility policies, objectives, and practices on a periodic basis.

 The
Nominating and Corporate Governance Committee is comprised of two members: Dr. Lewis-Hall (Chairperson) and Ms. Charles. The composition
of the Nominating and Corporate Governance Committee meets the requirements for independence under the current Nasdaq and SEC rules and
regulations.

Committee Interlocks and Insider Participation

 No
member of our Compensation Committee was at any time during fiscal year 2024, or at any other time, one of our officers or employees.
None of our executive officers have served as a director or member of a compensation committee (or other committee serving an equivalent
function) of any entity, one of whose executive officers served as a director of our board of directors or member of our Compensation
Committee.

 Family
Relationships

 There
are no family relationships among our directors and executive officers.

 Code
of Conduct

 We
adopted a written Code of Conduct applicable to all of our directors, officers, and employees, which is available on the Company's
website at  Our Internet website address is provided as an inactive textual reference only. The Code of
Conduct covers fundamental ethical and compliance-related principles and practices such as accurate accounting records and financial
reporting, avoiding conflicts of interest, the protection and use of property and information, and compliance with legal and regulatory
requirements. The Code of Conduct is a "code of ethics," as defined in Item 406(b) of Regulation S-K. The Company will make
any legally required disclosures regarding amendments to, or waivers of, provisions of its Code of Conduct on its corporate website.

and Officer Liability and Indemnification

 We
have purchased directors' and officers' liability insurance and have entered into indemnification agreements with each of
directors and executive officers. The indemnification agreements and our amended and restated certificate of incorporation and amended
and restated bylaws require us to indemnify our directors and officers to the fullest extent permitted by Delaware law.

 Insider
Trading Policy

 The
use of material non-public information in securities transactions or the communication of such information to others who use it in securities
trading ("Tipping") violates the federal securities laws. Such violations are likely to result in harsh consequences for
the individuals involved including exposure to investigations by the SEC, criminal and civil prosecution, disgorgement of any profits
realized or losses avoided through use of the non-public information and penalties equal to three times such profits or losses. Further,
insider trading violations expose the Company, its management, and other personnel acting in supervisory capacities to potential civil
liabilities and penalties for the actions of employees under their control who engage in Insider Trading violations.

 Our
Insider Trading Policy (the "Insider Trading Policy") prohibits our executive officers, the non-employee members of our board
of directors and certain other employees from engaging in the following transactions:

 selling
 any of our securities that they do not own at the time of the sale (referred to as a "short sale");

 passing
 material nonpublic information on to others or recommending that another engage in transactions in any securities that they have
 information on;

 buying
 or selling puts, calls, other derivative securities of the Company or any derivative securities that provide the economic equivalent
 of ownership of any of our securities or an opportunity, direct or indirect, to profit from any change in the value of our securities
 or engaging in any other hedging transaction with respect to our securities;

 using
 our securities as collateral in a margin account; and

 pledging
 our securities as collateral for a loan (or modifying an existing pledge).

 While
the Company has not adopted a formal policy governing transactions by the Company in its securities, the Company will not engage in transactions
in Company securities, or adopt any securities repurchase plans, while in possession of material non-public information relating to the
Company or its securities other than in compliance with applicable law, subject to the policies and procedures adopted by the Company.

 On
or around August 14, 2024, the Company was first made aware that one of its directors, through a wholly owned subsidiary, had
previously entered into certain collateral pledge agreements that resulted in the disposition of a substantial amount of shares in
the Company pursuant to those agreements without the Company's knowledge. In addition, the Company also became aware that
approximately 300,000 thousand shares (or 31% of our then outstanding common stock as of August 14, 2024) were subject to a
further third-party pledge arrangement with a then significant stockholder of the Company. Upon learning of these transactions, the
board of directors has appointed an independent committee of the board of directors (the "Special Committee") and
delegated to the Special Committee the authority to review these matters and determine action(s), if any, to be taken by the Company
in response thereto. Additionally, the Company formed another committee of the board of directors (the "Trading Review
Committee") and delegated to the Trading Review Committee the authority to investigate and review the trading patterns of
certain of the Company's stockholders and determine action(s), if any, to be taken by the Company in response thereto. The
Company values its stockholders and wants to have all available data at its disposal to act in its fiduciary capacity.

 Section
16(a) Beneficial Ownership Reporting Compliance

 Section
16(a) of the Exchange Act requires that our directors and executive officers, and persons who own more than ten percent of a registered
class of our equity securities, to file with the SEC initial reports of ownership and reports of changes in ownership of common stock
and other equity securities of the Company. Officers, directors and greater than ten percent stockholders are required by SEC regulation
to furnish us with copies of all Section 16(a) forms they file.

 To
our knowledge, based solely on a review of the copies of such reports furnished to us and written representations that no other
reports were required, during the year ended December 31, 2024, all Section 16(a) filing requirements applicable to our officers,
directors and greater than ten percent beneficial owners were complied with, except for the Form 4 filed Andrew Regan on September
19, 2024 reporting a pledging of shares on June 14, 2024 and the sale of shares from July 2, 2024 to July 17, 2024. The delinquent
filing was inadvertent.

 Item
11. Executive Compensation

 Fiscal
2024 Summary Compensation Table

 The
following table summarizes the compensation earned by or paid to our principal executive officer and our principal financial officer,
who constitute all of our executive officers, for fiscal 2024 and fiscal 2023. We have no defined benefit or actuarial pension plan,
and no deferred compensation plan.

 NAME AND PRINCIPAL POSITION

 FISCAL YEAR

 SALARY

 (1) ($)

 STOCK AWARDS

 (2) ($)

 OPTION AWARDS

 (3) ($)

 NONEQUITY INCENTIVE PLAN COMPENSATIONS

 ($)

 ALL OTHER COMPENSATION

 (4)

 TOTAL

 ($)

 2024

 $
 558,578

 $
 -

 $
 58,800

 $
 -

 $
 -

 $
 617,378

 Chief Executive Officer and Director

 2023

 $
 139,933

 $
 -

 $
 1,203,239

 $
 -

 $
 -

 $
 1,343,172

 James Bligh, Interim Chief Financial Officer

 2024

 $
 438,060

 $
 105,852

 $
 132,300

 $
 -

 $
 16,732

 $
 692,944

 Adam Sragovicz (5)

 2024

 $
 143,333

 $
 -

 $
 -

 $
 -

 $
 103,300

 $
 246,333

 Chief Financial Officer

 2023

 $
 116,667

 $
 410,743

 $
 -

 $

 -

 $
 -

 $
 527,410

 (1)

 Salaries
 converted from British Pounds to US Dollars based on the following exchange rate in effect as of December 31, 2024: 1.2549.

 (2)

 Reflects
 the grant date fair value of the 372 fully vested shares issued to Mr. Bligh in June 2024 to reflect his increased responsibilities
 as interim Chief Executive Officer, based on a stock price of $284 on the date of grant.

 (3)

 Reflects
 the grant date fair value of stock option awards for the applicable year computed in accordance with FASB ASC Topic 718. See Note
 11 to the consolidated financial statements included in this Annual Report for a discussion of the relevant assumptions used in calculating
 the grant date fair value pursuant to FASB ASC Topic 718. As required by SEC rules, the amounts shown exclude the impact of estimated
 forfeitures related to service-based vesting conditions. Our named executive officers will only realize compensation to the extent
 the trading price of our common stock is greater than the exercise price of such stock options.

 (4)

 The amounts shown for 2024 represent 401(k) matching contributions
of $16,732 and $3,300 for Mr. Bligh and Mr. Sragovicz, respectively.

 (5)

 For
 Mr. Sragovicz, includes severance benefits of continued payment of his base salary, and subsidized health insurance premiums, for
 a period of four months after the effective date of his resignation.

Adjustments for 2024

 Annual
Base Salaries

 We
provide a base salary to retain and attract key executive talent and to align our compensation with market practices. Base salaries are
reviewed and established by the Compensation Committee and the board of directors on a competitive basis each year to align with market
levels.

 In
2024, the board of directors (i) increased Dr. Tapolczay's base salary by 3%, and (ii) increased Mr. Bligh's base salary
by 60,000 to compensate for his additional duties as Chief Financial Officer.

 Equity
Awards

 The
Compensation Committee believes that a competitive long-term incentive program is an important component of the compensation of our named
executive officers because it: (i) enhances the retentive value of our compensation; (ii) rewards executives for increasing our stock
price and developing long-term value; and (iii) provides executives with an opportunity for stock ownership to align their interests
with those of our stockholders.

 In
November 2024, the board of directors, with the help of Aon, its independent compensation consultant, conducted a review of the long-term
incentive opportunities for our named executive officers. Based on a review of each executive's individual performance, Mr. Bligh's
additional duties as interim Chief Financial Officer, and the applicable market data, the board of directors approved the following stock
option grants: (i) Dr. Tapolczay received a stock option to purchase 8,400 shares, and (ii) Mr. Bligh received a stock option to purchase
18,900 shares. Each stock option vests 50% of the grant date and 50% in three equal annual installments thereafter. Also, Mr. Bligh received
a one-time grant of 372.72 full vested shares in June 2024, in recognition of his increased responsibilities as interim Chief Executive
Officer. These grant levels have been adjusted to reflect the 1-for-100 reverse stock split on January 24, 2025.

 Employment
Agreements

 We
entered into an employment agreement with our chief executive officer on September 22, 2023, which was the closing date of
the Business Combination. Mr. James Bligh is serving as the Company's interim chief
financial officer. These agreements are summarized below.

 Dr.
Tapolczay

 On
September 22, 2023, we entered into an employment agreement (the "Tapolczay Employment Agreement") with Dr. Tapolczay, pursuant
to which he serves as our Chief Executive Officer of and a member of our board of directors.

 Under
the Tapolczay Employment Agreement, Dr. Tapolczay is entitled to (i) an annual base salary of $550,000 increased to $566,500 effective November 1, 2024, and (ii) a target annual
bonus opportunity equal to 50% of his base salary, payable based on the achievement of performance objectives as determined by our
board of directors. In addition, the Tapolczay Employment Agreement provides that Dr. Tapolczay is entitled to receive a sign-on
stock option award to purchase 0.40% of the shares of our Common Stock pursuant to the terms of the 2023 Stock Incentive Plan, which
shall vest in equal annual installments on the first four anniversaries of the Business Combination. The Tapolczay Employment
Agreement provides that if we terminate Dr. Tapolczay's employment other than for cause or disability, or if he terminates his
employment for good reason, in either case other than the change in control protection period (described below), he would be
entitled to receive (i) continued payment of his annual base salary for 12 months following the date of termination, (ii) a lump sum
payment of his annual cash performance bonus that had been earned by him for a completed fiscal year or other measuring period but
that had not yet been paid to him as of the date of termination, (iii) a lump sum payment equal to his then target annual bonus
opportunity, pro-rated based on the total number of days elapsed in the calendar year through the date of termination, (iv) payment
or reimbursement of the COBRA premiums for him and his eligible dependents, or if COBRA is not available under our group health
plan, a cash amount equal to such payments or reimbursements (in either case, less the premiums he was paying for such coverage
while employed), until the earliest of (x) the last day of the applicable salary continuation period specified above, or (y) the
date he becomes eligible for comparable health insurance coverage under a subsequent employer's group health plan; and (v)
accelerated vesting of such number of his unvested equity awards as would have vested had he remained employed during the 12-month
period following his date of termination (provided, however, that, any equity awards that vest in whole or in part based on the
attainment of performance-vesting conditions shall be governed by the terms of the applicable award agreement).

 The
Tapolczay Employment Agreement provides that if we terminate Dr. Tapolczay's employment other than for cause or disability, or
if he terminates his employment for good reason, in either case within three months prior to or 12 months after a change in control (such
period, the change in control period), he would be entitled to receive (i) continued payment of his annual base salary for 18 months
following the date of termination, (ii) a lump sum payment of his annual cash performance bonus that had been earned by him for a completed
fiscal year or other measuring period but that had not yet been paid to him as of the date of termination, (iii) a lump sum payment equal
to 150% of his then target annual bonus opportunity (without pro-ration), (iv) payment or reimbursement of the COBRA premiums for him
and his eligible dependents, or if COBRA is not available under our group health plan, a cash amount equal to such payments or reimbursements
(in either case, less the premiums he was paying for such coverage while employed), until the earliest of (x) the last day of the applicable
salary continuation period specified above, or (y) the date he becomes eligible for comparable health insurance coverage under a subsequent
employer's group health plan; and (v) accelerated vesting of 100% of his unvested equity awards (provided, however, that, any equity
awards that vest in whole or in part based on the attainment of performance-vesting conditions shall be governed by the terms of the
applicable award agreement).

 Additionally,
to the extent that any payment or benefit received in connection with a change in control would be subject to an excise tax under Section
4999 of the Code, such payments and/or benefits will be subject to a "best pay cap" reduction if such reduction would result
in a greater net after-tax benefit to the executive than receiving the full amount of such payments.

 In
exchange for the severance benefits described above, Dr. Tapolczay must (i) sign and not revoke a release of claims in favor of the Company,
(ii) comply with his proprietary information and inventions assignment agreement, (iii) refrain from soliciting employees of the Company
for a period of one year after his termination of employment, and (iv) comply with the other provisions of the Tapolczay Employment Agreement.

 On November 15, 2024, Conduit
Pharmaceuticals Limited and Conduit UK Management LTD., wholly-owned subsidiaries of the Company, entered into an amended and restated
employment agreement (the "Bligh Employment Agreement") with James Bligh, pursuant to which Mr. Bligh will
continue to be employed by Conduit UK Management LTD. and continue to serve as the Interim Chief Financial Officer and Senior
Vice President - Strategy of the Company. Under the Bligh Employment Agreement, Mr. Bligh will receive an annual base salary
of 400,000 and will be entitled to a discretionary cash bonus of up to 40% of his base salary, subject to the achievement of certain
milestones that may be established by the Board of Directors or a committee thereof, from time to time. Mr. Bligh is also entitled to
reimbursement for reasonable out-of-pocket expenses incurred by him in the performance of his duties, subject to the terms of any expenses
policy the Company may have.

 The Bligh Employment Agreement requires at least six months' advanced
written notice for Mr. Bligh or Conduit UK Management LTD. to terminate Mr. Bligh's employment, except in the case
of a summary dismissal (as described in the Bligh Employment Agreement). However, Conduit UK Management LTD. may, at its sole discretion
and by written notice, terminate Mr. Bligh's employment immediately and provide compensation to Mr. Bligh for the unexpired
portion of such notice period. The Bligh Employment Agreement replaces and supersedes the prior employment agreement between Conduit Pharmaceuticals
Limited and Mr. Bligh.

 Mr.
Sragovicz

 On
May 10, 2024, Adam Sragovicz informed the Board of Directors of his intention to resign as Chief Financial Officer of the Company. In
connection with his resignation, Mr. Sragovicz agreed to continue in his current role, with the same responsibilities and obligations
as he previously had, through the day after the filing of this Quarterly Report on Form 10-Q, so that his resignation will become effective
on May 15, 2024. Mr. Sragovicz's resignation was not due to any disagreement with management or the Company's operations,
policies or practices.

 The
Company entered into a separation agreement with Mr. Sragovicz on May 12, 2024, which provides for continued payment of his base salary,
and subsidized health insurance premiums, for a period of four months after the effective date of his resignation. In exchange for these
benefits, Mr. Sragovicz has signed a mutual release of claims, agreed to a mutual non-disparagement covenant, and re-affirmed certain
confidentiality, non-solicitation and post-departure cooperation covenants.

 Outstanding
Equity Awards at 2024 Fiscal Year-End

 The
following table summarizes all of the outstanding equity-based awards held by our named executive officers as of December 31, 2024, the
end of our fiscal year. The option shares reported below have been adjusted to reflect the 1-for-100
reverse stock split on January 24, 2025.

 OPTION AWARDS

 NAME

 OPTION OR STOCK AWARD GRANT DATE

 NUMBER OF SECURITIES UNDERLYING UNEXERCISED OPTIONS (#) EXERCISABLE

 NUMBER OF SECURITIES UNDERLYING UNEXERCISED OPTIONS
(#) UNEXERCISABLE

 OPTION EXERCISE PRICE

($)

 OPTION EXPIRATION DATE

 11/18/2024
 (2)

 4,200

 4,200

 $
 9.20

 11/17/2034

 12/1/2023
 (1)

 2,236

 11/18/2024
 (2)

 9,450

 9,450

 $
 9.20

 11/17/2034

 11/18/2024
 (1)

 1,677

 (1)

 The
 stock option vests as to 1/4 of the underlying shares on each of the first four anniversaries of the vesting commencement date

 (2)

 The stock options vests 50% of the grant date and 50% in three equal annual installments thereafter

 2023
Stock Incentive Plan

 On
September 20, 2023, MURF stockholders approved the Conduit Pharmaceuticals Inc. 2023 Stock Incentive Plan (the "2023 Plan").
The 2023 Plan permits our board of directors or compensation committee to grant may grant or issue stock options, stock appreciation
rights, restricted stock, restricted stock units, performance stock units, other stock- or cash-based awards and dividend equivalents,
or any combination thereof, to officers, employees, directors or consultants of the Company.

 Subject
to adjustment for stock splits or similar events, the 2023 Plan initially reserved 114,976 shares of Common Stock for issuance
pursuant to awards, plus an annual increase on the first day of each calendar year beginning in 2024 and ending in 2033 equal to the
lesser of (i) 5% of the shares of Common Stock outstanding on the last day of the immediately preceding calendar year and (ii) such
smaller number of shares of Common Stock as determined by our board of directors. The 2023 Plan was increased
by 36,914 shares of common stock effective January 1, 2024, and by 69,240 shares of common stock effective January 1,
2025. On February 6, 2025, the Company filed a registration statement on Form S-8 that increased the number of shares of Common
Stock available for issuance under the 2023 Plan by 69,240 shares.

 Securities
Authorized for Issuance under Equity Compensation Plans

 The
following table provides a summary of the securities authorized for issuance under our equity compensation plans as of December 31, 2024.

 Plan category

 Number of securities to be issued upon exercise of outstanding options, warrants and rights

 Weighted-average exercise price of outstanding options,
 warrants and rights

 Number of securities
 remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a))

 (a)

 (b)

 (c)

 Equity compensation plans approved by security holders

 2023 Plan

 65,509

 $
 81.52

 84,885

 Equity compensation plans not approved by security holders

 -

 -

 -

 Total

 65,509

 $
 81.52

 84,885

 The
following table sets forth the compensation we paid to our non-employee directors during fiscal 2024:

 Name

 Fees earned or
 paid in cash

 ($)

 Stock
 awards
 ($) (1)(2)

 Option

 awards
 ($) (3)

 All Other

 TOTAL

($)

 Faith L. Charles

 $
 24,500

 $
 31,400

 $

 $
 -

 $
 76,900

 Chele Chiavacci Farley

 $
 27,500

 $
 133,352

 $

 $
 -

 $
 181,852

 Freda Lewis-Hall

 $
 40,250

 $
 40,250

 $

 $
 -

 $
 101,500

 Simon Fry

 $
 -

 $
 -

 $

 $
 -

 $

 Jennifer I. McNealey (4)

 $
 11,875

 $
 -

 $
 -

 $
 -

 $
 11,875

 Andrew Regan (5)

 $
 -

 $
 -

 $
 -

 $
 -

 $
 -

 (1)

 Dr.
 Lewis-Hall elected to receive $40,250 of her cash fees in the form of fully vested shares,
 Ms. Chiavacci Farley elected to receive $27,500 of her cash fees in the form of fully vested
 shares, and Ms. Charles elected to receive $24,500 of her cash fees in the form of fully
 vested shares.

 (2)

 Reflects
 the grant date fair value of (i) the 372 fully vested shares issued to Ms. Chiavacci Farley in June 2024, based on a stock price
 of $284 on the date of grant, and (ii) the 750 fully vested shares issued to Ms. Charles in November 2024, based on a stock price
 of $9.20 on the date of grant.

 (3)

 Amounts
 in this column represents the aggregate grant date fair value, determined in accordance with FASB ASC Topic 718, of option awards
 granted to participating non-employee directors in 2024. For a description of the assumptions we used to calculate these amounts,
 see Note 11 to the consolidated financial statements included in this Annual Report.

 (4)

 On May 12, 2024, Ms. McNealey announced her resignation, due to personal
reasons, as a member of the Board of Directors of the Company and from all committees on which she served, effective as of May 13, 2024.
Ms. McNealey's resignation was not due to any disagreement with management or the Company's operations, policies or practices.

 (5)

 Dr.
 Regan waived his right to receive any compensation for services as
a non-employee director of the Company, effective as of the closing of the Business Combination. As a result, Dr. Regan has not been
paid any cash retainers or received any equity retainers since the closing date.

 As of December 31, 2024, our non-employee directors held the following
stock options:

 OPTION AWARDS

 NAME

 OPTION OR

 STOCK AWARD

 GRANT DATE

 NUMBER OF

 SECURITIES

 UNDERLYING

 UNEXERCISED

 OPTIONS

 (#)

 EXERCISABLE

 NUMBER OF

 SECURITIES

 UNDERLYING

 UNEXERCISED

 OPTIONS
 (#)

 UNEXERCISABLE

 OPTION

 EXERCISE PRICE

 ($)

 OPTION

 EXPIRATION
DATE

 Faith L. Charles

 12/18/2024
 (2)

 -

 4,200

 $
 7.10

 12/17/2034

 12/1/2023
 (1)

 Chele Chiavacci Farley

 12/18/2024
 (2)

 -

 4,200

 $
 7.10

 12/17/2034

 12/1/2023
 (1)

 Freda Lewis-Hall

 12/18/2024
 (2)

 -

 4,200

 $
 7.10

 12/17/2034

 12/1/2023
 (1)

 Simon Fry

 12/18/2024
 (2)

 -

 4,200

 $
 7.10

 12/17/2034

 (1)

 The stock option vests as to 1/3 of the underlying shares on each of the first three anniversaries of the vesting commencement date

 (2)

 The stock options vests 100% of the underlying shares on the first anniversary of the vesting commencement date

Program for the Board of Directors

 We
adopted a compensation program for our board of directors, which became effective upon completion of the Business Combination, and was
amended on November 15, 2024. Under the compensation program, the non-employee directors will receive the following annual cash
retainers for their service on the board of directors and its committees:

 $35,000
 for each non-employee director;

 $30,000
 for the Chairperson of the board of directors;

 $15,000
 for the chair of the Audit Committee and $7,500 for each of the other members of that committee;

 $10,000
 for the chair of the Compensation Committee and $5,000 for each of the other members of that committee; and

 $8,000
 for the chair of the Nominating and Corporate Governance Committee and $4,000 for each of the other members of that committee.

 In addition, each non-employee director who is
initially elected or appointed to the board of directors will automatically be granted on the day of such first election or appointment
a stock option to purchase 4,200 shares of our Common Stock (the "Initial Award"). Each Initial Award will vest and become
exercisable in substantially equal installments on each of the first three anniversaries of the date of grant, subject to the non-employee
director continuing in service on the board of directors through each such vesting date.

 A non-employee director who is serving on the
board of directors as of the date of any annual meeting after the effective date of the new program, and who will continue to serve as
a non-employee director immediately following such meeting, will automatically be granted on the date of such annual meeting a stock option
to purchase 4,200 shares of our Common Stock, which amount is pro-rated for new directors to reflect their service since the last annual
meeting (the "Annual Award"). Each Annual Award will vest and become exercisable on the earlier of (i) the first anniversary
of the date of grant, or (ii) the date immediately prior to the next annual meeting of the Company's stockholders following the
date of grant, subject to the non-employee director continuing in service on the board of directors through such vesting date.

 Upon a change in control, all outstanding equity
awards that are held by a non-employee director shall become fully vested and exercisable.

 In 2024, the board of directors appointed Dr. Hall and Ms. Charles
to serve on the Special Committee and approved an additional cash retainer of $7,500 for each of them to reflect her service on the Special
Committee. In June 2024, the board of directors authorized the grant of a one-time additional equity retainer to Ms. Chiavacci Farley
in the form of 372 fully vested shares to recognize the significant time she has devoted to the Company since September 2023, in her capacity
as a member of the board, assisting and advising the Company on certain strategic transactions, financings and accounting matters. In
November 2024, the board of directors authorized the grant of a one-time additional equity retainer to Ms. Charles in the form of 750
fully vested shares to recognize the significant time she has devoted to the Company since September 2023, in her capacity as a member
of the board, assisting and advising the Company on certain strategic transactions and financings.

 Board members who are also
employees of the Company, such as Dr. Tapolczay and Mr. Bligh, are not eligible to participate in the non-employee director compensation
program described above and did not receive any compensation for service on the board of directors. Moreover, Dr. Regan waived his right
to receive any compensation under the program.

