10-K/A

 UNITED STATES

 SECURITIES AND EXCHANGE COMMISSION

 WASHINGTON, D.C. 20549

 FORM 10-K/A

 (Amendment No. 1)

 (Mark One)

 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 FOR THE FISCAL YEAR ENDED DECEMBER 31, 2024

 or

 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 FOR THE TRANSITION PERIOD FROM TO

 Commission file number: 001-35670

 Regulus Therapeutics Inc.

 (Exact name of registrant as specified in its charter)

 Delaware

 26-4738379

 (State or Other Jurisdiction of

 Incorporation or Organization)

 (I.R.S. Employer

 Identification No.)

 4224 Campus Point Court, Suite 210

 San Diego, CA

 92121

 (Address of Principal Executive Offices)

 (Zip Code)

 ( 858) 202-6300

 (Registrant's Telephone Number, Including Area Code)

 Securities registered pursuant to Section 12(b) of the Act:

 Title of Each Class

 Trading

 Symbol(s)

 Name of Each Exchange

 on Which Registered

 Common Stock, par value $0.001 per share

 RGLS

 The Nasdaq Stock Market LLC

 Securities registered pursuant to Section 12(g) of the Act: None

 Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes No

 Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes No
 Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes No
 Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T
 (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes No
 Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated
 filer, a smaller reporting company or an emerging growth company. See the definitions of "large accelerated filer", "accelerated filer", "smaller reporting company" and "emerging growth company" in Rule 12b-2
 of the Exchange Act.:

 Large accelerated filer

 Accelerated filer

 Non-accelerated filer

 Smaller reporting company

 Emerging growth company

 If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.
 Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.
 If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements.
 Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant's executive officers during the relevant recovery period pursuant to § 240.10D-1(b).

 Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2
 of the Securities Exchange Act of
1934). Yes No
 As of June 28, 2024, the last business day of the registrant's most recently completed second fiscal quarter, the aggregate market value of the registrant's common stock held by non-affiliates
 of the registrant was approximately $ 114.9 million, based on the closing price of the registrant's common stock on the Nasdaq Stock Market on June 28, 2024 of $1.785 per share.
 The number of outstanding shares of the registrant's common stock, par value $0.001 per share, as of March 7, 2025 was 66,243,384.
 DOCUMENTS INCORPORATED BY REFERENCE

 None.

 EXPLANATORY NOTE
 Regulus Therapeutics Inc. (the "Company," "Regulus," "our," "us" or "we") is filing this Amendment No. 1 on Form 10-K/A
 (this "Amendment") to its Annual Report on Form 10-K
 for the fiscal year ended December 31, 2024, originally filed with the Securities and Exchange Commission (the "SEC") on March 13, 2025 (the "Original Filing"). We are filing this Amendment to provide the information required by and not included in Part III of the Original Filing because we do not intend to file our definitive proxy statement within 120 days of the end of our fiscal year ended December 31, 2024. In connection with the filing of this Amendment and pursuant to the rules of the SEC, we are including with this Amendment new certifications by our principal executive and principal financial officers. Accordingly, Item 15 of Part IV has also been amended to reflect the filing of these new certifications. Because no financial statements have been included in this Amendment and this Amendment does not contain or amend any disclosure with respect to Items 307 and 308 of Regulation S-K,
 paragraphs 3, 4, and 5 of the certifications have been omitted. We are also not including the certifications under Section 906 of the Sarbanes-Oxley Act of 2002 as no financial statements are being filed with this Amendment.
 Except as described above, no other changes have been made to the Original Filing. The Original Filing continues to speak as of the date of the Original Filing, and we have not updated the disclosures contained therein to reflect any events which occurred at a date subsequent to the filing of the Original Filing other than as expressly indicated in this Amendment. Defined terms used in this Amendment but not defined herein shall have the meaning specified for such terms in the Original Filing.
 All statements in this Amendment that are not historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). These forward-looking statements can generally be identified as such because the context of the statement will include words such as "may," "will," "intend," "plans," "believes," "anticipates," "expects," "estimates," "predicts," "potential," "continue," "opportunity," "goals," or "should," the negative of these words or words of similar import. Similarly, statements that describe our future plans, strategies, intentions, expectations, objectives, goals or prospects are also forward-looking statements. These forward-looking statements are or will be, as applicable, based largely on our expectations and projections about future events and future trends affecting our business, and so are or will be, as applicable, subject to risks and uncertainties including but not limited to the risk factors discussed in the Original Filing, that could cause actual results to differ materially from those anticipated in the forward-looking statements. We caution investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements. Our views and the events, conditions and circumstances on which these future forward-looking statements are based, may change.

 REGULUS THERAPEUTICS INC.

 Explanatory Note

 Item 10

 Directors, Executive Officers and Corporate Governance

 Item 11

 Executive Compensation

 Item 12

 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 Item 13

 Certain Relationships and Related Transactions, and Director Independence

 Item 14

 Principal Accounting Fees and Services

 Item 15

 Exhibits, Financial Statement Schedules

 Signatures

 The Regulus Therapeutics logo is a trademark of Regulus Therapeutics Inc. We use "Regulus Therapeutics" as a trademark in the United States and other countries. We have registered this trademark in the United States, the European Union and Switzerland. All other product and company names are trademarks of their respective companies.

 i

 Item 10. Directors, Executive Officers and Corporate Governance
 BOARD OF DIRECTORS
 Our Board of Directors currently consists of ten directors. The following is a brief biography of each director, including their ages, and a discussion of the specific experience, qualifications, attributes or skills of each director.

 Name

 Age

 Position Held With the Company

 Dr. Stelios Papadopoulos

 Chair of the Board of Directors

 Ms. Kathryn J. Collier

 Dr. David Baltimore

 Mr. Joseph P. Hagan

 Director and Chief Executive Officer

 Dr. Alice S. Huang

 Dr. Preston S. Klassen

 Director, President and Head of Research & Dev.

 Mr. Jake R. Nunn

 Dr. William H. Rastetter

 Dr. Hugh Rosen

 Ms. Pascale Witz, MBA, MSc

 Stelios Papadopoulos, Ph. D. Chair of the Board, has served on our Board of Directors since our conversion to a corporation in January 2009 and as our Chair since June 2013, and prior to that was a director of Regulus Therapeutics LLC since July 2008. Since December 1994, Dr. Papadopoulos has served as a director and, since 1998, as Chair of the Board for Exelixis, Inc., a publicly held biotechnology company, which he co-founded. From July 2008 until June 2023, Dr. Papadopoulos served as a member of the board of directors of Biogen Inc. (formerly Biogen Idec Inc.), a publicly held biopharmaceutical company, and served as its Chair of the board of directors from June 2014 until June 2023. From August 2020 until June 2023, Dr. Papadopoulos served as Chair of the board of Eucrates Biomedical Acquisition Corp., a special purpose acquisition corporation. From 2000 to 2006, Dr. Papadopoulos served as Vice Chair with Cowen and Co., LLC, an investment banking firm. From 1987 to 2000, Dr. Papadopoulos served in several positions with PaineWebber, Incorporated, most recently as Chair of PaineWebber Development Corp., a PaineWebber subsidiary focusing on biotechnology. Dr. Papadopoulos holds an M.S. in Physics, a Ph. D. in Biophysics and an MBA in Finance from New York University. Our Nominating and Corporate Governance Committee believes that Dr. Papadopoulos is qualified to serve on our Board of Directors due to his knowledge and expertise regarding the biotechnology and healthcare industries, his broad leadership experience on various boards and his experience with financial matters.
 David Baltimore, Ph. D. has served on our Board of Directors since our conversion to a corporation in January 2009, and prior to that was a director of Regulus Therapeutics LLC since November 2007. Dr. Baltimore is currently President Emeritus and Judge Shirley Hufstedler Distinguished Professor of Biology at the California Institute of Technology ("Caltech"), and before that from 1997 to 2006, Dr. Baltimore served as President of the California Institute of Technology. From 1968 to 1972, Dr. Baltimore served as an associate professor at the Massachusetts Institute of Technology, and from 1972 to 1997 was a professor at the Massachusetts Institute of Technology. From 1990 to 1994, Dr. Baltimore served as professor at The Rockefeller University where he also served as the President from July 1990 to December 1991. Dr. Baltimore served as a director of Amgen Inc., a publicly held biotechnology company from 1997 to May 2018, and also served as a director of Immune Design Corp., a publicly held biotechnology company, from 1997 until its acquisition by Merck & Co., Inc. in February 2019. In 1975, Dr. Baltimore received the Nobel Prize in Medicine as a co-recipient. Dr. Baltimore holds a Ph. D. in Biology from The Rockefeller University and a B.A. with High Honors in Chemistry from Swarthmore College. Our Nominating and Corporate Governance Committee believes that Dr. Baltimore is qualified to serve on our Board of Directors due to the many years Dr. Baltimore has spent in scientific academia, which has provided him with a deep understanding of our industry and our activities.
 Kathryn J. Collier has served on our Board of Directors since April 2018. From March 2022 until January 2024, Ms. Collier served as the Senior Vice President of Corporate Finance for Pattern Energy Group LP, a privately held renewable energy company. From July 2019 to March 2022, Ms. Collier served as the Vice President for Audit Services of Sempra Energy ("Sempra"), a publicly traded energy services holding company overseeing the internal audit function for Sempra, including the Financial Leadership Program and audit oversight of Sempra's operating companies. From March 2019 to July 2019, Ms. Collier served as the Chief Strategy and Origination Officer for Sempra LNG, a wholly owned subsidiary of Sempra. From August 2018 to March 2019, Ms. Collier served as Chief Financial Officer and Chief Administrative Officer for Sempra North America Infrastructure. Ms. Collier also previously served as Vice President and Treasurer for Sempra from April 2012 to August 2018. Ms. Collier has previously served on the boards of two large-cap utilities in South America, primarily owned by Sempra (Luz del Sur, a public Peruvian utility traded on the Lima Stock Exchange, and Chilquinta Energia, a privately held utility, located in Chile) from 2017-2019 and prior to their ultimate sale. Prior to joining Sempra in 2012, Ms. Collier held several executive positions within global corporation and investment banking at Bank of America. Ms. Collier holds a B.S. in accounting from Valparaiso University. Our Nominating and Corporate Governance Committee believes that Ms. Collier is qualified to serve on our Board of Directors due to her extensive financial and operational experience, her experience in investment banking and her corporate governance experience with various boards.
 Joseph P. Hagan has served as our Chief Executive Officer and principal executive officer since May 2017. Mr. Hagan previously served as our President and Chief Executive Officer from May 2017 until June 2023 and our Chief Operating Officer, principal financial officer and principal accounting officer from January 2016 to May 2017. From June 2011 through December 2015, Mr. Hagan served as the Executive Vice President, Chief Financial Officer and Chief Business Officer of Orexigen Therapeutics, Inc. ("Orexigen"). From May 2009 to June 2011, Mr. Hagan served as Orexigen's Senior Vice President, Corporate Development, Strategy and Communications. From 2004 to April 2008, Mr. Hagan served as Managing Director of Amgen Ventures. Prior to starting the Amgen Ventures Fund, Mr. Hagan served as Head of Corporate Development for Amgen Inc. ("Amgen") from 1998 to 2004. Before joining Amgen, Mr. Hagan spent five years in the bioengineering labs at Genzyme and Advanced Tissue Sciences. Mr. Hagan served on the board of directors of Aurinia Pharmaceuticals, Inc. from February 2018 to June 2023, and he also previously served on the board of directors of Zosano Pharma Corp., from May 2015 to May 2022. He received an M.B.A. from Northeastern University and a B.S. in Physiology and Neuroscience from the University of California, San Diego. Our Nominating and Corporate Governance Committee believes that Mr. Hagan's expertise in business development, commercialization and financing of public companies qualify him to serve on our Board of Directors.

 Alice S. Huang, Ph. D. has served on our Board of Directors since January 2021. Dr. Huang is currently Senior Faculty Associate of Biology and Biological Engineering at the California Institute of Technology ("Caltech"), having joined Caltech in July 1997. Previous to her tenure at Caltech she was Dean for Science and Professor of Biology at New York University, Professor of Microbiology and Molecular Genetics at Harvard Medical School and Director, Laboratories of Infectious Disease at Boston Children's Hospital. She also served as director of Virus-Host Interactions in Cancer for 15 years, a training program at Harvard funded by the National Cancer Institute. Dr. Huang has served on the Board of Trustees of the Keck Graduate Institute since 1998 and has previously served on the Board of Trustees of Waksman Foundation for Microbiology, the Rockefeller Foundation, Public Agenda, Johns Hopkins University, the Health Effects Institute, and the University of Massachusetts. Dr. Huang has served on the advisory board of the Schlesinger Library at Radcliffe Institute since 2018. She has previously served on the advisory boards of the National Foundation for Infectious Diseases, the US Army Medical Research and Development Command and Food and Drug Administration. She has been a fellow of the American Association of Women in Science since 1978, American Academy of Microbiology since 1982, Academia Sinica in Taiwan since July 1990, and the American Association for the Advancement of Science since 2000, serving as its president from 2010 to 2011. Dr. Huang received her B.A., M.A. and Ph. D. degrees from the Johns Hopkins University. Our Nominating and Corporate Governance Committee believes that Dr. Huang is qualified to serve on our Board of Directors due to the many years she has spent in scientific academia, which has provided her with a deep understanding of our scientific activities.
 Preston S. Klassen, M.D. Dr. Klassen has served on our Board of Directors and as our President and Head of Research and Development since June 2023. Dr. Klassen previously served as President and Chief Operating Officer of Zura Bio Limited from February to April 2023. From June 2020 to February 2023, Dr. Klassen served as President and Chief Executive Officer and as a member of the Board of Directors of Metacrine, Inc., a biopharmaceutical company. From March 2017 to June 2020, Dr. Klassen served as Executive Vice President, Head of Research and Development and Chief Medical Officer of Arena Pharmaceuticals, Inc., a biopharmaceutical company. From June 2016 to March 2017, he was Chief Medical Officer of Laboratoris Sanifit S.L., a biotechnology company, and prior to that, from November 2009 to May 2016, was Executive Vice President, Head of Global Development at Orexigen Therapeutics, Inc. Dr. Klassen also held several positions of increasing responsibility at Amgen Inc., including Therapeutic Area Head for Nephrology. Before joining Amgen, he was a faculty member in the Division of Nephrology at Duke University Medical Center. From February 2014 to May 2020, Dr. Klassen served on the board of directors of Conatus Pharmaceuticals Inc., a publicly traded biotechnology company that merged with Histogen Inc. in May 2020. Dr. Klassen holds a B.S. in Chemistry from Central University of Iowa. Dr. Klassen received his medical degree from the University of Nebraska College of Medicine and completed his residency in internal medicine, fellowship in nephrology, and Master of Health Sciences degree at Duke University. Our Nominating and Corporate Governance Committee believes that Dr. Klassen's expertise in nephrology, business development, commercialization and research and development qualify him to serve on our Board of Directors.
 Jake R. Nunn has served on our Board of Directors since June 2019. Since June 2024, Mr. Nunn has served as a Venture Partner with SR One Capital Management, a life-science focused venture capital firm and previously served as a Venture Partner from January 2023 to June 2024. Previously, Mr. Nunn was a venture advisor at New Enterprise Associates, Inc. ("NEA"), a venture capital firm, where he was a partner from June 2006 until January 2019. Prior to joining NEA, he served as a partner and an analyst for the MPM BioEquities Fund, a life sciences fund at MPM Capital, L.P., a private equity firm. Previously, he was a healthcare research analyst and portfolio manager at Franklin Templeton Investments and an investment banker with Alex Brown & Sons. Mr. Nunn has served on the board of directors of Zenas Biopharma, a publicly-held biopharmaceutical company focused on immune disorders since May 2024, Addex Therapeutics Ltd., a publicly-held biopharmaceutical company focused on allosteric modulators for neurological disorders since June 2018. Mr. Nunn served on the board of directors of Trevena, Inc., a publicly held biotechnology company focused on the central nervous system from July 2013 to October 2024, Oventus Medical Ltd., a publicly held medical device company from February 2020 until September 2023 and Hexima Limited, a publicly-held biopharmaceutical company focused on novel anti-fungals from September 2021 until June 2022. Mr. Nunn also served on the board of directors of Dermira, Inc., a publicly held biopharmaceutical company focused on dermatology, from May 2011 until its acquisition by Eli Lilly and Company in February 2020. From 2009 to May 2015, Mr. Nunn served on the board of directors of Hyperion Therapeutics, Inc. and from 2008 to February 2016, Mr. Nunn served on the board of directors of TriVascular Technologies, Inc. Mr. Nunn received his A.B. in economics from Dartmouth College and his M.B.A. from the Stanford Graduate School of Business. He also holds the Chartered Financial Analyst designation and is a member of the CFA Society of San Francisco. Our Nominating and Corporate Governance Committee believes that Mr. Nunn is qualified to serve on our Board of Directors due to his extensive financial experience, his experience in investment banking and his corporate governance experience with various boards.
 William H. Rastetter, Ph. D. has served on our Board of Directors since April 2013. Dr. Rastetter is co-founder and Chairman of the non-profit, San Diego Squared, that focuses on preparing students from underserved communities for careers in STEM. From 2006 to February 2013, Dr. Rastetter served as a partner in the venture capital firm, Venrock. He served as Chief Executive Officer of IDEC Pharmaceuticals Corp. ("IDEC Pharmaceuticals") from December 1986 through November 2003, and as Chair from May 1996 to November 2003. Upon the merger of IDEC Pharmaceuticals and Biogen Inc. in November 2003, Dr. Rastetter served as Executive Chair of Biogen Idec until the end of 2005. Dr. Rastetter served as Chair of the board of Illumina, Inc., a publicly held biotechnology

company, from 2005 to January 2016 and served on its board of directors from 1998 to January 2016. He was a founder of Receptos, Inc. in 2009 and served as its Chair until the sale of the publicly held company to Celgene Corporation in 2015. Currently, he has served as the Chair of the board of directors of Fate Therapeutics, Inc., a publicly held biotechnology company, since November 2011; Chair of the board of directors of Neurocrine Biosciences, Inc., a publicly held biotechnology company, since May 2011 and on its board of directors since February 2010. He has served on the board of Iambic, a privately held company developing medicinal agents using proprietary artificial intelligence, since May 2023. Dr. Rastetter served on the board of directors of Grail, Inc., a privately held company, from January 2016 through its acquisition by Illumina in August 2021, and as its Chair from August 2017 to November 2018. Dr. Rastetter served on the board of directors of Cerulean Pharma Inc. ("Cerulean"), a publicly held biotechnology company since January 2014, as its lead independent director from April 2014 to June 2016, and as its Chair from June 2016 until July 2017 when Cerulean and Dar Bioscience Inc. completed a reverse merger and he currently serves as Chair of the board of the surviving company, Dar Bioscience Inc., a publicly-traded company. In addition, he serves as an advisor to Illumina Ventures. He is the author of numerous scientific papers and patent applications in the fields of organic and bioorganic chemistry, protein and enzyme engineering, and biotechnology. Dr. Rastetter holds an S.B. in Chemistry from the Massachusetts Institute of Technology and received his M.A. and Ph. D. in Chemistry from Harvard University. Our Nominating and Corporate Governance Committee believes that Dr. Rastetter's knowledge and expertise regarding the biotechnology industry and his leadership experience on various biotechnology company boards of directors qualifies him to serve on our Board of Directors.
 Hugh Rosen, M.D., Ph. D. has served on our Board of Directors since June 2016. Dr. Rosen has served as a professor at the Scripps Research Institute of La Jolla ("TSRI") since 2002 and as its Chair of Molecular and Cellular Biology since August 2023. From April 2017 until March 2023, Dr. Rosen served as the President and Chair of the Board of ActivX Biosciences, Inc., a wholly owned biopharmaceutical subsidiary of Kyorin Pharmaceutical Co., Ltd. Prior to joining TSRI, Dr. Rosen served in various capacities with Merck Research Laboratories most recently serving as Executive Director in Immunology, Rheumatology and Infectious Diseases and Chair of the Worldwide Business Strategy Team for Antibacterials and Antifungals, reporting to the Management Committee. Dr. Rosen was a scientific founder of Receptos, Inc., now a wholly owned biopharmaceutical subsidiary of Celgene Corporation, and of BlackThorn Therapeutics, now Neumora Therapeutics, Inc., a publicly held biopharmaceutical company. He received his M.D. from the University of Cape Town, South Africa and his Ph. D. in Physiological Sciences from Oxford. Our Nominating and Corporate Governance Committee believes that Dr. Rosen is qualified to serve on our Board of Directors due to the many years Dr. Rosen has spent in scientific academia as well as the biopharmaceutical industry, which has provided him with a deep understanding of our industry and our activities.
 Pascale Witz, MBA, MSc has served on our Board of Directors since June 2017. Ms. Witz is the founder and since November 2016, the president of PWH Advisors, a consultancy firm advising management at life science companies and investment firms. From September 2015 through May 2016, Ms. Witz served as the Executive Vice President, Diabetes & Cardiovascular for Sanofi, S.A. ("Sanofi"). Prior to that position, Ms. Witz served as the Executive Vice President, Global Divisions and Strategic Development, commencing in July 2013. During her tenure at Sanofi, she launched multiple medicines across three continents, and strengthened the pipeline through licensing and partnerships. From 2009 to 2013, Ms. Witz served as President and CEO of General Electric's ("GE") Pharmaceutical Diagnostics, an integrated pharmaceutical organization. Ms. Witz joined GE Healthcare in 1996, where she held various positions of increasing responsibilities and lead global businesses based out of the USA, France and the UK. She formerly worked for Becton Dickinson Pharmaceutical Systems from 1991 to 1996. Ms. Witz has served on the board of Fresenius Medical Care AG, since May 2016, and Revvity, Inc. (formerly PerkinElmer, Inc.), since October 2017. Ms. Witz also served on the board of Horizon Therapeutics from August 2017 until its acquisition by Amgen, Inc. in October 2023, TESARO, Inc., from May 2018 until its acquisition by GlaxoSmithKline plc in January 2019, and Savencia SA from May 2016 to April 2018. Ms. Witz received her MBA from INSEAD, Fontainbleu, France and her M.S. in Biochemistry from the Institut National des Sciences Appliqu es (INSA), Lyon, France. She was also previously a Ph. D. student in Molecular Biology at the Centre National de la Recherche Scientifique, Strasbourg, France from 1989 to 1991. Our Nominating and Corporate Governance Committee believes that Ms. Witz is qualified to serve on our Board of Directors due to her knowledge, expertise and prior employment in the pharmaceutical industry and her experience on other company boards, which has provided her with a deep understanding of our industry and our activities.

 Audit Committee
 Our Board of Directors has a standing Audit Committee established in accordance with Section 3(a)(58)(A) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). Our Audit Committee is currently composed of three directors: Ms. Collier (who Chairs the Audit Committee), Mr. Nunn and Dr. Papadopoulos. Our Board of Directors has adopted a written charter of the Audit Committee that is available to stockholders on the Company's website at www.regulusrx.com. Our Board of Directors reviews the Nasdaq listing standards definition of independence for Audit Committee members on an annual basis and has determined that all members of our Audit Committee are independent (as independence is currently defined in Rule 5605(c)(2)(A) of the Nasdaq listing standards).
 Our Board of Directors has determined that Ms. Collier qualifies as an "audit committee financial expert," as defined in applicable SEC rules. Our Board of Directors has made a qualitative assessment of Ms. Collier's level of knowledge and experience based on a number of factors, including her formal education, her experience in the investment banking industry and as the holder of various positions with responsibility for finance of a subsidiary of a major publicly traded energy services holding company.