 The
2023 Plan provides that the sum of the grant date fair value of all equity-based awards and the maximum amount of cash that may become
payable to any individual for services as a non-employee director during any calendar year may not exceed $750,000, increased to $1,000,000
in the calendar year of a non-employee director's initial service as a non-employee director. The plan administrator may make exceptions
to this limit for individual non-employee directors in extraordinary circumstances, as the plan administrator may determine in its discretion,
provided that the non-employee director receiving such additional compensation may not participate in the decision to award such compensation
or in other contemporaneous compensation decisions involving non-employee directors.

 Item
12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 The
following table sets forth beneficial ownership of the Company's Common Stock as of March 28, 2025 by:

 each
 person known to be the beneficial owner of more than 5% of the outstanding Common Stock of the Company;

 each
 of the Company's executive officers and directors; and

 all
 of the Company's current executive officers and directors as a group.

 Beneficial
ownership is determined according to the rules of the SEC, which generally provide that a person has beneficial ownership of a security
if he, she or it possesses sole or shared voting or investment power over that security. Under those rules, beneficial ownership includes
securities that the individual or entity has the right to acquire, such as through the exercise of warrants or stock options or the vesting
of restricted stock units, within 60 days of March 28, 2025. Shares subject to warrants or options that are currently exercisable or
exercisable within 60 days of March 28, 2025 or subject to restricted stock units that vest within 60 days of March 28, 2025 are considered
outstanding and beneficially owned by the person holding such warrants, options, or restricted stock units for the purpose of computing
the percentage ownership of that person but are not treated as outstanding for the purpose of computing the percentage ownership of any
other person.

 Except
as noted by footnote, and subject to community property laws where applicable, based on the information provided to the Company, the
persons and entities named in the table below have sole voting and investment power with respect to all shares shown as beneficially
owned by them. Unless otherwise indicated, the business address of each beneficial owner listed in the table below is c/o Conduit Pharmaceuticals
Inc., 4581 Tamiami Trail North, Suite 200 Naples, Florida 34103.

 The
beneficial ownership of our Common Stock is based on 6,662,755 shares of Common Stock issued and outstanding as of March 28, 2025, which
number excludes the shares of Common Stock issuable upon exercise of the warrants. Unless otherwise indicated, we believe that all persons
named in the table have sole voting and investment power with respect to all of the shares shown to be beneficially owned by them.

 Name and Address of Beneficial Owner (1)

 Number of
 shares of
 Common Stock

 % of
 Common Stock*

 Directors and executive officers

 10,381
 (2)

 *

 Faith L. Charles

 3,631
 (3)

 *

 Chele Chiavacci Farley

 5,914
 (4)

 *

 Freda Lewis-Hall

 34,836
 (5)

 *

 Andrew Regan

 302,926
 (6)

 4.55
 %

 30,987
 (7)

 *

 Simon Fry

 2,000
 (8)

 *

 All directors and executive officers as a group (6 individuals)

 390,675

 5.81
 %

 *

 Indicates
 beneficial ownership of less than 1%.

 (1)

 The
 table does not include Adam Sragovicz, the Company's former Chief Financial Officer, who resigned effective May 15, 2024, and
 following such resignation, to the Company's knowledge, did not beneficially own any securities of the Company.

 (2)

 of (i) 372 shares of Common Stock and (ii) options to purchase 10,009 shares Common Stock that are currently exercisable. Excludes
 11,127 unvested options to purchase shares of Common Stock that are not exercisable within 60 days.

 (3)

 of (i) 3,415 shares of Common Stock and (ii) options to purchase 216 shares of Common Stock that are currently exercisable. Excludes
 4,633 unvested options to purchase shares of Common Stock that are not exercisable within 60 days.

 (4)

 of (i) 3,515 shares of Common Stock, (ii) warrants to purchase 2,183 shares of Common Stock and (iii) options to purchase 216 shares
 of Common Stock that are currently exercisable. Excludes 4,633 unvested options to purchase shares of Common Stock that are not
 exercisable within 60 days.

 (5)

 Includes
 234,836 shares of Common Stock, of which (i) 4,379 are held directly by Dr. Lewis-Hall, (ii) 20,033 were issued to Intelmed LLC, of which
 Dr. Lewis-Hall is the Managing Director, (iii) 5,169 shares of Common Stock were received by Mr. Emerson Hall, Jr., Dr.
 Lewis-Hall's spouse, and (iv) 216 are underlying options that are currently exercisable and are held directly by Dr.
 Lewis-Hall, (v) warrants to purchase 1,033 shares of Common Stock held directly by Dr. Lewis-Hall and (vi) warrants to purchase
4,006 shares of Common Stock held by Intelmed LLC. By virtue of this relationship with both Intelmed LLC and her spouse, Dr. Lewis-Hall may be deemed to share beneficial
 ownership of the securities held of record by Intelmed LLC and Mr. Emerson Hall, Jr. Dr. Lewis-Hall disclaims any such beneficial
 ownership except to the extent of her pecuniary interest therein. Excludes 4,633 unvested options to purchase shares of Common Stock
 that are not exercisable within 60 days. The business address of
 Intelmed LLC is 11421 Golden Eagle Court Naples, Florida 34120.

 (6)

 of (i) 666 shares of Common Stock held directly by Dr. Regan, (ii) 300,484 shares of Common Stock held by Corvus Capital Limited, and
 (iii) 1,776 shares of Common Stock held by Algo Holdings, Inc. Dr. Regan is the Chief Executive Officer of Corvus Capital Limited and
 Algo Holdings, Inc. is a wholly owned subsidiary of Corvus Capital Limited. By virtue of this relationship, Dr. Regan may be deemed
 to share beneficial ownership of the securities held of record by Corvus Capital Limited and Algo Holdings, Inc. Dr. Regan disclaims
 any such beneficial ownership except to the extent of his pecuniary interest therein. Pursuant to a participation and inducement
 agreement with Nirland Limited, the 30,048 shares of Common Stock held by Corvus Capital Limited may, in certain circumstances, be
 subject to transfer to Nirland Limited and all such shares of Common Stock are subject to a pledge agreement with respect to such
 arrangement. The business address of Corvus Capital Limited is Floor 2, Willow House, Cricket Square PO Box 709 Grand Cayman KY1-1107,
 Cayman Islands.

 (7)

 of (i) 20,033 shares received pursuant to the Agreement and Plan of Merger, dated as of November 8, 2022 and as amended on January
 27, 2023 and May 11, 2023, by and among the Company, Conduit and the Merger Sub and (ii) options to purchase 4,945 shares of Common
 Stock that are currently exercisable and, (iii) warrants to purchase 6,009 shares of Common Stock. Excludes 6,436 options to purchase shares of Common Stock that are not exercisable within 60 days.

 (8)

 Consist of 2,000 shares of common stock and excludes 4,200 options
to purchase shares of Common Stock that are not exercisable within 60 days.

 Item
13. Certain Relationships and Related Transactions, and Director Independence

 In
addition to the compensation arrangements with directors and executive officers described under the sections titled "Executive
Compensation" and "Management," the following is a description of each transaction since January 1, 2023 and each currently
proposed transaction, in which:

 we
 have been or are to be a participant;

 the
 amount involved exceeds or will exceed $120,000; and

 any
 of our directors, executive officers, or beneficial holders of more than 5% of our capital stock, or any immediate family member
 of, or person sharing the household with, any of these individuals (other than tenants or employees), had or will have a direct or
 indirect material interest.

 Policies
and Procedures for Related Party Transactions

 Our
board of directors adopted a policy, at the closing of the Business Combination, with respect to the review, approval, and ratification
of related party transactions. Under the policy, the audit committee of the board of directors is responsible for reviewing and approving
related party transactions. In the course of its review and approval of related party transactions, the audit committee will consider
the relevant facts and circumstances to decide whether to approve such transactions. In particular, the policy requires the audit committee
to consider, among other factors it deems appropriate:

 the transaction was undertaken in the ordinary course of business of the Company;

 the related party transaction was initiated by the Company, a subsidiary, or the related party;

 the transaction with the related party is proposed to be, or was, entered into on terms no less favorable to the Company than terms
 that could have been reached with an unrelated third party;

 the
 purpose of, and the potential benefits to the Company of, the related party transaction;

 if
 the approximate dollar value of the amount involved in the related party transaction, particularly as it relates to the related party;

 the
 related party's interest in the related party transaction;

 the related party transaction would impair the independence of an otherwise independent director; and

 any
 other information regarding the related party transaction or the related party that would be material to investors in light of the
 circumstances of the particular transaction

 The
audit committee may approve the related party transaction only if the audit committee determines in good faith that, under all of the
circumstances, the transaction is in the best interests of the Company and its stockholders.

 Founder

 On
November 16, 2021, the Sponsor, Murphy Canyon Acquisition Sponsor LLC, previously an affiliate of MURF, purchased an aggregate of 43,125
shares of Common Stock for the aggregate price of $25,000 (the "Founder Shares"). The Founder Shares included an aggregate
of up to 7,500 shares subject to forfeiture by the Sponsor to the extent that the underwriters' over-allotment was not exercised
in full or in part, or 10,062 shares if the underwriters' over-allotment was exercised in full, so that the Sponsor would collectively
own 20% of the Company's issued and outstanding shares after the IPO (assuming that, in the IPO, the Sponsor only purchased Class
A common stock consisting of (i) the Founder Shares and (ii) the 7,540 shares of Class A common stock included in the units purchased
by the Sponsor in connection with the IPO (together, the "Private Shares"). As a result of the underwriters' election
to exercise their over-allotment option, on January 26, 2022, the Sponsor surrendered and forfeited 10,062 Founder Shares. Following
such forfeiture, the Sponsor held 33,062 Founder Shares.

 The
Sponsor agreed, subject to certain limited exceptions, not to transfer, assign or sell any of the Founder Shares until the earlier to
occur of: (A) six months after the completion of our initial business combination, and (B) subsequent to the initial business combination
if we complete a liquidation, merger, stock exchange or other similar transaction that results in all of our public stockholders having
the right to exchange their public shares for cash, securities or other property. Notwithstanding the foregoing, the Sponsor shall have
the right to transfer its ownership in the Founder Shares at any time to the extent that it determines, in good faith, that such transfer
is necessary to ensure that it and/or any of its parents, subsidiaries or affiliates are in compliance with the Investment Company Act
of 1940.

 Private
Units

 Contemporaneously
with the closing of the IPO and the exercise of the overallotment option, the Sponsor purchased an aggregate of 754,000 private units
of MURF in a private placement at a price of $10.00 per private unit. Each private unit consists of one Private Share and one Private
Warrant (the "Private Warrant"). The private units are identical to the units sold in the IPO except that the (a) the placement
units and their component securities will not be transferable, assignable or saleable until October 22, 2023 except to permitted transferees
and (b) the warrants and rights included as a component of the placement units, so long as they are held by the Sponsor or its permitted
transferees, will be entitled to registration rights, respectively. Additionally, the warrants underlying the placement units contain
a cashless exercise provision and shall be non-redeemable while held by the initial purchasers thereof or their permitted assignees.
The Sponsor had agreed not to transfer, assign or sell any of the private units and underlying securities (except in connection with
the same limited exceptions that the Private Shares may be transferred as described above) until after the Business Combination. In connection
with completion of the Business Combination, the Sponsor transferred 45,000 placement units (15,000 each) to each of Mrs. Knuettell and
Feinberg, former Directors of MURF, and Ms. Chiavacci Farley, former Director of MURF and current Director of Conduit.

 Sponsor
Support Agreement

 Concurrently
with the execution of the Merger Agreement, the Company entered into a support agreement with the Sponsor pursuant to which the Sponsor
agreed to, among other things, vote all of the shares of MURF common stock legally and beneficially owned by it in favor of the Business
Combination. On September 20, 2023, the Sponsor voted all of the shares of MURF common stock then legally and beneficially owned by it
in favor of the Business Combination.

 PIPE
Subscription Agreement

 In
September 2023, concurrently with the completion of the Business Combination, pursuant to the PIPE Subscription Agreement (the "PIPE
Subscription Agreement ") for an aggregate purchase price of $20.0 million, the Company issued an aggregate of 20,000 shares
of the Company's Common Stock and PIPE Warrants (the "PIPE Warrants") to purchase 20,000 shares of Company Common
Stock. In conjunction with the execution of the PIPE Subscription Agreement, Corvus Capital and its affiliates entered into a participation
and inducement agreement with the Private Placement Investor whereby Corvus agreed to provide certain payments and economic benefits
to such investor in the event Corvus Capital sold or pledged in a debt transaction any of the shares it was receiving in the Business
Combination. In certain circumstances, such investor may have a right to cause Corvus Capital to transfer certain of its shares to such
investor.

 The
PIPE Subscription Agreement contains registration rights, pursuant to which within 15 business days after the closing of the PIPE Financing,
the Company was required to use reasonable best efforts to file with the SEC a registration statement registering the resale of shares
of the Company's common stock. On October 17, 2023, the Company filed a registration statement on Form S-1 (SEC File No. 333-275056)
to satisfy that contractual requirement, which registration statement was declared effective by the SEC on December 15, 2023.

 The
PIPE Warrants are exercisable until September 22, 2028 (five years after the completion of the Business Combination) and have an exercise
price of $11.50 per share, subject to adjustment as set forth in the PIPE Warrants for stock splits, stock dividends, recapitalizations
and similar customary adjustments. The Private Placement Investor may exercise each PIPE Warrant on a cashless basis if the shares underlying
the PIPE Warrants are not then registered for resale pursuant to an effective registration statement.

 The
Company common stock and PIPE Warrants to purchase Company common stock issued pursuant to the PIPE Subscription Agreement were not registered
under the Securities Act and were issued in reliance upon the exemption provided under Section 4(a)(2) of the Securities Act and/or Regulation
D promulgated thereunder.

 On
December 11, 2024, the warrants were modified to reduce the exercise price to $0.0883 and the warrants were exercised on December 31, 2024.

 Consulting
Agreement with Jack K. Heilbron

 Jack
K. Heilbron, who served as the MURF's Chief Executive Officer, President, and Chairman of the board of directors until September
22, 2023, has entered into a Consulting Agreement (the "Consulting Agreement") with the Company, which became effective upon
the closing of the Business Combination. The Consulting Agreement provides that Mr. Heilbron will provide advisory and consulting services
from time to time to the Company until September 22, 2024. Pursuant to the terms of the Consulting Agreement, Mr. Heilbron is entitled
to rights as an observer to the Company's board of directors. Mr. Heilbron is entitled to be paid $25,000 per calendar quarter
for his consulting services and is also entitled to a stock option to purchase the number of shares of Common Stock determined by dividing
(i) $300,000, by (ii) the per share Black-Scholes valuation as of the grant date, utilizing the same assumptions used in preparation
of the financial statements, with the resulting quotient rounded down to the nearest whole share. Mr. Heilbron was award stock options to purchase 30,000 shares of Common
Stock on December 1, 2023. As of December 31, 2024, and subsequent
agreement between the parties, the Company has paid Mr. Heilbron approximately $25,000 and granted Mr. Heilbron 6,900 shares of the Company's
common stock.

 Shareholder
Support Agreements

 Concurrently
with the execution of the Merger Agreement, MURF, Old Conduit, and certain shareholders of Old Conduit (the "Old Conduit Shareholders")
entered into a certain shareholder support agreement dated November 8, 2022, pursuant to which the Old Conduit Shareholders agreed to
vote all Old Conduit shares beneficially owned by them, including any additional shares of Old Conduit they acquire ownership of or the
power to vote, in favor of the Business Combination and related transactions. Under the support agreements, each Old Conduit Shareholder
also agreed that, prior to the termination of the applicable support agreement, such Old Conduit Shareholder would not transfer or otherwise
enter into any agreement or understanding with respect to a transfer relating to any shares of Old Conduit owned by such shareholder.
The support agreements automatically terminated on September 22, 2023.

 Old
Conduit Shareholder Lockup Agreements

 Under
the Merger Agreement, as a condition to receiving Common Stock of the Company after the closing of the Business Combination in respect
of their Old Conduit shares, certain shareholders of Old Conduit executed lockup agreements pursuant to which such shareholders agreed
not to sell, transfer or take certain other actions with respect to such shares of our Common Stock for a period of 180 days after the
closing of the Business Combination, subject to certain customary exceptions.

 Transactions
with Corvus Capital Limited

 Corvus
Capital Limited ("Corvus Capital") received 311,484 shares of our common stock, pursuant to the terms of the Merger
Agreement, following the completion of the Business Combination. As of December 31, 2024, Corvus Capital owned 300,484 shares of our
Common Stock directly and 1,776 shares of our Common Stock through its wholly-owned subsidiary Algo Holdings, Inc., or in the
aggregate approximately 21.8% of the then outstanding shares of our Common Stock. Dr. Andrew Regan, the Chief Executive Officer of
Corvus Capital and 100% ultimate beneficial owner, is also a member of our board of directors.

 August

 On
August 6, 2024, the Company entered into a Senior Secured Promissory Note (the "August 2024 Nirland Note") with Nirland,
a related party of the Company, pursuant to which the Company issued and sold to Nirland the August 2024 Note in the original principal
amount of $2,650,000, inclusive of a $500,000 original issuance discount. Refer to Note 7 for additional details.

 On
October 31, 2024, the Company and Nirland amended the August 2024 Nirland Note, whereby the August 2024 Nirland Note was amended to (i)
provide for the conversion of the August 2024 Nirland Note into shares of Common Stock, at Nirland's discretion, in a multiple
of any unpaid amounts, if not otherwise previously paid, pursuant to the conversion rate contained therein, (ii) remove Nirland's
Mandatory Prepayment Right, and (iii) remove Nirland's right of first refusal to participate in any future equity or debt offerings
of the Company. The number of shares of Common Stock issuable upon conversion of any Conversion Amount pursuant to shall be determined
by dividing (x) such conversion amount by (y) the conversion price. Conversion amount means two and one quarter times the sum of (x)
portion of the principal to be converted, redeemed or otherwise with respect to which this determination is being made and (y) all accrued
and unpaid interest with respect to such portion of the principal amount, if any. Conversion price means, as of any conversion date or
other date of determination, $10, subject to adjustment as provided within the amended agreement.

 October 2024 Nirland Note

 On October 28, 2024, the Company issued a promissory note (the "October
2024 Nirland Note") to Nirland, a related party, in the original principal amount of $600,000 in exchange for funds in such amount.
In connection with the October 2024 Nirland Note, the Company paid Nirland a 1% arrangement fee. The October 2024 Nirland Note bears interest
at a rate of 12% per annum, is due and payable semi-annually in arrears, and matures on October 31, 2025. Refer to Note 8 for additional
details.

 Sarborg Agreement

 On December 12, 2024, the Company
entered into the Sarborg Agreement with Sarborg. Under the terms of the Sarborg Agreement, Sarborg will provide algorithmic
and cybernetic technology services to Conduit, including the development of decision-support tools and advanced cybernetic systems tailored
to enhance Conduit's decision-making processes and maximize the value of its pharmaceutical asset portfolio.

 Sarborg will perform the
services to Conduit comprised of three phases: the Initial Phase (0-24 weeks) focuses on establishing a foundation for collaboration and
aligning Sarborg's services with Conduit's strategic goals; the Development Phase (24-36 weeks) involves building technological
infrastructure, including dashboards and predictive models; and the Ongoing Services Phase (36-52 weeks) ensures the sustained functionality
and relevance of Sarborg's deliverables while supporting Conduit's growth through iterative improvements and updates. Sarborg will
create specific deliverables, including reports, computer programs, software applications, APIs, mobile applications, source code, written
technical specifications and designs, operating and maintenance manuals, and other recorded data and information arising from or relating
to the services. Sarborg will provide all necessary resources to perform the services and deliver the deliverables in accordance
with the Sarborg Agreement.

 The Sarborg Agreement has an
initial term of twelve months, commencing on the effective date, and may be renewed or extended upon mutual written agreement of the parties.
Either party may terminate the Sarborg Agreement for any reason upon ninety days' written notice or immediately upon written notice
if the other party breaches any material term of the Sarborg Agreement and fails to cure such breach within thirty days or becomes insolvent,
files for bankruptcy, or is placed under the control of a receiver, trustee, or similar authority.

 In consideration of the services,
Conduit has agreed to pay Sarborg an initial cash payment of $200,000 and $200,000 payable through the issuance of 22,727
shares of common stock, determined by the closing price on the day preceding the execution of the Sarborg Agreement. Further milestone
payments payable in conjunction with the achievement of certain milestones over the term of the Sarborg Agreement, totaling up to $1,800,000,
are payable in cash or shares, at the discretion of Conduit. Sarborg will be reimbursed for pre-approved, necessary, and reasonable
out-of-pocket expenses directly incurred in connection with the performance of the services.

 The Sarborg Agreement includes
provisions for the ownership and use of intellectual property. Sarborg will own its pre-existing intellectual property rights,
including proprietary tools and methodologies used in the performance of the services. Conduit will own all deliverables resulting from
the services performed by Sarborg under the Sarborg Agreement.

 The Sarborg Agreement provides Sarborg with
registration rights for any common stock of Conduit that Sarborg receives as consideration under the Sarborg Agreement. Conduit
must use commercially reasonable efforts to prepare and file a registration statement covering the resale of the common stock within sixty
days after the issuance of the shares to Sarborg. The Company must cause the registration statement covering such shares to become effective
withing ninety days of the filing of the registration statement. The Sarborg Agreement also includes confidentiality obligations, representations
and warranties, indemnification, limitation of liability, and insurance requirements.

 Dr. Andrew Regan, a member of Conduit's board of directors, also
sits on the board of directors of Sarborg.

 Directors
and Officers

 Certain
of the individuals that serve as members of our board of directors since completion of the Business Combination have relationships with
MURF, Old Conduit, and/or one of their respective stockholders. Dr. Freda Lewis-Hall, the Chairperson of our board of directors, was
an indirect shareholder of Conduit and indirectly received 2,003 shares of our Common Stock upon completion of the Business Combination.
Dr. David Tapolczay, our Chief Executive Officer and a member of our board of directors, was a shareholder of Old Conduit and received
2,003 shares of our Common Stock upon completion of the Business Combination. Dr. Tapolczay is also a director of Old Conduit. Dr. Andrew
Regan, a member of our board of directors, is a director of Old Conduit and received 67 shares of our Common Stock upon completion of
the Business Combination. James Bligh, a member of our board of directors and interim chief financial officer, was an employee of Old
Conduit and currently serves as a member of its board of directors. Faith L. Charles, a member of our board of directors, is a partner
at Thompson Hine LLP, a law firm that provides legal services to us.

 On April 22, 2024, the Company issued in a private placement common stock
purchase warrants (the "April Warrants") to third parties, including certain directors, to purchase up to an aggregate of
9,077 shares of the Company's common stock, in exchange for entering into a lock-up with respect to the shares of common stock held
by such holder and for such directors, $12.50 per warrant. The April Warrants are not exercisable until one year after their date of issuance.
Each April Warrant is exercisable into one share of the Company's common stock at a price per share of $312 (as adjusted from time
to time in accordance with the terms thereof) for a two-year period after the date of exercisability. There is no established public trading
market for the April Warrants. The issuance of the April Warrants were made in reliance on the exemption from registration provided by
Section 4(a)(3) of the Securities Act, and/or Regulation D promulgated thereunder.

 Item
14. Principal Accountant Fees and Services

 The
following is a summary of fees paid or to be paid to Marcum LLP, or Marcum, for services rendered.

 Audit
Fees. Audit fees consist of fees billed for professional services rendered for the audit of our year-end financial statements and
services that are normally provided by Marcum in connection with regulatory filings. The aggregate fees billed by Marcum for professional
services rendered for the audit of our annual financial statements for the year ended December 31, 2024 totaled approximately $341,200,
and for the year ended December 31, 2023 totaled approximately $440,200.

 Audit-Related Fees. Audit-related
services consist of fees billed for assurance and related services that are reasonably related to performance of the audit or review of
our financial statements and are not reported under "Audit Fees." Audit related fees primarily include review of regulatory
documents filed with the SEC. For the year ended December 31, 2024, we paid Marcum audit-related fees totaling approximately $120,170.
For the year ended December 31, 2023, we paid Marcum audit-related fees totaling approximately $118,525.

 Tax Fees. Tax fees consists
of fees billed for tax compliance, tax planning and tax advice. We paid Marcum tax fees for the year ended December 31, 2024 totaling
approximately $83,405. We did not pay Marcum tax fees for the year ended December 31, 2023.

 All
Other Fees. We did not pay Marcum for other services for the years ended December 31, 2024 or December 31, 2023.

 Pre-Approval
Policy

 Our
audit committee was formed upon the consummation of our initial public offering. As a result, the audit committee did not pre-approve
all of the foregoing services, although any services rendered prior to the formation of our audit committee were approved by our board
of directors. Since the formation of our audit committee, and on a going-forward basis, the audit committee has and will pre-approve
all auditing services and permitted non-audit services to be performed for us by our auditors, including the fees and terms thereof (subject
to the de minimis exceptions for non-audit services described in the Exchange Act which are approved by the audit committee prior
to the completion of the audit).