 EXECUTIVE OFFICERS

 The following table sets forth our current executive officers, their ages, and the positions held by each such person with the Company:

 Name

 Age

 Position Held With the Company

 Chief Executive Officer

 President and Head of Research & Development

 Chief Financial Officer

 Christopher Aker

 Senior Vice President and General Counsel

 The biographical information for Mr. Hagan and Dr. Klassen is set forth above under the heading "Board of Directors."
 Christopher Aker

has served as our Senior Vice President and General Counsel since January 2019, and before that served as our Senior Director, Legal Affairs from February 2011 to January 2019. Prior to joining us, Mr. Aker served as the Senior Director, Administration and Senior Corporate Counsel for Phenomix Corporation ("Phenomix"), a privately held biopharmaceutical company, and was responsible for operational and legal oversight. Prior to Phenomix, Mr. Aker was Senior Corporate Counsel at SUGEN, Inc. ("SUGEN"), a wholly- owned subsidiary of Pharmacia, until its acquisition by Pfizer Inc. Prior to SUGEN, Mr. Aker was in private practice with various law firms. Mr. Aker received his B.A. in International Relations from the University of California, Davis and his J.D. from Santa Clara University.

joined Regulus in August 2019 and currently serves as our Chief Financial Officer. Prior to joining us, she served as Chief Financial Officer for Sanifit Therapeutics, S.A. ("Sanifit") from December 2017 to August 2019. Prior to her employment with Sanifit, Ms. Calsada was self-employed as a finance consultant to various life sciences companies. From 2004 until its acquisition in 2015, she served in positions of increasing responsibility with Ambrx, Inc. ("Ambrx"), most recently serving as its Chief Operating Officer and Vice President of Finance. Prior to Ambrx, she worked for Sony Online Entertainment as its Executive Director of Finance and Controller. Earlier in her career, she practiced as a certified public accountant. Ms. Calsada received a B.S. in Business Administration with emphasis in Accounting from San Diego State University and an M.B.A. from the University of Southern California Marshall School of Business.
 CODE OF ETHICS

 The Company has adopted a Code of Business Conduct and Ethics that applies to all directors, officers (including our principal executive officer, principal financial officer and principal accounting officer) and employees. The Code of Business Conduct and Ethics is available on the Company's website at www.regulusrx.com under the Corporate Governance section of our Investor Relations page. If the Company makes any substantive amendments to the Code of Business Conduct and Ethics that applies to our principal executive officer, principal financial officer, principal accounting officer, controller or persons performing similar functions, or grants any waiver from a provision of the Code of Business Conduct and Ethics to any of these specified individuals that is required to be disclosed pursuant to SEC rules and regulations, the Company will promptly disclose the nature of the amendment or waiver on its website.
 FAMILY RELATIONSHIPS

 Except for David Baltimore, Ph. D. and Alice S. Huang, Ph. D., who are spouses, there are no family relationships between any of our directors or executive officers.
 INSIDER TRADING POLICY; HEDGING POLICY

 We have adopted an Insider Trading and Window Period Policy governing the purchase, sale, and/or other dispositions of the Company's securities by directors, officers and employees that is designed to promote compliance with insider trading laws, rules and regulations, as well as procedures designed to further the foregoing purposes. A copy of our Insider Trading and Window Period Policy is filed as an exhibit to our Original Filing. In addition, it is the Company's intent to comply with applicable laws and regulations relating to insider trading.

 The Company's Insider Trading and Window Period Policy also provides that no officer, director, other employee or consultant of the Company may engage in short sales, transactions in put or call options, hedging transactions or other inherently speculative transactions with respect to the Company's stock at any time. In addition, no officer, director, other employee or consultant of the Company may margin, or make any offer to margin, any of the Company's stock, including without limitation, borrowing against such stock, at any time.

 Item 11.

 Executive Compensation

 EXECUTIVE COMPENSATION
 The Company is a "smaller reporting company" under Item 10 of Regulation S-K promulgated under the Exchange Act, and the following compensation disclosure is intended to comply with the requirements applicable to smaller reporting companies.
 Named Executive Officers. The following individuals are our "Named Executive Officers" or "NEOs" for the year ended December 31, 2024:

 •

 Joseph P. Hagan, our Chief Executive Officer;

 •

 Preston S. Klassen, M.D., our President and Head of Research & Development; and

 •

 Cris Calsada, our Chief Financial Officer.

 Summary Compensation Table for Fiscal Year 2024
 The following table shows compensation awarded to, paid to, or earned by, the Named Executive Officers for the years indicated.

 Name

 Year

 Salary
($)

 Stock
Awards
($) (1)

 Option
Awards
($) (2)

 Non Equity
Incentive Plan
Compensation
($) (3)

 All Other
Compensation
($) (4)

 Total ($)

 2024

 640,440

 161,200

 2,657,159

 422,644

 —

 3,881,443

 Chief Executive Officer

 2023

 615,800

 88,000

 1,528,091

 332,532

 9,900

 2,574,323

 Preston S. Klassen, M.D. (5)

 2024

 494,000

 78,000

 1,404,127

 266,760

 —

 2,242,887

 President and Head of Research & Development

 2024

 425,000

 54,600

 1,208,262

 233,750

 10,350

 1,931,962

 Chief Financial Officer

 2023

 390,000

 33,300

 455,674

 179,400

 9,900

 1,068,274

 (1)

 In accordance with SEC rules, this column reflects the aggregate grant date fair value of the restricted stock units ("RSUs") granted during the years indicated, computed in accordance with Financial Accounting Standard Board ASC Topic 718 for stock-based compensation transactions ("ASC 718"). These amounts do not reflect the actual economic value that will be realized by the Named Executive Officer upon the vesting of the RSU or the sale of the common stock underlying such stock awards. The grant date fair value of time-based restricted stock unit awards are based on the market price of the stock on the grant date. The grant date fair value of the RSUs granted during 2023 and 2024 that vest based on performance conditions is reported based on the probable outcome of such performance conditions, as determined in accordance with ASC 718, which is the same as the grant date fair value of such awards at the grant date, assuming that the highest level of performance conditions will be achieved.

 (2)

 In accordance with SEC rules, this column reflects the aggregate grant date fair value of stock options granted during the years indicated, computed in accordance with ASC 718. Assumptions used in the calculation of these amounts are included in Note 10 to the Financial Statements in our Annual Report on Form 10-K for the year ended December 31, 2024. These amounts do not reflect the actual economic value that will be realized by the Named Executive Officer upon the exercise of the stock options, or the sale of the common stock underlying such stock options.

 (3)

 Amounts shown include annual performance bonuses paid to Mr. Hagan, Dr. Klassen and Ms. Calsada, earned for the years indicated. For more information, see below under "Annual Performance-Based Bonus Opportunity."

 (4)

 Amounts shown represent 401(k) plan matching contributions.

 (5)

 Dr. Klassen commenced his employment with the Company on June 12, 2023 and was not a Named Executive Officer in 2023.

 Narrative Disclosure to Summary Compensation Table
 The three principal components of our executive compensation program for our Named Executive Officers in 2024 were base salary, annual performance-based (cash) bonus opportunity and equity compensation. We do not have any formal policies for allocating compensation among salary, performance bonus awards and equity grants, short-term and long-term compensation or among cash and non-cash compensation. Instead, the Compensation Committee uses its judgment to establish a total compensation program for each Named Executive Officer that is a mix of current, short-term and long-term incentive compensation, and cash and non-cash compensation, that it believes appropriate to achieve the goals of our executive compensation program and our corporate objectives. In line with our pay for performance philosophy, we structured a significant portion of our Named Executive Officers' 2024 compensation to be variable, at risk and tied directly to our measurable performance in the form of performance-based bonuses and equity incentives.
 Pay for Performance/At-Risk Pay
 Our executive compensation program is designed to reward achievement of the specific strategic goals that we believe will advance our business strategy and create long-term value for our stockholders. Consistent with our goal of attracting, motivating and retaining a high-caliber executive team, our executive compensation program is designed to pay for performance. We utilize compensation elements that meaningfully align our NEOs' interests with those of our stockholders to create long-term value. As such, a significant portion of our Chief Executive Officer's and other executive officers' compensation is "at-risk", performance-based compensation, in the form of long-term equity awards (including, in 2024, performance-vesting equity awards) and annual cash incentives that are only earned if we achieve measurable corporate metrics.
 Base Salary
 In December 2023, the Compensation Committee reviewed the base salaries for our Named Executive Officers, the market data from Aon/Radford, our 4% Company-wide corporate merit increase target for base salaries, the scope of each executive's responsibilities for 2023, each executive's prior experience and internal pay equity in order to determine 2024 base salaries of our NEOs. In addition, Ms. Calsada's salary was increased to more closely align with the 25th percentile of base salary for positions similar to that at the Company's peer companies.
 The Named Executive Officers' 2024 annual base salaries (effective January 1, 2024) and increases from 2023 annual base salaries approved by the Compensation Committee (or the Board of Directors, with respect to Mr. Hagan) were as follows:

 Name

 2024 Base Salary
($)

 Increase from 2023 Base
Salary (%)

 640,440

 4.0

 %

 494,000

 4.0

 %

 425,000

 8.9

 %

 The annual base salaries for Mr. Hagan, Dr. Klassen and Ms. Calsada were increased, effective January 1, 2025, to $666,016, $513,760 and $442,000, respectively.
 Annual Performance-Based Bonus Opportunity
 The annual performance-based (cash) bonus each Named Executive Officer is eligible to receive is based on (1) the individual's target bonus, as a percentage of base salary, (2) a Company-based performance factor ("CPF"), and (3) an individual performance factor ("IPF"). The actual performance-based bonus paid, if any, is calculated by taking into consideration the executive officer's annual base salary, target bonus percentage, percentage attainment of the CPF and percentage attainment of the IPF.

 Each Named Executive Officer's target bonus for 2024, represented as a percentage of base salary, or a target bonus percentage, was 50% of base salary, with the exception of Mr. Hagan, which was 60% of base salary. The Compensation Committee determined that the target bonuses of each of our NEOs, other than our Chief Executive Officer, should be consistent to promote internal equity and reinforce teamwork across our leadership team.
 Except for the Chief Executive Officer whose entire annual bonus depends upon the CPF, 80% of each NEO's annual bonus is dependent upon the CPF, with the remaining 20% dependent upon such individual's IPF.
 At the end of the year, our Compensation Committee approves the extent to which we achieved the CPF based on the achievement of the applicable annual corporate goals. The extent to which each individual Named Executive Officer achieves his or her IPF is determined based on our Chief Executive Officer's review and recommendation to our Compensation Committee. Our Compensation Committee makes the final decisions with respect to each IPF.
 Additionally, our Compensation Committee has the discretion to determine the weighting of each of the goals that comprise the CPF and IPF. Our Compensation Committee may award a bonus in an amount above or below the amount resulting from the calculation described above, based on other factors that our Compensation Committee determines, in its sole discretion, are material to our corporate performance and provide appropriate incentives to our executives; for example, based on events or circumstances that arise after the original CPF and IPF goals are set.
 The CPF and IPF goals are determined by our Compensation Committee and communicated to our Named Executive Officers each year, prior to or shortly following the beginning of the year to which they relate. The CPF is composed of several goals that relate to our annual corporate goals and various business accomplishments which vary from time to time depending on our overall strategic objectives. The IPF is composed of factors that relate to each Named Executive Officer's ability to drive his or her own performance and the performance of his or her direct employee reports towards reaching our corporate goals. The proportional emphasis placed on each goal within the CPF and IPF may vary from time to time depending on our overall strategic objectives and our Compensation Committee's subjective determination of which goals have more impact on our performance.
 For 2024, the CPF goals related primarily to advancing our most promising program, farabursen (formerly RGLS8429) for the treatment of autosomal dominant polycystic kidney disease ("ADPKD") in the clinic, while also making progress on our preclinical pipeline. The specific 2024 CPF goals were as follows:
 Goals Related to our Lead Clinical Program of farabursen in ADPKD:

 •

 Complete the weight-based cohorts of our Phase 1b Multiple Ascending Dose Study ("MAD") in ADPKD by the end of Q3 2024.

 •

 Successful completion of our End of Phase 1 meeting with the U.S. Food and Drug Administration ("FDA") in December 2024.

 •

 Perform Phase 3 readiness activities to commence the Phase 3 of the ADPKD program in 2025.

 Goals related to our Preclinical Pipeline:

 •

 Advance our research pipeline for the top central nervous system ("CNS") programs and other kidney indications.