 PART
IV

 Item
15. Exhibits, Financial Statement Schedules

 The
following documents are filed as part of this annual report:

 1.

 Financial
 Statements: (see "Financial Statements and Supplementary Data" at Item 8 and incorporated herein by reference).

 2.

 Financial
 Statement Schedule: (Schedules to the Financial Statements have been omitted because the information required to be set forth therein
 is not applicable or is shown in the accompanying Financial Statements or notes thereto).

 3.

 Exhibits:
 The exhibits listed in the accompanying "Exhibit Index" are filed or incorporated by reference as part of this Annual
 Report on Form 10-K.

 EXHIBIT

 Exhibit
 No.

 Description

 2.1

 Agreement
 and Plan of Merger Agreement dated as of November 8, 2022, by and among Murphy Canyon Acquisition Corp., Conduit Merger Sub, Inc.
 and Conduit Pharmaceuticals Limited (filed as Annex A-1 to the Registrant's Proxy Statement/Prospectus filed on August 11,
 2023, and incorporated herein by reference).

 2.2

 Amendment
 to Agreement and Plan of Merger dated as of January 27, 2023, by and among Murphy Canyon Acquisition Corp., Conduit Merger Sub, Inc.
 and Conduit Pharmaceuticals Limited (filed as Annex A-2 to the Registrant's Proxy Statement/Prospectus filed on August 11,
 2023, and incorporated herein by reference).

 2.3

 Second
 Amendment to Agreement and Plan of Merger dated as of May 11, 2023, by and among Murphy Canyon Acquisition Corp., Conduit Merger
 Sub, Inc. and Conduit Pharmaceuticals Limited (filed as Annex A-3 to the Registrant's Proxy Statement/Prospectus filed on August
 11, 2023, and incorporated herein by reference).

 3.1

 Second
 Amended and Restated Certificate of Incorporation of the Registrant (filed as Exhibit 3.1 to the Registrant's Current Report
 on Form 8-K filed on September 29, 2023, and incorporated herein by reference).

 3.2

 Amended
 and Restated Bylaws of the Registrant (filed as Exhibit 3.2 to the Registrant's Current Report on Form 8-K filed on September
 29, 2023, and incorporated herein by reference).

 3.3

 Amendment No.1 to the Amended and Restated Bylaws (filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on November 19, 2024, and incorporated herein by reference)

 3.4

 Certificate of Amendment filed with the Delaware Secretary of State on January 22, 2025 (filed as Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on January 23, 2025, and incorporated herein by reference).

 4.1*

 Description of Registered Securities

 4.2

 Form of Senior Secured Promissory Note (filed as Exhibit 4.1 to the Registrant's Current Report on Form 8-K filed on August 7, 2024, and incorporated herein by reference).

 4.4

 Form of Warrant (Filed as Exhibit 4.2 to the Registrant's Current Report on Form 8-K filed on November 1, 2024, and incorporated herein by reference).

 4.5

 Nirland Note (Filed as Exhibit 4.3 to the Registrant's Current Report on Form 8-K filed on November 1, 2024, and incorporated herein by reference).

 4.6

 Amendment to the Senior Secured Promissory Note and Security Agreement, dated October 31, 2024, between Nirland Limited and Conduit Pharmaceuticals Inc. (filed as Exhibit 4.4 to the Registrant's Current Report on Form 8-K filed on November 1, 2024, and incorporated herein by reference).

 4.7

 Convertible Promissory Note, dated November 25, 2024, between Conduit Pharmaceuticals Inc. and A.G.P./Alliance Global Partners (filed as Exhibit 4.1 to the Registrant's Current Report on Form 8-K filed on November 25, 2024, and incorporated herein by reference).

 4.8

 Second Amendment to the Senior Secured Promissory Note, dated November 22, 2024, between Conduit Pharmaceuticals Inc. and Nirland Limited (filed as Exhibit 4.2 to the Registrant's Current Report on Form 8-K filed on November 25, 2024, and incorporated herein by reference).

 10.1

 Letter
 Agreement, dated February 2, 2022, among Murphy Canyon Acquisition Corp., Murphy Canyon Acquisition Sponsor, LLC, and each of the
 executive officers and directors of Murphy Canyon Acquisition Corp. (filed as Exhibit 10.1 to the Registrant's Current Report
 on Form 8-K filed on February 8, 2022, and incorporated herein by reference).

 10.2

 Underwriting
 Agreement (filed as Exhibit 1.1 to the Registrant's Current Report on Form 8-K filed February 8, 2022, and incorporated herein
 by reference).

 10.3

 Promissory
 Note, dated November 4, 2021, issued to Murphy Canyon Acquisition Sponsor, LLC, by Murphy Canyon Acquisition Corp. (filed as Exhibit
 10.2 to the Registrant's Registration Statement on Form S-1 (File No. 333-262036) filed on January 6, 2022, and incorporated
 herein by reference).

 10.4

 Investment
 Management Trust Agreement, dated February 2, 2022, between Murphy Canyon Acquisition Corp. and Wilmington Trust Company (filed as
 Exhibit 10.2 to the Registrant's Current Report on Form 8-K filed on February 2, 2022, and incorporated herein by reference).

 10.5

 Registration
 Rights Agreement, dated February 2, 2022, among Murphy Canyon Acquisition Corp. and certain securityholders (filed as Exhibit 10.3
 to the Registrant's Current Report on Form 8-K filed on February 2, 2022, and incorporated herein by reference)

 10.6

 Securities
 Subscription Agreement, dated November 4, 2021, between Murphy Canyon Acquisition Corp. and Murphy Canyon Acquisition Sponsor, LLC
 (filed as Exhibit 10.5 to the Registrant's Registration Statement on Form S-1 (File No. 333-262036) filed on January 6, 2022,
 and incorporated herein by reference).

 10.7

 Placement
 Unit Purchase Agreement, dated February 2, 2022, between Murphy Canyon Acquisition Corp. and Murphy Canyon Acquisition Sponsor, LLC
 (filed as Exhibit 10.4 to the Registrant's Current Report on Form 8-K filed on February 8, 2022, and incorporated herein by
 reference).

 10.8

 Form
 of Conduit Pharmaceuticals Inc. Indemnity Agreement (filed as Exhibit 10.9 to the Registrant's Current Report on Form 8-K filed
 on September 29, 2023, and incorporated herein by reference).

 10.9

 Administrative
 Support Agreement, dated February 2, 2022, by and between Murphy Canyon Acquisition Corp. and Murphy Canyon Management Group, Inc.
 (filed as Exhibit 10.6 to the Registrant's Current Report on Form 8-K filed on February 8, 2022, and incorporated herein by
 reference).

 10.10

 Form
 of Lock-Up Agreement (filed as Exhibit 10.2 to the Registrant's Current Report on Form 8-K filed on November 14, 2022, and
 incorporated herein by reference).

 10.11

 Sponsor
 Support Agreement, dated as of November 8, 2022, by and among Murphy Canyon Acquisition Corp. and each of the Persons set forth on
 Schedule I attached thereto (filed as Exhibit 10.3 to the Registrant's Current Report on Form 8-K filed on November 14, 2022,
 and incorporated herein by reference).

 10.12

 Shareholder
 Support Agreement dated as of November 8, 2022, by and among Murphy Canyon Acquisition Corp., Conduit Pharmaceuticals Limited and
 each of the Persons set forth on Schedule I attached thereto (filed as Exhibit 10.4 to the Registrant's Current Report on Form
 8-K filed November 14, 2022, and incorporated herein by reference).

 10.13

 Form
 of Amended and Restated Warrant (filed as Exhibit 4.1 to the Registrant's Current Report on Form 8-K filed on January 30, 2023,
 and incorporated herein by reference).

 10.14

 Form
 of Note, issued March 7, 2023, by and between Murphy Canyon Acquisition Corp. and Murphy Canyon Acquisition Sponsor, LLC (filed as
 Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed March 7, 2023, and incorporated herein by reference).

 10.15

 Form
 of Subscription Agreement between Murphy Canyon Acquisition Corp. and the investor named therein (filed as Exhibit 10.1 to the Registrant's
 Current Report on Form 8-K filed on September 13, 2023, and incorporated herein by reference).

 10.16

 Form
 of PIPE Warrant (filed as Exhibit 4.1 to the Registrant's Current Report on Form 8-K filed on September 13, 2023, and incorporated
 herein by reference).

 10.17#

 Pharmaceuticals Inc. 2023 Stock Incentive Plan (filed as Annex C to the Registrant's Proxy Statement/Prospectus filed on August
 11, 2023, and incorporated herein by reference).

 10.18#

 Form
 of Stock Option Agreement under Conduit Pharmaceuticals Inc. 2023 Stock Incentive Plan (filed as Exhibit 10.17 to the Registrant's
 Registration Statement on Form S-4 (File No. 333-271903) filed on May 12, 2023, and incorporated herein by reference).

 10.19#

 Form
 of Employment Agreement with David Tapolczay (filed as Exhibit 10.17 to the Registrant's Amendment No. 2 to Registration Statement
 on Form S-4 (File No. 333-271903) filed on July 28, 2023, and incorporated herein by reference).

 10.22+

 Project Funding Agreement For Use In Renal Transplant between St George Street Capital Limited and Conduit Pharmaceuticals Limited,
 dated November 2, 2022 (filed as Exhibit 10.21 to the Registrant's Registration Statement on Form S-4 (File No. 333-271903)
 filed on May 12, 2023, and incorporated herein by reference).

 10.23+

 Project Funding Agreement For Use In Preterm Labor between St George Street Capital Limited and Conduit Pharmaceuticals Limited,
 dated November 2, 2022 (filed as Exhibit 10.22 to the Registrant's Registration Statement on Form S-4 (File No. 333-271903)
 filed on May 12, 2023, and incorporated herein by reference).

 10.24+

 Project Funding Agreement For Use In Hashimoto's Thyroiditis between St George Street Capital Limited and Conduit Pharmaceuticals
 Limited, dated November 2, 2022 (filed as Exhibit 10.23 to the Registrant's Registration Statement on Form S-4 (File No. 333-271903)
 filed on May 12, 2023, and incorporated herein by reference).

 10.25+

 Project Funding Agreement For Use In Uveitis between St George Street Capital Limited and Conduit Pharmaceuticals Limited, dated
 November 2, 2022 (filed as Exhibit 10.24 to the Registrant's Registration Statement on Form S-4 (File No. 333-271903) filed
 on May 12, 2023, and incorporated herein by reference).

 10.26+

 Project Funding Agreement between St George Street Capital Limited and Conduit Pharmaceuticals Limited, dated November 2, 2022 (filed
 as Exhibit 10.25 to the Registrant's Registration Statement on Form S-4 (File No. 333-271903) filed on May 12, 2023, and incorporated
 herein by reference).

 10.27#

 Consulting
 Agreement between with Jack Heilbron and Murphy Canyon Acquisition Corp. (filed as Exhibit 10.24 to the Registrant's Amendment
 No. 1 to Registration Statement on Form S-4 (File No. 333-271903) filed on July 11, 2023, and incorporated herein by reference).

 10.28#

 Form
 of Non-Employee Director Compensation Program (filed as Exhibit 10.26 to the Registrant's Amendment No. 2 to Registration Statement
 on Form S-4 (File No. 333-271903) filed on July 28, 2023, and incorporated herein by reference).

 10.29

 Separation Agreement, dated May 12, 2024, between Mr. Sragovicz and Conduit Pharmaceuticals Inc. (filed as Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q filed on May 14, 2024, and incorporated herein by reference).

 10.30

 Security Agreement, dated August 6, 2024, between Nirland Limited and Conduit Pharmaceuticals Inc. (filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on August 7, 2024, and incorporated herein by reference).

 10.31

 Convertible Promissory Note between Conduit Pharmaceuticals Limited and Vrezh and Sharon Lee Isayan, dated March 20, 2023 (filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on October 15, 2024, and incorporated herein by reference).

 10.32

 Bridge Loan Agreement, dated October 29, 2024, between A.G.P./Alliance Global Partners and Conduit Pharmaceuticals (filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on November 1, 2024, and incorporated herein by reference).

 10.33#

 Employment Agreement, dated November 15, 2024, between James Bligh, Conduit Pharmaceuticals Limited and Conduit UK Management LTD. (filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on November 19, 2024, and incorporated herein by reference).

 10.34

 Services Agreement dated December 12, 2024, between Conduit Pharmaceuticals Inc. and SARBORG Limited. (filed as Exhibit 10.1 to the Registrant's Current Report on Form 8-K filed on December 17, 2024, and incorporated herein by reference).

 19.1*

 Conduit Pharmaceuticals, Inc. Insider Trading Policy

 21.1

 Subsidiaries
 of Conduit Pharmaceuticals Limited (filed as Exhibit 21.1 to the Registrant's Amendment No. 2 to Registration Statement on
 Form S-4 (File No. 333-271903) filed on July 28, 2023, and incorporated herein by reference).

 23.1*

 Consent of Marcum LLP, independent public accounting firm of Conduit Pharmaceuticals Inc.

 24.1

 Power of Attorney (reference is made to the signature page hereto).

 31.1*

 Certification of Principal Executive Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15(d)-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

 31.2*

 Certification of Principal Financial Officer pursuant to Securities Exchange Act Rules 13a-14(a) and 15(d)-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

 32.1§

 Certification of Principal Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

 32.2§

 Certification of Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

 97.1

 Conduit Pharmaceuticals, Inc. Compensation Recovery Policy (filed as Exhibit 97.1 to the Registrant's Annual Report filed on April 16, 2024, and incorporated herein by reference).

 101.INS*

 101.CAL*

 101.SCH*

 101.DEF*

 101.LAB*

 101.PRE*

 Cover

 *
Filed herewith.

 #
Management contract or compensatory plan or arrangement.

 +
Certain portions of this Exhibit have been omitted in accordance with Item 601(b)(10) of Regulation S-K. The Registrant agrees to furnish
supplementally an unredacted copy of this Exhibit to the SEC upon its request.

 §
In accordance with Item 601(b)(32)(ii) of Regulation S-K and SEC Release Nos. 33-8238 and 34-47986, Final Rule: Management's Reports
on Internal Control Over Financial Reporting and Certification of Disclosure in Exchange Act Periodic Reports, the certifications furnished
in Exhibits 32.1 and 32.2 hereto is deemed to accompany this Annual Report on Form 10-K and will not be deemed "filed" for
purposes of Section 18 of the Exchange Act. Such certification will not be deemed to be incorporated by reference into any filing under
the Securities Act or the Exchange Act, except to the extent that the registrant specifically incorporates it by reference.

 Item
16. Form 10–K Summary

 None.

 SIGNATURES

 Pursuant
to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed
on its behalf by the undersigned, thereunto duly authorized.

 Date:
 March 28, 2025

 By:

 /s/

 Name:

 David
 Tapolczay

 Title:

 Chief
 Executive Officer

 POWER
OF ATTORNEY

 KNOW
ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints David Tapolczay and James Bligh,
and each of them, as his or her attorneys-in-fact, with the power of substitution, for him or her in any and all capacities, to sign
any amendments to this report, and to file the same, with exhibits thereto and other documents in connection therewith with the Securities
and Exchange Commission, hereby ratifying and confirming all that said attorneys-in-fact, and each of them, or his or her substitute
or substitutes may lawfully do or cause to be done by virtue hereof.

 Pursuant
to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the
registrant and in the capacities and on the dates indicated.

 Signature

 Title

 Date

 /s/

 Chief
 Executive Officer and Director

 March

 David
 Tapolczay

 (Principal
 Executive Officer)

 /s/

 Interim
 Chief Financial Officer

 March

 Jamie
 Bligh

 (Principal
 Financial Officer and Principal Accounting Officer)

 /s/
 Freda Lewis-Hall

 and Chairperson of the Board of Directors

 March

 Freda
 Lewis-Hall

 /s/

 March

 James
 Bligh

 /s/
 Faith L. Charles

 March

 Faith
 L. Charles

 /s/
 Chele Chiavacci Farley

 March

 Chele
 Chiavacci Farley

 /s/
 Simon Fry

 March

 Simon
 Fry

 /s/
 Andrew Regan

 March

 Andrew
 Regan

TO FINANCIAL STATEMENTS

 Page

 Audited
 Financial Statements of Conduit Pharmaceuticals Inc.:

 Report of Independent Registered Public Accounting Firm (PCAOB No. 688)

 Consolidated Balance Sheets as of December 31, 2024 and 2023

 Consolidated Statements of Operations and Comprehensive Income (Loss) for the years ended December 31, 2024 and 2023

 Consolidated Statements of Changes in Stockholders' Deficit for the years ended December 31, 2024 and 2023

 Consolidated Statements of Cash Flows for the years ended December 31, 2024 and 2023

 Notes to Financial Statements

 F- 1

 REPORT
OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

 To
the Shareholders and Board of Directors of

Pharmaceuticals Inc.

 Opinion
on the Financial Statements

 We
have audited the accompanying consolidated balance sheets of Conduit Pharmaceuticals Inc. (the "Company") as of December
31, 2024 and 2023, the related consolidated statements of operations and comprehensive income (loss), stockholders' deficit and
cash flows for each of the two years in the period ended December 31, 2024, and the related notes (collectively referred to as the "financial
statements"). In our opinion, the financial statements present fairly, in all material respects, the financial position of the
Company as of December 31, 2024 and 2023, and the results of its operations and its cash flows for each of the two years in the period
ended December 31, 2024, in conformity with accounting principles generally accepted in the United States of America.

 Explanatory
Paragraph – Going Concern

 The
accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As more
fully described in Note 1, the Company has a significant working capital deficiency, has incurred significant losses and needs to raise
additional funds to meet its obligations and sustain its operations. These conditions raise substantial doubt about the Company's
ability to continue as a going concern. Management's plans in regard to these matters are also described in Note 1. The consolidated
financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 Basis
for Opinion

 These
financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on the Company's
financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board
(United States) ("PCAOB") and are required to be independent with respect to the Company in accordance with the U.S. federal
securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

 We
conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain
reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company
is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits
we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion
on the effectiveness of the Company's internal control over financial reporting. Accordingly, we express no such opinion.

 Our
audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error
or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding
the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant
estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits
provide a reasonable basis for our opinion.

 /s/
 Marcum LLP

 Marcum
LLP

 We
have served as the Company's auditor since 2022.

 Morristown, NJ

 March 28, 2025

 F- 2

 CONSOLIDATED
BALANCE SHEETS

 (in
thousands, except share amounts)

2024

2023

 ASSETS

 Current assets

 Cash and cash equivalents

 $

 $
 4,228

 Prepaid expenses

 2,161

 1,505

 Total current assets

 2,715

 5,733

 Operating lease right-of-use assets. net

 -

 Property, plant and equipment, net

 -

 Prepaid expenses and other long-term assets

 1,175

 1,491

 Total assets

 $
 4,193

 $
 7,224

 LIABILITIES AND STOCKHOLDERS' DEFICIT

 Current liabilities

 Accounts payable

 $
 1,428

 $

 Accrued expenses and other current liabilities

 1,963

 Operating lease liability, current portion

 -

 Convertible promissory note payable

 Convertible promissory notes payable at fair value

 2,985

 -

 Convertible promissory notes payable at fair value – related parties

 2,871

 -

 Convertible promissory notes payable at fair value

 2,871

 -

 Notes payable

 Notes payable – related parties

 -

 Notes payable

 -

 Total current liabilities

 10,741

 1,801

 Operating lease liability, non-current portion

 -

 Derivative warrant liability

 Deferred commission payable

 -

 5,738

 Total liabilities

 10,986

 7,681

 Commitments and contingencies (see note 15)

 -

 -

 Stockholders' deficit

 Common stock, par value $ 0.0001;
 250,000,000 shares authorized at December
31, 2024 and December 31, 2023, respectively, 1,384,801
 shares and 738,295 shares issued
and outstanding at December 31, 2024 and December 31, 2023, respectively

 Preferred stock, par value $ 0.0001; 1,000,000 shares authorized at December 31, 2024 and December 31, 2023, respectively; nil shares issued and outstanding at December 31, 2024 and December 31, 2023

 -

 -

 Additional paid-in capital

 21,880

 10,424

 Accumulated deficit

 ( 29,101
)

 ( 11,299
)

 Accumulated other comprehensive income

 Total stockholders' deficit

 ( 6,793
)

 ( 457
)

 Total liabilities and stockholders' deficit

 $
 4,193

 $
 7,224

 The
accompanying notes are an integral part of these consolidated financial statements.

 F- 3

 CONSOLIDATED
STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS)

 (in
thousands, except share amounts and per share data)

 2024

 2023

 Year Ended December 31,

 2024

 2023

 Operating expenses:

 Research and development expenses

 $
 3,378

 $

 General and administrative expenses

 12,041

 5,172

 Total operating costs and expenses

 15,419

 5,262

 Operating loss

 ( 15,419
)

 ( 5,262
)

 Other income (expenses):

 Other income (expense), net

 ( 890
)

 4,923

 Interest income

 Interest expense, net

 ( 1,506
)

 ( 211
)

 Total other (expense) income, net

 ( 2,383
)

 4,727

 Net income (loss)

 $
)

 $
 ( 535
)

 Less: Change in fair value and income impact of option liabilities

 -

 ( 5,521
)

 Net income (loss) - diluted

)

 ( 6,056
)

 Basic earnings/(net loss) per share

 $
 ( 20.53
)

 $
 ( 0.79
)

 Diluted earnings/(net loss) per share

 $
 ( 20.53
)

 $
 ( 8.92
)

 Basic weighted-average common shares outstanding

 867,096

 669,739

 Diluted weighted-average common shares outstanding

 867,096

 678,939

 Comprehensive income (loss):

 Foreign currency translation adjustment

 ( 264
)

 Total comprehensive income (loss)

 $
 ( 17,799
)

 $
 ( 799
)

 The
accompanying notes are an integral part of these consolidated financial statements.

 F- 4

 CONSOLIDATED
STATEMENTS OF CHANGES IN STOCKHOLDERS' DEFICIT

 (in
thousands, except share amounts)

 capital

 income

 Common stock

 Additional
 paid-in

 Accumulated

 Accumulated
 other
 comprehensive

 Total
 stockholders'

 capital

 income

 Balance at January 1, 2023

 $
 -

 $
 -

 $
 ( 10,764
)

 $

 $
 ( 10,089
)

 Retroactive application of Merger

 646,244

 ( 6
)

 -

 -

 -

 Reclassification of additional paid-in-capital **

 -

 -

 ( 6
)

 -

 -

 Adjusted Balances, beginning of period *

 646,264

 $

 $
 -

 $
 ( 10,770
)

 $

 $
 ( 10,089
)

 Reclassification of additional paid-in-capital ***

 -

 -

 ( 6
)

 -

 -

 Issuance of Conduit Pharmaceuticals Inc. common stock to holders of Conduit Pharmaceuticals Limited convertible notes on the Closing Date (Note 2)

 3,735

 -

 3,685

 -

 -

 3,685

 Issuance of common stock upon conversion of MURF Class A & Class B common stock in connection with merger (Note 2)

 41,183

 ( 15,219
)

 -

 -

 ( 15,218
)

 Issuance of Conduit Pharmaceuticals Inc. common stock in connection with PIPE Financing (Note 2)

 20,000

 -

 19,779

 -

 -

 19,779

 Issuance of Conduit Pharmaceuticals Inc. common stock to Cizzle Biotechnology Holding PLC

 3,955

 -

 -

 -

 Issuance of Conduit Pharmaceuticals Inc. common stock to Vela Technologies PLC

 10,158

 -

 -

 -

 Issuance of Conduit Pharmaceuticals Inc. common stock to an advisor for services directly related to the Merger (Note 2)

 13,000

 -

 -

 -

 -

 -

 Reduction of excise tax liability associated with the Merger (Note2)

 -

 -

 1,141

 1,141

 Capital contribution - related party

 -

 -

 -

 -

 Stock-based compensation

 -

 -

 -

 -

 Foreign currency translation adjustment

 -

 -

 -

 ( 264
)

 ( 264
)

 Net loss

 -

 -

 -

 ( 535
)

 -

 ( 535
)

 Balance at December 31, 2023

 738,295

 $

 $
 10,424

 $
 ( 11,299
)

 $

 $
 ( 457
)

 *

 of legacy common stock have been retroactively restated to give effect to the Merger.

 **

 Reclassification
 is made as additional paid-in capital cannot be presented as a negative for either its beginning or ending balance.

 ***

 Reclassification
 is made as the impact of the retroactive application of the Merger can be shown as a reduction to additional paid-in capital during
 the period as presenting the reduction does not result in additional paid-in capital being presented as a negative for its ending
 balance.