 Goals related to our operations:

 •

 Secure additional financing to extend case runway at least three months beyond the End of Phase 1 meeting with FDA.

 In January 2025, after careful review, our Board of Directors, upon the recommendation of our Compensation Committee, concluded that we had exceeded our goals and awarded a CPF of 110%, based on the following:

 •

 We completed the weight-based cohorts in our Phase 1 clinical study in ADPKD ahead of schedule and the resulting data demonstrated encouraging results consistent with our understanding of PC1 and PC2 in preclinical models.

 •

 We successfully completed our End of Phase 1 meeting with the FDA, reaching alignment with it regarding the acceptability of the farabursen program's manufacturing, non-clinical and clinical pharmacology plans and key components of a Phase 3 trial design as a single pivotal study.

 •

 We completed our planned Phase 3 readiness activities including completing an upsized enrollment of the fourth cohort of patients in our Phase 1b which provided further confidence in the fixed dose selected for the Phase 3; made improvements in our process development for farabursen and completed our CMC readiness activities to support Phase 3 commencement.

 •

 We successfully advanced our preclinical pipeline for CNS and other kidney indications, completing key pre-clinical proof-of-concept studies and non-GMP toxicology studies with lead development candidates.

 •

 Following the successful outcome of our second cohort in the Phase 1b farabursen study, we were able to raise an additional $100 million in an over-subscribed private placement, providing us funds into 2026 and exceeding the goal of three months of cash post End of Phase 1 meeting.

 The IPF goals varied by individual and included individual performance contributions towards accelerating our development of farabursen, advancing our preclinical pipeline and supporting our growth with additional capital, fostering a culture of value creation, attracting and retaining key talent and building good processes and policies.
 Based on our Chief Executive Officer's recommendations and our Compensation Committee's deliberations with respect to each Named Executive Officer's individual performance against the IPF, our Compensation Committee and Board of Directors approved a performance-based bonus for each of our Named Executive Officers as set forth in the table below based on a 110% CPF achievement and the achievement of IPF as indicated in the table below:

 Name

 Target Bonus ($)

 IPF Achievement (%)

 Cash Bonus Paid ($)

 $

 384,240

 —

 $

 422,644

 Preston S. Klassen, M.D. (1)

 $

 247,000

 %

 $

 266,760

 Cris Calsada (2)

 $

 212,500

 %

 $

 233,750

 (1)

 Dr. Klassen's performance-based bonus was approved based on 110% CPF and 100% IPF in recognition of his leadership of the development teams responsible for execution on the farabursen Phase 1b multiple ascending dose clinical study, his leadership of our regulatory team resulting in a successful End of Phase 1 meeting with FDA and his leadership of our preclinical teams resulting in advancement of those programs toward clinical development.

 (2)

 Ms. Calsada's performance-based bonus was approved based on the 110% CPF and 110% IPF in recognition of her leadership in securing the financing in March 2024, financial oversight of and strategic input on our ongoing farabursen development activities and managing personnel associated with manufacturing.

 Equity-Based Incentive Awards
 The Compensation Committee believes equity incentives motivate executive officers to achieve our business objectives by tying incentives to the appreciation of our common stock and, in the case of performance-vesting awards, measurable performance goals. In the recent past, we have primarily granted equity awards in the form of RSUs that vest based on achievement of specific Company performance goals. As part of our annual grants to NEOs, the Compensation Committee granted performance-vesting RSUs in addition to time-vesting stock options. In addition, on May 20, 2024 following our 2024 Annual Meeting of Stockholders wherein our stockholders voted in favor of a proposal to increase the aggregate number of shares available under our 2019 Equity Incentive Plan ("2019 Plan"), we made an additional grant of time-vesting stock options to all employees and additional performance-vesting stock option grants to our executive team, including our NEOs. The additional grants were made to enable us to have a competitive equity incentive program to compete with our peer group for key talent.
 2024 Stock Option Awards and RSUs. In 2024, each of our Named Executive Officers were granted time-vesting stock options, performance-vesting RSUs and performance-vesting stock options in the amounts listed below.

 Name

 Time-Vesting Stock Options(# of shares) (1)

 Performance-Vesting RSUs(# of shares) (2)

 Performance-Vesting Stock Options (# of shares) (3)

 1,239,000

 124,000

 510,000

 648,000

 60,000

 272,000

 547,000

 42,000

 238,000

 (1)

 Consists of (a) stock options in the amounts of 249,000 to Mr. Hagan, 120,000 to Dr. Klassen and 85,000 to Ms. Calsada granted on January 12, 2024 at an exercise price of $1.30 per share and (b) stock options in the amounts of 990,000 to Mr. Hagan, 528,000 to Dr. Klassen and 462,000 to Ms. Calsada granted on May 20, 2024 at an exercise price of $2.01 per share. Each such option vests in equal monthly installments over a 48 month period following either January 12, 2024 (for options granted on January 12, 2024) or May 20, 2024 (for options granted on May 20, 2024), subject to the recipient's Continuous Service (as defined in the 2019 Plan) to the Company through each such vesting date.

 (2)

 Consists of a performance-vesting RSU award granted on January 12, 2024. The shares were to commence vesting upon achievement of a specified development goal related to our farabursen program. In order for 100% of the shares to vest, the goal had to be achieved by March 31, 2025. After this date, the percentage of the shares that are eligible to vest would be reduced, and if not achieved by December 31, 2025, the award would be cancelled in its entirety. On January 9, 2025, the Compensation Committee concluded the goal had been achieved and vesting of the shares commenced. Fifty percent of the shares subject to the award immediately vested upon achievement with the remaining shares vesting on the first anniversary of the vesting commencement date, subject to the recipient's Continuous Service (as defined in the 2019 Plan) to the Company through such vesting date.

 (3)

 Consists of a performance-vesting stock option award granted on May 20, 2024 at an exercise price of $2.01 per share. The shares will commence vesting only upon achievement of a specified development goal related to our farabursen program. Once the development goal is achieved, 50% of the shares subject to the grant will immediately vest with the remaining 50% vesting in equal monthly installments over the 24 months following the vesting commencement date, subject to the recipient's Continuous Service (as defined in the 2019 Plan) to the Company through each such vesting date.

 Other Compensation
 Our Named Executive Officers are eligible to participate in all of our employee benefit plans, including our medical, dental, vision, group life and disability insurance plans, in each case on the same basis as other employees. We also pay the premiums for term life insurance and long-term disability for all of our employees, including our Named Executive Officers. None of our Named Executive Officers participate in or have account balances in qualified or non-qualified defined benefit plans sponsored by us. We generally do not provide perquisites or personal benefits to our Named Executive Officers, although we may from time to time provide reasonable benefits as our Compensation Committee determines appropriate.
 All of our full-time employees in the United States, including our Named Executive Officers, are eligible to participate in our 401(k) plan, which is a retirement savings defined contribution plan established in accordance with Section 401(a) of the Internal Revenue Code of 1986, as amended (the "Code"). Pursuant to our 401(k) plan, employees may elect to defer their eligible compensation into the plan on a pre-tax basis, up to the statutorily prescribed annual limit under the Code, and to have these amounts contributed to our 401(k) plan. In 2024, we provided a $0.50 match for every dollar our employees elected to defer up to 6% of their eligible compensation. In general, eligible compensation for purposes of the 401(k) plan includes an employee's wages, salaries, fees for professional services and other amounts received for personal services actually rendered in the course of employment with us to the extent the amounts are includible in gross income, and subject to certain adjustments and exclusions required under the Code. The 401(k) plan currently does not offer the ability to invest in our securities.
 Agreements with Named Executive Officers
 Employment Agreements. We have entered into employment agreements with each of our Named Executive Officers, each of which provides for at-will employment and are described below.
 Employment Agreement with Mr. Hagan. We previously entered into an employment agreement with Mr. Hagan, with an effective date of January 1, 2016. Pursuant to his employment agreement, Mr. Hagan is entitled to receive an annual base salary and is eligible to earn an annual performance bonus.
 Employment Agreement with Dr. Klassen. In June 2023, we entered into an employment agreement with Dr. Klassen. Pursuant to his employment agreement, Dr. Klassen is entitled to receive an annual base salary and is eligible to earn an annual performance bonus.
 Employment Agreement with Ms. Calsada. In August 2019, we entered into an employment agreement with Ms. Calsada upon her commencement of employment as our Chief Financial Officer. Pursuant to her employment agreement, Ms. Calsada is entitled to receive an annual base salary and is eligible to earn an annual performance bonus.
 Change in Control and Severance Benefits
 Under the terms of the employment agreements with each of our Named Executive Officers described above, either we or the executive may terminate the executive's employment at any time. Each of our Named Executive Officers is eligible, under the terms of his or her respective employment agreement, to receive, in exchange for a release of claims, severance benefits upon the termination of employment either by us without cause or by the executive for good reason, with additional severance benefits provided in the event the termination is in connection with a change in control.
 If we terminate a Named Executive Officer's employment "without cause" (other than due to his/her death or complete disability) or if the Named Executive Officer resigns for "good reason" at any time other than during the period beginning one month before and ending 12 months following a change in control, the Named Executive Officer will receive, subject to our receiving an effective release and waiver of claims, (1) 12 months (or 18 months for the Chief Executive Officer) of such Named Executive Officer's then-current base salary (disregarding any decrease that forms the basis for a resignation for good reason) paid in a lump sum (with respect to Mr. Hagan and Ms. Calsada) or installments (with respect to Dr. Klassen), (2) a lump sum cash amount equal to 229.56% multiplied by the total cost of the projected premiums for group medical, dental and vision insurance for a period of 12 months (or 18 months for the Chief Executive Officer) and (3) vesting acceleration of all outstanding options and other equity incentive awards subject to time-vesting held by the Named Executive Officer as of such termination or resignation.

 If we terminate a Named Executive Officer's employment without cause (other than due to his/her death or complete disability) or if the Named Executive Officer resigns for good reason, in each case during the period beginning one month before and ending 12 months following a change in control, in addition to the severance payment described above, we will also be obligated to pay, subject to receiving an effective release and waiver of claims, a lump sum payment equal to the target amount of the Named Executive Officer's annual performance bonus for the year of termination or resignation.
 In addition, pursuant to each Named Executive Officer's employment agreement, all outstanding stock options subject to vesting based on Company performance that are held by such Named Executive Officer immediately before a change in control shall become fully vested and exercisable as of immediately before, and contingent upon, the change in control, provided that such Named Executive Officer remains employed by us as of such date. These options are described below in the table entitled Outstanding Equity Awards at Fiscal Year-End.
 Additionally, the terms of the equity awards granted to our Named Executive Officers are subject to the terms of our equity plans and award agreements thereunder, which includes accelerated vesting provisions upon certain material change in control transactions. We do not provide any excise tax gross-ups on change-in-control benefits.