 F- 5

 Common stock

 Additional
 paid-in

 Accumulated

 Accumulated
 other
 comprehensive

 Total
 stockholders'

 capital

 income

 Balance at January 1, 2024

 738,295

 $

 $
 10,424

 $
 ( 11,299
)

 $

 $
 ( 457
)

 Balance

 738,295

 $

 $
 10,424

 $
 ( 11,299
)

 $

 $
 ( 457
)

 Correction of immaterial error related to franchise tax expense

 -

 -

 Issuance of Common Stock for services

 19,500

 -

 -

 -

 Issuance of Common Stock upon vesting of restricted stock units

 -

 -

 -

 -

 -

 Issuance of Common Stock for note payable

 95,045

 -

 -

 Issuance of Common Stock for licensing right

 125,000

 1,567

 -

 -

 1,568

 Issuance of Common Stock under the ATM Program

 323,273

 3,218

 -

 -

 3,221

 Issuance of Common Stock in Exchange for Debt Modification

 39,193

 -

 -

 Issuance of Common Stock upon Exercise of Conversion Option

 23,000

 -

 -

 -

 Issuance of Warrants

 -

 -

 2,890

 -

 -

 2,890

 Issuance of Common Stock Upon Exercise of Warrants

 20,000

 -

 -

 -

 Stock-based compensation

 -

 1,632

 -

 -

 1,632

 Foreign currency translation adjustment

 -

 -

 -

 -

 Net loss

 -

 -

 -

)

 -

)

 Balance at December 31, 2024

 1,384,801

 $

 $
 21,880

 $
 ( 29,101
)

 $

 $
 ( 6,793
)

 Balance

 1,384,801

 $

 $
 21,880

 $
 ( 29,101
)

 $

 $
 ( 6,793
)

 The
accompanying notes are an integral part of these consolidated financial statements.

 F- 6

 CONSOLIDATED
STATEMENTS OF CASH FLOWS

 (in
thousands)

 2024

 2023

 Year Ended December 31,

 2024

 2023

 Cash flows from operating activities:

 Net loss

 $
)

 $
 ( 535
)

 Adjustments to reconcile net loss to net cash used in operating activities:

 Gain on change in fair value of Cizzle option

 -

 ( 1,280
)

 Gain on change in fair value of Vela option

 -

 ( 970
)

 Loss on issuance of Vela option

 -

 Change in reserve for related party uncollectible loan

 -

 ( 240
)

 Loss on debt extinguishment, net

 -

 Loss on related party loan forgiveness

 -

 Realized gain on short-term investments

 ( 8
)

 -

 Unrealized foreign exchange gain

 ( 39
)

 Loss (gain) on change in fair value of convertible notes payable

 ( 2,018
)

 Gain on change in FV of the warrants

 ( 221
)

 ( 81
)

 Non-cash reduction of deferred income upon exercise of option liability

 -

 ( 4,254
)

 Loss on issuance of warrants

 2,710

 -

 Non-cash lease expense

 -

 Stock-based compensation expense

 1,632

 Issuance of Common Stock for licensing right

 1,568

 -

 Non-cash interest expense

 Depreciation expense

 -

 Amortization of financed Directors and Officers insurance

 1,666

 Amortization Expense

 -

 Amortization of debt discount

 -

 Issuance of common stock for services

 -

 Changes in operating assets and liabilities:

 Prepaid expenses and other current assets

 ( 2,273
)

 ( 990
)

 Accounts payable

 1,225

 Accrued expenses and other current liabilities

 1,030

 ( 1,746
)

 Lease liability

 ( 124
)

 -

 Intangible assets

 -

 Net cash flows from operating activities

 ( 9,682
)

 ( 7,725
)

 Cash flows from investing activities:

 Issuance of loan - related party

 -

 ( 357
)

 Purchases of property and equipment

 ( 51
)

 -

 Purchases of short-term investments

 ( 490
)

 -

 Proceeds from the sale of short-term investments

 -

 Proceeds from issuance of option

 -

 Proceeds from loan repayment - related party

 -

 Net cash flows from investing activities

 ( 43
)

 Cash flows from financing activities:

 Proceeds from Merger and related PIPE Financing, net of transaction costs

 -

 8,493

 Proceeds from the issuance of notes payable – related parties

 2,626

 -

 Proceeds from the issuance of notes payable – related parties

 -

 Capital contribution - related party

 -

 Proceeds from issuance of common shares related to ATM program

 3,328

 -

 Exercise of warrants

 -

 Repayment of notes payable

 ( 776
)

 -

 Proceeds from issuance of warrants

 -

 Proceeds from issuance of convertible promissory note payable, carried at cost

 -

 2,286

 Net cash flows from financing activities

 6,067

 10,929

 Net change in cash and cash equivalents before effect of exchange rate changes

 ( 3,658
)

 3,929

 Effect of exchange rate changes on cash and cash equivalents

 ( 16
)

 Net change in cash

 ( 3,674
)

 4,228

 Cash and cash equivalents at beginning of period

 4,228

 -

 Cash and cash equivalents at end of period

 $

 $
 4,228

 Non-cash investing and financing activities

 Right of Use Asset obtained in exchange for Operating Lease Liabilities

 $

 $
 -

 Correction of immaterial error related to franchise tax expense

 $

 $
 -

 Issuance of Common Stock upon exercise of conversion option

 $

 $
 -

 Issuance of Common Stock in exchange for debt extension

 $

 $
 -

 Conversion of deferred commission payable to convertible promissory note

 $
 5,378

 $
 -

 Issuance of Conduit Pharmaceuticals Inc. common stock to Cizzle Biotechnology Holding PLC upon exercise of option

 $
 -

 $

 Issuance of Conduit Pharmaceuticals Inc. common stock to Vela Technologies PLC upon exercise of option

 $
 -

 $

 Exchange of Conduit Pharmaceuticals Limited convertible notes for shares of Conduit Pharmaceuticals Inc. common stock in connection with the Merger

 $
 -

 $
 3,685

 Deferred Underwriting Costs

 $
 -

 $
 5,738

 Prepaid expense of directors and officers insurance paid out of PIPE financings proceeds in connection with the Merger

 $
 -

 $
 2,253

 Accumulated deficit assumed to APIC as a result of the business combination

 $
 -

 $
 6,124

 Initial value of warrant liabilities issued in connection with PIPE Financing

 $
 -

 $

 Non-Cash Assets Assumed in the Merger Financing

 $
 -

 Non-Cash Liabilities Assumed in the Merger Financing

 $
 -

 Supplemental Cash Disclosures

 Cash paid for interest

 $

 The
accompanying notes are an integral part of these consolidated financial statements.

 F- 7

 NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS

 1.
 Nature of the Business, Basis of Presentation and Summary of Significant Accounting Policies

Pharmaceuticals Inc., a Delaware corporation ("Conduit" or the "Company"), is a clinical-stage specialty
biopharmaceutical company that was formed to facilitate the development and commercialization of clinical assets. The Company has
developed a unique business model that allows it to act as a conduit to bring clinical assets from pharmaceutical companies and
develop new treatments for patients. Our novel approach addresses unmet medical needs and lengthens the intellectual property for
our existing assets through cutting-edge solid-form technology with the expectation of commercializing these products with life
science companies. Our initial development plan is to conduct a Phase II clinical trial on AZD1656 in Lupus (including Lupus
Nephritis) and ANCA Vasculitis (AAV). We anticipate developing our Initial Pipeline (which has already undergone pre-clinical and
clinical trials) through the Phase II stage and then monetizing such clinical assets through a license, royalty, or other
transaction at this stage. At this time, we do not expect that we will commercialize any clinical assets or seek marketing approval
from the FDA (or similar organizations) as we intend to enter into agreements with third parties following Phase II clinical trials
for each such clinical asset that would provide that such third party would pursue the further development, commercialization, and
marketing of such assets.

 Merger
Agreement

 On
September 22, 2023 (the "Closing Date"), a merger transaction between Conduit Pharmaceuticals Limited ("Old Conduit"),
Murphy Canyon Acquisition Corp ("MURF") and Conduit Merger Sub, Inc., a Cayman Islands exempted company and a wholly owned
subsidiary of MURF ("Merger Sub"), was completed (the "Merger", see Note 2) pursuant to the initial merger agreement
dated November 8, 2022 and subsequent amendments to the merger agreement dated January 27, 2023 and May 11, 2023 (together, the "Merger
Agreement"). Pursuant to the terms of the Merger Agreement, on the Closing Date, (i) Merger Sub merged with and into Old Conduit,
with Old Conduit surviving the merger as a wholly-owned subsidiary of MURF, and (ii) MURF changed its name from Murphy Canyon Acquisition
Corp. to Conduit Pharmaceuticals Inc. The common stock of the Company (the "Common Stock") commenced trading on The Nasdaq
Global Market under the symbol "CDT" on September 25, 2023, and the Company's warrants commenced trading on The Nasdaq
Capital Market under the symbol "CDTTW" on September 25, 2023. On March 7, 2025, the Company filed an application to list our Common Stock on The Nasdaq Capital Market as part
of our plan to regain compliance with all NASDAQ rules. See Note 20 for additional details.

 The
Merger was accounted for as a reverse recapitalization in accordance with accounting principles generally accepted in the United States
of America ("U.S. GAAP"). Under the reverse recapitalization method, MURF was treated as the acquired company for financial
reporting purposes, and the accounting acquirer was assumed to have issued shares of stock for the net assets of MURF, with no goodwill
or other intangible assets recorded.

 Basis
of Presentation

 The
accompanying consolidated financial statements have been prepared by the Company in accordance with U.S. GAAP as set forth by the Financial
Accounting Standards Board ("FASB") and pursuant to the rules and regulations of the United States Securities and Exchange
Commission ("SEC"). References to U.S. GAAP issued by the FASB in these notes to the accompanying consolidated financial
statements are to the FASB Accounting Standards Codifications ("ASC") and Accounting Standards Update ("ASUs").

 Principles
of Consolidation

 The
accompanying consolidated financial statements include the accounts of Conduit Pharmaceuticals, Inc. and its wholly owned subsidiaries
Conduit UK Management Ltd. (United Kingdom) and Conduit Pharmaceuticals, Ltd. (Cayman Islands). As used herein, references to the "Company"
include references to Conduit Pharmaceuticals, Inc, and its subsidiaries. All intercompany balances and transactions have been eliminated
in consolidation.

 Liquidity
and Going Concern

 In
accordance with ASC 205-40, Going Concern, the Company has evaluated whether there are conditions and events, considered in the aggregate,
that raise substantial doubt about the Company's ability to continue as a going concern within one year after the date the financial
statements are issued. Since its inception, the Company has generated significant losses and as of December 31, 2024, the Company had
an accumulated deficit of $ 29.1 million. As of December 31, 2024 and December 31, 2023, the Company had cash and cash equivalents and
short-term investments of $ 0.6 million and $ 4.2 million, respectively. For the year ended December 31, 2024 and 2023, the Company had
net operating losses of $ 15.4 million and $ 5.3 million, respectively, and cash used in operating activities of $ 9.7 million and $ 7.7
million, respectively. Management has determined that it does not have sufficient cash and other sources of liquidity to fund its current
business plan. These factors raise substantial doubt regarding the Company's ability to continue as a going concern for at least
the next 12 months from the financial statement filing date.

 The
Company's expectation is to generate operating losses and negative operating cash flows in the future and will need additional
funding to support its current business plan in addition to the remaining at the market offering program (the "Sales
Agreement") of $ 12.0 million (See Note 20), as of the financial statement release date. Management's plans to alleviate the
conditions that raise substantial doubt through the pursuit of additional cash resources through public or private equity or debt
financings. However, there is no assurance that such funding will be available when needed or on acceptable terms. If additional
funding is not available when required, the Company would need to delay or curtail its operations and its research and development
activities until such funding is received, all of which could have a material adverse effect on the Company and its financial
condition.

 These
financial statements have been prepared assuming the Company will continue as a going concern and do not include adjustments to reflect
the possible effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result
from the outcome of this uncertainty.

 Reverse
Stock Split

 On
January 24, 2025, the Company amended its Second Amended and Restated Certificate of Incorporation with the Secretary of State of the
State of Delaware in order to effect a 1-for-100 reverse stock split of its outstanding shares of common stock (the "Reverse Stock
Split"). As a result of the reverse stock split, every 100 shares of the Company's common stock issued or outstanding were
automatically reclassified into one new share of common stock, subject to the treatment of fractional shares as described below, without
any action on the part of the holders. All historical share and per-share amounts reflected throughout the accompanying consolidated
financial statements and other financial information in this Annual Report on Form 10-K have been retroactively adjusted to reflect the
2025 Reverse Stock Split as if the split occurred as of the earliest period presented. The Reverse Stock Split did not affect the number
of authorized shares of common stock or the par value of the common stock. No fractional shares were issued in connection with the Reverse
Stock Split. Stockholders who would otherwise have been entitled to receive fractional shares as a result of the Reverse Stock Split
were entitled to a cash payment in lieu thereof at a price equal to the fraction to which the stockholder would otherwise be entitled
multiplied by the closing price per share of the common stock (as adjusted to give effect to the Reverse Stock Split) on The Nasdaq Global
Market on January 24, 2025.

 F- 8

 Other
Risks and Uncertainties

 The
Company is subject to risks common to companies in the development stage and pharmaceutical industry including, but not limited to, uncertainties
related to pre-clinical and clinical outcomes competitor products, regulatory approvals, dependence on key products, dependence on key
suppliers and protection of intellectual property rights (see note 15 for details on a claim against our AZD 1656 co-crystal patent).
Clinical assets currently under development will require significant additional research and development efforts, including extensive
preclinical and clinical testing and regulatory approval prior to commercialization. These efforts will require significant amounts of
additional capital, adequate personnel, infrastructure, and extensive compliance and reporting capabilities. Even if the Company's
efforts are successful, it is uncertain when, if ever, the Company will realize significant revenue from royalties or product sales.

 The
Company licenses clinical assets from AstraZeneca. See Note 10. If there is a breach or other termination of such agreements, there could
be a material adverse effect on the Company's business, financial condition, operating results, and prospects.

 The Company is also subject
to risks associated with the Nasdaq Stock Market Correspondence and Subsequent Nasdaq Capital Market Listing. See note 20 for further
details.

 Summary
of Significant Accounting Policies

 Cash
and Cash Equivalents

 Cash
and cash equivalents are primarily maintained with major financial institutions in the United States, United Kingdom, and Switzerland.
The Company considers cash equivalents to be short-term, highly liquid investments that (a) are readily convertible into known amounts
of cash, (b) are traded and held for cash management purposes, and (c) have original maturities of three months or less at the time of
purchase. The Switzerland bank accounts holding cash balances are uninsured, and the UK bank account, with a year-end balance of approximately
 100,000 (or approximately $ 125,000) exceeds the country's deposit limit of 85,000 (approximately $ 107,000). The Company's
US depository bank participates in the Demand Deposit Marketplace program, insuring deposits up to $ 10 million by sweeping amounts in
excess of the $ 250,000 deposit insurance limit among participating banks. The Company has not experienced any losses on any accounts
through the year ended December 31, 2024.

 The
Company had $ 0.6 million
and $ 4.2 million
in cash and cash equivalents on hand as of December 31, 2024 and December 31, 2023, respectively. As of December 31, 2024, $ 0.2
 million of the Company's $ 0.6
 million cash and cash equivalents balance was
invested in money market funds. The money market funds do not have significant liquidity restrictions that would require the exclusion
from cash and cash equivalents.

 Property,
Plant and Equipment

 Property,
plant and equipment are initially recorded at cost. Depreciation and amortization are computed using the straight-line method over the
estimated useful lives of the assets or, for leasehold improvements, the life of the lease, if shorter. When assets are retired or otherwise
disposed of, the cost and related accumulated depreciation are removed from the accounts and any resulting gain or loss is reflected
in other income or expense for the period. As of December 31, 2024, property, plant and equipment primarily consisted of leasehold improvements.

 Leases

 In
accordance with ASC 842, Leases (ASC 842), the Company records a right-of-use (ROU) asset and a lease liability on the balance sheet
for all leases with terms longer than 12 months and classifies them as either operating or finance leases.

 At
the inception of an arrangement, the Company determines whether the arrangement is or contains a lease based on the unique facts and
circumstances present and the classification of the lease including whether the contract involves the use of a distinct identified asset,
whether the Company obtains the right to substantially all the economic benefit from the use of the asset, and whether the Company has
the right to direct the use of the asset. Leases with a term greater than one year are recognized on the balance sheet as ROU assets,
lease liabilities and, if applicable, long-term lease liabilities. The Company has elected not to recognize on the balance sheet leases
with terms of one year or less under practical expedient in paragraph ASC 842-20-25-2. For contracts with lease and non-lease components,
the Company has elected not to allocate the contract consideration, and to account for the lease and non-lease components as a single
lease component.

 Lease
liabilities and their corresponding ROU assets are recorded based on the present value of lease payments over the expected lease term.
The implicit rate within our operating leases is generally not determinable and, therefore, the Company uses the incremental borrowing
rate at the lease commencement date to determine the present value of lease payments. The determination of the Company's incremental
borrowing rate requires judgment. The Company determines the incremental borrowing rate for each lease using our estimated borrowing
rate, adjusted for various factors including level of collateralization, term and currency to align with the terms of the lease. The
operating lease ROU asset also includes any lease prepayments, offset by lease incentives.

 An
option to extend the lease is considered in connection with determining the ROU asset and lease liability when it is reasonably certain
we will exercise that option. An option to terminate is considered unless it is reasonably certain we will not exercise the option.

 F- 9

 Use
of Estimates

 The
preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the
reported amounts of assets and liabilities and related disclosures of contingent assets and liabilities at the date of the financial
statements as well as the reported amounts of revenues and expenses during the reporting period. Estimates are based on several factors
including the facts and circumstances available at the time the estimates are made, historical experience, risk of loss, general economic
conditions and trends, and the assessment of the probable future outcome. Actual results could differ materially from such estimates.
Estimates and assumptions are reviewed periodically by management and changes in estimates are made as management becomes aware of changes
in circumstances surrounding the estimates. The effects of changes are reflected in the financial statements in the period that they
are determined.

 Fair
Value Measurements

 ASC
Topic 820, Fair Value Measurements and Disclosures, defines fair value, establishes a framework for measuring fair value, and
expands disclosures about fair value measurements. Fair value is to be determined based on the exchange price that would be received
for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability
in an orderly transaction between market participants. In determining fair value, the Company used various valuation approaches. A fair
value hierarchy has been established for inputs used in measuring fair value that maximizes the use of observable inputs and minimizes
the use of unobservable inputs by requiring that the most observable inputs be used when available. Observable inputs are those that
market participants would use in pricing the asset or liability based on market data obtained from sources independent of the Company.

 Unobservable
inputs reflect the Company's assumption about the inputs that market participants would use in pricing the asset or liability developed
based on the best information available in the circumstances. The fair value hierarchy is categorized into three levels, based on the
inputs, as follows:

 Level
 1—Valuations based on quoted prices for identical instruments in active markets. Since valuations are based on quoted prices
 that are readily and regularly available in an active market, valuation of these instruments does not entail a significant degree
 of judgment.

 Level
 2— Valuations based on observable inputs other than quoted prices included in Level 1, such as quoted prices for either similar
 instruments in active markets, identical or similar instruments in markets that are not active, or model-derived valuations whose
 inputs or significant value drivers are observable or can be corroborated by observable market data.

 Level
 3—Valuations based on inputs that are unobservable. These valuations require significant judgment.

 The
Company's Level 1 assets consist of cash and cash equivalents, including money market funds, in the accompanying balance sheets
and the value of accrued expenses and other current liabilities approximate fair value due to the short-term nature of these assets and
liabilities.

 As
of December 31, 2024, the Company has two financial liabilities, warrant liabilities for which the fair value is determined based on
Level 2 and Level 3 inputs, and convertible debt carried at fair value for which the fair value is
determined based on Level 3 input. The Level 2 inputs are valued based on observable inputs other than quoted
prices included in Level 1, such as quoted prices for similar instruments in active markets. The level 3 inputs as such inputs are based
on unobservable inputs and require significant judgement. As of December 31 2023, the Company has one financial liability, a warrant liability for which the fair value is determined
based on Level 2 inputs as such inputs are valued based on observable inputs other than quoted prices included in Level 1, such as
quoted prices for similar instruments in active markets. See Note 3 for further information on the Company's
financial liabilities carried at fair value.

 F- 10

 Fair
Value Option

 The
Company has elected the fair value measurement option for convertible debt with embedded derivatives that would otherwise require bifurcation
and has recorded the entire hybrid financial instrument at fair value under the guidance in ASC 825, Financial Instruments. As a result,
the August 2024 Nirland Note was recorded at fair value subsequent to the Second Amendment and the A.G.P. Convertible Note was recorded
at fair value upon issuance. The notes will subsequently be remeasured at fair value each reporting date until settled or converted.
The Company reports interest expense, including accrued interest, related to the convertible debt under the fair value option, separately
from within the change in fair value of the convertible debt in the accompanying consolidated statement of operations and comprehensive
income (loss). Any changes in fair value caused by instrument-specific credit risk are presented separately in other comprehensive income.
During the year ended December 31, 2024, the Company did not record any changes in fair value related to instrument-specific credit risk.

and Development

and development expenses consist primarily of costs incurred in connection with the research and development of our clinical assets
and programs, see Note 10 for further discussion of research and development expense. Conduit holds all licenses to conduct clinical
research through a third-party pharmaceutical company. The Company expenses research and development costs and intangible assets
acquired that have no alternative future use as incurred. These expenses include:

 expenses
 incurred under agreements with organizations that support the Company's drug discovery and development activities;

 expenses
 incurred in connection with the preclinical and clinical development of the Company's clinical assets and programs, including
 under agreements with contract research organizations, or CROs

 costs
 related to contract manufacturing organizations, or CMOs, that are primarily engaged to provide drug substance and product for our
 clinical trials, research and development programs, as well as investigative sites and consultants that conduct the Company's
 clinical trials, nonclinical studies and other scientific development services

 the
 costs of acquiring and manufacturing nonclinical and clinical trial materials, including manufacturing registration and validation
 batches

 employee-related
 expenses, including salaries, related benefits and equity-based compensation expense, for employees engaged in research and development
 functions

 acquisition costs related to the purchase of licensed intellectual property;

 costs
 related to compliance with quality and regulatory requirements

 payments
 made under third-party licensing agreements and

 direct
 and allocated costs related to facilities, information technology, personnel and other overhead.

 Advance
payments that we make for goods or services to be received in the future for use in research and development activities are recorded
as prepaid expenses. Such amounts are recognized as an expense as the goods are delivered or consumed or the related services are performed,
or until it is no longer expected that the goods will be delivered, or the services rendered.

and Administrative Expenses

and administrative expenses consist primarily of salaries and related costs for personnel in executive management, finance, corporate
and business development, and administrative functions. General and administrative expenses also include legal fees relating to patent
and corporate matters professional fees for accounting, auditing, tax, and administrative consulting services insurance costs
administrative travel expenses and other operating costs.

 Income
Taxes

 ASC
Topic 740, Income Taxes, sets forth standards for financial presentation and disclosure of income tax liabilities and expense.
Interest and penalties recognized have been classified in the consolidated statements of operations and comprehensive income (loss) as
income taxes. Deferred tax assets and liabilities are recognized for future tax consequences attributable to temporary differences between
the financial statement carrying amount of existing assets and liabilities and their respective tax bases and operating losses carried
forward. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in
which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change
in tax rates is recognized in the consolidated statements of operations and comprehensive income (loss) in the period that includes the
enactment date. The measurement of deferred tax assets is reduced, if necessary, by a valuation allowance for any tax benefits of which
future realization is uncertain.

 F- 11

 Earnings/(Net
Loss) per Share

 The
Company calculates basic and diluted earnings/(net loss) per share under ASC Topic 260, Earnings Per Share. Basic earnings/(net
loss) per share is computed by dividing the net income/(loss) by the number of weighted-average common shares outstanding for the period.
Diluted earnings/(net loss) is computed by adjusting net income/(loss) based on the impact of any dilutive instruments. Diluted earnings/(net
loss) per share is computed by dividing the diluted net income/(loss) by the number of weighted-average common shares outstanding for
the period including the effect, if dilutive, of any instruments that can be settled in common shares. When computing diluted net income/(loss)
per share, the numerator is adjusted to eliminate the effects that have been recorded in net income/(loss) (net of tax, if any) attributable
to any liability-classified dilutive instruments.