 Outstanding Equity Awards at 2024 Fiscal Year-End
 The following table shows certain information regarding outstanding equity awards as of December 31, 2024, for the Named Executive Officers:

 Option Awards (1)

 Stock Awards

 Name

 Grant Date

 Vesting
Commencement
Date

Securities
Underlying
Unexercised
Stock
Options (#)
Exercisable

Securities
Underlying
Unexercised
Stock Options
(#)
Unexercisable

 Equity
Incentive
Plan
Awards:
Securities
Underlying
Unexercised
Unearned
Options (#)

 Option
Exercise
Price
($)

 Option
Expiration
Date

 Equity
Incentive
Plan
Awards:
of
Shares
or Units
of Stock
That
Have
Not
Vested
(#)

 Equity
Incentive
Plan
Awards:
Market
Value
of
Shares
or
Units of
Stock
That
Have
Not
Vested
($)

 2/5/2019

 (2)

 1/1/2019

 6,500

 9.50

 2/4/2029

 2/5/2019

 (3)

 5/14/2019

 1,000

 9.50

 2/4/2029

 10/10/2019

 (2)

 10/10/2019

 99,999

 6.40

 10/9/2029

 (2)

 1/1/2020

 90,000

 13.10

 (4)

 5/10/2022

 29,999

 13.10

 29,999

 (10)

 13.10

 2/4/2021

 (2)

 1/1/2021

 58,750

 1,250

 15.90

 2/3/2031

 1/12/2022

 (2)

 1/1/2022

 116,669

 43,331

 2.60

 1/11/2032

 1/11/2023

 (2)

 1/1/2023

 47,916

 52,084

 1.48

 1/20/2033

 1/11/2023

 (7)

 30,000

 47,400

 (2)

 437,499

 875,001

 1.36

 8/09/2033

 (5)

 437,500

 691,250

 (2)

 1/1/2024

 57,062

 191,938

 1.30

 1/11/2034

 (5)

 124,000

 195,920

 (2)

 144,375

 845,625

 2.01

 (9)

 437,500

 2.01

 6/12/2023

 (8)

 131,250

 218,750

 1.46

 6/11/2023

 (2)

 75,000

 150,000

 1.36

 8/9/2033

 75,000

 118,500

 (2)

 27,500

 92,500

 1.30

 1/11/2034

 (5)

 60,000

 94,800

 (2)

 77,000

 451,000

 2.01

 (9)

 60,000

 2.01

 8/30/2019

 (6)

 8/30/2019

 10,000

 6.20

 8/29/2029

 10/10/2019

 (2)

 10/10/2019

 21,000

 6.40

 10/9/2029

 (4)

 5,000

 13.10

 5,000

 (10)

 13.10

 (2)

 15,000

 13.10

 2/4/2021

 (2)

 1/1/2021

 14,687

 15.90

 2/3/2031

 1/12/2022

 (2)

 1/1/2022

 34,999

 13,000

 2.60

 1/11/2032

 1/11/2023

 (2)

 1/1/2023

 21,562

 23,438

 1.48

 1/10/2033

 1/11/2023

 (7)

 11,250

 17,775

 (2)

 124,992

 250,008

 1.36

 8/09/2033

 (5)

 125,000

 197,500

 (2)

 1/1/2024

 19,479

 65,521

 1.30

 1/11/2034

 (5)

 42,000

 66,360

 (2)

 5/20/2025

 67,375

 394,625

 2.01

 (9)

 125,000

 2.01

 (1)

 Stock awards granted prior to October 2019 were granted under the 2012 Equity Incentive Plan. Stock awards granted thereafter were granted under the 2019 Plan.

 (2)

 Consists of stock options vesting in equal monthly installments over a 48 month period, subject to the recipient's continued service to the Company through each such vesting date.

 (3)

 Consists of a performance-vesting stock option with an exercise price of $9.50 per share, which only vests upon achievement of a previously specified performance objective. On May 14, 2019, the Board of Directors concluded the Company had met the criteria to commence vesting of the performance-vesting stock option consisting of a Board-approved transaction which the Board, in its sole discretion, determines is reasonably expected to provide adequate cash runway for achievement of the Company's strategic objectives. Because of the achievement of the performance objective, 50% of the shares subject to the grant immediately vested with the remaining shares vesting in equal monthly installments over the following 24 months.

 (4)

 Consists of a performance-vesting stock option with an exercise price of $13.10 per share which only vest upon achievement of a previously specified performance objective related to our most advanced clinical program, and in each case only if achieved by December 31, 2024. Upon achievement of the performance objective, 100% of the shares subject to the grant immediately vest. On May 10, 2022, our Board of Directors concluded the Company had met the criteria to commence vesting of one of the performance-vesting stock option consisting of the submission by the Company of a regulatory filing in support of its clinical program. Because of the achievement of the performance objective, 100% of the shares subject to the grant immediately vested.

 (5)

 Consists of a performance-vesting RSU award which vests only upon achievement of a specified development goal related to our farabursen program, with the number of eligible shares determined based on date of goal achievement. Upon achievement of the goal, 50% of the shares eligible to vest will immediately vest with the remaining shares vesting on the first anniversary of the vesting commencement date, subject to the recipient's continued service to the Company through such vesting date. In January 2025, the Compensation Committee concluded that the goal had been achieved and vesting of the shares commenced.

 (6)

 Consists of a stock option that vests as follows: 25% of the shares subject to the grant vest on the first anniversary of the grant with the remainder vesting in equal monthly installments over a 36 month period, subject to the recipient's continued service to the Company through each such vesting date.

 (7)

 Consists of a performance-vesting RSU which vests only upon achievement of a specified development goal related to our farabursen program. On January 12, 2024, our Compensation Committee concluded the Company had met the criteria to commence vesting of the RSU based upon the Company's full enrollment in Cohort 3 of the Company's clinical study. Because of the achievement of the performance objective, 50% of the shares subject to the goal immediately vested with the remaining to vest on the first anniversary of the vesting commencement date, subject to the recipient's continued service to the Company through such vesting date.

 (8)

 Consists of a stock option that vests as follows: 25% of the shares subject to the grant vest on the first anniversary of the grant date with the remainder vesting in equal monthly installments over a 36 month period, subject to the recipient's continued service to the Company through each such vesting date. This stock award was granted under the 2021 Inducement Plan, which was not approved by the Company's stockholders.

 (9)

 Consists of a performance-vesting stock option which vests only upon achievement of a specified development goal related to our farabursen program. Upon achievement of the goal, 50% of the shares subject to the award will immediately vest with the remaining shares vesting on an equal monthly basis over the 24 months following the vesting commencement date, subject to the recipient's continued service to the Company through each such vesting date.

 (10)

 Consists of performance-vesting stock options which would vest only upon achievement of a specified development goal related to a preclinical program. As the goal was not met before the end of the performance period on December 31, 2024, the grant was cancelled on March 6, 2025.

 Policies and Practices Related to the Grant of Certain Equity Awards Close in Time to the Release of Material Nonpublic Information

 From time to time, the Company grants stock options to its employees, including the Named Executive Officers. Historically, the Company has typically granted new-hire
 option awards on or soon after a new hire's employment start date and promotion option awards on or soon after the employee's promotion date. Annual refresh employee option grants are typically granted in January of each year, with the effective date tied to the effectiveness of the Company's Form S-8
 registration statement registering the shares automatically added to the equity incentive plan on January 1st of each year pursuant to the plan's annual evergreen provision, which grants are typically recommended and approved at regularly scheduled meetings of the Compensation Committee and the Board of Directors in the fourth quarter of the prior fiscal year. Also, non-employee
 directors receive automatic grants of initial and annual stock option awards, at the time of a director's initial appointment or election to the board and at the time of each annual meeting of the Company's stockholders, respectively, pursuant to the non-employee
 director compensation policy, as further described under the heading, "Director Compensation—Non-Employee
 Director Compensation Policy," below. The Company does not otherwise maintain any written policies on the timing of awards of stock options, stock appreciation rights, or similar instruments with option-like features. Because we have a practice of generally granting stock options for new hires, promotions and refresh grants at specified times as described above, the Compensation Committee generally does not take material nonpublic information ("MNPI") into account when determining the timing or terms of stock option awards and generally does not seek to time the award of stock options in relation to the Company's public disclosure of MNPI. For grants made outside of the circumstances described above, the Compensation Committee considers whether there is any MNPI about the Company when determining the timing of stock option grants and does not seek to time the award of stock options in relation to the Company's public disclosure of MNPI. The Company has not timed the release of MNPI for the purpose of affecting the value of executive compensation.

 The following table is provided pursuant to Item 402(x)(2) of Regulation S-K.

 Name
(a)

 Grant
date
(b)

securities
underlying the
award
(c)

 Exercise price of
the award ($/Sh)
(d)

 Grant
date fair value
of the award
(e)

 Percentage change in the
closing market price of the
securities underlying the award
between the trading day ending
immediately prior to the disclosure
of material nonpublic information
and the trading day beginning
immediately following the
disclosure of material nonpublic
information
(f)

 990,000

 $

 2.01

 $

 1,581,612

 0.5

 %

 528,000

 $

 2.01

 $

 843,526

 0.5

 %

 462,000

 $

 2.01

 $

 738,085

 0.5

 %

 The above grants were granted one business day following the Company's filing of a Form 8-K
 to disclose its 2024 annual meeting results. The exercise price for the options granted above is the same as the closing price on the trading day following the filing of such Form 8-K.

 DIRECTOR COMPENSATION
 The following table shows certain information with respect to the compensation of all non-employee directors of the Company for the fiscal year ended December 31, 2024:

 Name

 Fees
Earned
or
Paid in
Cash($) (1)

 Option
Awards
($) (2)(3)(4)

 Total ($)

 David Baltimore, Ph. D.

 48,000

 180,516

 Kathryn J. Collier

 60,000

 192,516

 Alice S. Huang, Ph. D.

 46,000

 178,516

 Jake Nunn

 50,000

 182,516

 Stelios Papadopoulos, Ph. D.

 84,000

 216,516

 William H. Rastetter, Ph. D.

 52,000

 184,516

 Hugh Rosen, M.D., Ph. D.

 46,000

 178,516

 Pascale Witz

 46,000

 178,516

 (1)

 Amounts listed represent cash payments made for service on the Board of Directors or a committee of the Board of Directors which were earned in 2024.

 (2)

 Amounts listed represent the aggregate grant date fair value amount computed as of the grant date of each option awarded during 2024 in accordance with ASC 718. Assumptions used in the calculation of these amounts are included in Note 10 to the Financial Statements in our Annual Report on Form 10-K for the fiscal year ended December 31, 2024.

 (3)

 Represents (i) the annual option grant to purchase 30,000 shares of our common stock granted to each of our non-employee directors serving on May 16, 2024 under our non-employee director compensation policy, as further described below, with grant date fair value equal to $44,025, and (ii) a special option grant to purchase 60,000 shares of our common stock granted to each non-employee director on May 20, 2024, with grant date fair value equal to $88,491. The latter grant is further explained below.

 (4)

 As of December 31, 2024, each non-employee director held outstanding options to purchase 154,975 shares with the exception of Dr. Huang who held 159,000 shares. As of December 31, 2024, none of our non-employee directors held unvested stock awards other than options.

 Non-Employee Director Compensation Policy
 We maintain a non-employee director compensation policy (our "director compensation policy"), that became effective following our initial public offering. Under our director compensation policy as in effect for the year ended December 31, 2024, we provide cash compensation in the form of an annual retainer of $40,000 to each of our non-employee directors (our "Eligible Directors") other than the chair of the Board, to whom we provide a $70,000 cash retainer. We also pay an additional annual retainer of $20,000 to the chair of our Audit Committee, $10,000 to other Eligible Directors who serve on our Audit Committee, $12,000 to the chair of our Compensation Committee, $6,000 to other Eligible Directors who serve on our Compensation Committee, $8,000 to the chair of our Nominating and Corporate Governance Committee and $4,000 to other Eligible Directors who serve on our Nominating and Corporate Governance Committee. We have reimbursed and will continue to reimburse our non-employee directors for travel, lodging and other reasonable expenses incurred in attending meetings of our Board of Directors and committees of our Board of Directors.
 Directors who are also employees do not receive cash or equity compensation for service on our Board of Directors in addition to the compensation payable for their service as our employees.
 Pursuant to our director compensation policy, each Eligible Director who is first elected to our Board of Directors is granted an option to purchase shares and/or RSU awards covering shares of the Company's common stock on the date of his or her initial election to our Board of Directors. Each continuing Eligible Director also receives an annual option grant and/or RSU award at our annual meeting of stockholders. Per the director compensation policy, the Board of Directors will determine the number of shares underlying the awards and the vesting schedules.

 In December 2023, the Board of Directors, upon the recommendation of the Compensation Committee, approved an annual option grant to purchase 30,000 shares to each Eligible Director re-elected at our annual meeting of stockholders in 2024. No recommendation was made for any new Eligible Director as none were expected to be appointed in 2024. In May 2024, the Board of Directors, upon the recommendation of the Compensation Committee, granted a stock option to purchase 60,000 shares to each Eligible Director. The recommendation was made following analysis and recommendations by Aon concerning the total options held by our directors as compared with the Company's peers as a percentage of the Company. In December 2024, the Board of Directors, upon the recommendation of the Compensation Committee, approved an annual option grant to purchase 125,000 shares to each Eligible Director re-elected at our annual meeting of stockholders in 2025.
 Each initial option granted to such Eligible Directors described above will vest and become exercisable with respect to one-third of the shares subject to the option on the first anniversary of the date of grant and the balance of the shares will vest and become exercisable in a series of 24 equal monthly installments thereafter, such that the option is fully vested on the third anniversary of the date of grant, subject to the Eligible Director continuing to provide services to us through such dates. Each annual option granted to such Eligible Directors described above will vest and become exercisable in 12 equal monthly installments such that the option will be fully vested on the first anniversary of the date of grant, or as of the date of the next annual meeting of the Company's stockholders, whichever occurs first and subject to the Eligible Director continuing to provide services to us through such dates. The term of each option granted to an Eligible Director is 10 years and, in general, may remain exercisable with respect to the then-vested shares for up to 12 months following the termination of such Eligible Director's continuous service. All awards granted under our director compensation policy will vest in full upon the closing of a change in control of the Company.

 Item 12.

 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

 SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 The following table sets forth certain information regarding the ownership of the Company's common stock as of March 31, 2025 by: (i) each of our directors; (ii) each of our Named Executive Officers as defined above under the heading "Executive Compensation"; (iii) each person known by us to beneficially own more than 5% of our common stock and (iv) all of our current executive officers and directors as a group.
 Beneficial ownership is determined in accordance with the rules of the SEC and includes voting and investment power with respect to the securities. This table is based upon information supplied by officers, directors and principal stockholders and Schedules 13D and 13G filed with the SEC. Except as indicated by footnote, and subject to applicable community property laws, we believe the persons named in the table have sole voting and investment power with respect to all shares of common stock shown as beneficially owned by them.
 Percentage of beneficial ownership is based on 66,283,250 shares of common stock outstanding as of March 31, 2025. The number of shares of common stock used to calculate the percentage ownership of each listed person includes the shares of common stock underlying shares of convertible preferred stock and warrants and options held by such persons that are exercisable and restricted stock units which will vest, within 60 days following March 31, 2025. Unless otherwise indicated, the address for the persons and entities listed in the table below is c/o Regulus Therapeutics Inc., 4224 Campus Point Court, Suite 210, San Diego, CA 92121.

 Beneficial Ownership

 Beneficial Owner

of Shares

 Percent of
Total

 Greater than 5% Stockholders

 Federated Hermes Kaufmann Funds (1)

 13,274,254

 19.90

 %

 4000 Ericsson Drive
 Warrendale, PA 15086

 Deep Track Biotechnology Master Fund Ltd (2)

 7,002,214

 9.99

 %

 200 Greenwich Ave, 3rd Floor
 Greenwich, CT 06830

 Entities affiliated with New Enterprise Associates, Inc. (3)

 6,646,102

 9.99

 %

 1954 Greenspring Dr., Suite 600
 Timonium Maryland 21093

 Entities affiliated with Octagon Investments Master Fund LP (4)

 6,849,476

 9.99

 %

 654 Madison Avenue, 21st Floor
 New York, NY 10065

 Vivo Opportunity Fund Holdings, L.P. (5)

 5,000,000

 7.55

 %

 192 Lytton Avenue
 Palo Alto, CA 94301

 BlackRock, Inc. (6)

 4,236,569

 6.40

 %

 50 Hudson Yards
 New York, NY 10001

 The Vanguard Group (7)

 3,967,091

 5.99

 %

 100 Vanguard Blvd.
 Malvern, PA 19355

 Named Executive Officers and Directors

 David Baltimore, Ph. D. (8)

 177,144

 *

 Cris Calsada (9)

 543,746

 *

 Kathryn J. Collier (10)

 161,715

 *

 Joseph P. Hagan (11)

 1,790,169

 2.64

 %

 Alice S. Huang, Ph. D. (12)

 156,000

 *

 Preston Klassen, M.D. (13)

 530,449

 *

 Jake R. Nunn (14)

 154,975

 *

 Stelios Papadopoulos, Ph. D. (15)

 1,192,877

 1.79

 %

 William H. Rastetter, Ph. D. (16)

 194,031

 *

 Hugh Rosen, M.D., Ph. D. (17)

 156,746

 *

 Pascale Witz, MBA, MSc (18)

 166,478

 *

 All current executive officers and directors as a group (12 persons) (19)

 8.17

 %

 *

 Less than one percent.

 (1)

 Consists of an aggregate of 12,852,654 shares of common stock and 421,600 shares of common stock issuable upon conversion of Series A-4 convertible preferred stock held collectively by (i) Federated Hermes Kaufmann Small Cap Fund, a portfolio of Federated Hermes Equity Funds ("Federated Hermes Kaufmann Small Cap Fund"), (ii) Federated Hermes Kaufmann Fund, a portfolio of Federated Hermes Equity Funds ("Federated Hermes Kaufmann Fund"), and (iii) Federated Hermes Kaufmann Fund II, a portfolio of Federated Hermes Insurance Series ("Federated Hermes Kaufmann Fund II" and, collectively with the Federated Hermes Kaufmann Small Cap Fund and the Federated Hermes Kaufmann Fund, the "Federated Hermes Kaufmann Funds"). The number of shares beneficially owned by the Federated Hermes Kaufmann Funds in the aggregate is limited by a beneficial ownership limitation applicable to shares of nonvoting Class A-4 convertible preferred stock held by the Federated Hermes Kaufmann Funds, which limit the number of shares the Federated Hermes Kaufmann Funds can beneficially own upon conversion of the Class A-4 convertible preferred stock to a maximum of 19.90% of our outstanding common stock, a beneficial ownership limitation applicable to shares of nonvoting Class A-5 convertible preferred stock held by the Federated Hermes Kaufmann Funds, which limit the number of shares the Federated Hermes Kaufmann Funds can beneficially own upon conversion of the Class A-5 convertible preferred stock to a maximum of 9.99% of our outstanding common stock and a beneficial ownership limitation applicable to shares of our nonvoting Class A-6 convertible preferred stock held by the Federated Hermes Kaufmann Funds, which limit the shares that the Federated Hermes Kaufmann Funds can beneficially own upon conversion of the Class A-6 convertible preferred stock to a maximum of 14.99% of our outstanding stock.

 (2)

 Consists of 3,262,564 shares of common stock and 3,739,650 shares of common stock issuable upon conversion of Class A-6 convertible preferred stock held by Deep Track Biotechnology Master Fund Ltd. ("Deep Track Master Fund"). The number of shares beneficially owned by Deep Track Master Fund in the aggregate is limited by beneficial ownership limitations applicable to shares of Class A-6 convertible preferred stock, which limit the number of shares Deep Track Master Fund can beneficially own to a maximum of 9.99% of our outstanding common stock. Deep Track Capital, LP (the "Investment Manager") serves as the investment manager of Deep Track Master Fund and may be deemed to beneficially own the shares held by Deep Track Master Fund. Deep Track Capital GP, LLC (the "General Partner") is the general partner of the Investment Manager. David Kroin is the Chief Investment Officer of the Investment Manager and managing member of the General Partner and may be deemed to beneficially own the shares held by Deep Track Master Fund.

 (3)

 Consists of 6,467,802 shares of common stock and 178,300 shares of common stock issuable upon exercise of warrants (collectively, the "GEO Shares") held by Growth Equity Opportunities Fund V, LLC ("GEO V"). New Enterprise Associates 16, L.P. ("NEA 16"), is the sole member of GEO V, NEA Partners 16, L.P. ("NEA Partners 16"), is the sole general partner of NEA 16 and NEA 16 GP, LLC ("NEA 16 LLC"), is the sole general partner of NEA Partners 16. Forest Baskett, Ali Behbahani, Carmen Chang, Anthony A. Florence, Jr., Mohamad H. Makhzoumi, Scott D. Sandell and Paul Walker (collectively, the "Managers"), are the managers of NEA 16 LLC. The persons named herein are referred to individually herein as a NEA Reporting Person and collectively as the NEA Reporting Persons. GEO V is the record owner of the GEO V Shares. As the sole member of GEO V, NEA 16 may be deemed to own beneficially the GEO V Shares. As the general partner of NEA 16, NEA Partners 16 may be deemed to own beneficially the GEO V Shares. As the sole general partner of NEA Partners 16, NEA 16 LLC may be deemed to own beneficially the GEO V Shares. Each of the Managers of NEA 16 LLC may be deemed to own beneficially the GEO V Shares. The number of shares beneficially owned by the NEA Reporting Persons in the aggregate is limited by beneficial ownership limitations applicable to shares issuable upon exercise of warrants to purchase common stock and shares issuable upon conversion of shares of Class A-1 convertible preferred stock, Class A-2 convertible preferred stock, Class A-3 convertible preferred stock, Class A-4 convertible preferred stock, Class A-5 convertible preferred stock, and Class A-6 convertible preferred stock held by GEO V, which limit the number of shares the NEA Reporting Persons can beneficially own to a maximum of 9.99% of our outstanding common stock.

 (4)

 Consists of (i) 4,637,076 shares of common stock and 2,212,400 shares of common stock issuable upon conversion of Class A-6 convertible preferred stock (collectively the "Octagon shares") held by Octagon Investments Master Fund LP and (by Octagon Private Opportunities Fund II LP. The number of shares beneficially owned by the Octagon entities is limited by beneficial ownership limitations applicable to shares of Class A-6 convertible preferred stock, which limit the number of shares the Octagon entities can beneficially own to a maximum of 9.99% of our outstanding common stock. The entities affiliated with Octagon are managed by Octagon Capital Advisors LP.

 (5)

 Consists of 5,000,000 shares of common stock held by Vivo Opportunity Fund Holdings, L.P. Vivo Opportunity, LLC is the general partner of Vivo Opportunity Fund Holdings, L.P.

 (6)

 Consists of 4,236,569 shares held by BlackRock, Inc.

 (7)

 Consist of 3,967,091 shares held by The Vanguard Group.

 (8)

 Consists of 22,169 shares of common stock held by Dr. Baltimore and 154,975 shares of common stock that Dr. Baltimore has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options. Does not include shares beneficially owned by Dr. Huang and reflected in note (12) below. Drs. Baltimore and Huang are spouses and therefore they may be deemed to beneficially own the shares held by one another.

 (9)

 Consists of 56,728 shares of common stock held by Ms. Calsada and 487,018 shares of common stock that Ms. Calsada has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (10)

 Consists of 6,740 shares of common stock held by Ms. Collier and 154,975 shares of common stock that Ms. Collier has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (11)

 Consists of (i) 290,808 shares of common stock held by Joseph P. Hagan and 1,496,385 shares of common stock that Mr. Hagan has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options and 2,976 shares of common stock issuable upon the exercise of warrants to purchase common stock.

 (12)

 Consists of 156,000 shares of common stock that Dr. Huang has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options. Does not include shares beneficially owned by Dr. Baltimore and reflected in note (8) above. Drs. Baltimore and Huang are spouses and therefore they may be deemed to beneficially own the shares held by one another.

 (13)

 Consists of 36,055 shares of common stock held by Dr. Klassen and 494,394 shares of common stock that Dr. Klassen has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (14)

 Consists of 154,975 shares of common stock that Mr. Nunn has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (15)

 Consists of 978,388 shares of common stock, 59,514 shares of common stock issuable upon the exercise of warrants to purchase common stock and 154,975 shares of common stock that Dr. Papadopoulos has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (16)

 Consists of 39,056 shares of common stock and 154,975 shares of common stock that Dr. Rastetter has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options held by The Rastetter Family Trust (the "Rastetter Trust"). Dr. Rastetter is trustee of the Rastetter Trust and may be deemed to be the beneficial owner of the shares held by the Rastetter Trust.

 (17)

 Consists of 1,771 shares of common stock held by Dr. Rosen and 154,975 shares of common stock that Dr. Rosen has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (18)

 Consists of 4,733 shares of common stock, 6,770 shares of common stock issuable upon the conversion of Class A-2 preferred stock held by Pascale Witz and 154,975 shares of common stock that Ms. Witz has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 (19)

 Includes all shares described in notes (8) through (18) above, as well as 60,796 shares held by one other executive officer and 475,973 shares such executive officer has the right to acquire from us within 60 days of March 31, 2025 pursuant to the exercise of stock options.