 Warrants

 The
Company determines the accounting classification of Warrants as either liability or equity by first assessing whether the Warrants meet
liability classification in accordance with ASC 480, Distinguishing Liabilities from Equity ("ASC 480"). Under ASC 480, a
financial instrument that embodies an unconditional obligation, or a financial instrument other than an outstanding share that embodies
a conditional obligation, that the issuer must or may settle by issuing a variable number of its equity shares must be classified as
a liability (or an asset in some circumstances) if, at inception, the monetary value of the obligation is based solely or predominantly
on any one of the following: (a) a fixed monetary amount known at inception; (b) variations in something other than the fair value of
the issuer's equity shares; or (c) variations inversely related to changes in the fair value of the issuer's equity shares.

 If
financial instruments, such as the Warrants, are not required to be classified as liabilities under ASC 480, the Company assesses whether
such instruments are indexed to the Company's own stock under ASC 815-40. In order for an instrument to be considered indexed to
an entity's own stock, its settlement amount must always equal the difference between the following: (a) the fair value of a fixed
number of the Company's equity shares, and (b) a fixed monetary amount or a fixed amount of a debt instrument issued by the Company.
The Company determined that the settlement amount of the Equity Classified Warrants would equal the difference between the fair value
of a fixed number of shares and a fixed monetary amount (or a fixed amount of a debt instrument) and must be classified as equity, while
the settlement amount of the Liability Classified Warrants would not equal the difference between the fair value of a fixed number of
shares and a fixed monetary amount (or a fixed amount of a debt instrument) and must be classified as a liability.

 The
Equity Classified Warrants are recorded in stockholders' deficit and the Liability Classified Warrants are recorded as liabilities
in the Consolidated Balance Sheet. The Liability Classified Warrants are remeasured each period with changes in fair value recorded in
the Consolidated Statements of Operations and Comprehensive Income (Loss).

Currency Translation

 The
Company translated the assets and liabilities of foreign subsidiaries from their respective functional currency, the British pound, to
United States dollars at the appropriate spot rates as of the balance sheet date. Income and expenses of operations are translated to
United States dollars using weighted average exchange rates during the year. The foreign subsidiaries use the local currency as their
functional currency. The effects of foreign currency translation adjustments are included as a component of accumulated other comprehensive
income in the accompanying consolidated statements of changes in stockholders' deficit. Non-monetary items in the subsidiaries'
functional currency are re-measured into the reporting currency at the historical exchange rate (i.e., the rate of exchange at the date
of the transaction).

 F- 12

 Emerging
Growth Company Status

 The
Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the "JOBS Act"). Under
the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of
the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period
for complying with new or revised accounting standards that have different effective dates for public and private companies until the
earlier of the date that: (i) is no longer an emerging growth company or (ii) affirmatively and irrevocably opts out of the extended
transition period provided in the JOBS Act. As a result, these financial statements may not be comparable to companies that comply with
the new or revised accounting pronouncements as of public company effective dates.

the Merger, the Company will remain an emerging growth company, as defined by the Jumpstart Our Business Startups act of 2012, until
the earliest of (i) the last day of the combined entity's first fiscal year following the fifth anniversary of the completion of
MURF's initial public offering (the "MURF IPO"), (ii) the last day of the fiscal year in which the combined entity
has total annual gross revenue of at least $1.235 billion, (iii) the last day of the fiscal year in which the combined entity is deemed
to be a large accelerated filer, which means the market value of the combined entity's common stock that is held by non-affiliates
exceeds $700.0 million as of the prior December 31st or (iv) the date on which the combined entity has issued more than $1.0 billion
in non-convertible debt securities during the prior three year period.

 Recently
Adopted Accounting Pronouncements

 In
November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) ("ASU 2023-07"), which enhances the segment disclosure
requirements for public entities on an annual and interim basis. Under this proposal, public entities are required to disclose significant
segment expenses that are regularly provided to the chief operating decision maker (the "CODM") and included within each
reported measure of segment profit or loss. Additionally, current annual disclosures about a reportable segment's profit or loss
and assets will be required on an interim basis. Entities are also required to disclose information about the CODM's title and
position at the Company along with an explanation of how the CODM uses the reported measures of segment profit or loss in their assessment
of segment performance and deciding whether how to allocate resources. Finally, ASU 2023-07 requires all segment disclosures for public
entities, even those with a single reportable segment. The amendments are effective for fiscal years beginning after December 15, 2023,
and interim periods within fiscal years beginning after December 15, 2024, and should be applied on a retrospective basis to all periods
presented. As of December 31, 2024, the Company only has one reportable segment. The Company adopted this accounting standard as of January
1, 2024. See Note 19 for the Company's segments disclosures.

 F- 13

 Recently
Issued Accounting Standards Not Yet Adopted

 In
December 2023, the FASB issued ASU 2023-09, Income Taxes (Topic 740): Improvements to Income Tax Disclosures ("ASU 2023-09").
ASU 2023-09 modifies the reporting requirements for income tax disclosures related to effective tax rates and cash income taxes paid.
Pursuant to ASU 2023-09, public business entities are required to disclose certain categories in the income tax rate reconciliation,
as well as additional information for reconciling items that meet a specific quantitative threshold. Additionally, ASU 2023-09 requires
annual disclosures of income taxes paid for all entities, including the amount of income taxes paid, net of refunds received, disaggregated
by federal, state, and foreign jurisdictions. The standard is effective for fiscal years beginning after December 15, 2024, with early
adoption permitted. The Company is currently evaluating the impact of ASU 2023-09 on its consolidated financial statements.

 In
November 2024, the FASB issued ASU 2024-03, Income Statement-Reporting Comprehensive Income-Expense Disaggregation Disclosures (Subtopic
220-40): Disaggregation of Income Statement Expenses, which is intended to provide more detailed information about specified categories
of expenses (purchases of inventory, employee compensation, depreciation and amortization) included in certain expense captions presented
on the consolidated statements of operations and comprehensive income (loss). The guidance in this ASU is effective for fiscal years
beginning after December 15, 2026, and interim periods within fiscal years beginning after December 15, 2027. Early adoption is permitted.
The amendments may be applied either (1) prospectively to financial statements issued for periods after the effective date of this ASU
or (2) retrospectively to all prior periods presented in the consolidated financial statements. The Company is currently evaluating the
impact that the adoption of ASU 2024-03 will have on its consolidated financial statements and disclosures.

 2.
 Merger and Financing

 As
discussed in Note 1 – Nature of the Business, Basis of Presentation and Summary of Significant Accounting Policies, on September
22, 2023, the Company and MURF completed the Merger. Upon the closing of the Merger, the following occurred:

 Each
 share of Old Conduit common stock issued and outstanding immediately prior to the closing of the Merger, which totaled 2,000 shares,
 was exchanged for the right to receive 323 shares of the Company's Common Stock ("Common Stock") resulting
 in the issuance of 646,264 shares of Conduit Pharmaceuticals, Inc. Common Stock.

 In
 addition to the shares issued to legacy Conduit shareholders noted above, an additional 3,735 shares of Common Stock was issued
 to Conduit convertible note holders, resulting in a total of 650,000 shares of Common Stock being issued to Conduit shareholders
 and holders of Conduit convertible notes payable.

 In
 connection with the Merger, 450 shares of MURF Class A common stock held by the MURF Sponsor was transferred to MURF Directors. Each
 share was exchanged on a one-for-one basis for shares of Common Stock.

 Each
 share of MURF Class A common stock held by the MURF Sponsor prior to the closing of the Merger, which totaled 7,090 shares, was exchanged
 for, on a one-for-one basis for shares of Common Stock.

 Each
 share of MURF common stock subject to possible redemption that was not redeemed prior to the closing of the Merger, which totaled
 580 shares, was exchanged for, on a one-for-one basis for shares of Common Stock.

 In
 connection with the Merger, 33,062 shares of MURF Class B common stock held by the Sponsor was automatically converted into shares
 of MURF Class A common stock and then subsequently converted into shares of Common Stock on a one-for-one basis.

 F- 14

 In
 connection with the Merger, A.G.P./Alliance Global Partners ("A.G.P."), whom acted as a financial advisor to both MURF
 and Conduit, was due to receive (i) a cash fee of $ 6.5 million, 13,000 shares of Common Stock and warrants to purchase 540 shares
 of Common Stock at an exercise price of $ 1,100 per share pursuant to its engagement agreement with Conduit entered into on August
 2, 2022 and (ii) $ 4.6 million of deferred underwriting fees as a result of its engagement for MURF's initial public offering.
 Upon closing of the Merger, A.G.P. received a cash payment of $ 5.6 million, 13,000 shares of Common Stock, and 540 warrants to purchase
 540 shares of Common Stock. The remaining $ 5.7 million of cash payments due to A.G.P upon closing of the Merger was deferred and
 to be paid on or before March 21, 2025, with annual interest of 5.5 %. The remaining cash payments due, which were directly attributable
 to the Merger, were accounted for as a liability with an offset to additional paid-in capital in accordance with SAB Topic 5.A on
 the Company's consolidated balance sheet. See Note 7 for discussion of amendment of the note that took place during the year ended December 31, 2024.

 In
 connection with the Merger, MURF entered into subscription agreements (the "Subscription Agreements") with certain accredited
 investors (the "PIPE Investors") for an aggregate of 20,000 units, with each unit consisting of one share of Company
 common stock (the "PIPE Shares"), together with one warrant exercisable into one share of Company common stock (the "PIPE
 Warrants"), at a purchase price of $ 1,000 per unit, for an aggregate purchase price of $ 20,000,000 (the "PIPE Financing").
 Upon the closing of the PIPE Financing (which closed in connection with the closing of the Merger), the Company received $ 20.0 million
 in cash from the PIPE Financing, which was used to settle related party promissory notes issued by MURF to the MURF Sponsor and an
 affiliate of the MURF Sponsor as well as transaction costs.

 The
 proceeds received by the Company from the Merger and PIPE Financing, net of transaction costs, and other payments for existing liabilities
 and prepayments, totaled $8.5 million.

 The
 Merger was accounted for as a reverse recapitalization in accordance with U.S. GAAP. Under this method of accounting, MURF was treated
 as the acquired company for financial reporting purposes (see Note 1 for further details). Accordingly, for accounting purposes,
 the Merger was treated as the equivalent of the Company issuing shares for the net assets of MURF, accompanied by a recapitalization.
 The net assets of MURF were stated at historical cost with no goodwill or other intangible assets recorded.

 The
following table presents the total Common Stock outstanding immediately after the closing of the Merger:

of Common Stock Outstanding

 Number of

 Exchange of MURF common stock subject to possible redemption for Conduit Pharmaceuticals Inc. common stock

 Exchange of MURF Class A common stock held by MURF Directors for Conduit Pharmaceuticals Inc. common stock

 Exchange of MURF Class A common stock held by MURF Sponsor for Conduit Pharmaceuticals Inc. common stock

 40,152

 Subtotal - Merger, net of redemptions

 41,182

 Issuance of Conduit Pharmaceuticals Inc. common stock in connection with PIPE Financing

 20,000

 Exchange of Conduit Pharmaceuticals Limited ordinary shares for Conduit Pharmaceuticals Inc. common stock on the Closing Date

 646,264

 Issuance of Conduit Pharmaceuticals Inc. common stock to holders of Conduit Pharmaceuticals Limited convertible notes on the Closing Date

 3,735

 Issuance of Conduit Pharmaceuticals Inc. common stock to an advisor for services directly related to the Merger

 13,000

 Total - Conduit Pharmaceuticals Inc. common stock outstanding as a result of the Merger, PIPE Financing, exchange of Conduit Pharmaceuticals Limited shares for shares of Conduit Pharmaceuticals Inc., issuance of Conduit Pharmaceuticals Inc. common stock to holders of Conduit Pharmaceuticals Limited convertible notes, and advisors.

 724,181

 F- 15

 3.
 Fair Value

the period ended December 31, 2024, there were no transfers between Level 1 and Level 2, nor into or out of Level 3. The following
table presents as of December 31, 2024 the Company's assets and liabilities subject to measurement at fair value on a
recurring basis (in thousands):

of Assets Subject to Measurement at Fair Value on Recurring Basis

 Fair Value Measurements as of December 31, 2024

 Level 1

 Level 2

 Level 3

 Total

 Assets:

 Cash equivalents

 $

 $
 -

 $
 -

 $

 Total Assets

 $

 $
 -

 $
 -

 $

 Liabilities:

 Convertible notes payable at fair value

 $
 -

 $
 -

 $
 5,856

 $
 5,856

 Liability Classified Warrants

 -

 Total Liabilities

 $
 -

 $
 -

 $
 5,994

 $
 5,994

 The
following table presents as of December 31, 2023 the Company's liabilities subject to measurement at fair value on a recurring
basis (in thousands):

 Fair Value Measurements as of December 31, 2023

 Level 1

 Level 2

 Level 3

 Total

 Liabilities:

 Liability Classified Warrants

 $
 -

 $

 $
 -

 $

 Total Liabilities

 $
 -

 $

 $
 -

 $

 Cash
equivalents consist of highly liquid money market funds with maturities of three months or less and are reflected in the Consolidated
Balance Sheets at carrying value, which approximates fair value due to their short-term nature.

 The
following table presents additional information about the Convertible Notes Payable subject to measurement at fair value on a recurring
basis and warrant liabilities, for which the Company used significant unobservable inputs (Level 3) (in thousands):

of Additional Information About the Financial Liabilities Subject To Measurement at Fair Value

 Convertible Notes
 Payable

 Liability Classified Warrants

 Balance as of December 31, 2023

 $
 -

 $
 -

 Fair value at Issuance

 7,899

 Conversion of convertible note

 ( 92
)

 -

 Change in fair value

 ( 1,951
)

 ( 91
)

 Balance as of December 31, 2024

 $
 5,856

 $

 Convertible
Notes Payable

 As
discussed in Note 7, during on October 31, 2024, the Company and Nirland agreed to amend the August 2024 Nirland Note, whereby the
August 2024 Nirland Note was amended to provide for the conversion of the August 2024 Nirland Note into shares of common stock, at
Nirland's discretion, in a multiple of any unpaid amounts, if not otherwise previously paid, pursuant to the conversion rate
contained therein. The August 2024 Nirland Note was then amended for a second time on November
22, 2024.Additionally, as discussed in Note 7, during November 2024, the Company issued to A.G.P. a convertible promissory
note (the "A.G.P. Convertible Note") in the principal amount of $ 5.7
million to evidence the A.G.P.'s currently owed deferred commission payable. The Company elected to account for the August
2024 Nirland Note and A.G.P. Convertible Note (collectively the "Convertible Notes Payable") at fair value. The fair
value of the Convertible Notes Payable is estimated each period using a binomial lattice model. Significant estimates in the
binomial lattice model include the Company's stock price, volatility, risk-free rate, corporate bond yield, credit
spread, probability of default, and recovery upon default.

 The
fair value of the August 2024 Nirland Note and A.G.P. Convertible Note as of December 31, 2024 were estimated using a binomial
lattice model.

 The following
table outlines the range of significant unobservable inputs used in calculating the fair value of the August 2024 Nirland Note as of
the dates noted below:

of Fair Value of Assumptions

 October 31,

 2024

 November 22,

 2024

 2024

 Stock Price

 $

 9.10

 $

 10.40

 $
 6.90

 Term (years)

 0.8

 0.7

 0.6

 Corporate bond yield

 9.1

 %

 8.7

 %

 11.4
 %

 Credit Spread

 15.9

 %

 15.9

 %

 15.9
 %

 Probability of default

 %

 %

 %

 Recovery upon default

 %

 %

 %

 Volatility

 103.2

 %

 96.5

 %

 123.7
 %

 The
following table outlines the range of significant unobservable inputs used in calculating the fair value of the A.G.P. Convertible
Note as of the dates noted below:

of Fair Value of Assumptions

 November 25,

 2024

 2024

 Stock Price

 $

 9.10

 $
 6.90

 Term (years)

 0.9

 Corporate bond yield

 8.8

 %

 9.0
 %

 Credit Spread

 26.2

 %

 26.2
 %

 Probability of Default

 %

 %

 Recovery upon default

 %

 %

 Volatility

 108.7

 %

 101.6
 %

 F- 16

 Liability
Classified Warrants

 The
PIPE Warrants, A.G.P. Warrants, and A.G.P. 2024 Warrants, as defined in Note 18, are accounted for as liabilities in accordance with ASC 815-40 and are presented
within Warrant liabilities in the consolidated balance sheets. Warrant liabilities are measured at fair value at inception and on a recurring
basis, with changes in fair value presented within other income (expense), net in the consolidated statements of operations and comprehensive
income (loss).

 The
measurement of the PIPE Warrants and the measurement of the A.G.P warrants are classified as Level 2 fair value measurements due to the
use of an observable market quote for the Company's publicly traded warrants, which are considered to be a similar asset in an
active market.

 The
PIPE Warrant and A.G.P. Warrant liabilities are calculated by multiplying the quoted market price of the Company's publicly traded
warrants by the number of liability classified warrants.

 On
December 11, 2024, the Company amended the exercise price of the PIPE Warrants to be $ 8.83,
at which time all PIPE Warrants were exercised. As the exercise price was amended on the same date that the PIPE Warrants were
exercised, the Company remeasured the warrant liability immediately before exercise based on the difference between the closing
stock price of the Company's common stock on December 11, 2024, and the amendment exercise price of the PIPE Warrants,
resulting in a gain on the change in fair value of warrant liability of approximately $ 12
thousand. Refer to Note 18 for additional information. Upon exercise of the PIPE Warrants, less than $ 1
thousand of Level 2 liability classified warrants remain on the consolidated balance sheet as of December 31, 2024.

 The
measurement of the A.G.P. 2024 Warrants is classified as Level 3 due to the use of an option-pricing model that utilizes unobservable inputs and requires significant judgement. The Company estimated
the fair value of the warrants issued as the issuance date, October 29, 2024, and as of December 31, 2024, using a Black-Scholes
option-pricing model utilizing the following assumptions:

of Fair Value of Assumptions

 October 29, 2024

 December 31, 2024

 Closing stock price

 $

 10.48

 $
 6.90

 Contractual exercise price

 $

 $
 10.00

 Risk-free rate

 4.11

 %

 4.38
 %

 Estimated volatility

 98.4

 %

 98.6
 %

 Time period to expiration (in years)

 5.2

 5.0

 4.
 Balance Sheet Details – Current Assets

 Current
assets consisted of the following as of December 31, 2024 and December 31, 2023 (in thousands):

of Balance Sheet Details

 As of

 As of

 December 31, 2024

 December 31, 2023

 Prepaid directors' and officers' insurance

 $
 1,187

 $
 1,365

 Prepaid expenses

 Prepaid expenses – related parties

 -

 Other receivables

 -

 Total prepaid expenses and other current assets

 $
 2,161

 $
 1,505

 F- 17

 5.
 Leases

the year ended December 31, 2024, we entered into an operating lease for laboratory space. The remaining lease terms for our operating
lease is approximately two years and does not provide a renewal option. We apply the short-term lease policy election, which allows us
to exclude from recognition leases with an original term of 12 months or less.

 Upon
commencement of the laboratory lease on March 7, 2024, the Company recorded a right-of-use asset of $ 0.4 million, short-term lease liability
of $ 0.2 million, and long-term lease liability of $ 0.2 million.

 Lease
costs associated the Company's operating and short-term leases are recorded within general and administrative expense in the consolidated
statement of operations and comprehensive income (loss). The following table sets forth information about our lease costs for the year
ended December 31, 2024 (in thousands):

of Lease Cost

 Lease Cost

2024

 Operating lease cost

 $

 Short-term lease cost

 Variable lease cost

 Total lease cost

 $

 The
following table sets forth information about our operating lease for the year ended December 31, 2024 (in thousands):

of Operating Lease Liabilities

 Supplemental cash flow and other information

2024

 Cash paid for amounts included in the measurement of lease liabilities:

 Operating cash flows from operating leases

 $

 ROU assets obtained in the exchange for lease liabilities

 $

 Weighted-average remaining lease term (in years)

 2.0

 Weighted-average discount rate

 11.2
 %

 The
Company's future minimum lease payments for our operating lease as of the year ended December 31, 2024, are as follows (in thousands):

of Future Minimum Lease Payments For Operating Lease

2024

 Year ending December 31,

 2025

 $

 2026

 Total

 Less: imputed interest

 ( 27
)

 Total lease liability

 $

 6.
 Liability Related to the Sale of Future Revenue

 Vela
Technologies PLC

 The
Company entered into an Agreement with SGSC to approve an Indirect Investment from Vela Technologies PLC ("Vela") on October
20, 2020, whereby Vela agreed to provide funding to the Company for an indirect investment in AZD 1656 for use in the field in exchange
for 8 % of future revenue earned if AZD 1656 is commercialized (the "Vela Agreement"). Total consideration under the Vela
Agreement was $ 2.9 million ( 2.35 million), consisting of $ 1.6 million ( 1.25 million) cash and the issuance of 1.1 billion
common shares in Vela, which based on the Vela's fair value per share and was $ 1.3 million. During the year ended December 31,
2021, the Company sold all 1.1 billion of its Vela shares for $ 1.2 million and recorded a loss of $ 0.1 million on the sale. The Company
received the $ 1.6 million ( 1.25) million cash consideration during the year ended December 31, 2020. This consideration was recorded
as a liability related to the future sale of revenue on the balance sheet in accordance with ASC 470-10.

 In
April 2023, the Company entered into an agreement with Vela which granted Vela the right, but not the obligation, to sell its 8 % royalty
interest in AZD 1656 back to Conduit. Vela paid a one-time, non-refundable option fee to Conduit of $ 0.5 million ( 0.4 million).
Total consideration payable to Vela upon exercise of the option was 4.0 million ($ 5.08 million on the exercise date) worth of
new common shares in the combined entity after the Merger between Conduit Pharmaceuticals Limited and MURF, following the consummation
of the Merger, at a price per share equal to the volume-weighted average price per share over the ten (10) business days prior to the
date of the notice of exercise. The option contained a provision stating that in no event would the price per share for the consideration
shares be lower than $ 5 or higher than $ 15. The option was exercisable in whole at any time from the close of the Merger (the "Effective
Time") until the earlier of (i) the date that was six (6) months from the Effective Time, and (ii) February 7, 2024, the expiration
date of the term.

 On
November 30, 2023, Vela exercised its option to sell back its indirect investment in AZD 1656 in exchange for 10,157 shares of the Common
Stock. The Company recognized the $ 2.8 million of deferred revenue and recorded $ 2.8 million to other income (expense), net, on the consolidated
statement of operations and comprehensive income (loss) for the year ended December 31, 2023. As of December 31, 2023, there was no liability
for the sale of future revenue related to Vela.

 F- 18

 Cizzle
Biotechnology Holdings PLC

 On
February 11, 2022, the Company entered into an agreement with Cizzle PLC ("Cizzle") whereby Cizzle agreed to purchase a percentage
of future revenue earned in AZD 1656, should it reach the commercialization stage. Total consideration under the agreement is specified
as $ 1.6 million ( 1.2 million), consisting of the issuance of the fair value of 25.0 million new common shares in Cizzle on the
date of the agreement and the fair value of 22.0 million shares to be issued at the earlier of Cizzle's shareholder approval or
one year from the date of the agreement. The 22.0 million shares were received by the Company in the fourth quarter of 2022 and were
subsequently sold within the fourth quarter of 2022. The Company recorded a liability related to deferred revenue of $ 1.4 million for
the consideration received from Cizzle as of December 31, 2022.

 The
payments received for the sale of future revenue were classified as a liability related to the future sale of revenue. Under ASC 470-10-25,
a seller of future revenue should evaluate whether the proceeds received should be accounted for as debt or deferred income. In assessing
the factors that created a rebuttable presumption of debt within the guidance, the Company determined that there were factors present
to overcome the debt presumption and deferred income classification to be appropriate. The main factors the Company considered were that
the transactions in form were sales, and not debt transactions. Each agreement does not guarantee a return to each purchaser, the return
is based solely on future performance of AZD 1656 should it reach commercialization, with neither purchaser having an involvement in
generating future cash flows from AZD 1656.

 On
December 15, 2022, the Company entered into an agreement with Cizzle whereby the Company granted Cizzle the option, but not the obligation,
to sell its economic interest in AZD 1656 back to the Company. The agreement contained an option period of nine months from the date
of the agreement for Cizzle to notify the Company of its intent to exercise the option to sell its economic interest in AZD 1656. Upon
closing of the agreement, Cizzle agreed to pay the Company an option fee of $ 0.1 million ( 0.1 million).

 On
September 26, 2023, Cizzle exercised its option to sell back its indirect investment in AZD 1656 in exchange for 3,954
 shares of the Common Stock. The Company recognized
the $ 1.5
 million of deferred revenue and recorded $ 1.5
 million to other income (expense), net, on the
consolidated statements of operations and comprehensive income (loss) for the year ended December 31, 2023. As of December 31, 2023,
there was no liability for the sale of future revenue related to Cizzle.