 Equity Compensation Plan Information
 The following table provides information as of December 31, 2024, with respect to shares of our common stock that may be issued under our existing equity compensation plans:

 (a)

 (b)

 (c)

 Plan Category

securities to be
issued upon
exercise of
outstanding
options, awards,
warrants
and rights

 Weighted-averageexercise price of
outstanding
options, awards,
warrants and
rights (1)

securities
remaining
available for
future issuance
under equity
compensation
plans (excluding
securities reflected
in column (a))

 Equity compensation plans approved by stockholders:

 2012 Equity Incentive Plan

 13,275

 (2)

 $

 16.2157

 —

 2019 Equity Incentive Plan (4)

 14,895,913

 (3)

 $

 2.0046

 3,127,229

 2022 Employee Stock Purchase Plan (5)

 —

 —

 133,054

 Equity compensation plans not approved by stockholders:

 2021 Inducement Plan (6)

 530,000

 (2)

 $

 1.7166

 500,000

 (1)

 The weighted average exercise price does not take into account the shares subject to outstanding restricted stock units, including performance-based restricted stock units, which have no exercise price.

 (2)

 All shares issuable upon exercise of options.

 (3)

 Consists of 13,506,913 shares issuable upon exercise of options and 1,389,000 shares issuable upon settlement of restricted stock units, including 1,389,000 performance-based restricted stock units.

 (4)

 Pursuant to an "evergreen" provision contained in the 2019 Plan, on January 1 of each year through 2029, the number of shares authorized for issuance under the 2019 Plan is automatically increased by a number equal to 5% of the sum of (a) (i) the total number of shares of common stock outstanding on December 31st of the preceding calendar year plus (ii) the total number of shares of common stock issuable upon conversion of shares of convertible preferred stock outstanding on December 31st of the preceding calendar year plus (iii) the total number of shares of common stock issuable upon cash exercise of prefunded warrants outstanding on December 31st of the preceding calendar year or (b) a number determined by our Board of Directors that is less than the amount in the foregoing clause.

 (5)

 Pursuant to an "evergreen" provision contained in the 2022 Employee Stock Purchase Plan, on January 1 of each year from 2023 until (and including) 2032, the number of shares authorized for issuance under the 2022 Employee Stock Purchase Plan is automatically increased by a number equal to the least of: (a) 1% of the total number of shares of common stock outstanding on December 31st of the preceding calendar year; (b) 50,000 shares of common stock; and (c) a number determined by our Board of Directors that is less than the amounts set forth in the foregoing clauses (a) and (b).

 (6)

 The 2021 Inducement Plan, which was adopted by our Board of Directors in November 2021, provides for the grant of NSOs, stock appreciation rights, restricted stock awards, restricted stock unit awards, performance-based stock and cash awards, and other forms of equity compensation, or collectively, stock awards which may be granted only to persons as a material inducement to their commencement of employment with us, pursuant to Rule 5635(c)(4) of the Nasdaq Listing Rules. Our Board of Directors, or a duly authorized committee thereof, has the authority to administer the 2021 Inducement Plan. Our Board of Directors has delegated its authority to administer the 2021 Inducement Plan to our Compensation Committee under the terms of our Compensation Committee's charter. Grants under the 2021 Inducement Plan must be approved by the Compensation Committee (comprised of independent directors) or a majority of our independent directors (as defined in Rule 5605(a)(2) of the Nasdaq Listing Rules) in order to comply with the exemption from the stockholder approval requirement for "inducement grants" provided under Rule 5635(c)(4) of the Nasdaq Listing Rules. The terms of the Inducement Plan and awards granted thereunder are generally the same as the terms of our 2019 Plan as it relates to similar awards granted under our 2019 Plan. As of December 31, 2024, under the 2021 Inducement Plan, there were outstanding stock options to purchase 530,000 shares of our common stock and 500,000 shares of our common stock remained available for the grant of stock awards under the 2021 Inducement Plan.

 Item 13.

 Certain Relationships and Related Transactions and Director Independence

 TRANSACTIONS WITH RELATED PERSONS
 We have adopted a written related-person transactions policy that sets forth our policies and procedures regarding the identification, review, consideration, approval and oversight of "related-person transactions." A "related-person transaction" is a past, present or future transaction, arrangement or relationship (or any series of similar transactions, arrangements or relationships) in which we and any "related person" are participants involving an amount that exceeds the lesser of $120,000 or 1% of the average of our total assets at year-end of the last two completed fiscal years.
 Transactions involving compensation for services provided to us by an employee, consultant or director are not considered related-person transactions under this policy. A "related person," as determined since the beginning of our last fiscal year, is any executive officer, director or a holder of more than five percent of our common stock, including any of their immediate family members and any entity owned or controlled by such persons.
 The policy imposes an affirmative duty upon each director and executive officer to identify any transaction involving them, their affiliates or immediate family members that may be considered a related party transaction before such person engages in the transaction. Under the policy, where a transaction has been identified as a related-person transaction, management must present information regarding the proposed related-person transaction to our audit committee (or, where review by our audit committee would be inappropriate, to another independent body of our Board of Directors) for review. The presentation must include a description of, among other things, the material facts, the direct and indirect interests of the related persons, the benefits of the transaction to us and whether any alternative transactions are available. In considering related-person transactions, our audit committee or other independent body of our Board of Directors takes into account the relevant available facts and circumstances including, but not limited to:

 •

 the risks, costs and benefits to us of the transaction;

 •

 the impact on a director's independence in the event the related person is a director, immediate family member of a director or an entity with which a director is affiliated;

 •

 the terms of the transaction;

 •

 the availability of other sources for comparable services or products; and

 •

 the terms available to or from, as the case may be, unrelated third parties or to or from our employees generally.

 In the event a director has an interest in the proposed transaction, the director must recuse himself or herself from the deliberations and approval. Our policy requires that, in reviewing a related party transaction, our audit committee must consider, in light of known circumstances, and determine in the good faith exercise of its discretion whether the transaction is in, or is not inconsistent with, the best interests of us and our stockholders.
 Other than those transactions related to executive and director compensation that are not required to be disclosed under this Item pursuant to the instructions to Item 404 of Regulation S-K, we describe below transactions and series of similar transactions, since January 1, 2023 with respect to which we were a party, will be a party, or otherwise benefited, in which:

 •

 the amounts involved exceeded or will exceed the lesser of $120,000 or 1% of the average of our total assets at year end of the last two completed fiscal years; and

 •

 a director, executive officer, holder of more than 5% of our common stock or any member of their immediate family had or will have a direct or indirect material interest.

 We also describe below certain other transactions with our directors, executive officers and stockholders. We believe that the terms obtained or consideration that we paid or received, as applicable, in connection with the transactions described below were comparable to terms available or the amounts that would be paid or received, as applicable, in arm's-length transactions.
 Private Placement Financing Transactions
 On March 11, 2024, we entered into a Securities Purchase Agreement (the "2024 Purchase Agreement") with certain institutional and other accredited investors, pursuant to which we agreed to sell and issue shares of common stock and shares of our newly designated non-voting convertible preferred stock (the "2024 Private Placement").

 On March 14, 2024, we completed the closing of the 2024 Private Placement (the "2024 Closing") pursuant to which we sold and issued (i) 45,108,667 shares of common stock at a purchase price of $1.60 per share, and (ii) 173,915 shares of non-voting Class A-6 convertible preferred stock, in lieu of shares of common stock, at a price of $160.00 per share. Each share of non-voting Class A-6 convertible preferred stock is convertible into 100 shares of common stock, subject to certain beneficial ownership conversion limitations.
 The participants in the 2024 Private Placement included the following directors and holders of more than five percent of our common stock or entities affiliated with them. The following table sets forth the aggregate number of shares of common stock and Class A-6 convertible preferred stock issued to these related parties in the 2024 Closing.

 Name of Related Person

 Common
Stock
Issued in
the 2024
Closing

 Class A-6Convertible
Preferred
Stock
Issued in
the 2024
Closing

 Aggregate
Purchase Price of
Common Stock
and Preferred
Stock Purchased
in the Private
Placement

 Federated Hermes Kaufmann Funds

 8,977,076

 66,480

 $

 25,000,121.60

 Entities affiliated with New Enterprise Associates, Inc.

 4,522,223

 17,278

 $

 10,000,036.80

 Entities affiliated with DAFNA Life Science Funds

 625,000

 —

 $

 1,000,000.00

 Stelios Papadopoulos, Ph. D.
 Chair of the Board

 250,000

 —

 $

 400,000.00

 On April 13, 2023, we entered into a Securities Purchase Agreement (the "2023 Purchase Agreement") with certain institutional and other accredited investors, pursuant to which we agreed to sell and issue shares of common stock and shares of our non-voting Class A-5 convertible preferred stock (the "2023 Private Placement").
 On April 14, 2023, we completed the closing of the 2023 Private Placement (the "2023 Closing") pursuant to which we sold and issued (i) 2,615,536 shares of common stock at a purchase price of $0.9001 per share, and (ii) 140,827 shares of non-voting Class A-5 convertible preferred stock, in lieu of shares of common stock, at a price of $90.01 per share. Each share of non-voting Class A-5 convertible preferred stock is convertible into 100 shares of common stock, subject to certain beneficial ownership conversion limitations.
 The participants in the 2023 Private Placement included the following directors and holders of more than five percent of our common stock or entities affiliated with them. The following table sets forth the aggregate number of shares of common stock and Class A-5 convertible preferred stock issued to these related parties in the 2023 Closing.

 Name of Related Person

 Common
Stock
Issued in
the 2023
Closing

 Class A-5Convertible
Preferred
Stock
Issued in
the 2023
Closing

 Aggregate
Purchase Price of
Common Stock
and Preferred
Stock Purchased
in the Private
Placement

 Federated Hermes Kaufmann Funds

 970,752

 90,282

 $

 9,000,056.70

 Entities affiliated with New Enterprise Associates, Inc.

 500,465

 50,545

 $

 5,000,024.00

 Stelios Papadopoulos, Ph. D.
 Chair of the Board

 222,198

 —

 $

 200,000.42

 Indemnification Agreements
 We have entered into separate indemnification agreements with our directors and executive officers, in addition to the indemnification provided for in our bylaws. These agreements, among other things, require us to indemnify our directors and executive officers for certain expenses, including attorneys' fees, judgments, fines and settlement amounts incurred by a director or executive officer in any action or proceeding arising out of his or her services as one of our directors or executive officers or any other company or enterprise to which the person provides services at our request. We believe that these indemnification agreements, together with the provisions in our bylaws, are necessary to attract and retain qualified persons as directors and officers.

 INDEPENDENCE OF THE BOARD OF DIRECTORS

 As required under the Nasdaq Stock Market ("Nasdaq") listing standards, a majority of the members of a listed company's Board of Directors must qualify as "independent," as affirmatively determined by the Board of Directors. The Board of Directors consults with the Company's counsel to ensure that the Board of Directors' determinations are consistent with relevant securities and other laws and regulations regarding the definition of "independent," including those set forth in pertinent listing standards of Nasdaq, as in effect from time to time.
 Consistent with these considerations, after review of all relevant identified transactions or relationships between each director, or any of his family members, and the Company, its senior management and its independent auditors, the Board of Directors has affirmatively determined that all of our directors, except for Mr. Hagan and Dr. Klassen who are executive officers of the Company, are independent directors within the meaning of the applicable Nasdaq listing standards.

 Item 14.

 Principal Accounting Fees and Services

 PRINCIPAL ACCOUNTING FEES AND SERVICES

 Our independent registered public accounting firm is Ernst & Young LLP, San Diego, California, Auditor Firm ID: 42.
 The following table represents aggregate fees incurred by the Company for the fiscal years ended December 31, 2024 and December 31, 2023, by Ernst & Young LLP ("Ernst & Young"), the Company's principal accountant. All fees described below were pre-approved
 by the Audit Committee.