 F- 19

 7.
 Convertible Notes Payable

 Convertible
Promissory Notes Payable

March 2023, the Company issued a convertible promissory note payable (the "Convertible Promissory Notes Payable") with an
aggregate principal amount of $ 0.8
 million to a non-related third party. The
Convertible Promissory Note Payable had a maturity date of 18 months from the date of issuance. The
note carries interest at a rate of 20 %
annually, which is payable every six (6) months from the date of the note until the maturity date.

 On
October 9, 2024, the Company and the loan holder signed an extension to extend the maturity date from September 20, 2024 to October
20, 2024 with the option for the Company to further extend the maturity date two times, each by an additional 30-day period. The
Company exercised both options to extend the maturity date to December 19, 2024 which included interest previously payable as well as the principal. As consideration for extending the maturity date,
the Company amended the form of repayment of the remaining interest due on the loan. As payment for the interest, the Company issued
the loan holder, (i) $ 80,000 worth
of Common Stock to be issued at the closing market price on the date prior to issuance and (ii) 20,000 shares
of Common Stock. On October 11, 2024, the Company issued the loan holder 27,812 shares
of Common Stock in satisfaction of the obligations in (i) and (ii) in the preceding sentence.

 The
extension met the criteria for as a debt extinguishment under ASC 470-50. As of October 9, 2024, the Company recorded a gain on debt extinguishment
of $ 0.1
million, calculated as the difference between (i) the $ 0.8 million
carrying value of the Convertible Promissory Note Payable immediately prior to the amendment (ii) the $ 0.4
million fair value of the Convertible Promissory Note Payable immediately after the amendment and (iii) the $ 0.3
million fair value of the shares issued to the holder as consideration for extending the maturity date. The difference between the
$ 0.8 million
carrying value immediately prior to the amendment and the $ 0.4
million fair value immediately after the amendment was recorded as a debt discount and amortized over the amended maturity date of
the Convertible Promissory Note using the effective interest method.

 In
connection with the extension of the loan, the Company entered into a consulting agreement with an unrelated third party to negotiate
the extension of the of the convertible note with the loan holder on behalf of the Company. The Company issued the third-party 8,500 shares
on October 11, 2024, in exchange for services provided. The fair value of the shares were $ 0.1 million, as determined
by multiplying the closing share price on October 10, 2024 (day prior to issuance) of $ 10.24 by the total number of shares issued, 8,500.
This amount was capitalized as a debt issuance cost and accreted over the amended term of the Convertible Promissory Notes Payable
using the effective interest method.

 For
the year ended December 31, 2024, and December 31, 2023, the Company incurred interest expense on the Convertible Promissory Note
Payable of $ 0.5
million and $ 0.1
million, respectively. The promissory note payable remained outstanding as of December 31, 2024, therefore the Company was
considered to be in default. On March 6, 2025, the Company reached an agreement with the loan holder to pay $ 0.7
million in order to settle the March 2023 Convertible Note in full. The Company repaid the loan holder the settlement amount $ 0.7
million on March 13, 2025. See Note 20 for additional details.

 August

 On
August 6, 2024, the Company entered into a Senior Secured Promissory Note (the "August 2024 Nirland Note") with Nirland,
a related party of the Company, pursuant to which the Company issued and sold to Nirland the August 2024 Note in the original principal
amount of $ 2.7 million, inclusive of a $ 0.5 million original issuance discount. See Note 16 for further reference to the relationship
between the Company and Nirland. Of the total amount of the August 2024 Nirland Note, $ 1.7 million was issued upon execution of
the August 2024 Nirland Note. In connection with the August 2024 Nirland Note, the Company issued to Nirland 125,000 shares
of the Company's Common Stock on August 6, 2024. The balance of $ 0.5 million became payable to the Company when the shares
were registered for resale in September 2024. In the event the Company completes any public or private equity or debt financing, the
Company shall be required to mandatorily prepay ("Mandatory Prepayment Right"), any amounts that may be then outstanding
under the August 2024 Nirland Note, within two business days following the closing of such financing, in an amount of no less than 75 %
of the net proceeds received. Per the terms of the August 2024 Nirland Note, the Company is prohibited from entering into a variable
rate transaction without prior written consent from Nirland. The August 2024 Nirland Note bears interest at a rate of 12 % per annum,
accruing daily on a 365-day basis, payable monthly in arrears as cash, or accrued at Nirland's discretion. The August 2024
Nirland Note matures 12 months from August 6, 2024.

 As noted above, the Company issued to Nirland 125,000 shares
of the Company's Common Stock on August 6, 2024. The Company determined that loan agreement and share issuance should were part
of a basket transaction and allocated the net proceeds on a relative fair value basis. Of the total $ 2.2 net proceeds, $ 1.2 million
was allocated to the August 2024 Nirland Note including $ 1.5 million gross proceeds, less $ 0.3 million Original Issue Discount
("OID"). The remaining $ 1.0 million was allocated to the common stock, including $ 1.2 million gross proceeds less
$ 0.2 OID. The $ 1.2 million allocated to the common stock was considered to be a discount on the August 2024 Nirland Note making
the balance of the note to be $ 2.7 million note payable, less a total debt discount of $ 1.5 million. The debt discount will
be amortized to interest expense using the effective interest method over the life of the note.

 On
October 31, 2024, the Company and Nirland amended the August 2024 Nirland Note (the "First Amendment"), whereby the August
2024 Nirland Note was amended to (i) provides for the conversion of the August 2024 Nirland Note into shares of Common Stock, at Nirland's
discretion, in a multiple of any unpaid amounts, if not otherwise previously paid, pursuant to the conversion rate contained therein,
(ii) removes Nirland's Mandatory Prepayment Right, and (iii) removes Nirland's right of first refusal to participate in any
future equity or debt offerings of the Company. The number of shares of Common Stock issuable upon conversion of any Conversion Amount
pursuant to shall be determined by dividing (x) such conversion amount by (y) the conversion price. Conversion amount means two
and one quarter times the sum of (x) portion of the principal to be converted, redeemed or otherwise with respect to which this determination
is being made and (y) all accrued and unpaid interest with respect to such portion of the principal amount, if any. Conversion price
means, as of any conversion date or other date of determination, $ 10.00, subject to adjustment as provided within the amended agreement.

 We
evaluated the conversion feature of this note offering for embedded derivatives in accordance with ASC 815, Derivatives
and Hedging, and the substantial premium model in accordance with ASC 470, Debt. Based on our assessment,
separate accounting for the conversion feature of this note offering is not required and will be accounted for under the substantial
premium model. Under the substantial premium model, the excess above the fair value of the August 2024 Nirland Note will be recorded
in additional paid-in-capital. The August 2024 Nirland Note will be carried at amortized cost using the effective interest method.

 F- 20

 The
Company determined the fair value of the August 2024 Nirland Note to be $ 3.6 million as of October 31, 2024 through the use of a binomial
lattice model. See Note 3 for additional information regarding the fair value measurement of the August 2024 Nirland Note. The Company
accounted for the First Amendment as a debt extinguishment, as the First Amendment added a substantive conversion option. As of October
31, 2024, a loss on debt extinguishment of $ 2.2 million was recorded consisting of (i) the derecognition of the $ 1.3 million carrying
value immediately prior to the First Amendment (ii) recognition of the $ 2.7 million par value and (iii) recognition of the $ 0.8 million
substantial premium.

 On
November 22, 2024, the Company and Nirland entered into a Second Amendment to the August 2024 Nirland Note (the "Second
Amendment"). Pursuant to the Second Amendment, the Nirland Note may not be converted (other than partial conversions that may
be permitted pursuant to the rules and regulations of NASDAQ (or any successor entity)) prior to receipt of stockholder approval to
provide for such conversion of the Nirland Note, and subsequent issuance of the Company's Common Stock, pursuant to the
stockholder approval rules under the rules and regulations of The Nasdaq Stock Market. If the Company has not held a special meeting
of the stockholders to approve the full conversion of the August 2024 Nirland Note on or before January 9, 2025, then the Company
shall be obligated to pay Nirland a penalty of $ 0.1
million per day until the special meeting is held. In addition, the existing conversion rate was amended to be two and one half
times the sum of (x) the portion of the principal to be converted, redeemed or otherwise with respect to which this determination is
being made and (y) all accrued and unpaid interest (including default interest) with respect to such portion of the principal
amount, if any divided by $ 0.10, prior to the Reverse Stock Split, (or following any reverse splits that may occur in a ratio greater than 10 to 1, the lower of
such reverse split price and the market price per share at the time of the Conversion Date, but in no event less than $1.00),
subject to adjustment as provided therein and to take into account any future share splits or reverse splits to maintain the
economic equivalence of the conversion rights as at the amendment effective date. The Company notes that the reverse split provision
in the preceding sentence was tripped, effective January 25, 2025, following the 1-for-100
reverse stock split that occurred on that date.

 As
of the Second Amendment, the Company elected to account for the August 2024 Nirland Note at fair value under ASC 825. The Company determined that the amendment to the conversion features present in the Second Amendment fall under the
guidance within ASC 825 that notes that if a significant modification of debt occurs an entity is able to make an accounting election
on that date to account for that debt under the fair value option. At the end of each
reporting period, the Company calculates the fair value of the August 2024 Nirland Note, and any changes in fair value are reported in
the current period's consolidated statements of operations and comprehensive income (loss).

 The
Company remeasured the fair value of the August 2024 Nirland Note as of the Second Amendment date and calculated a fair value of $ 4.5
million using a binomial lattice model. See Note 3 for additional information regarding the fair value measurement of the August 2024
Nirland Note. The Company accounted for the Second Amendment as a debt extinguishment, as the terms of the August 2024 Nirland Note were
deemed to be substantially different after the Second Amendment. As of November 22, 2024, a loss on debt extinguishment of $ 0.9 million
was recorded consisting of (i) the derecognition of the 2.7 million carrying value immediately prior to the First Amendment (ii) derecognition
of $ 0.1 million in accrued interest (iii) derecognition of the $ 0.8 million substantial premium and (iv) recognition of the $ 4.4 million
fair value.

 On
December 9, 2024, and prior to obtaining shareholder approval, Nirland exercised their conversion option and converted $ 0.1 million of
principal for 23,000 shares of common stock pursuant to the rules and regulations of the NASDAQ. As of December 31, 2024, $ 2.6 million
of principal and accrued interest remains outstanding. As of December 31, 2024, the August 2024 Nirland Note had a fair value of approximately $ 2.8 million and is included
within Convertible promissory notes payable at fair value –
related parties on the consolidated balance sheets.

 For
the year ended December 31, 2024, the Company recorded a $ 1.5 million
gain from the change in fair value of convertible promissory note and interest expense of approximately $ 0.4
million. The interest expense of $ 0.4 million is comprised of (i) accrued interest of $ 0.2 million and (ii) $ 0.2 million in
amortization expense related to the initial debt discount of $ 1.5 million. The $ 2.2
million loss on debt extinguishment from the Frist Amendment, $ 0.9
million loss on debt extinguishment from the Second Amendment, and the $ 1.5
million gain on the change in fair value are presented within other income (expense), net, while the $ 0.4
million of interest expense is presented within Interest expense, net, in the consolidated statement of operations and comprehensive
income (loss).

 A.G.P.
Convertible Note

 On
November 25, 2024, the Company issued to A.G.P. a convertible promissory note (the "A.G.P. Convertible Note") in the principal
amount of $ 5.7 million to evidence the A.G.P.'s currently owed deferred commission payable. Refer to the Note 9 for additional
information. Unless earlier converted as specified in the Convertible Note, the principal amount, plus all accrued but unpaid interest,
is due on November 25, 2025 (the "Maturity Date"). The convertible promissory note accrues interest at 5.5 % per annum.

 F- 21

 At
any time prior to the full payment of the convertible promissory note, provided that the A.G.P. has given at least three business
days written notice to the Company, A.G.P., in its sole discretion, may elect to have all or any portion of the outstanding
principal amount and all interest accrued converted into shares of the Company's common stock, at a fixed price of $ 10.00
(or following any reverse splits that may occur in a ratio greater than 10 to 1, the lower of such reverse split price and the
market price per share at the time of the conversion date, but in no event less than $ 1.00),
subject to adjustment as provided therein and to take into account any future share splits or reverse splits. The
Company notes that the reverse split provision in the preceding sentence was tripped, effective January 25, 2025, following the 1-for-100 reverse stock split
that occurred on that date. However, the conversion of the convertible promissory note may not occur prior to the
Company having sufficiently authorized shares of common stock to permit the entire conversion of the convertible promissory note. In
addition, the conversion of the convertible promissory note may also not occur prior to receipt of stockholder approval to provide
for such conversion of the convertible promissory note, and subsequent issuance of the Company's common stock, pursuant to the
stockholder approval rules under the rules and regulations of The Nasdaq Stock Market. Further, following the A.G.P.'s ability
to convert the convertible promissory note, if at all, A.G.P. will not be entitled to receive the Company's common stock upon
conversion, if such conversion would result in A.G.P. owning greater than 9.99 %
of the Company's then currently outstanding common stock. A.G.P. is also entitled to resale registration rights as identified
in the convertible promissory note.

 The
Company may prepay the convertible promissory note in whole or in part. In the event of certain Events of Default (as defined in the
convertible promissory note), all outstanding principal and accrued interest under the Convertible Note will become, or may become at
A.G.P.'s election, immediately due and payable to the A.G.P.

 The
Company elected to account for the A.G.P. Convertible Note at fair value under ASC 825. The Company determined that the substantive
conversion option within the A.G.P. Convertible Note falls under the guidance within ASC 825 that notes that if a significant
modification of debt occurs an entity is able to make an accounting election on that date to account for that debt under the fair
value option. At the end of each reporting period, the Company calculates the fair value of the A.G.P. Convertible Note, and any
changes in fair value are reported in the current period's consolidated statements of operations and comprehensive income
(loss). The change in fair value attributable to instrument-specific credit risk, if any, will be recognize within other
comprehensive income each reporting period. As an accounting policy, the Company elected to present interest expense separately from
other changes in the A.G.P. Convertible Note's fair value. Interest expense will be presented within Interest expense, net,
while the other changes in the fair value with be presented within other income (expense), net in the consolidated statements of
operations and comprehensive income (loss).

 The
Company determined the fair value of the A.G.P. Convertible Note to be $ 3.4 million as of November 25, 2024 through the use of a binomial
lattice model. See Note 3 for additional information regarding the fair value measurement of the A.G.P Convertible Promissory Note. The
Company accounted for the issuance on the A.G.P. Convertible Promissory Note as a debt extinguishment, as it was issued to evidence the
A.G.P.'s currently owed deferred commission payable discussed in Note 9. A gain on debt extinguishment of $ 2.4 million was recorded
as of November 25, 2024, consisting of (i) the derecognition of the $ 5.7 million deferred commission payable and (ii) recognition of
the $ 3.4 million fair value of the A.G.P. Convertible Note. For the year ended December 31, 2024, the Company recorded a $ 0.5 million
gain in the change in fair value of the A.G.P. Convertible Note and interest expense of approximately $ 32 thousand. The $ 2.4 million
gain on extinguishment and $ 0.5 million gain on the change in fair value are presented within other income (expense), net, while the
$ 32 thousand of interest expense is presented within Interest expense, net, in the consolidated statement of operations and comprehensive
income (loss).

 8.
 Loans Payable

 Loans

 On
May 1, 2022, the Company entered into Loan Agreements (the "Loans") with two lenders, totaling $ 0.2 million. The Loans
mature two years from the date of the agreement and bear no interest. Each loan was made available to the Company by the lenders in
three tranches of (i) $ 33 thousand ( 30 thousand); (ii) $ 33 thousand ( 30 thousand) and (iii) $ 28 thousand ( 25
thousand), totaling $ 0.2 million. The Loans provided for events of default, including, among others, failure to make payment,
bankruptcy and non-compliance with the terms of the Loans. As of December 31, 2024, the Company utilized all three tranches of the
first loan and two out of three tranches of the second loan, with loans payable totaling $ 0.2 million at December 31, 2023 and
December 31, 2024 respectively.

 F- 22

 On
October 9, 2024, the Company and the Loans holders amended the loan agreements (the "Loans Amendment") to extend the maturity
date for the Loans to December 19, 2024. The Loans Amendment also modified the payment terms for the Loans from a cash payment of
 85,000 per loan to (1) a cash payment of 60,000, (2) 25,000 worth of shares of Common Stock converted
into USD at the prevailing exchange rate, to be issued at the closing market price on the date prior to issuance, and in consideration
for the extension, and (3) 2,500 additional shares of Common stock. On October 11, 2024, the Company issued each of the Loan
holders 5,690 shares ( 11,380 in total). The Loans remain outstanding as of December 31, 2024.

 The
extension was accounted for as a debt extinguishment. On October 9, 2024, the Company recorded a loss on debt extinguishment of approximately
$ 42 thousand calculated as the difference between (i) the $ 0.2 million carrying value of the Loans immediately prior to the Loans Amendment
(ii) the $ 0.1 million fair value of the Loans immediately after the Loans Amendment and (iii) the $ 0.1 million fair value of the shares
issued to the holder as consideration for extending the maturity date. The difference between the $ 0.2 million carrying value immediately
prior to the Loans Amendment and the $ 0.1 million fair value immediately after the Loans Amendment was recorded as a debt discount and
amortized over the term date of the Loans using the effective interest method.

the year ended December 31, 2024, the Company incurred interest expense on the Loans of approximately $ 40
 thousand related to the amortization of the debt
discount recorded as a result of the Loans Amendment. No
 interest expense was recorded for the year ended
December 31, 2023. The Loans remained outstanding as of December 31, 2024, therefore the Company was considered to be in default. The
Company repaid the lenders the outstanding principal balance of $ 0.1
 million in February 2025. See Note 20 for additional
details.

 F- 23

 October

 On
October 28, 2024, the Company issued a promissory note (the "October 2024 Nirland Note") to Nirland, a related party, in
the original principal amount of $ 0.6
million in exchange for funds in such amount. See Note 16 for further reference to the relationship between the Company and Nirland.
The Nirland Note bears interest at a rate of 12 %
per annum, is due and payable semi-annually in arrears, and matures on October 31, 2025. If an event of default under and as defined
in the Nirland Note occurs, the interest rate will be increased to 18 %
per annum or to the maximum rate permitted by law. In connection with the Nirland Note, the Company has agreed to pay Nirland a 1 %
arrangement fee, which will be included with the principal and interest owed under the Nirland Note. The 1 %
arrangement fee is accounted for as a debt discount and will be amortized to interest expense, net in the consolidated statement of
operations and comprehensive income (loss) using the effective interest method over the life of the October 2024 Nirland
Note.

the year ended December 31, 2024, the Company recorded approximately $ 14,000 of interest expense. The interest expense of $ 14,000 is comprised of (i) accrued interest of $ 13,000 based on the coupon rate of the debt and (ii) amortization of the debt discount of $ 1 thousand,
with both components recorded within interest expense, net in the consolidated statement of operations and comprehensive income
(loss). Accrued interest of $ 13,000 was recorded as a liability on the Company's consolidated balance sheet within accrued expenses and other current liabilities.
The $ 1,000 amortization of the debt discount decreased the debt discount contra-liability included within the Loans payable, current portion on
the consolidated balance sheets.

 A.G.P.
Bridge Note

 On
October 29, 2024, the Company entered into a Bridge Loan Agreement (the "Bridge Agreement"), with A.G.P., pursuant to which
AGP. made an advance (the "Advance") to the Company in an amount not to exceed $ 0.6 million (the "Commitment").
As partial consideration for the Advance, the Company entered into a Common Stock Purchase Warrant Agreement (the "Warrant Agreement")
and issued AGP warrants to purchase up to 28,625 shares of the Company's common stock, $ 0.0001 par value per share, which is equal
to 50 % of the sum of the Commitment divided by the closing price of the Company's Common Stock on October 29, 2024, at an exercise
price of $ 10.48 per share. Refer to Note 18 for additional information on the warrants issued to A.G.P.

 In
connection with the Advance, the Company issued a promissory note (the "A.G.P. Bridge Note") to A.G.P. in the original principal
amount of $ 0.6 million. The Bridge Note bears interest at a rate of 4.21 % per annum and is due and payable on December 31, 2024.

 As
noted above, the Company issued to A.G.P. warrants to purchase up to 28,625
shares of the Company's common stock. The Company determined that the Bridge Note and Warrant Agreement issuance were part of
a basket transaction and allocated the net proceeds using the residual value method. The warrants issued under the Warrant Agreement
were initially recorded at their fair value of $ 0.2
million. The warrants were classified as derivative liabilities because they do not meet the criteria in ASC 815-40 to be considered
indexed to the entity's own stock. Refer to Note 18 for additional information and discussion of liability classification. The $ 0.2 million
recorded for the warrants was considered to be a discount on the A.G.P. Bridge Note making the balance of the note to be $ 0.6 million
note payable, less a total debt discount of $ 0.2 million.
The debt discount will be amortized to interest expense using the effective interest method over the life of the note.

the year ended December 31, 2024, the Company recorded and paid approximately $ 1 thousand of interest expense related to the A.G.P. Additionally,
the entire debt discount of $ 0.2 million was amortized and recorded as interest expense during the year. The interest expense of $ 1 thousand
and amortization of the debt discount of $ 0.2 million were recorded within Interest expense, net in the consolidated statement of operations
and comprehensive income (loss). As of December 31, 2024, the A.G.P. Bridge note was fully repaid.

 F- 24

 9.
 Deferred Commission Payable

 As
discussed in Note 2, A.G.P was a financial advisor to both MURF and Old Conduit in connection with the Merger transaction. Upon the completion
of the Merger, A.G.P.: (i) received a cash fee of $ 6.5 million, 13,000 shares of Common Stock, and warrants to purchase 540 shares of
Common Stock at an exercise price of $ 1,100 per share pursuant to its engagement agreement with Old Conduit entered into on August 2,
2022, and (ii) agreed to defer payment, to be paid in the future under certain circumstances by a date no later than March 21, 2025,
of $ 5.7 million of fees plus annual interest of 5.5 % as a result of its engagement for MURF's IPO. The $ 5.7 million deferred commissions
payable was recorded as a non-current liability on the Company's consolidated balance sheet as of December 31, 2023. Accrued interest
was recorded as a liability on the Company's consolidated balance sheet under accrued expenses and other current liabilities and
totaled $ 0.4 million and $ 0.1 million as of December 31, 2024, and December 31, 2023, respectively.

 On
November 25, 2024, the Company issued the A.G.P. Convertible Note in the principal amount of $ 5.7 million to evidence the currently owed
deferred commission payable, at which time the deferred commission payable balance was removed. Refer to the Note 7 for additional information.

 10.
 Research and Development Expense

 August
2024 License Agreement

 On August 7, 2024, the Company and AstraZeneca AB (PUBL) ("AstraZeneca") entered into a License Agreement, dated August 7,
2024 (the "August 2024 License Agreement"). Pursuant to the August 2024 License Agreement, AstraZeneca agreed to grant a
license to the Company under certain intellectual property rights controlled by AstraZeneca related to HK-4 Glucokinase activators AZD1656
and AZD5658 in all indications and myeloperoxidase inhibitor AZD5904 for the treatment, prevention, and prophylaxis of idiopathic male
infertility. The Company will be responsible for the development and commercialization of the Licensed Products under the August
2024 License Agreement.

 As
consideration for the grant of the license, the Company (i) granted AstraZeneca Common Stock pursuant to a stock issuance agreement
(the "Issuance Agreement"), (ii) paid AstraZeneca an up-front payment of $ 1.5 million,
and (iii) is obligated to pay AstraZeneca a percentage (on a tiered basis) of any amounts it may receive in connection with a grant
of a sublicense (subject to various customary exceptions). The Issuance Agreement called for the Company to issue AstraZeneca 95,044
shares of the Company's Common Stock. The Issuance Agreement provides AstraZeneca with resale registration rights for such
shares. As of December 31, 2024, the Company recorded $ 1.6 million
and $ 1.5 million
in research and development expenses related to the share issuance and upfront payment to AstraZeneca, respectively.

 AstraZeneca
has been granted a right of first negotiation to develop, manufacture, and commercialize a Licensed Product if the Company receives an
offer for, or solicits, a transaction where a third party would obtain the right to develop, manufacture, or commercialize a Licensed
Product. If AstraZeneca exercises such right, the parties will negotiate in good faith for an agreed period of time on an exclusive basis.

 Either
party may terminate the August 2024 License Agreement for material breach (subject to a cure period) or insolvency of the other party.
The Company may terminate the August 2024 License Agreement for convenience (in its entirety or on a Licensed Product-by-Licensed Product
basis). In addition, AstraZeneca may terminate the August 2024 License Agreement in certain circumstances, including (but not limited
to) the Company ceasing development of all Licensed Products (subject to certain exceptions for normal pauses or gaps between clinical
studies).

 As
a result of the above, the Company will no longer fund the development of AZD1656 or AZD5904 under the terms of the Exclusive Funding
Agreement, dated March 26, 2021 with St George Street Capital (the "Funding Agreement"). In this regard, the Company previously
entered into a deed of amendment amending such Funding Agreement. The parties agreed that the project funding provisions of such Funding
Agreement whereby the Company had the right to fund a project or refer other parties to St George Street Capital, were amended to provide
that St George Street Capital must still include the Company in any project funding opportunities and requests but may now seek other
third-parties to fund projects in addition to the Company. In November and December 2024, the Company received a letter from St George Street Capital and formal complaints
filed with the Intellectual Property Office claiming the Company was not the sole owner of the AZD 1656 co-crystal patent. See note 15
for additional details on the claim.

 SARBORG
Service Agreement

 On
December 12, 2024, the Company entered into a Services Agreement (the "Sarborg Service Agreement") with SARBORG Limited
("Sarborg"), a Cayman Islands company and related party of the Company. See Note 16 for further reference to the
relationship between the Company and Sarborg. Under the terms of the Sarborg Service Agreement, Sarborg will provide algorithmic and
cybernetic technology services to Conduit, including the development of decision-support tools and advanced cybernetic systems
tailored to enhance Conduit's decision-making processes and maximize the value of its pharmaceutical asset
portfolio.

 F- 25

will perform the services to Conduit comprised of three phases: the Initial Phase (0-24 weeks) focuses on establishing a foundation for
collaboration and aligning Sarborg's services with Conduit's strategic goals; the Development Phase (24-36 weeks) involves
building technological infrastructure, including dashboards and predictive models; and the Ongoing Services Phase (36-52 weeks) ensures
the sustained functionality and relevance of Sarborg's deliverables while supporting Conduit's growth through iterative improvements
and updates. Sarborg will create specific deliverables, including reports, computer programs, software applications, APIs, mobile applications,
source code, written technical specifications and designs, operating and maintenance manuals, and other recorded data and information
arising from or relating to the services. Sarborg will provide all necessary resources to perform the services and deliver the deliverables
in accordance with the Sarborg Service Agreement.

 The
Sarborg Service Agreement has an initial term of 12 months, which commenced on the effective date, and may be renewed or extended
upon mutual written agreement of the parties. Either party may terminate the Sarborg Service Agreement for any reason upon 90
days' written notice or immediately upon written notice if the other party breaches any material term of the Sarborg Service
Agreement and fails to cure such breach within thirty days or becomes insolvent, files for bankruptcy, or is placed under the
control of a receiver, trustee, or similar authority.

 The
Sarborg Service Agreement includes provisions for the ownership and use of intellectual property. Sarborg will own its pre-existing
intellectual property rights, including proprietary tools and methodologies used in the performance of the services. Conduit will
own all deliverables resulting from the services performed by Sarborg under the Sarborg Service Agreement.

 The Sarborg Service Agreement provides Sarborg with registration rights
for any Common Stock of Conduit that Sarborg receives as consideration under the Sarborg Service Agreement. In such event, Conduit will
use commercially reasonable efforts to (i) file a registration statement covering the resale of the Common Stock within 60 days after
the issuance; and (ii) ensure that such registration statement becomes effective within 90 days after filing. This Agreement also includes
confidentiality obligations, representations and warranties, indemnification, limitation of liability, and insurance requirements.

 In
consideration of the services, Conduit agreed to pay Sarborg an initial cash payment of $ 0.2
million and $ 0.2
million payable through the issuance of 22,727
shares of common stock, determined by the closing price on the day preceding the execution of the Sarborg Service Agreement.
Further milestone payments payable in conjunction with the achievement of certain milestones over the term of the Sarborg Service
Agreement, totaling up to $ 1.8
million, are payable in cash or shares, at the discretion of Conduit. Sarborg will be reimbursed for pre-approved, necessary, and
reasonable out-of-pocket expenses directly incurred in connection with the performance of the services.

determined that the cost incurred under the Sarborg Service Agreement should be recorded to research and development expense in the
statement of operations and comprehensive income (loss), as the Sarborg Service Agreement is designed to provide the
Company with software/dashboard to aid in research and development activities. The initial cash payment of $ 0.2
million and issuance of 22,727
shares of Common Stock were recorded to prepaid expense and will be amortized over the initial term of the Sarborg Service Agreement to research and
development expense. As of December 31, 2024, the 22,727
shares of common stock were yet to be issued and are recorded within accrued expense and other current liabilities in the
consolidated balance sheets. As of December 31, 2024, the Company has recognized $ 0.2
million of amortization within research and development expense in the consolidated statement of operations and comprehensive income
(loss).

 11.
 Share Based Compensation

 On
September 22, 2023, in connection with the Merger, the Company adopted the Conduit Pharmaceuticals Inc. 2023 Stock Incentive Plan
(the "2023 Plan"). The 2023 Plan became effective upon the closing of the Merger. The 2023 Plan initially provided for
the issuance of up to 114,976 shares
of Common Stock. Pursuant to the 2023 Plan's "evergreen" provision, on February 6, 2025, the Company increased the
number of shares of Common Stock available for issuance under the 2023 Plan by 69,240
shares. Total shares available for issuance is 154,125 effective January
1, 2025. The number of authorized shares will automatically increase on January 1, 2026 and
continuing annually on each anniversary thereof through (and including) January 1, 2033, equal to the lesser of (i) 5 %
of the shares of common stock outstanding on the last day of the immediately preceding fiscal year and (ii) such smaller number of
shares of common stock as determined by the Board or the applicable committee of the Board. The 2023 Plan allows for awards to be
issued to employees and non-employee directors in the form of options, stock appreciation rights, restricted stock, restricted stock
units ("RSUs"), performance stock units, dividend equivalents, other stock-based, or other cash-based awards. As of
December 31, 2024, there were 84,885 shares
of Common Stock available for issuance under the 2023 Plan.

 F- 26

 During the year ended December 31, 2024, the Company issued a total of
 56,700 stock options to employees and non-employee directors with an aggregate grant date fair value of $ 0.4 million. For
the year ended December 31, 2024 and December 31, 2023, there was a total of $ 1.6 million and $ 0.2 million, respectively in stock-based
compensation expense recognized within General and Administrative expenses on the consolidated statements of operations and Comprehensive
Loss, respectively.

 On
June 24, 2024, in connection with a services agreement with an unrelated third party to provide marketing services, the Company
issued 961 shares of its Common Stock (the "Service Shares"). The Company valued the Service Shares at $ 156 per
share, the closing price of the Company's Common Stock on June 21, 2024, adjusted for the Reverse Stock Split. The total
compensation for these shares is $ 0.2 million
which will be recognized within general and administrative expense over the service period of the agreement.

 On
November 18, 2024, certain non-employee directors elected to receive a portion of their unpaid cash retainers due under the Director
Compensation Program in the form of shares. In total, $ 0.1 million
of unpaid retainers was settled through the issuance 10,027 shares
of Common Stock (the "Retainer Shares"). The Company valued the Retainer Shares at $ 9.0 per
share, the closing price of the Company's Common Stock on November 18, 2024, adjusted for the Reverse Stock Split. The Company
previously accrued in the unpaid retainers in Accrued expenses and other current liabilities in the Company's consolidated
balance sheets. Upon issuance of the shares of Common Stock, the accrual was reduced based on the value of the shares
issued.

 On
November 18, 2024, the Board of Directors approved a one-time equity retainer in the form of 750 fully
vested shares of Common Stock (the "Board Shares") to a member of the Board of Directors for prior services. The Company
valued the Board Shares at $ 9.20 per
share, the closing price of the Company's Common Stock on November 18, 2024, adjusted for the Reverse Stock Split. The total
compensation for these shares is $ 75 thousand
which was immediately recognized within General and administrative expense in the consolidated statement of operations and
comprehensive income (loss). The shares of common stock were issued under the 2023 Plan.

 November
18, 2024, Mr. Heilbron elected to have the $ 0.1 million owed to him under the Consulting Agreement paid in share of the Company's
Common Stock. In total 8,161 shares are to be issued to Mr. Heilbron based on the closing price of the Company's Common Stock on
November 18, 2024, $ 9.20 per share, adjusted for the Reverse Stock Split. As of December 31, 2024, the shares had not been issued to Mr.
Heilbron. The value of the shares are recorded as an accrued expense and other current liability on the consolidated balance sheets as
of December 31, 2024.

 F- 27

 Restricted
Stock

 In
connection with the Merger, as discussed in Notes 1 and 2, and by Unanimous Written Consent of the Board of Directors, the then
Chief Financial Officer of the Company was granted 745 RSUs
on December 1, 2023 at a weighted average grant date fair value of $ 551 per unit.
The RSUs were to vest in equal annual instalments on the first three anniversaries of the closing of the Merger. Upon the then Chief
Financial Officer's resignation, effective May 15, 2024, all such RSUs were forfeited. On June 7, 2024, by Unanimous Written
Consent of the Board of Directors, the Interim Chief Financial Officer of the Company and a Board member were each
granted 372 shares
of immediately vested restricted stock at a weighted average grant date fair value of $ 284.
The shares of restricted stock were fully vested as of the grant date. No additional
RSU's or shares of restricted common stock were granted during the year ended December 31, 2024. There were 745 shares
of restricted common stock vested as of December 31, 2024 and no RSUs
vested as of December 31, 2023.

 The
following table summarizes restricted stock activity for the 2023 Plan:

of Restricted Stock Activity

 Number of
 Awards

 Weighted Average Grant Date Fair Value Per Unit

 Outstanding at December 31, 2023

 $

 Granted

 $

 Cancelled/forfeited

 ( 745
)

 $
 ( 551
)

 Vested

 ( 745
)

 $
 ( 284
)

 Outstanding at December 31, 2024

 -

 $
 -

 Stock
Options

 The
Company estimates the fair value of each option award on the date of grant using the Black-Scholes option-pricing model. The Company
then recognizes the grant date fair value of each option as compensation expense ratably using the straight-line attribution method over
the service period (generally the vesting period). The Black-Scholes model incorporates the following assumptions:

 Expected
 volatility – the Company estimates the volatility of the share price of their peer companies at the date of grant using a "look-back"
 period which coincides with the expected term, defined below. The Company believes using a "look-back" period which coincides
 with the expected term is the most appropriate measure for determining expected volatility.

 Expected
 term – the Company estimates the expected term using the "simplified" method outlined in SEC Staff Accounting Bulletin
 No. 107, "Share-Based Payment."

 Risk-free
 interest rate – the Company estimates the risk- free interest rate using the U.S. Treasury Yield curve for periods equal to
 the expected term of the options in effect at the time of grant.

 Dividends
 – the Company uses an expected dividend yield of zero because the Company has not declared nor paid a cash dividend, nor are
 there any plans to declare a dividend.

 The
Company estimated the fair value of stock options granted in the periods presented using a Black-Scholes option-pricing model utilizing
the following assumptions:

 Schedule of Fair Value
of Stock Option Granted

 For the year ended December 31,

 2024

 2023

 Expected volatility (%)

 83.2 - 85.4
 %

 79.0 % - 80.0
 %

 Expected term (years)

 5.5 - 5.6

 3.5 - 6.5

 Risk-free interest rate (%)

 4.28 % - 4.40
 %

 4.16 % - 4.35
 %

 Expected dividend yield (%)

 %

 %

 The
Company accounts for forfeitures as they occur, which may result in the reversal of compensation costs in subsequent periods as the forfeitures
arise.

 The
following table summarizes stock option activity for the 2023 Plan:

of Stock Option Activity

 Number of Options

 Weighted Average Exercise Price

 Weighted Average Remaining Contractual Term (years)

 Aggregate

 Intrinsic Value (in thousands)

 Outstanding at December 31, 2023

 10,717

 $

 8.85

 $
 -

 Granted

 56,700

 $
 8.58

 -

 $
 -

 Cancelled/forfeited

 1,908

 $

 -

 $
 -

 Exercised

 -

 $
 -

 -

 $
 -

 Outstanding at December 31, 2024

 65,509

 $
 81.52

 9.72

 $
 -

 Exercisable

 23,154

 $
 84.18

 9.66

 $
 -

 Unvested

 42,355

 $
 80.07

 9.76

 $
 -

 F- 28

 The
aggregate intrinsic value of options is calculated as the difference between the exercise price of the underlying options and the fair
value of the Company's common stock for those options that had exercise prices lower than the fair value of the Company's
common stock. As of December 31, 2024, the total compensation cost related to non-vested option awards not yet recognized was $ 2.4 million
with a weighted average remaining vesting period of 2.07 years.

 12.
 Income Taxes

 Loss from operations before income
taxes for the years ended December 31, 2024 and 2023 is summarized below (in thousands):

 Schedule of Income before Income Tax, Domestic and Foreign

 2024

 2023

 For the year ended December 31,

 2024

 2023

 Loss from operations before income taxes:

 US

 ( 12,855
)

 ( 1,990
)

 ( 4,947
)

 1,454

 Loss from operations before income taxes

)

 ( 536
)

 The
provision (benefit) for income taxes for the years ended December 31, 2024 and December 31, 2023 is as follows (in thousands):

 Schedule of Provision for Income Tax

 2024

 2023

 For The Years Ended

 2024

 2023

 Current

 Federal

 -

 -

 State

 -

 -

 -

 -

 Current income tax

 -

 -

 Deferred

 Federal

 ( 2,429
)

 ( 843
)

 State

 ( 355
)

 ( 931
)

 ( 251
)

 Deferred income tax

 ( 3,005
)

 ( 1,449
)

 Change in Valuation Allowance

 3,005

 1,449

 Net Income Tax Expense

 -

 -

 Income
tax provision differed from the amount computed by applying the U.S. federal income tax rate of 21 % to income (loss) before taxes, as
follows (in thousands):

of Federal Income Tax Rate

 US

 For The Year Ended

 2024

 US

 Taxes at federal statutory rate

 $
 ( 2,705
)

 $
 ( 1,039
)

 $
 ( 3,744
)

 Foreign Rate Differential

 -

 Meals & Entertainment

 -

 Eq Comp Perm

 -

 Convertible Debt Adjustment

 -

 State Re-Rate

 -

 Other

 ( 76
)

 ( 59
)

 Change In Valuation Allowance

 2,074

 3,005

 Total provision (benefit) for income taxes

 $
 -

 $
 -

 $
 -

 US

 For The Year Ended

 2023

 US

 Taxes at federal statutory rate

 $
 ( 417
)

 $

 $
 ( 112
)

 State Taxes

 ( 175
)

 -

 ( 175
)

 Foreign Rate Differential

 -

 Meals & Entertainment

 Eq Comp Perm

 -

 Convertible Debt Adjustment

 -

 ( 1,048
)

 ( 1,048
)

 Purchase Accounting Adjustment

 ( 609
)

 -

 ( 609
)

 Change In Valuation Allowance

 1,198

 1,449

 Total provision (benefit) for income taxes

 $
 -

 $
 -

 $
 -

 The
tax effects of temporary differences which give rise to significant portions of deferred tax assets are as follows as of December 31
(in thousands):

of Deferred Tax Assets and Liabilities

 US

 For The Year Ended

 2024

 US

 Deferred Tax Assets

 Stock options

 $

 $
 -

 $

 Transaction Costs

 -

 Research & Development

 -

 Accruals

 -

 Net operating loss

 1,788

 1,182

 2,970

 Total deferred tax asset

 3,273

 1,182

 4,455

 Valuation allowance

 ( 3,273
)

 ( 1,182
)

 ( 4,455
)

 Net deferred tax assets (liability)

 $
 -

 $
 -

 $
 -

 US

 For The Year Ended

 2023

 US

 Deferred Tax Assets

 Stock options

 $

 $
 -

 $

 Transaction Costs

 Net operating loss

 Total deferred tax asset

 1,198

 1,449

 Valuation allowance

 ( 1,198
)

 ( 251
)

 ( 1,449
)

 Net deferred tax assets (liability)

 $
 -

 $
 -

 $
 -

 F- 29

 As
of December 31, 2024 and December 31, 2023, the Company had net operating loss ("NOL") carryforwards for U.S.
federal" purposes of approximately $ 8.5
million and $ 1.9
million, respectively, which carryforward indefinitely and can offset 80 %
of taxable income in future years. As of December 31, 2024 and December 31, 2023, the Company had state NOL carryforwards of nil and $ 1.9
million, respectively. As of December 31, 2024 and December 31, 2023, the Company had net
operating loss ("NOL") carryforwards for foreign purposes of approximately $ 4.7
million and $ 1.0
million, respectively, which carryforward indefinitely. Net operating loss (NOL) carryforwards are subject to limitations in
the event of a change in control under Section 382 of the Internal Revenue Code. This section limits the amount of taxable income
that can be offset by NOLs after an ownership change. The limitation is calculated as the value of the old loss corporation
multiplied by the long-term tax-exempt rate. If the new loss corporation does not continue the business enterprise of the old loss
corporation for a specified period, the NOL carryforwards may be disallowed. The Company has not yet conducted a Section 382 study
to determine whether any ownership changes have occurred that would impose annual limitations on its ability to utilize its NOL
carryforwards. Until such a study is completed, there is substantial uncertainty regarding the amount of NOL carryforwards that
could be utilized annually to offset future taxable income.

 The
Company establishes a valuation allowance when it is more likely than not that the Company's recorded net deferred tax asset
will not be realized. In determining whether a valuation allowance is required, the Company must take into account all positive and
negative evidence with regard to the utilization of a deferred tax asset. As of December 31, 2024 and December 31, 2023, the
valuation allowance for deferred tax assets totaled approximately $ 4.5
million and $ 1.4
million, respectively.

 13.
 Common Stock and Preferred Stock

 Common
Stock

 As
of December 31, 2024, and December 31, 2023, the Company has authorized the issuance of up to 250,000,000 shares
of common stock, respectively, at a par value $ 0.0001 per
share.

 As
of December 31, 2024, and December 31, 2023 there were 1,384,801 and 738,295 shares of Common Stock issued and outstanding, respectively.
 No cash dividends have been declared or paid as of December 31, 2024.

 Holders
of the Common Stock are entitled to one vote per share, and to receive dividends, on and if declared by the board of directors and, upon
liquidation or dissolution, are entitled to receive all assets available for distribution, subordinate to the rights, preferences, and
privileges of any outstanding preferred shares (if any) with respect to dividends and in connection with liquidation, winding up and
dissolution of the Company. The holders have no preemptive or other subscription rights.

 Preferred
Stock

 As
of December 31, 2024, the Company has authorized the issuance of up to 1,000,000 shares of Conduit Pharmaceuticals, Inc. preferred stock
(the "Preferred Stock"). As of December 31, 2024, and December 31, 2023, no preferred shares were issued and outstanding.

 At-the-Market
Offering

 On
October 23, 2024, the Company entered into the Sales Agreement with A.G.P. relating to shares of the Company's Common Stock. In
accordance with the terms of the Sales Agreement, the Company may offer and sell shares of our Common Stock having an aggregate offering
price of up to $ 3.6
 million from time to time through A.G.P.,
acting as our sales agent or principal.

 The
compensation to A.G.P. for sales of common stock sold pursuant to the Sales Agreement will be equal to 3.0 % of the gross proceeds of
any shares of common stock sold under the sales agreement.

the year ended December 31, 2024, the Company sold 323,273
 shares of Common Stock under the Sales Agreement
and generated $ 3.3
 million in net proceeds after paying fees
to A.G.P. and other issuance costs of $ 0.2
 million. See Note 20 for information on the issuances
and increases to the aggregate offering price subsequent to December 31, 2024.

 F- 30

 14.
 Earnings/(Net Loss) Per Share

 The
following table presents the calculation of basic and diluted earnings/(net loss) per share (in thousands, except share amounts and per
share data):

of Basic and Diluted Net Loss Per Share

 2024

 2023

 For
 the years ended

 2024

 2023

 Numerator:

 Net income (loss) - basic

 $
)

 $
 ( 535
)

 Less: Change in fair value and income impact of option liabilities

 -

 ( 5,521
)

 Net income (loss) - diluted

 $
)

 $
 ( 6,056
)

 Denominator:

 Weighted average common stock outstanding, basic

 867,096

 669,739

 Add: Option liability conversion shares

 -

 9,200

 Weighted average shares used in computing net loss per share - diluted

 867,096

 678,939

 Net income (loss) per share, basic

 $
 ( 20.53
)

 $
 ( 0.79
)

 Net income (loss) per share, diluted

 $
 ( 20.53
)

 $
 ( 8.92
)

 The
Company notes that the adjustment to the numerator in 2023 for the change in fair value and income impact of Vela and Cizzle
accounts for changes in fair value of each option, gains (losses) at the time of issuance of each option and the statement of
operations impact of the derecognition of deferred revenue that originated upon the initial sale of royalties to both Vela and
Cizzle.

 Potentially
dilutive securities (upon conversion) that were not included in the diluted per share calculations because they would have been anti-dilutive
were as follows:

of Potentially Dilutive Securities

 As of

 As of

 December 31, 2024

 December 31, 2023

 Public warrants

 139,790

 139,790

 PIPE Warrants

 -

 20,000

 A.G.P. Warrants

 Convertible Promissory Notes Payable

 Stock Options

 65,509

 10,717

 Restricted stock Units

 -

 1,470

 August 2024 Nirland Note

 672,007

 -

 A.G.P. Convertible Note

 576,949

 -

 March 2024 Warrants

 2,600

 -

 April 2024 Warrants

 14,477

 -

 A.G.P. 2024 Warrants

 28,626

 -

 Antidilutive Securities

 1,501,298

 173,322

 15.
 Commitments and Contingencies

 Legal
Proceedings

 The
Company is subject to certain claims and contingent liabilities that arise in the normal course of business. While we do not expect that
the ultimate resolution of any of these pending actions will have a material effect on our consolidated results of operations, financial
position or cash flows, litigation is subject to inherent uncertainties. As such, there can be no assurance that any pending legal action,
does not become material in the future.

 In
August 2023, prior to the Business Combination, our now wholly-owned subsidiary, Conduit Pharmaceuticals Limited, received a letter
from Strand Hanson Limited ("Strand") claiming it was owed advisory fees pursuant to a previously executed letter.
Conduit rejected the claim from Strand and disputed the substance of the letter in full. Following such rejection, on September 7,
2023, Strand filed a claim in the Business and Property Courts of England and Wales claiming it is entitled to be paid the sum of
$ 2
million and, as a result of the completion of the Business Combination, to be issued 65
thousand shares of common stock. As of December 31, 2024, the potential contingency is considered probable and reasonably estimable
and as such, the Company accrued an estimated liability of $ 0.4 million
in the accompanying financial statements. The trial in this matter remains scheduled for October 20, 2025. We intend to vigorously
defend against these claims. Regardless of its outcome, the litigation may impact our business due to, among other things, legal
costs and the diversion of the attention of our management.

 In November and
December 2024, the Company received a letter from St George Street Capital and formal complaints filed with the Intellectual
Property Office claiming the Company was assigned the US Application, and was not the sole owner, of the AZD 1656 co-crystal patent.
In January 2025, Conduit issued a counter statement to the Intellectual Property Office disputing the claim filed by St George
Street Capital. As of December 31, 2024, the damages sought by St George Street Capital are unknown and the potential contingency is
not considered probable. As such, the Company has not accrued a loss contingency in the accompanying
financial statements. We intend to vigorously defend against these claims. Regardless of its outcome, the litigation may impact our
business due to, among other things, legal costs and the diversion of the attention of our management.

 F- 31

 16.
 Related Party Transactions

 Corvus
Capital Limited

 Corvus
Capital Limited ("Corvus") is a significant investor in the Company through subscribing to 1,000 common
shares prior to the closing of the Merger on September 22, 2023. As discussed in Note 2, the shares held by Corvus on the closing
date of the Merger were exchanged for shares of Conduit Pharmaceuticals Inc. common stock. The Chief Executive Officer and principal
owner of Corvus is a member of Conduit's board of directors. Occasionally, Corvus provides advisory services to the Company
and is paid a fee for the services. As of December 31, 2024, and December 31, 2023, no advisory fees were due to Corvus.

 For
the years ended December 31, 2024 and 2023, the Company incurred director travel expenses payable to the board of directors member
of approximately $ 0.4 million
and $ 1.0 million,
respectively. As of December 31, 2024, and December 31, 2023, the Company did not owe the CEO of Corvus any director's fees as
the CEO of Corvus and the Company agreed to cease director's fees to the CEO of Corvus effective at the closing of the Merger.
Amounts owed to this director are included in accrued expenses and other current liabilities in the
balance sheet.

the year ended December 31, 2023, Corvus provided a $ 0.2 million cash contribution to the Company to maintain liquidity through the closing
of the Merger. There was no intention of repayment by both Corvus and the Company, and as such, the Company recorded the contribution
to the consolidated statement of changes in stockholders' deficit.