 Fiscal Year
Ended

 2024

 2023

 (in thousands)

 Audit Fees (1)

 $

 $

 Audit-related Fees

 —

 —

 Tax Fees

 —

 —

 All Other Fees

 —

 —

 Total Fees

 $

 $

 (1)

 Audit fees consist of fees incurred for professional services by Ernst & Young for audit and quarterly review of our financial statements and review of our registration statements on Form S-3
 and Form S-8,
 and related services that are normally provided in connection with statutory and regulatory filings or engagements.

 In connection with the audit of each of the 2024 and 2023 financial statements, the Company entered into engagement agreements with Ernst & Young, which sets forth the terms by which Ernst & Young will perform audit services for the Company. Such agreements are subject to alternative dispute resolution procedures.
 Pre-Approval
 Policies and Procedures

 The Audit Committee must pre-approve
 all audit, audit-related and permitted non-audit
 services rendered by the Company's independent registered public accounting firm, and the related fees and terms. Pre-approval
 may be given as part of the Audit Committee's approval of the scope of the engagement of the independent auditor or on an individual, explicit, case-by-case

 basis before the independent auditor is engaged to provide each service. The pre-approval
 of services may be delegated to one or more members of the Audit Committee, but the decision must be reported to the full Audit Committee at its next scheduled meeting. The Chair of the Audit Committee, in his or her sole discretion, shall have the authority to pre-approve up to $50,000 in services on behalf of the Audit Committee.

 Item 15.

 Exhibits, Financial Statement Schedules

 Financial Statements. No financial statements are filed with this Amendment. These items were included as part of the Original Filing.
 Financial Statement Schedules. Financial statement schedules have been omitted because they are either not required, not applicable, or the information is otherwise included in the Original Filing.
 Exhibits. The exhibits listed in the Original Filing are required by Item 601 of Regulation S-K. A list of the exhibits filed with this Amendment are provided below.

 3.1

 Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on August 3, 2016.

 3.2

 Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on October 2, 2018).

 3.3

 Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant. (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on June 16, 2021).

 3.4

 Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on June 27, 2022).

 3.5

 Certificate of Designation of Preferences, Rights and Limitations of Class A-1 Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on May 9, 2019).

 3.6

 Certificate of Designation of Preferences, Rights and Limitations of Class A-2 Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on December 26, 2019).

 3.7

 Certificate of Designation of Preferences, Rights and Limitations of Class A-3 Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrants' Current Report on Form 8-K (File No. 001-35670) filed with the SEC on December 4, 2020).

 3.8

 Certificate of Designation of Preferences, Rights and Limitations of Class A-4 Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (file No. 001-35670), filed with the SEC on November 30, 2021).

 3.9

 Certificate of Amendment to the Certificate of Designation of Preferences, Rights and Limitations of Class A-1 Convertible Preferred Stock (incorporated by reference to Exhibit 3.2 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on December 4, 2020).

 3.10

 Certificate of Amendment to the Certificate of Designation of Preferences, Rights and Limitations of Class A-2 Convertible Preferred Stock (incorporated by reference to Exhibit 3.3 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on December 4, 2020).

 3.11

 Certificate of Designation of Preferences, Rights and Limitations of Class A-5 Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (file No. 001-35670), filed with the SEC on April 13, 2023).

 3.12

 Certificate of Decrease of Class A-1 Convertible Preferred Stock, Class A-2 Convertible Preferred Stock and Class A-3 Convertible Preferred Stock (incorporated by reference to Exhibit 3.12 to the Registrant's Annual Report on Form 10-K (File No. 001-35670), filed with the SEC on March 21, 2024).

 3.13

 Certificate of Designation of Preferences, Rights and Limitations of Class A-6 Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K, filed with the SEC on March 14, 2024).

 3.14

 Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on June 8, 2016).

 4.1

 Reference is made to Exhibits 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 3.10, 3.11, 3.12, 3.13 and 3.14.

 4.2

 Form of Common Stock Certificate of the Registrant (incorporated by reference to Exhibit 4.2 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on August 11, 2022).

 4.3

 Description of Common Stock (incorporated by reference to Exhibit 4.3 to the Original Filing).

 4.4

 Form of Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.2 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on December 4, 2020).

 10.1*

 Form of Indemnity Agreement between the Registrant and its directors and officers (incorporated by reference to Exhibit 10.1 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-183384), originally filed with the SEC on August 17, 2012).

 10.2*

 Regulus Therapeutics Inc 2012 Equity Incentive Plan and Form of Stock Option Agreement and Form of Stock Option Grant Notice thereunder (incorporated by reference to Exhibit 10.3 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-183384), originally filed with the SEC on August 17, 2012).

 10.3*

 Non-Employee Director Compensation Policy, as amended (incorporated by reference to Exhibit 10.6 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on November 12, 2019).

 10.4*

 Regulus Therapeutics Inc. 2022 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on August 11, 2022).

 10.5*

 Regulus Therapeutics Inc. 2019 Equity Incentive Plan, as amended (incorporated by reference to Exhibit 99.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on May 17, 2024).

 10.6*

 Form of Stock Option Grant Notice and Option Agreement under the Regulus Therapeutics Inc. 2019 Equity Incentive Plan (incorporated by reference to Exhibit 99.2 to the Registrant's Registration Statement on Form S-8 (Registration No. 333-233414, filed with the SEC on August 22, 2019).

 10.7*

 Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement under the Regulus Therapeutics Inc. 2019 Equity Incentive Plan (incorporated by reference to Exhibit 99.3 to the Registrant's Registration Statement on Form S-8 (Registration No. 333-233414, filed with the SEC on August 22, 2019).

 10.8*

 Regulus Therapeutics Inc. 2021 Inducement Plan, as amended (incorporated by reference to Exhibit 99.5 to the Registrant's Registration Statement on Form S-8 (File No. 333-276484), filed with the SEC on January 12, 2024).

 10.9*

 Form of Stock Option Grant Notice, Form of Option Agreement and Notice of Exercise under the Regulus Therapeutics Inc. 2021 Inducement Plan (incorporated by reference to Exhibit 99.6 to the Registrant's Registration Statement on Form S-8 (File No. 333-269184), filed with the SEC on January 11, 2023).

 10.10*

 Employment Agreement, effective January 1, 2016, by and between the Registrant and Joseph P. Hagan (incorporated by reference to Exhibit 10.10 to the Registrant's Annual Report on Form 10-K (File No. 001-35670), filed with the SEC on February 23, 2016).

 10.11*

 Employment Agreement between the Registrant and Christopher Aker, dated July 24, 2018 (incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on May 10, 2019).

 10.12*

 Employment Agreement between the Registrant and Cris Calsada, dated August 30, 2019 (incorporated by reference to Exhibit 10.7 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on November 12, 2019).

 10.13*

 Employment Agreement, by and between the Registrant and Preston Klassen, M.D., dated June 12, 2023 (incorporated by reference to Exhibit 10.2 to the Registrant's Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on August 8, 2023.

 10.14*

 Joseph P. Hagan, Yearly Discretionary Base Salary Increase, effective January 1, 2025 (incorporated by reference to Exhibit 10.14 to the Original Filing).

 10.15*

 Christopher Aker, Yearly Discretionary Base Salary Increase, effective January 1, 2025 (incorporated by reference to Exhibit 10.15 to the Original Filing).

 10.16*

 Cris Calsada, Yearly Discretionary Base Salary Increase, effective January 1, 2025 (incorporated by reference to Exhibit 10.16 to the Original Filing).

 10.17*

 Preston Klassen, Yearly Discretionary Base Salary Increase, effective January 1, 2025 (incorporated by reference to Exhibit 10.17 to the Original Filing).

 10.18

 Amended and Restated License and Collaboration Agreement among the Registrant, Alnylam Pharmaceuticals, Inc. and Ionis Pharmaceuticals, Inc. (formerly known as Isis Pharmaceuticals, Inc.), dated January 1, 2009 (incorporated by reference to Exhibit 10.3 to the Registrant's Registration Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on May 14, 2021).

 10.19

 Amendment Number One to the Amended and Restated License and Collaboration Agreement among the Registrant, Alnylam Pharmaceuticals, Inc. and Ionis Pharmaceuticals, Inc. (formerly known as Isis Pharmaceuticals, Inc.), dated June 10, 2010 (incorporated by reference to Exhibit 10.4 to the Registrant's Registration Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on May 14, 2021).

 10.20

 Amendment Number Two to the Amended and Restated License and Collaboration Agreement among the Registrant, Alnylam Pharmaceuticals, Inc. and Ionis Pharmaceuticals, Inc. (formerly known as Isis Pharmaceuticals, Inc.), dated October 25, 2011 (incorporated by reference to Exhibit 10.5 to the Registrant's Registration Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on May 14, 2021).

 10.21

 Amendment Number Three to the Amended and Restated License and Collaboration Agreement among the Company, Alnylam Pharmaceuticals, Inc. and Isis Pharmaceuticals, Inc., dated August 2, 2013 (incorporated by reference to Exhibit 10.6 to the Registrant's Registration Quarterly Report on Form 10-Q (File No. 001-35670), filed with the SEC on May 14, 2021).

 10.22

 Assignment Agreement between the Registrant and Ionis Pharmaceuticals, Inc. (formerly known as Isis Pharmaceuticals, Inc.), dated July 13, 2009 (incorporated by reference to Exhibit 10.26 to the Registrant's Registration Statement on Form S-1, as amended (File No. 333-183384), originally filed with the SEC on August 17, 2012).

 10.23

 Lease Agreement, dated February 11, 2021, by and between the Registrant and ARE-SD Region No. 44 LLC (incorporated by reference to Exhibit 10.44 to the Registrant's Annual Report on Form 10-K (File No. 001-35670), filed with the SEC on March 9, 2021).

 10.24

 Assignment and Assumption of Lease, dated February 11, 2021, by and between the Registrant and Turning Point Therapeutics, Inc. (incorporated by reference to Exhibit 10.45 to the Registrant's Annual Report on Form 10-K (File No. 001-35670), filed with the SEC on March 9, 2021)

 10.25

 First Amendment to Lease Agreement, dated as of February 28, 2025, by and between the Registrant and ARE-SD Region No. 61, LLC (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on March 4, 2025).

 10.26 W

 Securities Purchase Agreement, dated March 11, 2024, by and among the Company and the Purchasers thereto (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on March 14, 2024).

 10.27 W

 Patent & Technology License Agreement, dated as of October 22, 2024, by and between Regulus Therapeutics Inc. and The Board of Regents of The University of Texas System, an agency of the State of Texas on behalf of The University of Texas at Southwestern Medical Center (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K (File No. 001-35670), filed with the SEC on October 24, 2024).

 19.1

 Insider Trading Policy (incorporated by reference to Exhibit 19.1 to the Original Filing).

 23.1

 Consent of Independent Registered Public Accounting Firm (previously filed with the Original Filing).

 24.1

 Power of Attorney. Reference is made to the signature page hereto (previously filed with the Original Filing).

 31.1

 Certification of the Principal Executive Officer pursuant to Rule 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934 (previously filed with the Original Filing).

 31.2

 Certification of the Principal Financial Officer pursuant to Rule 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934 (previously filed with the Original Filing).

 31.3

 Certification of the Principal Executive Officer pursuant to Rule 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934.

 31.4

 Certification of the Principal Financial Officer pursuant to Rule 13a-14(a) or 15d-14(a) of the Securities Exchange Act of 1934.

 32.1**

 Certification of the Principal Executive Officer and Principal Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (previously filed with the Original Filing).

 Incentive Compensation Recoupment Policy (incorporated by reference to Exhibit 97 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on March 21, 2024).

 101.INS

 101.SCH

 101.CAL

 101.DEF

 101.LAB

 101.PRE

 Certain portions of this exhibit (indicated by "[***]") have been omitted pursuant to Item 601(b)(10)(iv) of Regulation S-K.

 W

 Schedules and exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K.

 *

 Indicates management contract or compensatory plan.

 **

 This certification is being furnished solely to accompany this annual report pursuant to 18 U.S.C. Section 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934 and is not to be incorporated by reference into any filing of the Registrant, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

 SIGNATURES
 Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 Regulus Therapeutics Inc.

 Date: April 30, 2025

 By:

 /s/ Cris Calsada

 Chief Financial Officer

 (Principal Financial Officer)