January and February 2023, the Company issued convertible notes payable with an aggregate principal amount of $ 0.4
 million ( 0.3
 million) to this related party. The convertible
notes payable mature three years after issuance and bear 5 %
interest, only to be paid in the event of a material breach by the Company. In the event of a Change of Control, the convertible notes
payable automatically convert into common shares of the Company at a conversion price equal to a 20 %
discount to the price per share paid for the most senior class of shares in respect of such Change of Control. All of the convertible
notes payable converted into Common Stock upon the closing of the Merger at a 20 %
discount as specified. Refer to Note 2 above for additional information.

 At the time of the execution of the PIPE Subscription Agreement, Corvus
and its affiliates entered into a participation and inducement agreement with Nirland whereby Corvus agreed to provide certain payments
and economic benefits to Nirland. In certain circumstances, Nirland may have a right to cause Corvus to transfer 300,484 shares held to Nirland.

 Related
Party Loan

 The
loans made to a related party were stated at a total principal amount of $ 0.8 million, with no balance outstanding at December 31, 2024
and December 31, 2023, respectively. The loan carried no interest, and as such, no interest receivable was recorded. The Company recorded
a full reserve against the loan as the related party did not have the ability to repay the loans as of December 31, 2022. On September
22, 2023, the related party paid back a significant portion of its outstanding loan and the Company forgave the remaining portion of
the loan and the Company recorded the $ 0.3 million payoff as a gain within general and administrative expense on the consolidated statement
of operations and comprehensive income (loss), as it had previously been fully reserved.

 Nirland

 On
August 6, 2024, the Company entered into the August 2024 Nirland Note with Nirland, a related party of the Company. The Company
determined that Nirland was a related party due to Nirland's ownership interest in the Company concurrently with the execution
of the August 2024 Nirland Note. Additionally, on October 28, 2024, the Company issued the October 2024 Nirland Note to Nirland, and
on October 31, 2024, the Company and Nirland amended the August 2024 Nirland Note, and on November 22, 2024, the Company and Nirland
amended the August 2024 Nirland Note for a second time. Refer to Note 7, Note 8 and Note 20 above for additional
information.

 SARBORG

 On
December 12, 2024, the Company entered into the Sarborg Service Agreement with Sarborg. Dr. Andrew Regan, a member of
Conduit's board of directors, also sits on the board of directors of Sarborg but does not have an equity interest in Sarborg.
During the year ended December 31, 2024, the Company recorded $ 0.1
million as research and development expense related to the Sarborg Service Agreement. Refer to Note 10 above for additional
information.

 Officers and
Directors

 On April 22, 2024,
the Company issued in a private placement common stock purchase warrants (the "April Warrants") to third parties which also
included certain directors, to purchase up to an aggregate of 9,077
 shares of the Company's common stock, in exchange for entering into a lock-up with respect to the shares of common stock
held by such holder and for such directors, $ 12.50
 per warrant. The April Warrants are not exercisable until one year after their date of issuance. Each April Warrant is exercisable
into one share of the Company's common stock at a price per share of $ 312
 (as adjusted from time to time in accordance with the terms thereof) for a two-year period after the date of exercisability.

 F- 32

 17.
 Other Income (expense), net

 The
following table presents other income (expense), net, for the years ended December 31, 2024 and 2023 (in thousands):

of Other Expense, Net

 2024

 2023

 For the years ended

 2024

 2023

 Other income:

 Recognition of Cizzle deferred revenue upon option exercise

 $
 -

 $
 1,480

 Recognition of Vela deferred revenue upon option exercise

 -

 2,774

 Change in fair value of Cizzle option

 -

 1,280

 Change in fair value of Vela option

 -

 Change in fair value of warrant liability

 Change in fair value of convertible note payment

 2,018

 -

 Gain on debt extinguishment

 2,473

 -

 Interest Income

 Income Tax Refund

 -

 Unrealized foreign currency transaction gain

 Other

 Total other income:

 5,048

 6,754

 Other expense:

 Loss on issuance of Vela option

 -

 Change in fair value of convertible notes payable

 -

 Interest expense

 Amortization of debt issuance costs

 -

 Loss on issuance of warrants

 2,710

 -

 Loss on Debt Extinguishment

 3,179

 -

 Realized foreign currency transaction loss

 Other expense

 -

 Total other expense

 7,431

 2,027

 Total other (expense) income, net

 $
 ( 2,383
)

 $
 4,727

 18.
 Warrants

 Upon
the closing of the Merger, the Company assumed (i) the warrants initially included in the MURF units issued in MURF's initial public
offering (the "Publicly Traded Warrants"), and (ii) the warrants that were included in the private placement units issued
to the Sponsor simultaneously with the closing of MURF's initial public offering (the "Private Placement Warrants").
In connection with the Merger, the Company also issued warrants to the PIPE Investors (the "PIPE Warrants") pursuant to the
Subscription Agreements and to an advisor (the "A.G.P. Warrants," and together with the PIPE Warrants, the "Liability
Classified Warrants") pursuant to the Company's engagement agreement with the advisor.

 The
Company determined that the settlement amount of the Publicly Traded Warrants and the Private Placement Warrants would equal the difference
between the fair value of a fixed number of shares and a fixed monetary amount (or a fixed amount of a debt instrument) and must be classified
as equity, while the settlement amount of the Liability Classified Warrants would not equal the difference between the fair value of
a fixed number of shares and a fixed monetary amount (or a fixed amount of a debt instrument) and must be classified as a liability.

 On
March 20, 2024, the Company issued in a private placement equity classified common stock purchase warrants (the "March 2024
Warrants") to an investor to purchase up to an aggregate 2,600
shares of the Company's Common Stock, in exchange for entering into a lock-up with respect to the shares of common stock held
by such holder (the "March Lock-Up Agreement"). The Company recognized at $ 0.5
million loss on the issuance of the warrants during the year ended December 31, 2024. The Company determined that the March 2024 Warrants
should be classified within equity and estimated the fair value of the warrants issued as of March 20, 2024, using a Black-Scholes
option-pricing model utilizing the following assumptions:

of Black-Scholes Option Pricing Model

 March 20, 2024

 Closing stock price

 $

 Contractual exercise price

 $

 Risk-free rate

 4.41
 %

 Estimated volatility

 78.5
 %

 Time period to expiration

 3 Years

 F- 33

 On
April 20, 2024, the Company issued in a private placement equity classified common stock purchase warrants (the "April 2024 Warrants")
to shareholders' of the Company to purchase up to an aggregate 14,477 shares of the Company's Common Stock, in exchange for
(1) $ 12.50 per warrant and (2) entering into a lock-up with respect to the shares of common stock held by such holders (the "April
Lock-Up Agreement"). 9,077 of the total April 2024 Warrants issued were issued to directors, related parties and management of
the Company. The Company received cash of $ 0.2 million and recognized a $ 2.2 million loss on the issuance of the warrants during the year ended December 31, 2024. The Company determined that the April 2024 Warrants should be classified within equity and estimated the
fair value of the warrants issued as of April 20, 2024, using a Black-Scholes option-pricing model utilizing the following assumptions:

 April 20, 2024

 Closing stock price

 $

 Contractual exercise price

 $

 Risk-free rate

 4.81
 %

 Estimated volatility

 78.3
 %

 Time period to expiration

 3 Years

 As
partial consideration for the Advance issued to the Company by A.G.P. on October 29, 2024, the Company issued A.G.P. Warrants (the "A.G.P.
2024 Warrants") to purchase up to 28,625 shares of the Company's Common Stock at an exercise price of $ 0.1048 per
share. The Company determined that the A.G.P. 2024 Warrants should be classified as a liability and estimated the fair value of the warrants
as of October 29, 2024, and December 31, 2024, using a Black-Scholes option-pricing model. Refer to Note 3 above for additional information.

 Equity
Classified Warrants

 Pursuant
to MURF's initial public offering, the Company sold 132,250 units at a price of $ 10.00 per unit. Each unit consisted of one share
of MURF Class A common stock and one redeemable Publicly Traded Warrant. Each whole Publicly Traded Warrant entitled the holder to purchase
one share of Class A common stock at a price of $ 11.50 per share, subject to adjustment. The warrants are publicly traded on The Nasdaq
Capital Market under the trading symbol CDTTW.

 Simultaneously
with the closing of its initial public offering, MURF consummated the private sale to the Sponsor of 7,540 private placement units at
a price of $ 10.00 per private placement unit. Each private placement unit was comprised of one share of MURF Class A common stock and
one Private Placement Warrant. Each Private Placement Warrant was exercisable to purchase one share of MURF Class A common stock at a
price of $ 11.50 per share, subject to adjustment. The private placement units (including the Class A common stock issuable upon exercise
of the warrants included in the private placement units) were not transferable, assignable, or saleable until 30 days after the completion
of a Merger, subject to certain exceptions.

 In
connection with the closing of the Merger on September 22, 2023, the Equity Classified Warrants were amended to entitle each holder to
purchase one share of the Company's Common Stock.

 The
Equity Classified Warrants became exercisable 30 days after the Closing Date of the Merger. The Equity Classified Warrants will expire
five years after the Closing Date of the Merger or earlier upon redemption or liquidation.

 The
Company will not be obligated to deliver any shares of Common Stock pursuant to the exercise of an Equity Classified Warrant and will
have no obligation to settle such exercise unless a registration statement under the Securities Act with respect to the shares of Common
Stock underlying the warrants is then effective and a prospectus relating thereto is current, subject to our satisfying our obligations
described below with respect to registration. No Equity Classified Warrant will be exercisable and we will not be obligated to issue
shares of Common Stock upon exercise unless the Common Stock issuable upon such exercise has been registered, qualified or deemed to
be exempt under the securities laws of the state of residence of the registered holder of the Equity Classified Warrant. In the event
that the conditions in the two immediately preceding sentences are not satisfied with respect to an Equity Classified Warrant, the holder
of such warrant will not be entitled to exercise such warrant and such warrant may have no value and expire worthless. In no event will
we be required to net cash settle any Equity Classified Warrant. In the event that a registration statement is not effective for the
exercised Equity Classified Warrant, the purchaser of a unit containing such Equity Classified Warrant will have paid the full purchase
price for the unit solely for the share of Common Stock underlying such unit.

 F- 34

may call the Publicly Traded Warrants in whole and not in part, at a price of $ 1.00 per warrant,

 upon
 not less than 30 days' prior written notice of redemption to each Publicly Traded Warrant holder; and

 if,
and only if, the reported last sale price of the Common Stock equals or exceeds $ 1,800.00 per share (as adjusted for stock splits, stock
dividends, reorganizations, recapitalizations and the like) for any 20 trading days within a 30-trading day period commencing once the
Publicly Traded Warrants become exercisable and ending three business days before we send the notice of redemption to the warrant holders.

 If
and when the Publicly Traded Warrants become redeemable by Conduit, Conduit may not exercise its redemption right if the issuance of
shares of Common Stock upon exercise of the Publicly Traded Warrants is not exempt from registration or qualification under applicable
state blue sky laws or Conduit are unable to effect such registration or qualification. Conduit will use its best efforts to register
or qualify such shares of Common Stock under the blue sky laws of the state of residence in those states in which the Publicly Traded
Warrants were offered by Conduit in the offering.

 If
Conduit calls the Publicly Traded Warrants for redemption as described above, Conduit's management will have the option to require
any holder that wishes to exercise its Publicly Traded Warrant to do so on a "cashless basis." In determining whether to
require all holders to exercise their Publicly Traded Warrants on a "cashless basis," Conduit's management will consider,
among other factors, Conduit's cash position, the number of Publicly Traded Warrants that are outstanding and the dilutive effect
on Conduit stockholders of issuing the maximum number of shares of Common Stock issuable upon the exercise of our Publicly Traded Warrants.
If Conduit's management takes advantage of this option, all holders of Publicly Traded Warrants would pay the exercise price by
surrendering their Publicly Traded Warrants for that number of shares of Common Stock equal to the quotient obtained by dividing (x)
the product of the number of shares of Common Stock underlying the Publicly Traded Warrants, multiplied by the difference between the
exercise price of the Publicly Traded Warrants and the "fair market value" (defined below) by (y) the fair market value.
The "fair market value" for this purpose shall mean the average reported last sale price of the Common Stock for the 10 trading
days ending on the third trading day prior to the date on which the notice of redemption is sent to the holders of Publicly Traded Warrants.
If Conduit's management takes advantage of this option, the notice of redemption will contain the information necessary to calculate
the number of shares of Common Stock to be received upon exercise of the Publicly Traded Warrants, including the "fair market value"
in such case. Requiring a cashless exercise in this manner will reduce the number of shares to be issued and thereby lessen the dilutive
effect of a Publicly Traded Warrant redemption.

 The
Private Placement Warrants are identical to the Publicly Traded Warrants, except that such warrants will be exercisable for cash or on
a cashless basis, at the holder's option, and will not be redeemable by Conduit, in each case so long as they are still held by
the Sponsor or its permitted transferees.

 As
summarized above, the Company has the option to redeem all of the Publicly Traded Warrants at a cash price of $ 0.01 per warrant during
the exercisability period if the Company's common stock has closed at a trading price above $ 18.00 for 20 days during a 30-day
trading window. Management notes that this option is within the Company's control, therefore it does not represent an "obligation"
and does not create a liability under ASC 480. Management considered the guidance within ASC 815-40-15-7A, noting that an exercise contingency
would not preclude permanent equity classification if all of the other equity criteria are met. As all other criteria to be classified
as permanent equity are met, the Publicly Traded Warrants are classified as permanent equity on the Consolidated Balance Sheets.

 F- 35

assessed the Private Placement Warrants and determined that the warrants are considered to be indexed to the entity's own stock
and met all the criteria for permanent equity classification. As such, the Publicly Traded Warrants are classified as permanent equity
on the Consolidated Balance Sheets.

 The March 2024 Warrants are not exercisable until one year after their date of issuance. Each March
2024 Warrant is exercisable into one share of the Company's Common Stock at a price per share of $ 3.18 (as adjusted from time to
time in accordance with the terms thereof) for a two-year period after the date of exercisability. There is no established public trading
market for the March 2024 Warrants. Notwithstanding the foregoing, the March 2024 Warrants shall vest, and not be subject to forfeiture,
with respect to 25% of such March 2024 Warrants commencing on the 90th day after the date of the March Lock-Up Agreement and 25% on each
subsequent 90-day anniversary, in each case vesting only if the holder agrees to continue to have its shares of common stock remain locked
up pursuant to the March Lock-Up Agreement on such date.

 The
April 2024 Warrants are not exercisable until one year after their date of issuance. Each April 2024 Warrant is exercisable into one
share of the Company's Common Stock at a price per share of $ 312 (as adjusted from time to time in accordance with the terms thereof)
for a two-year period after the date of exercisability. There is no established public trading market for the April 2024 Warrants. Notwithstanding
the foregoing, the April 2024 Warrants shall vest, and not be subject to forfeiture, with respect to 25% of such March 2024 Warrants
commencing on the 90th day after the date of the April Lock-Up Agreement and 25% on each subsequent 90-day anniversary, in each case
vesting only if the holder agrees to continue to have its shares of common stock remain locked up pursuant to the April Lock-Up Agreement
on such date.

 Liability
Classified Warrants

 As
discussed in Note 2, 20,000 PIPE Warrants were issued to the PIPE Investors as of the closing of the Merger pursuant to subscription
agreements. The warrants provide the PIPE Investors the right to purchase up to 20,000 shares of Common Stock at an exercise price of
$ 1,150. Additionally, on the Closing Date of the Merger, the Company issued 540 A.G.P. Warrants to an advisor for services provided directly
related to the Merger. The warrants provide the advisor the right to purchase up to 540 shares of Common Stock at an exercise price of
$ 1,100 per share.

 The
warrants issued to the PIPE Investors and the advisor contain materially the same terms and are exercisable for a period of five years,
beginning on October 22, 2023.

 The
PIPE Warrants are exercisable for cash or on a cashless basis, at the holder's option. The PIPE Warrants are not redeemable by
the Company.

 The
A.G.P. Warrants are exercisable for cash or on a cashless basis, at the holder's option. The Company may call the A.G.P. Warrants
for redemption, in whole and not in part, at any time after the A.G.P. Warrants become exercisable and prior to their expiration, at
a price of $ 1.00 per A.G.P. Warrant,

 upon
 not less than 30 days' prior written notice of redemption to each warrant holder;

 if,
 and only if, the reported last sale price of the Common Stock equals or exceeds $ 1,800 per share (as adjusted for stock splits, stock
 dividends, recapitalizations and other similar events) for any 20 trading days within a 30-trading day period commencing once the
 A.G.P. Warrants become exercisable and ending three business days before we send the notice of redemption to the warrant holders;
 and

 provided
 there is a current registration statement in effect with respect to the shares of Common Stock underlying the A.G.P. Warrants for
 each day in the 30-trading day period and continuing each thereafter until the redemption date.

 If
the Company calls the A.G.P. Warrants for redemption as described above, our management will have the option to require any holder that
wishes to exercise its A.G.P. Warrant to do so on a "cashless basis." If our management takes advantage of this option, holders
of A.G.P. Warrants would pay the exercise price by surrendering their A.G.P. Warrants for that number of shares of Common Stock as calculated
pursuant to the A.G.P. Warrant. Requiring a cashless exercise in this manner will reduce the number of shares to be issued and thereby
lessen the dilutive effect of an A.G.P. Warrant redemption.

 The
exercise of the A.G.P. 2024 Warrants and the issuance of the shares of Common Stock underlying the Warrants is subject to stockholder
approval under applicable rules and regulations of Nasdaq. The warrants are exercisable for a period of five years, beginning on the
stockholder approval date. The A.G.P 2024 Warrants are exercisable for cash, or on a cashless basis if at the time of exercise there
is no effective registration statement registering the resale of the warrant shares. The A.G.P. 2024 Warrants are not redeemable by the
Company. On October 29, 2024, the Company recorded a warrant liability of $ 0.2 million. As part of the special meeting of stockholders
taking place on January 9, 2025, the stockholders approved the issuance of up to an aggregate of 28,625 shares of the Company's
common stock upon exercise of the A.G.P. 2024 Warrants.

 The
PIPE Warrants, A.G.P. Warrants, and the A.G.P 2024 Warrants (collectively the "Liability Classified Warrants") are classified
as derivative liabilities because they do not meet the criteria in ASC 815-40 to be considered indexed to the entity's own stock
as the warrants could be settled for an amount that is not equal to the difference between the fair value of a fixed number of the entity's
shares and a fixed monetary amount. The Liability Classified Warrants are initially measured at fair value and are remeasured at fair
value at subsequent financial reporting period end dates and upon exercise (see Note 7 for additional information regarding fair value).

 On
December 11, 2024, the Company reduced the exercise price of the PIPE Warrants to be $ 8.83, at which time all PIPE Warrants were exercised.
The Company received approximately $ 0.2 million of proceeds from the exercise of the Warrants, all of which was used to pay down the
October 2024 Nirland Note.

 For
the years ended December 31, 2024, and December 31, 2023, the Company remeasured the fair value of the Liability Classified Warrants
and recorded a gain on the change in the fair value of $ 0.2
 million and $ 0.1
 million, respective. The gains were recorded
to other income (expense), net, on the consolidated statements of operations and comprehensive income (loss). As of December 31, 2024
and December 31, 2024, the balance sheets contained warrant liabilities of $ 0.1
 million and $ 0.01
 million, respectively.

 F- 36

 19.
 Segments

 The
Company has one operating segment focused on the research and development of clinical assets. The accounting policies of the single operating
segment are identical to those described in Note 1. The CODM, which the Company has identified as David Tapolczay, Chief Executive
Officer, manages the Company's operations on a consolidated basis, assesses performance for the operating segment and decides how
to allocate resources based on consolidated net loss, which is reported on the consolidated statements of operations and comprehensive
income (loss). Depreciation expense, amortization expense, stock-based compensation expense, and non-cash lease expense are significant
noncash items included in consolidated net loss reviewed by the CODM and are reported on the consolidated statements of cash flows. The
measure of segment assets is reported on the consolidated balance sheets as total consolidated assets. Expenditures for additions to
long-lived assets, which include purchases of property and equipment, are included in total consolidated assets reviewed by the chief
operating decision maker and are reported on the consolidated statements of cash flows.

 The
CODM uses consolidated net loss and budget-to-actual variances to assess the performance of the operating segment and determine if the
Company is progressing towards its goals.

 The
following table presents certain financial data for the Company's reportable segment (in thousands):

of Financial Data for the Company's Reportable Segment

 2024

 2023

 2024

 2023

 Research & development expense – new licenses

 $
 3,114

 $
 —

 Research & development expense – clinical asset development

 General and administrative expenses – legal & professional fees

 2,258

 General and administrative expenses – accounting & audit fees

 1,625

 3,064

 General and administrative expenses – salaries, payroll and stock-based compensation

 4,098

 General and administrative expenses – other

 4,060

 1,073

 Loss from segment operations

 $
 15,419

 $
 5,262

 Other
segment items consist of the items within Note 17 to the consolidated financial statements.

 20.
 Subsequent Events

 Reverse
Stock Split

 On
January 24, 2025, the Company effected the Reverse Stock Split, pursuant to which every 100 shares of the Company's common stock
issued or outstanding were automatically reclassified into one new share of common stock, subject to the treatment of fractional shares
as previously described, without any action on the part of the holders. For a description of the Reverse Stock Split, refer to Note 1
above.

 Nirland Notes
Repayment

 On February 7, 2025,
the Company fully repaid its outstanding October 2024 Nirland Note to Nirland Limited in the principal amount of $ 600,000.
This payment settled all obligations under the October 2024 Nirland Note.

 With
respect to the August 2024 Nirland Note, the Lender converted approximately $ 1.7 million
of the original principal amount of $ 2,650,000 under
into shares of common stock of the Company. Of the $ 1.7 million of original principal that was converted into shares of common stock
of the Company, $ 0.1 million was converted on December 12, 2024, while the remaining $ 1.6 million was converted between January 13,
2025 and February 10, 2025. On February 13, 2025, the Company paid the remaining outstanding portion of the August 2024
Nirland Note, approximately $ 0.9
million, and, accordingly, satisfied all of its obligations in all respects to Nirland. As a result of satisfying its obligations under the
August 2024 Nirland Note, all of the Company's assets are once again free and clear of any liens, security interests or
encumbrances.

 March 2023 Convertible Note
Repayment

 On March 13, 2025,
the Company fully repaid its outstanding March 2023 Convertible Note. The Company notes that the note holder agreed on March 6, 2025
to reduce the principal from $ 0.8
million to $ 0.7
million. This payment settled all obligations under the March 2023 Convertible Note. The March 2023 Convertible Note Repayment was considered
to be in default until payment on March 13, 2025.

 Nasdaq Stock
Market Correspondence and Subsequent Nasdaq Capital Market Listing

 On
February 11, 2025, the Company presented its plan of compliance to The Nasdaq Stock Market LLC Hearing Panel (the "Panel")
and requested an extension of time to achieve compliance with Nasdaq Listing Rules, the Minimum Bid Price ("Bid Price"),
Market Value of Publicly Held Shares ("MVPHS") and Market Value of Listed Securities ("MVLS") rules, respectively.

 On
March 5, 2025, the Company received a written notification from the Panel confirming it has granted the Company such an extension for
the Company to regain compliance with the MVPHS and MVLS rules, provided that the Company, (i) on or before March 12, 2025, files an
application to transfer to the Nasdaq Capital Market, which application was submitted on March 7, 2025, and (ii) on or before March 31,
2025, demonstrates compliance with all Nasdaq listing rules, which it intends to do. Additionally, the Company was also notified in the
Notice that as of February 26, 2025, it had regained compliance with the Bid Price rule. The Company notes that there is no assurance
that the Company can maintain ongoing compliance with the Bid Price Rule. The Company expects to submit its compliance document with
respect to the MVPHS and MVLS rules which will be subject to review by the Panel. The Panel, may, in its discretion, request additional
information before determining that the Company has complied with the terms of the exception. There can be no assurances that the Panel's
decision will agree with the Company's compliance document.

 Common Stock
Issuances in Relation to the Sales Agreement

 The Company
increased the aggregate offering price under the Sales Agreement to up to $ 4,835,433,
$ 8,183,156,
$ 13,450,017,
$ 17,816,270,
and $ 23,922,782 on January 15, 2025, February 6, 2025, February 10, 2025, February 19, 2025, and March 10, respectively. From
January 22, 2025 through the issuance of the Company's consolidated financial statements, the Company sold 4,345,913
shares of the Company's Common Stock through the Sales Agreement. The Company received proceeds of $ 8.1
million, net of commissions payable to A.G.P. of $ 0.2
million. As of the financial statement filing date, the Company has $ 12.0 million
available under the Sales Agreement.

 F- 37